"Catalytic Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
| Descriptor ID |
D020134
|
| MeSH Number(s) |
G02.111.570.120.704 G02.111.570.820.709.275.750.188
|
| Concept/Terms |
Catalytic Domain- Catalytic Domain
- Catalytic Domains
- Domain, Catalytic
- Domains, Catalytic
- Catalytic Subunit
- Catalytic Subunits
- Subunit, Catalytic
- Subunits, Catalytic
- Catalytic Region
- Catalytic Regions
- Region, Catalytic
- Regions, Catalytic
- Catalytic Core
- Catalytic Cores
- Core, Catalytic
- Cores, Catalytic
Active Site- Active Site
- Active Sites
- Site, Active
- Sites, Active
- Catalytic Site
- Catalytic Sites
- Site, Catalytic
- Sites, Catalytic
- Reactive Site
- Reactive Sites
- Site, Reactive
- Sites, Reactive
|
Below are MeSH descriptors whose meaning is more general than "Catalytic Domain".
Below are MeSH descriptors whose meaning is more specific than "Catalytic Domain".
This graph shows the total number of publications written about "Catalytic Domain" by people in this website by year, and whether "Catalytic Domain" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 2 | 2 |
| 2000 | 1 | 2 | 3 |
| 2001 | 1 | 3 | 4 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 5 | 5 |
| 2006 | 0 | 6 | 6 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 6 | 6 |
| 2009 | 0 | 9 | 9 |
| 2010 | 0 | 7 | 7 |
| 2011 | 2 | 10 | 12 |
| 2012 | 1 | 6 | 7 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 8 | 8 |
| 2015 | 3 | 10 | 13 |
| 2016 | 0 | 5 | 5 |
| 2017 | 0 | 7 | 7 |
| 2018 | 1 | 4 | 5 |
| 2019 | 0 | 6 | 6 |
| 2020 | 1 | 4 | 5 |
| 2021 | 0 | 6 | 6 |
| 2023 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "Catalytic Domain" by people in Profiles.
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Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis. J Am Chem Soc. 2023 02 08; 145(5):2830-2839.
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Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'-S-phosphorothiolate Linkage. J Org Chem. 2021 10 01; 86(19):13231-13244.
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Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach. Bioorg Med Chem. 2021 10 01; 47:116393.
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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936.
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Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB. Protein Sci. 2021 09; 30(9):1904-1918.
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Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.
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Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 01 27; 12(1):636.
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A regulatory role of membrane by direct modulation of the catalytic kinase domain. Small GTPases. 2021 07; 12(4):246-256.
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Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2. Protein Sci. 2020 07; 29(7):1596-1605.
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The Positively Charged Active Site of the Bacterial Toxin RelE Causes a Large Shift in the General Base pKa. Biochemistry. 2020 05 05; 59(17):1665-1671.