"Protein Phosphatase 2C" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
|Protein Phosphatase 2C
- Protein Phosphatase 2C
- 2C, Protein Phosphatase
- Phosphatase 2C, Protein
- PPM1 Protein Phosphatases
- Phosphatases, PPM1 Protein
- Protein Phosphatases, PPM1
- Ptc2 Phosphatase
- Phosphatase, Ptc2
- PPM1 Magnesium-Dependent Protein Phosphatases
- PPM1 Magnesium Dependent Protein Phosphatases
Protein Phosphatase 2C delta
- Protein Phosphatase 2C delta
- Protein Phosphatase 1D Magnesium-Dependent, delta isoform
- Protein Phosphatase 1D Magnesium Dependent, delta isoform
- PPM1D Phosphatase
- Phosphatase, PPM1D
Below are MeSH descriptors whose meaning is more general than "Protein Phosphatase 2C".
Below are MeSH descriptors whose meaning is more specific than "Protein Phosphatase 2C".
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Below are the most recent publications written about "Protein Phosphatase 2C" by people in Profiles.
The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells. Cell Stem Cell. 2018 11 01; 23(5):634-635.
Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis. J Biol Chem. 2009 Jun 26; 284(26):17428-37.
MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008 Dec; 22(12):4126-35.