Synthetic Lethal Mutations
"Synthetic Lethal Mutations" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mutations in genes which lead to cell or organism death when occurring in combination with mutations in one or more other genes.
| Descriptor ID |
D000072020
|
| MeSH Number(s) |
G05.365.590.917
|
| Concept/Terms |
Synthetic Lethal Mutations- Synthetic Lethal Mutations
- Synthetic Lethal Mutation
- Lethal Mutation, Synthetic
- Lethal Mutations, Synthetic
- Mutation, Synthetic Lethal
- Mutations, Synthetic Lethal
|
Below are MeSH descriptors whose meaning is more general than "Synthetic Lethal Mutations".
Below are MeSH descriptors whose meaning is more specific than "Synthetic Lethal Mutations".
This graph shows the total number of publications written about "Synthetic Lethal Mutations" by people in this website by year, and whether "Synthetic Lethal Mutations" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synthetic Lethal Mutations" by people in Profiles.
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Attenuation of SRC Kinase Activity Augments PARP Inhibitor-mediated Synthetic Lethality in BRCA2-altered Prostate Tumors. Clin Cancer Res. 2021 03 15; 27(6):1792-1806.
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NatB regulates Rb mutant cell death and tumor growth by modulating EGFR/MAPK signaling through the N-end rule pathways. PLoS Genet. 2020 06; 16(6):e1008863.