"RNA, Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Short chains of RNA (100-300 nucleotides long) that are abundant in the nucleus and usually complexed with proteins in snRNPs (RIBONUCLEOPROTEINS, SMALL NUCLEAR). Many function in the processing of messenger RNA precursors. Others, the snoRNAs (RNA, SMALL NUCLEOLAR), are involved with the processing of ribosomal RNA precursors.
| Descriptor ID |
D012342
|
| MeSH Number(s) |
D13.444.735.628.818 D13.444.735.790.552.937
|
| Concept/Terms |
RNA, Small Nuclear- RNA, Small Nuclear
- snRNA
- Small Nuclear RNA
- Low Molecular Weight Nuclear RNA
- Small Molecular Weight RNA
|
Below are MeSH descriptors whose meaning is more general than "RNA, Small Nuclear".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Nuclear".
This graph shows the total number of publications written about "RNA, Small Nuclear" by people in this website by year, and whether "RNA, Small Nuclear" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 1 | 2 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "RNA, Small Nuclear" by people in Profiles.
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De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome. Nature. 2024 Aug; 632(8026):832-840.
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Inter-species association mapping links splice site evolution to METTL16 and SNRNP27K. Elife. 2023 10 03; 12.
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Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease. Neurobiol Aging. 2023 06; 126:25-33.
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m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5' splice site. Elife. 2022 11 21; 11.
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Termination of pre-mRNA splicing requires that the ATPase and RNA unwindase Prp43p acts on the catalytic snRNA U6. Genes Dev. 2019 11 01; 33(21-22):1555-1574.
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Sensitive and quantitative probing of pseudouridine modification in mRNA and long noncoding RNA. RNA. 2019 09; 25(9):1218-1225.
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Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell. 2018 09 20; 71(6):973-985.e5.
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Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing. Nat Genet. 2017 Mar; 49(3):457-464.
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Structure of a spliceosome remodelled for exon ligation. Nature. 2017 02 16; 542(7641):377-380.
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Cryo-EM structure of the spliceosome immediately after branching. Nature. 2016 09 08; 537(7619):197-201.