Polycomb Repressive Complex 2
"Polycomb Repressive Complex 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex that catalyzes the METHYLATION of chromosomal HISTONE H3. It works in conjunction with POLYCOMB REPRESSIVE COMPLEX 1 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063151
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| MeSH Number(s) |
D05.500.781.750 D08.811.913.555.500.800.400.500 D12.776.660.235.600.200 D12.776.664.235.800.200 D12.776.930.780.890.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 2".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 2".
This graph shows the total number of publications written about "Polycomb Repressive Complex 2" by people in this website by year, and whether "Polycomb Repressive Complex 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 3 | 0 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 3 | 0 | 3 |
| 2018 | 3 | 0 | 3 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Polycomb Repressive Complex 2" by people in Profiles.
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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing. Mol Cell. 2022 12 15; 82(24):4611-4626.e7.
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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 10; 54(10):1514-1526.
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The roles of Polycomb repressive complexes in mammalian development and cancer. Nat Rev Mol Cell Biol. 2021 05; 22(5):326-345.
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CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Sci Adv. 2019 07; 5(7):eaax2887.
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Targeting the MTF2-MDM2 Axis Sensitizes Refractory Acute Myeloid Leukemia to Chemotherapy. Cancer Discov. 2018 11; 8(11):1376-1389.
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Signaling function of PRC2 is essential for TCR-driven T cell responses. J Exp Med. 2018 04 02; 215(4):1101-1113.
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Novel de novo mutation affecting two adjacent aminoacids in the EED gene in a patient with Weaver syndrome. J Hum Genet. 2018 Apr; 63(4):517-520.
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Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma. BMC Syst Biol. 2017 Oct 03; 11(Suppl 5):92.
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas. Nat Med. 2017 Apr; 23(4):493-500.
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The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 04; 13(4):389-395.