 G-Quadruplexes
"G-Quadruplexes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
| Descriptor ID |
D054856
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| MeSH Number(s) |
G02.111.570.790.486.550 G05.360.580.550
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| Concept/Terms |
G-Quadruplexes- G-Quadruplexes
- G Quadruplexes
- Guanine-Quadruplexes
- Guanine Quadruplexes
Guanine-Tetrads- Guanine-Tetrads
- Guanine Tetrads
- Guanine-Tetrad
- Guanine-Quartets
- Guanine Quartets
- Guanine-Quartet
G-Quadruplexes, DNA- G-Quadruplexes, DNA
- G Quadruplexes, DNA
- Tetraplex DNA
- DNA, Tetraplex
- DNA G-Quadruplexes
- DNA G Quadruplexes
- DNA, Quadruplex
- Quadruplex DNA
G-Quadruplexes, RNA- G-Quadruplexes, RNA
- G Quadruplexes, RNA
- RNA G-Quadruplexes
- RNA, G-Quadruplexes
- G-Quadruplexes RNA
- G-Quadruplexes RNAs
- RNA, G Quadruplexes
- RNAs, G-Quadruplexes
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Below are MeSH descriptors whose meaning is more general than "G-Quadruplexes".
Below are MeSH descriptors whose meaning is more specific than "G-Quadruplexes".
This graph shows the total number of publications written about "G-Quadruplexes" by people in this website by year, and whether "G-Quadruplexes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "G-Quadruplexes" by people in Profiles.
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Rocher V, Genais M, Nassereddine E, Mourad R. DeepG4: A deep learning approach to predict cell-type specific active G-quadruplex regions. PLoS Comput Biol. 2021 08; 17(8):e1009308.
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Shelke SA, Shao Y, Laski A, Koirala D, Weissman BP, Fuller JR, Tan X, Constantin TP, Waggoner AS, Bruchez MP, Armitage BA, Piccirilli JA. Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif. Nat Commun. 2018 10 31; 9(1):4542.
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Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA. Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen. Nucleic Acids Res. 2016 Nov 16; 44(20):9565-9577.
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DasGupta S, Shelke SA, Li NS, Piccirilli JA. Spinach RNA aptamer detects lead(II) with high selectivity. Chem Commun (Camb). 2015 May 28; 51(43):9034-7.
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Jiang HX, Cui Y, Zhao T, Fu HW, Koirala D, Punnoose JA, Kong DM, Mao H. Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures. Sci Rep. 2015 Mar 19; 5:9255.
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Abraham Punnoose J, Cui Y, Koirala D, Yangyuoru PM, Ghimire C, Shrestha P, Mao H. Interaction of G-quadruplexes in the full-length 3' human telomeric overhang. J Am Chem Soc. 2014 Dec 31; 136(52):18062-9.
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Selvam S, Koirala D, Yu Z, Mao H. Quantification of topological coupling between DNA superhelicity and G-quadruplex formation. J Am Chem Soc. 2014 Oct 08; 136(40):13967-70.
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Huang H, Suslov NB, Li NS, Shelke SA, Evans ME, Koldobskaya Y, Rice PA, Piccirilli JA. A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol. 2014 Aug; 10(8):686-91.
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Yangyuoru PM, Zhang AY, Shi Z, Koirala D, Balasubramanian S, Mao H. Mechanochemical properties of individual human telomeric RNA (TERRA) G-quadruplexes. Chembiochem. 2013 Oct 11; 14(15):1931-5.
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Dhakal S, Cui Y, Koirala D, Ghimire C, Kushwaha S, Yu Z, Yangyuoru PM, Mao H. Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions. Nucleic Acids Res. 2013 Apr 01; 41(6):3915-23.
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