Voltage-Gated Sodium Channels
"Voltage-Gated Sodium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of membrane proteins that selectively conduct SODIUM ions due to changes in the TRANSMEMBRANE POTENTIAL DIFFERENCE. They typically have a multimeric structure with a core alpha subunit that defines the sodium channel subtype and several beta subunits that modulate sodium channel activity.
| Descriptor ID |
D061566
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| MeSH Number(s) |
D12.776.157.530.400.875.750 D12.776.543.550.450.875.750 D12.776.543.585.400.875.750 D12.776.631.960
|
| Concept/Terms |
Voltage-Gated Sodium Channels- Voltage-Gated Sodium Channels
- Channels, Voltage-Gated Sodium
- Voltage Gated Sodium Channels
- Sodium Channels, Voltage-Gated
- Sodium Channels, Voltage Gated
|
Below are MeSH descriptors whose meaning is more general than "Voltage-Gated Sodium Channels".
Below are MeSH descriptors whose meaning is more specific than "Voltage-Gated Sodium Channels".
This graph shows the total number of publications written about "Voltage-Gated Sodium Channels" by people in this website by year, and whether "Voltage-Gated Sodium Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2013 | 2 | 1 | 3 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 4 | 0 | 4 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Voltage-Gated Sodium Channels" by people in Profiles.
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Molecular Dynamics Simulations of Ion Permeation in Human Voltage-Gated Sodium Channels. J Chem Theory Comput. 2023 May 23; 19(10):2953-2972.
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Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 2022 06; 29(6):537-548.
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Continuum Gating Current Models Computed with Consistent Interactions. Biophys J. 2019 01 22; 116(2):270-282.
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Molecular Dynamics of Ion Conduction through the Selectivity Filter of the NaVAb Sodium Channel. J Phys Chem B. 2018 11 08; 122(44):10126-10142.
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The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation. J Gen Physiol. 2018 09 03; 150(9):1333-1347.
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Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932.
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Nav channel binder containing a specific conjugation-site based on a low toxicity ß-scorpion toxin. Sci Rep. 2017 11 27; 7(1):16329.
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Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):E1857-E1865.
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A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14.
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EPR Studies of Gating Mechanisms in Ion Channels. Methods Enzymol. 2015; 557:279-306.