 Wnt Signaling Pathway
"Wnt Signaling Pathway" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A complex signaling pathway whose name is derived from the DROSOPHILA Wg gene, which when mutated results in the wingless phenotype, and the vertebrate INT gene, which is located near integration sites of MOUSE MAMMARY TUMOR VIRUS. The signaling pathway is initiated by the binding of WNT PROTEINS to cells surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN.
| Descriptor ID |
D060449
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| MeSH Number(s) |
G02.149.115.800.925
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| Concept/Terms |
Wnt Signaling Pathway- Wnt Signaling Pathway
- Pathway, Wnt Signaling
- Pathways, Wnt Signaling
- Signaling Pathway, Wnt
- Signaling Pathways, Wnt
- Wnt Signaling Pathways
- Wnt Pathway
- Pathway, Wnt
- Pathways, Wnt
- Wnt Pathways
Wnt beta-Catenin Signaling Pathway- Wnt beta-Catenin Signaling Pathway
- Wnt beta Catenin Signaling Pathway
- Wnt Pathway, Canonical
- Canonical Wnt Pathway
- Canonical Wnt Pathways
- Pathway, Canonical Wnt
- Pathways, Canonical Wnt
- Wnt Pathways, Canonical
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Below are MeSH descriptors whose meaning is more general than "Wnt Signaling Pathway".
Below are MeSH descriptors whose meaning is more specific than "Wnt Signaling Pathway".
This graph shows the total number of publications written about "Wnt Signaling Pathway" by people in this website by year, and whether "Wnt Signaling Pathway" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2011 | 1 | 0 | 1 | | 2012 | 0 | 3 | 3 | | 2013 | 5 | 5 | 10 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 1 | 3 | | 2016 | 1 | 3 | 4 | | 2017 | 4 | 2 | 6 | | 2018 | 2 | 2 | 4 | | 2019 | 1 | 2 | 3 | | 2020 | 1 | 3 | 4 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Wnt Signaling Pathway" by people in Profiles.
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Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484.
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Joshi P, Skromne I. A theoretical model of neural maturation in the developing chick spinal cord. PLoS One. 2020; 15(12):e0244219.
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Tsutsumi N, Mukherjee S, Waghray D, Janda CY, Jude KM, Miao Y, Burg JS, Aduri NG, Kossiakoff AA, Gati C, Garcia KC. Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife. 2020 08 07; 9.
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Hou Q, Dong Y, Yu Q, Wang B, Le S, Guo Y, Zhang B. Regulation of the Paneth cell niche by exogenous L-arginine couples the intestinal stem cell function. FASEB J. 2020 08; 34(8):10299-10315.
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El Andaloussi A, Al-Hendy A, Ismail N, Boyer TG, Halder SK. Introduction of Somatic Mutation in MED12 Induces Wnt4/ß-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell. Reprod Sci. 2020 03; 27(3):823-832.
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Wang X, Yuan C, Huang B, Fan J, Feng Y, Li AJ, Zhang B, Lei Y, Ye Z, Zhao L, Cao D, Yang L, Wu D, Chen X, Liu B, Wagstaff W, He F, Wu X, Luo H, Zhang J, Zhang M, Haydon RC, Luu HH, Lee MJ, Moriatis Wolf J, Huang A, He TC, Zeng Z. Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells. ACS Synth Biol. 2019 09 20; 8(9):2092-2105.
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Luke JJ, Bao R, Sweis RF, Spranger S, Gajewski TF. WNT/ß-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers. Clin Cancer Res. 2019 May 15; 25(10):3074-3083.
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Baeten JT, Waarts MR, Pruitt MM, Chan WC, Andrade J, de Jong JLO. The side population enriches for leukemia-propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia. Haematologica. 2019 07; 104(7):1388-1395.
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Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T, Salhia B, Carpten J, Llor X, Ellis NA. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis. 2018 12 13; 39(11):1331-1341.
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Sheng W, Zhang ZC, Shi DY, Wang BC, Wu Q, Shao ZW, Yang SH, He TC, Liu JX. Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation. Chem Biol Interact. 2018 Dec 25; 296:1-8.
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