"5-Methylcytosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.
| Descriptor ID |
D044503
|
| MeSH Number(s) |
D03.383.742.698.421.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "5-Methylcytosine".
Below are MeSH descriptors whose meaning is more specific than "5-Methylcytosine".
This graph shows the total number of publications written about "5-Methylcytosine" by people in this website by year, and whether "5-Methylcytosine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 7 | 8 |
| 2012 | 0 | 6 | 6 |
| 2013 | 2 | 7 | 9 |
| 2014 | 1 | 2 | 3 |
| 2015 | 2 | 7 | 9 |
| 2016 | 1 | 3 | 4 |
| 2017 | 1 | 0 | 1 |
| 2019 | 5 | 0 | 5 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 2 | 4 |
| 2023 | 2 | 1 | 3 |
| 2024 | 5 | 0 | 5 |
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Below are the most recent publications written about "5-Methylcytosine" by people in Profiles.
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5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. JCO Precis Oncol. 2024 Oct; 8:e2400277.
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RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature. 2024 Oct; 634(8035):986-994.
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5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer. Gynecol Oncol. 2024 03; 182:82-90.
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Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Nat Biotechnol. 2024 Oct; 42(10):1559-1570.
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5-Hydroxymethylcytosine Profiling of Cell-Free DNA Identifies Bivalent Genes That Are Prognostic of Survival in High-Risk Neuroblastoma. JCO Precis Oncol. 2024 Jan; 8:e2300297.
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PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines. Database (Oxford). 2023 06 10; 2023.
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PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines. Database (Oxford). 2023 06 10; 2023.
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Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease. J Alzheimers Dis. 2023; 93(3):1135-1151.
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Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma. J Hematol Oncol. 2022 08 16; 15(1):106.
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MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia. Epigenetics. 2022 12; 17(13):2056-2074.