 Thymus Gland
"Thymus Gland" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
| Descriptor ID |
D013950
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| MeSH Number(s) |
A10.549.750 A15.382.520.604.750
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| Concept/Terms |
Thymus Gland- Thymus Gland
- Gland, Thymus
- Glands, Thymus
- Thymus Glands
- Thymus
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Below are MeSH descriptors whose meaning is more general than "Thymus Gland".
Below are MeSH descriptors whose meaning is more specific than "Thymus Gland".
This graph shows the total number of publications written about "Thymus Gland" by people in this website by year, and whether "Thymus Gland" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1980 | 0 | 1 | 1 | | 1981 | 0 | 2 | 2 | | 1983 | 1 | 1 | 2 | | 1984 | 0 | 1 | 1 | | 1985 | 0 | 1 | 1 | | 1987 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1990 | 2 | 1 | 3 | | 1991 | 1 | 2 | 3 | | 1992 | 0 | 2 | 2 | | 1993 | 1 | 2 | 3 | | 1994 | 1 | 2 | 3 | | 1995 | 2 | 6 | 8 | | 1996 | 3 | 1 | 4 | | 1997 | 3 | 8 | 11 | | 1998 | 0 | 6 | 6 | | 1999 | 2 | 1 | 3 | | 2000 | 1 | 2 | 3 | | 2001 | 8 | 2 | 10 | | 2002 | 4 | 2 | 6 | | 2003 | 5 | 2 | 7 | | 2004 | 2 | 0 | 2 | | 2005 | 3 | 3 | 6 | | 2006 | 4 | 4 | 8 | | 2007 | 7 | 5 | 12 | | 2008 | 1 | 4 | 5 | | 2009 | 5 | 2 | 7 | | 2010 | 1 | 5 | 6 | | 2011 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2013 | 3 | 1 | 4 | | 2014 | 1 | 4 | 5 | | 2015 | 2 | 3 | 5 | | 2016 | 2 | 1 | 3 | | 2017 | 2 | 0 | 2 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Thymus Gland" by people in Profiles.
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Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN, Hekim C, Jeschke JC, Aggarwal P, Broeckel U, LaRue RS, Henzler CM, Alegre ML, Anderson MS, August A, Marson A, Zheng Y, Williams CB, Farrar MA. Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol. 2019 02; 20(2):195-205.
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Ott JA, Castro CD, Deiss TC, Ohta Y, Flajnik MF, Criscitiello MF. Somatic hypermutation of T cell receptor a chain contributes to selection in nurse shark thymus. Elife. 2018 04 17; 7.
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Koh AS, Miller EL, Buenrostro JD, Moskowitz DM, Wang J, Greenleaf WJ, Chang HY, Crabtree GR. Rapid chromatin repression by Aire provides precise control of immune tolerance. Nat Immunol. 2018 02; 19(2):162-172.
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Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA. Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 07 18; 47(1):107-117.e8.
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Gabrielli S, Sun M, Bell A, Zook EC, de Pooter RF, Zamai L, Kee BL. Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. Eur J Immunol. 2017 05; 47(5):800-805.
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Malchow S, Leventhal DS, Lee V, Nishi S, Socci ND, Savage PA. Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage. Immunity. 2016 05 17; 44(5):1102-13.
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Oh B, Furtmüller GJ, Sosin M, Fryer ML, Gottlieb LJ, Christy MR, Brandacher G, Dorafshar AH. A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice. J Vis Exp. 2016 Jan 23; (107):e53442.
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Malhotra D, Linehan JL, Dileepan T, Lee YJ, Purtha WE, Lu JV, Nelson RW, Fife BT, Orr HT, Anderson MS, Hogquist KA, Jenkins MK. Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 2016 Feb; 17(2):187-95.
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LaFlam TN, Seumois G, Miller CN, Lwin W, Fasano KJ, Waterfield M, Proekt I, Vijayanand P, Anderson MS. Identification of a novel cis-regulatory element essential for immune tolerance. J Exp Med. 2015 Nov 16; 212(12):1993-2002.
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Yoshida H, Bansal K, Schaefer U, Chapman T, Rioja I, Proekt I, Anderson MS, Prinjha RK, Tarakhovsky A, Benoist C, Mathis D. Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4448-57.
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