"Neurofibromin 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A membrane protein homologous to the ERM (Ezrin-Radixin-Moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. Alterations in neurofibromin 2 are the cause of NEUROFIBROMATOSIS 2.
| Descriptor ID |
D025581
|
| MeSH Number(s) |
D12.776.543.685 D12.776.624.776.612
|
| Concept/Terms |
Neurofibromin 2- Neurofibromin 2
- Moesin-Ezrin-Radixin-Like Protein
- Moesin Ezrin Radixin Like Protein
- Schwannomin Protein
- Protein, Schwannomin
- Neurofibromatosis Type 2 Protein
- NF2 Gene Product
- Gene Product, NF2
- Schwannomin
- Merlin
- Neurofibromatosis 2 Gene Product
|
Below are MeSH descriptors whose meaning is more general than "Neurofibromin 2".
Below are MeSH descriptors whose meaning is more specific than "Neurofibromin 2".
This graph shows the total number of publications written about "Neurofibromin 2" by people in this website by year, and whether "Neurofibromin 2" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2000 | 1 | 1 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2021 | 0 | 2 | 2 |
| 2022 | 2 | 1 | 3 |
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Below are the most recent publications written about "Neurofibromin 2" by people in Profiles.
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Merlin immunohistochemistry is useful in diagnosis of tumours within the spectrum of biphasic hyalinizing psammomatous renal cell carcinoma. Histopathology. 2022 Nov; 81(5):577-586.
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The emerging role of NF2 alterations in new and established subtypes of renal cell carcinoma. Hum Pathol. 2023 03; 133:87-91.
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NF2-mutated Renal Carcinomas Have Common Morphologic Features Which Overlap With Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma: A Comprehensive Study of 14 Cases. Am J Surg Pathol. 2022 05 01; 46(5):617-627.
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Spectrum of biphasic renal cell carcinomas with hyalinized stroma and psammoma bodies associated and not associated with NF2 alteration. Hum Pathol. 2022 03; 121:11-18.
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Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription. Elife. 2021 02 08; 10.
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Reply to K. Masuda et al. J Clin Oncol. 2019 09 01; 37(25):2294-2295.
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Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study. J Clin Oncol. 2019 04 01; 37(10):790-798.
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Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Dev Cell. 2017 03 13; 40(5):478-490.e3.
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In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. PLoS One. 2014; 9(3):e90853.
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9.