 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol.
| Descriptor ID |
D019307
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| MeSH Number(s) |
D02.886.590.700.545 D03.383.606.527 D03.438.531.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
Below are MeSH descriptors whose meaning is more specific than "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine".
This graph shows the total number of publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in this website by year, and whether "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1992 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 1 | 1 | | 2010 | 1 | 1 | 2 | | 2011 | 1 | 1 | 2 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine" by people in Profiles.
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Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. Stroke. 2019 03; 50(3):738-744.
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Shenkar R, Shi C, Austin C, Moore T, Lightle R, Cao Y, Zhang L, Wu M, Zeineddine HA, Girard R, McDonald DA, Rorrer A, Gallione C, Pytel P, Liao JK, Marchuk DA, Awad IA. RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations. Stroke. 2017 01; 48(1):187-194.
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Jiang R, Ai ZS, Jiang X, Yuan P, Liu D, Zhao QH, He J, Wang L, Gomberg-Maitland M, Jing ZC. Intravenous fasudil improves in-hospital mortality of patients with right heart failure in severe pulmonary hypertension. Hypertens Res. 2015 Aug; 38(8):539-44.
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Shenkar R, Shi C, Rebeiz T, Stockton RA, McDonald DA, Mikati AG, Zhang L, Austin C, Akers AL, Gallione CJ, Rorrer A, Gunel M, Min W, De Souza JM, Lee C, Marchuk DA, Awad IA. Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. Genet Med. 2015 Mar; 17(3):188-196.
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Wang QM, Stalker TJ, Gong Y, Rikitake Y, Scalia R, Liao JK. Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury. Vasc Med. 2012 Dec; 17(6):379-85.
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McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb; 43(2):571-4.
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Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y. Rho-associated kinase activity, endothelial function, and cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2353-9.
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Hata T, Goto C, Soga J, Hidaka T, Fujii Y, Idei N, Fujimura N, Maruhashi T, Mikami S, Kihara Y, Chayama K, Noma K, Liao JK, Higashi Y. Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil. Atherosclerosis. 2011 Jan; 214(1):117-21.
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Stockton RA, Shenkar R, Awad IA, Ginsberg MH. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010 Apr 12; 207(4):881-96.
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Feske SK, Sorond FA, Henderson GV, Seto M, Hitomi A, Kawasaki K, Sasaki Y, Asano T, Liao JK. Increased leukocyte ROCK activity in patients after acute ischemic stroke. Brain Res. 2009 Feb 27; 1257:89-93.
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