"NADPH Oxidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
| Descriptor ID |
D019255
|
| MeSH Number(s) |
D08.811.682.608.575 D12.776.331.894 D12.776.543.653
|
| Concept/Terms |
NADPH Oxidases- NADPH Oxidases
- Oxidases, NADPH
- NAD(P)H oxidase
- NADPH Oxidase
- Oxidase, NADPH
- Nox Proteins
- NAD(P)H Oxidases
|
Below are MeSH descriptors whose meaning is more general than "NADPH Oxidases".
Below are MeSH descriptors whose meaning is more specific than "NADPH Oxidases".
This graph shows the total number of publications written about "NADPH Oxidases" by people in this website by year, and whether "NADPH Oxidases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 1 | 0 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 1 | 1 |
| 2003 | 2 | 1 | 3 |
| 2004 | 0 | 1 | 1 |
| 2006 | 2 | 1 | 3 |
| 2007 | 1 | 2 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 3 | 3 | 6 |
| 2011 | 7 | 1 | 8 |
| 2012 | 2 | 3 | 5 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 3 | 5 |
| 2015 | 2 | 1 | 3 |
| 2016 | 2 | 1 | 3 |
| 2017 | 2 | 2 | 4 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "NADPH Oxidases" by people in Profiles.
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Mitochondria in human neutrophils mediate killing of Staphylococcus aureus. Redox Biol. 2022 02; 49:102225.
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Sorting nexin 1 loss results in increased oxidative stress and hypertension. FASEB J. 2020 06; 34(6):7941-7957.
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Superoxide anions mediate the effects of angiotensin (1-7) analog, alamandine, on blood pressure and sympathetic activity in the paraventricular nucleus. Peptides. 2019 08; 118:170101.
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Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease. Gastroenterology. 2018 06; 154(8):2097-2110.
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Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance. Front Cell Infect Microbiol. 2017; 7:373.
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Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein a Signaling. Immunity. 2017 08 15; 47(2):363-373.e5.
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Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017 08; 16(4):837-846.
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Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins. BMC Cell Biol. 2017 01 17; 18(Suppl 1):7.
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Eotaxin Augments Calcification in Vascular Smooth Muscle Cells. J Cell Biochem. 2017 03; 118(3):647-654.
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PKCe mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia. Atherosclerosis. 2016 10; 253:29-37.