Promyelocytic Leukemia Zinc Finger Protein
"Promyelocytic Leukemia Zinc Finger Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Krupple-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
| Descriptor ID |
D000075722
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| MeSH Number(s) |
D12.776.260.522.625 D12.776.930.375.625
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Promyelocytic Leukemia Zinc Finger Protein".
Below are MeSH descriptors whose meaning is more specific than "Promyelocytic Leukemia Zinc Finger Protein".
This graph shows the total number of publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in this website by year, and whether "Promyelocytic Leukemia Zinc Finger Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Promyelocytic Leukemia Zinc Finger Protein" by people in Profiles.
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The transcription factor BCL-6 controls early development of innate-like T cells. Nat Immunol. 2020 09; 21(9):1058-1069.
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Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils. JCI Insight. 2019 03 21; 4(6).
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A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863.
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Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7602-7.
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The Innate Lymphoid Cell Precursor. Annu Rev Immunol. 2016 05 20; 34:299-316.
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Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage. Nat Immunol. 2016 Mar; 17(3):269-76.
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Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016 Feb; 137(2):591-600.e1.
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PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A. 2015 Apr 21; 112(16):5123-8.
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PLZF staining identifies peripheral T-cell lymphomas derived from innate-like T-cells with TRAV1-2-TRAJ33 TCR-a rearrangement. Blood. 2014 Apr 24; 123(17):2742-3.
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A committed precursor to innate lymphoid cells. Nature. 2014 Apr 17; 508(7496):397-401.