"5-Methylcytosine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A methylated nucleotide base found in eukaryotic DNA. In ANIMALS, the DNA METHYLATION of CYTOSINE to form 5-methylcytosine is found primarily in the palindromic sequence CpG. In PLANTS, the methylated sequence is CpNpGp, where N can be any base.
| Descriptor ID |
D044503
|
| MeSH Number(s) |
D03.383.742.698.421.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "5-Methylcytosine".
Below are MeSH descriptors whose meaning is more specific than "5-Methylcytosine".
This graph shows the total number of publications written about "5-Methylcytosine" by people in this website by year, and whether "5-Methylcytosine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 7 | 8 |
| 2012 | 0 | 6 | 6 |
| 2013 | 2 | 7 | 9 |
| 2014 | 1 | 3 | 4 |
| 2015 | 2 | 7 | 9 |
| 2016 | 2 | 3 | 5 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 6 | 0 | 6 |
| 2020 | 3 | 1 | 4 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 2 | 4 |
| 2023 | 2 | 1 | 3 |
| 2024 | 5 | 0 | 5 |
| 2025 | 3 | 0 | 3 |
| 2026 | 1 | 2 | 3 |
To return to the timeline,
click here.
Below are the most recent publications written about "5-Methylcytosine" by people in Profiles.
-
Prognostic Significance of Cell-Free DNA Derived 5-Hydroxymethylcytosine Signatures in Newly Diagnosed Multiple Myeloma. JCO Precis Oncol. 2026 Jul; 10(7):e2501121.
-
Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma. Clin Transl Sci. 2026 03; 19(3):e70508.
-
DMN-seq enriches DNA hypomethylated regions for biomarker discovery using 5-methylcytosine glycosylase. Genome Biol. 2026 Feb 11; 27(1).
-
Ultra-mild bisulfite outperforms existing methods for 5-methylcytosine detection with low input DNA. Nat Commun. 2025 Nov 13; 16(1):9939.
-
Brain-derived 5-hydroxymethylcytosine epigenetic scores are related to Alzheimer's disease pathology and cognitive decline. Acta Neuropathol. 2025 Oct 28; 150(1):45.
-
Bisulfite Sequencing to Map 5-Methylcytosine Sites in Human Respiratory Syncytial Virus RNA. Methods Mol Biol. 2025; 2948:233-247.
-
5-Hydroxymethylated Biomarkers in Cell-Free DNA Predict Occult Colorectal Cancer up to 36 Months Before Diagnosis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. JCO Precis Oncol. 2024 10; 8:e2400277.
-
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature. 2024 10; 634(8035):986-994.
-
5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer. Gynecol Oncol. 2024 03; 182:82-90.
-
Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Nat Biotechnol. 2024 Oct; 42(10):1559-1570.