 MicroRNAs
"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
| Descriptor ID |
D035683
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| MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
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| Concept/Terms |
MicroRNAs- MicroRNAs
- miRNAs
- miRNA
- Micro RNA
- RNA, Micro
- MicroRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
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Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2004 | 2 | 0 | 2 | | 2005 | 3 | 0 | 3 | | 2006 | 1 | 1 | 2 | | 2007 | 4 | 2 | 6 | | 2008 | 10 | 4 | 14 | | 2009 | 16 | 4 | 20 | | 2010 | 12 | 5 | 17 | | 2011 | 17 | 5 | 22 | | 2012 | 29 | 6 | 35 | | 2013 | 14 | 7 | 21 | | 2014 | 25 | 12 | 37 | | 2015 | 26 | 7 | 33 | | 2016 | 16 | 4 | 20 | | 2017 | 13 | 9 | 22 | | 2018 | 12 | 6 | 18 | | 2019 | 10 | 4 | 14 | | 2020 | 6 | 4 | 10 | | 2021 | 10 | 5 | 15 | | 2022 | 5 | 0 | 5 |
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Below are the most recent publications written about "MicroRNAs" by people in Profiles.
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Yang Q, Bariani MV, Falahati A, Khosh A, Lastra RR, Siblini H, Boyer TG, Al-Hendy A. The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma. Cells. 2022 Jul 10; 11(14).
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Watkins CP, Zhang W, Wylder AC, Katanski CD, Pan T. A multiplex platform for small RNA sequencing elucidates multifaceted tRNA stress response and translational regulation. Nat Commun. 2022 05 05; 13(1):2491.
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Amin NB, Darekar A, Anstee QM, Wong VW, Tacke F, Vourvahis M, Lee DS, Charlton M, Alkhouri N, Nakajima A, Yunis C. Efficacy and safety of an orally administered DGAT2 inhibitor alone or coadministered with a liver-targeted ACC inhibitor in adults with non-alcoholic steatohepatitis (NASH): rationale and design of the phase II, dose-ranging, dose-finding, randomised, placebo-controlled MIRNA (Metabolic Interventions to Resolve NASH with fibrosis) study. BMJ Open. 2022 03 30; 12(3):e056159.
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He F, Ni N, Wang H, Zeng Z, Zhao P, Shi D, Xia Y, Chen C, Hu DA, Qin KH, Wagstaff W, Qin D, Hendren-Santiago B, Ho SH, Haydon RC, Luu HH, Reid RR, Shen L, Gan H, Fan J, He TC. OUHP: an optimized universal hairpin primer system for cost-effective and high-throughput RT-qPCR-based quantification of microRNA (miRNA) expression. Nucleic Acids Res. 2022 02 28; 50(4):e22.
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Sun Z, Hu J, Ren W, Fang Y, Hu K, Yu H, Liao D, Liu S, Zhou L, He T, Zhang Y. LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone metastasis of breast cancer by modulating the miR-1273g-3p/BMP3 axis. Biochem Biophys Res Commun. 2022 02 26; 594:117-123.
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Zhou Z, Yeh CF, Mellas M, Oh MJ, Zhu J, Li J, Huang RT, Harrison DL, Shentu TP, Wu D, Lueckheide M, Carver L, Chung EJ, Leon L, Yang KC, Tirrell MV, Fang Y. Targeted polyelectrolyte complex micelles treat vascular complications in vivo. Proc Natl Acad Sci U S A. 2021 12 14; 118(50).
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Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, Reiter RJ, Cen B, Yuan Y. Pan-cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer. J Pineal Res. 2021 Oct; 71(3):e12758.
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Pusic KM, Kraig RP, Pusic AD. IFN?-stimulated dendritic cell extracellular vesicles can be nasally administered to the brain and enter oligodendrocytes. PLoS One. 2021; 16(8):e0255778.
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Magnaye KM, Naughton KA, Huffman J, Hogarth DK, Naureckas ET, White SR, Ober C. A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma. Eur Respir J. 2021 07; 58(1).
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Ibrahim S, Johnson M, Stephens CH, Xu J, Moore R, Mariani A, Contreras C, Syed F, Mirmira RG, Anderson RM, Sims EK. ß-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. Mol Metab. 2021 11; 53:101289.
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