"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1998 | 2 | 1 | 3 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 4 | 1 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 2 | 3 | 5 |
| 2011 | 2 | 2 | 4 |
| 2012 | 2 | 6 | 8 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 4 | 3 | 7 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 3 | 5 |
| 2020 | 1 | 4 | 5 |
| 2021 | 1 | 6 | 7 |
| 2022 | 2 | 1 | 3 |
| 2023 | 1 | 3 | 4 |
| 2024 | 4 | 7 | 11 |
| 2025 | 5 | 1 | 6 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model. Alcohol. 2026 Feb; 130:57-72.
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PICALM Alzheimer's risk allele causes aberrant lipid droplets in microglia. Nature. 2025 Oct; 646(8087):1178-1186.
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The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model. Cell Rep. 2025 Aug 26; 44(8):116012.
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Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation. Nature. 2025 Jul; 643(8071):509-518.
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Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain. Nat Commun. 2025 May 17; 16(1):4590.
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NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression. Immunity. 2025 Feb 11; 58(2):326-343.e11.
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Basic Science and Pathogenesis. Alzheimers Dement. 2024 Dec; 20 Suppl 1:e093573.
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Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. Sci Adv. 2024 11 08; 10(45):eado5820.
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Microglial modulation as a therapeutic strategy in Alzheimer's disease: Focus on microglial preconditioning approaches. J Cell Mol Med. 2024 Aug; 28(15):e18554.
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Role of the gut microbiome in mediating sex-specific differences in the pathophysiology of Alzheimer's disease. Neurotherapeutics. 2024 Oct; 21(6):e00426.