Pleckstrin Homology Domains
"Pleckstrin Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS.
|Pleckstrin Homology Domains
- Pleckstrin Homology Domains
- Domain, Pleckstrin Homology
- Domains, Pleckstrin Homology
- Homology Domain, Pleckstrin
- Homology Domains, Pleckstrin
- PH Domain
- Domain, PH
- Domains, PH
- PH Domains
- Pleckstrin Homology Domain
Below are MeSH descriptors whose meaning is more general than "Pleckstrin Homology Domains".
Below are MeSH descriptors whose meaning is more specific than "Pleckstrin Homology Domains".
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Below are the most recent publications written about "Pleckstrin Homology Domains" by people in Profiles.
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun. 2017 12 13; 8(1):2101.
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1. Oncotarget. 2016 Nov 15; 7(46):75023-75037.