"Dysferlin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane protein that contains multiple C2 DOMAINS. It is highly expressed in skeletal muscle and functions as a calcium ion sensor in SYNAPTIC VESICLE-PLASMA MEMBRANE fusion, as well as in SARCOLEMMA repair following mechanical stress. Mutations in the dysferlin (DYSF) gene are associated with several hereditary MUSCULAR DYSTROPHIES.
| Descriptor ID |
D000073939
|
| MeSH Number(s) |
D12.776.210.500.248 D12.776.543.225
|
| Concept/Terms |
Dysferlin- Dysferlin
- Fer-1-like Protein 1
- Fer 1 like Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Dysferlin".
Below are MeSH descriptors whose meaning is more specific than "Dysferlin".
This graph shows the total number of publications written about "Dysferlin" by people in this website by year, and whether "Dysferlin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dysferlin" by people in Profiles.
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The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility. Matrix Biol. 2024 May; 129:44-58.
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Loss of dysferlin or myoferlin results in differential defects in excitation-contraction coupling in mouse skeletal muscle. Sci Rep. 2021 08 05; 11(1):15865.
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Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption. Am J Pathol. 2016 06; 186(6):1610-22.
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Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Hum Mol Genet. 2015 Oct 15; 24(20):5711-9.
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Dysferlin and myoferlin regulate transverse tubule formation and glycerol sensitivity. Am J Pathol. 2014 Jan; 184(1):248-59.
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Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. J Biol Chem. 2011 Mar 04; 286(9):7379-88.
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Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy. Hum Mol Genet. 2011 Feb 15; 20(4):779-89.
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Diaphragm displays early and progressive functional deficits in dysferlin-deficient mice. Muscle Nerve. 2010 Jul; 42(1):22-9.
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Genetic manipulation of dysferlin expression in skeletal muscle: novel insights into muscular dystrophy. Am J Pathol. 2009 Nov; 175(5):1817-23.
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Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. J Biol Chem. 2007 Oct 19; 282(42):30745-53.