 Protein Unfolding
"Protein Unfolding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Conformational transitions of the shape of a protein to various unfolded states.
| Descriptor ID |
D058767
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| MeSH Number(s) |
E05.793 G01.154.100.640.750 G01.595.100.640.750 G02.111.087.690.750 G02.149.115.690.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Unfolding".
Below are MeSH descriptors whose meaning is more specific than "Protein Unfolding".
This graph shows the total number of publications written about "Protein Unfolding" by people in this website by year, and whether "Protein Unfolding" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Unfolding" by people in Profiles.
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Pan M, Zheng Q, Yu Y, Ai H, Xie Y, Zeng X, Wang C, Liu L, Zhao M. Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat Commun. 2021 01 05; 12(1):121.
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Bowman MA, Riback JA, Rodriguez A, Guo H, Li J, Sosnick TR, Clark PL. Properties of protein unfolded states suggest broad selection for expanded conformational ensembles. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23356-23364.
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Wei Y, Wang C, Jiang B, Sun CC, Middaugh CR. Developing Biologics Tablets: The Effects of Compression on the Structure and Stability of Bovine Serum Albumin and Lysozyme. Mol Pharm. 2019 03 04; 16(3):1119-1131.
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Rimmerman D, Leshchev D, Hsu DJ, Hong J, Abraham B, Henning R, Kosheleva I, Chen LX. Probing Cytochrome c Folding Transitions upon Phototriggered Environmental Perturbations Using Time-Resolved X-ray Scattering. J Phys Chem B. 2018 05 24; 122(20):5218-5224.
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Chin J, Mustafi D, Poellmann MJ, Lee RC. Amphiphilic copolymers reduce aggregation of unfolded lysozyme more effectively than polyethylene glycol. Phys Biol. 2017 02 08; 14(1):016003.
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Skinner JJ, Yu W, Gichana EK, Baxa MC, Hinshaw JR, Freed KF, Sosnick TR. Benchmarking all-atom simulations using hydrogen exchange. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):15975-80.
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Wang L, Popko B, Tixier E, Roos RP. Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol Dis. 2014 Nov; 71:317-24.
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Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, Rice DW, Freire E, McLeod R, Prigge ST. Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry. 2013 Dec 23; 52(51):9155-66.
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Yoo TY, Meisburger SP, Hinshaw J, Pollack L, Haran G, Sosnick TR, Plaxco K. Small-angle X-ray scattering and single-molecule FRET spectroscopy produce highly divergent views of the low-denaturant unfolded state. J Mol Biol. 2012 May 04; 418(3-4):226-36.
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Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9.
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