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Raymond P. Roos

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.

    Collapse Biography 
    Collapse education and training
    Columbia College, NYC, NYAB06/1964Chemistry, Premed
    SUNY, Downstate Medical Center, Brookly, NYC, NYmedicine06/1964Medicine
    Kings County Hospital, Brooklyn, NYC, NY06/1969Internship in Medicine
    NINDS, NIH, Bethesda, MD06/1971Slow Virus (prion) Laboratory of D.C. Gajdusek
    Johns Hopkins Hospital, Baltimore, MD06/1974Neurology Residency
    Johns Hopkins Hospital, Baltimore, MD06/1976Neurovirology and Neuroimmunology Post-doctoral fellowship
    University of Utah Medical Center, Salt Lake City, UT07/1981Visiting Professor in poliovirus lab of Dr. Ellie Ehrenfeld
    University of California, Irvine, Irvine, CA01/1989Visiting Professor in poliovirus lab of Dr. Bert Semler
    Collapse awards and honors
    2004Fellow in Medical Science, AAAS
    2006Society for Scholars, Johns Hopkins Medical School
    2018Dr. Frank L. Babbott, MD Memorial Award , SUNY Downstate

    Collapse Research 
    Collapse research activities and funding
    Not assigned     (Paschalis Kratsios)Jan 1, 2019 - Dec 31, 2019
    Association for Frontotemporal Dementia
    A C. elegans model to study the disease-producing effects of dipeptide repeats from the C9ORF72 locus
    Role Description: To clarify the translation initiation factors important in translation of dipeptide repeats from the expanded repeat in C9ORF72
    Role: Co-PI

    18-DDC-434     (Raymond P. Roos)Nov 30, 2017 - Oct 31, 2019
    ALS Association
    Combating stress in G85R ALS mice
    Role Description: To test the effects of perturbing CHOP in G85R mice
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Baumgartner NW, Hill JP, Bhatnagar S, Roos R, Soliven B, Rezania K, Issa NP. Added load increases the peak frequency of intermuscular coherence. J Electromyogr Kinesiol. 2024 Mar 31; 76:102881. PMID: 38574588.
      Citations:    Fields:    
    2. Sonobe Y, Lee S, Krishnan G, Gu Y, Kwon DY, Gao FB, Roos RP, Kratsios P. Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons. Elife. 2023 09 07; 12. PMID: 37675986; PMCID: PMC10541178.
      Citations: 2     Fields:    Translation:Humans
    3. Gleason AC, Ghadge G, Sonobe Y, Roos RP. Kozak Similarity Score Algorithm Identifies Alternative Translation Initiation Codons Implicated in Cancers. Int J Mol Sci. 2022 Sep 12; 23(18). PMID: 36142475; PMCID: PMC9506484.
      Citations: 1     Fields:    Translation:HumansCells
    4. Gleason AC, Ghadge G, Chen J, Sonobe Y, Roos RP. Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions. PLoS One. 2022; 17(6):e0256411. PMID: 35648796; PMCID: PMC9159584.
      Citations: 9     Fields:    Translation:Humans
    5. Sonobe Y, Aburas J, Krishnan G, Fleming AC, Ghadge G, Islam P, Warren EC, Gu Y, Kankel MW, Kiskinis E, Gendron TF, Gao FB, Roos RP, Kratsios P, Brown AEX. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation. Nat Commun. 2021 10 15; 12(1):6025. PMID: 34654821; PMCID: PMC8519953.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    6. Pulst S, Pandolfo M, Roos R, Milone M, Jayadev S. Neurology: Genetics Year in Review. Neurol Genet. 2021 Feb; 7(1):e556. PMID: 33889725; PMCID: PMC8057061.
      Citations:    
    7. Masaki K, Sonobe Y, Ghadge G, Pytel P, Lépine P, Pernin F, Cui QL, Antel JP, Zandee S, Prat A, Roos RP. RNA-binding protein altered expression and mislocalization in MS. Neurol Neuroimmunol Neuroinflamm. 2020 05; 7(3). PMID: 32217641; PMCID: PMC7176246.
      Citations: 11     Fields:    Translation:HumansCells
    8. Ghadge GD, Sonobe Y, Camarena A, Drigotas C, Rigo F, Ling KK, Roos RP. Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS. Neurobiol Dis. 2020 03; 136:104702. PMID: 31837419.
      Citations: 12     Fields:    Translation:Animals
    9. Pulst SM, Roos RP, Durr A, Vance JM, Milone M, Pandolfo M. 2018: Year in Review and Message from the Editors to Our Reviewers. Neurol Genet. 2019 Feb; 5(1):e309. PMID: 30842976.
      Citations:    
    10. Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos RP. TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection. PLoS Pathog. 2019 02; 15(2):e1007574. PMID: 30742696; PMCID: PMC6390522.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    11. Ghadge GD, Kay BK, Drigotas C, Roos RP. Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice. Neurobiol Dis. 2019 01; 121:131-137. PMID: 30176351.
      Citations: 13     Fields:    Translation:AnimalsCells
    12. Sonobe Y, Ghadge G, Masaki K, Sendoel A, Fuchs E, Roos RP. Translation of dipeptide repeat proteins from the C9ORF72 expanded repeat is associated with cellular stress. Neurobiol Dis. 2018 08; 116:155-165. PMID: 29792928; PMCID: PMC6331062.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    13. Riehm JJ, Wang L, Ghadge G, Teng M, Correa AM, Marks JD, Roos RP, Allen MJ. Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS. Neurobiol Dis. 2018 07; 115:115-126. PMID: 29627580; PMCID: PMC5943144.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Pulst SM, Johnson NE, Pandolfo M, Roos RP, Vance JM. 2017 Year in Review and Message from the Editors to Our Reviewers. Neurol Genet. 2018 Feb; 4(1):e221. PMID: 29552636; PMCID: PMC5852863.
      Citations:    
    15. Rezania K, Pytel P, Derani L, Greenwald R, Roos RP. A Masked Marauder: Hepatitis C Neuropathy. Am J Med. 2018 Jan; 131(1):33-36. PMID: 28882660.
      Citations: 1     Fields:    Translation:Humans
    16. Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, Murray ME, Kato M, Fryer JD, Petrucelli L, Zinman L, Weintraub S, Mesulam M, Keith J, Zivkovic SA, Hirsch-Reinshagen V, Roos RP, Graff-Radford NR, Petersen RC, Caselli RJ, Wszolek ZK, Finger E, Lippa C, Lacomis D, Stewart H, Dickson DW, Kim HJ, Rogaeva E, Bigio E, Boylan KB, Taylor JP, Rademakers R, Züchner S. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017 Aug 16; 95(4):808-816.e9. PMID: 28817800; PMCID: PMC5576574.
      Citations: 290     Fields:    Translation:HumansCells
    17. Jara JH, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Genç B, Özdinler PH. Evidence for an early innate immune response in the motor cortex of ALS. J Neuroinflammation. 2017 06 26; 14(1):129. PMID: 28651542; PMCID: PMC5485686.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    18. Pulst SM, Johnson NE, Durr A, Pandolfo M, Roos RP, Vance JM. 2016 in Review and Message from the Editors to our Reviewers. Neurol Genet. 2017 Feb; 3(1):e132. PMID: 28251178; PMCID: PMC5314733.
      Citations:    
    19. Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Genç B, Özdinler PH. Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Sci Rep. 2017 02 06; 7:41765. PMID: 28165465; PMCID: PMC5292972.
      Citations: 49     Fields:    Translation:HumansCells
    20. Issa NP, Frank S, Roos RP, Soliven B, Towle VL, Rezania K. Intermuscular coherence in amyotrophic lateral sclerosis: A preliminary assessment. Muscle Nerve. 2017 06; 55(6):862-868. PMID: 27699797.
      Citations: 5     Fields:    Translation:Humans
    21. Antinone SE, Ghadge GD, Ostrow LW, Roos RP, Green WN. S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects. Sci Rep. 2017 01 25; 7:41141. PMID: 28120938; PMCID: PMC5264640.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Roos RP. Zika Virus-A Public Health Emergency of International Concern. JAMA Neurol. 2016 12 01; 73(12):1395-1396. PMID: 27695847.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    23. Kak M, Issa NP, Roos RP, Sweitzer BJ, Gottlieb O, Guralnick A, White SR, Semrad CE, Soliven B, Baroody J, Rezania K. Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis. Neurol Res. 2017 Jan; 39(1):16-22. PMID: 27876446.
      Citations: 5     Fields:    Translation:Humans
    24. Labuschagne I, Cassidy AM, Scahill RI, Johnson EB, Rees E, O'Regan A, Queller S, Frost C, Leavitt BR, Roos R, Owen G, Borowsky B, Tabrizi SJ, Stout JC, TRACK-HD Investigators, Dürr A. Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease. J Int Neuropsychol Soc. 2016 07; 22(6):595-608. PMID: 27211109.
      Citations: 14     Fields:    Translation:Humans
    25. Beversdorf DQ, Lennon V, Mehler M, Roos R. Author Response. Neurology. 2016 Feb 09; 86(6):585-6. PMID: 27280229.
      Citations:    Fields:    Translation:Humans
    26. Bennett SJ, Katzman GL, Roos RP, Mehta AS, Ali S. Neoplastic cauda equina syndrome: a neuroimaging-based review. Pract Neurol. 2016 Feb; 16(1):35-41. PMID: 26442520.
      Citations: 2     Fields:    Translation:Humans
    27. Beversdorf DQ, Roos RP, Hauser WA, Lennon VA, Mehler MF. Animal extremists' threats to neurologic research continue: Neuroreality II. Neurology. 2015 Aug 25; 85(8):730-4. PMID: 26156507; PMCID: PMC4553027.
      Citations: 3     Fields:    Translation:Humans
    28. Visscher AP, Schuur D, Roos R, Van der Mijnsbrugge GJ, Meijerink WJ, Felt-Bersma RJ. Long-term follow-up after surgery for simple and complex cryptoglandular fistulas: fecal incontinence and impact on quality of life. Dis Colon Rectum. 2015 May; 58(5):533-9. PMID: 25850841.
      Citations: 30     Fields:    Translation:Humans
    29. Roos RP. D. CARLETON GAJDUSEK. Proc Am Philos Soc. 2015 Mar; 159(1):97-106. PMID: 27011963.
      Citations:    Fields:    
    30. Jara JH, Cox GA, Bohn MC, Roos RP, Macklis JD, Ulupinar E, Genç B, Özdinler PH. Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cereb Cortex. 2015 Nov; 25(11):4259-72. PMID: 25596590; PMCID: PMC4626833.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    31. Rezania K, Gottlieb O, Guralnick A, Prachand V, Sweitzer BJ, Vigneswaran W, White SR, Roos RP. Venous thromboembolism after diaphragm pacing in amyotrophic lateral sclerosis. Muscle Nerve. 2014 Nov; 50(5):863-5. PMID: 25111569.
      Citations: 1     Fields:    Translation:Humans
    32. Wang L, Popko B, Tixier E, Roos RP. Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis. Neurobiol Dis. 2014 Nov; 71:317-24. PMID: 25134731; PMCID: PMC4179984.
      Citations: 64     Fields:    Translation:AnimalsCells
    33. Wang L, Popko B, Roos RP. An enhanced integrated stress response ameliorates mutant SOD1-induced ALS. Hum Mol Genet. 2014 May 15; 23(10):2629-38. PMID: 24368417; PMCID: PMC3990163.
      Citations: 58     Fields:    Translation:AnimalsCells
    34. Antinone SE, Ghadge GD, Lam TT, Wang L, Roos RP, Green WN. Palmitoylation of superoxide dismutase 1 (SOD1) is increased for familial amyotrophic lateral sclerosis-linked SOD1 mutants. J Biol Chem. 2013 Jul 26; 288(30):21606-17. PMID: 23760509; PMCID: PMC3724620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    35. Ghadge GD, Pavlovic JD, Koduvayur SP, Kay BK, Roos RP. Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1. Neurobiol Dis. 2013 Aug; 56:74-8. PMID: 23607939; PMCID: PMC3725968.
      Citations: 11     Fields:    Translation:HumansCells
    36. Rezania K, Roos RP. Spinal cord: motor neuron diseases. Neurol Clin. 2013 Feb; 31(1):219-39. PMID: 23186902.
      Citations: 7     Fields:    Translation:Humans
    37. Wang L, Pytel P, Feltri ML, Wrabetz L, Roos RP. Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice. Neurobiol Dis. 2012 Oct; 48(1):52-7. PMID: 22668777.
      Citations: 15     Fields:    Translation:AnimalsCells
    38. Allen MJ, Ramachandran S, Capone R, Whitlock JL, Ghadge GD, Arnsdorf MF, Roos RP, Lal R, Lacroix JJ. Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiol Dis. 2012 Mar; 45(3):831-8. PMID: 21930207; PMCID: PMC3384721.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    39. Ghadge GD, Wollmann R, Baida G, Traka M, Roos RP. The L-coding region of the DA strain of Theiler's murine encephalomyelitis virus causes dysfunction and death of myelin-synthesizing cells. J Virol. 2011 Sep; 85(18):9377-84. PMID: 21752920; PMCID: PMC3165738.
      Citations: 3     Fields:    Translation:AnimalsCells
    40. Stavrou S, Ghadge G, Roos RP. Apoptotic and antiapoptotic activity of L protein of Theiler's murine encephalomyelitis virus. J Virol. 2011 Jul; 85(14):7177-85. PMID: 21561911; PMCID: PMC3126581.
      Citations: 12     Fields:    Translation:HumansCells
    41. Rezania K, Soliven B, Rezai KA, Roos RP. Impaired glucose tolerance and metabolic syndrome in idiopathic polyneuropathy: the role of pain and depression. Med Hypotheses. 2011 Apr; 76(4):538-42. PMID: 21255940.
      Citations: 4     Fields:    Translation:Humans
    42. Wang L, Popko B, Roos RP. The unfolded protein response in familial amyotrophic lateral sclerosis. Hum Mol Genet. 2011 Mar 01; 20(5):1008-15. PMID: 21159797; PMCID: PMC3033190.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    43. Wang L, Gutmann DH, Roos RP. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Hum Mol Genet. 2011 Jan 15; 20(2):286-93. PMID: 20962037.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    44. Stavrou S, Feng Z, Lemon SM, Roos RP. Different strains of Theiler's murine encephalomyelitis virus antagonize different sites in the type I interferon pathway. J Virol. 2010 Sep; 84(18):9181-9. PMID: 20610716; PMCID: PMC2937600.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Wang L, Grisotti G, Roos RP. Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons. J Neurochem. 2010 Apr; 113(1):166-74. PMID: 20132483; PMCID: PMC2913968.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    46. Stavrou S, Baida G, Viktorova E, Ghadge G, Agol VI, Roos RP. Theiler's murine encephalomyelitis virus L* amino acid position 93 is important for virus persistence and virus-induced demyelination. J Virol. 2010 Feb; 84(3):1348-54. PMID: 19923182; PMCID: PMC2812333.
      Citations: 5     Fields:    Translation:AnimalsCells
    47. Thomas AG, Bodner A, Ghadge G, Roos RP, Slusher BS. GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity. J Neurovirol. 2009 Sep; 15(5-6):449-57. PMID: 19995130.
      Citations: 8     Fields:    Translation:AnimalsCells
    48. Wang L, Sharma K, Grisotti G, Roos RP. The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis. Neurobiol Dis. 2009 Aug; 35(2):234-40. PMID: 19442735; PMCID: PMC2706919.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    49. Wang L, Deng HX, Grisotti G, Zhai H, Siddique T, Roos RP. Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum Mol Genet. 2009 May 01; 18(9):1642-51. PMID: 19233858; PMCID: PMC2667291.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    50. Roos RP, Soliven B, Goldenberg F, Badruddin A, Baron JM. An elderly patient with Bickerstaff brainstem encephalitis and transient episodes of brainstem dysfunction. Arch Neurol. 2008 Jun; 65(6):821-4. PMID: 18541805.
      Citations: 8     Fields:    Translation:Humans
    51. Baida G, Popko B, Wollmann RL, Stavrou S, Lin W, Tretiakova M, Krausz TN, Roos RP. A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination. J Virol. 2008 Jun; 82(12):5879-86. PMID: 18400855; PMCID: PMC2395141.
      Citations: 4     Fields:    Translation:AnimalsCells
    52. Wang L, Sharma K, Deng HX, Siddique T, Grisotti G, Liu E, Roos RP. Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology. Neurobiol Dis. 2008 Mar; 29(3):400-8. PMID: 18054242.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    53. Ghadge GD, Wang L, Sharma K, Monti AL, Bindokas V, Stevens FJ, Roos RP. Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord. Neurobiol Dis. 2006 Jan; 21(1):194-205. PMID: 16084730.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    54. Guest S, Pilipenko E, Sharma K, Chumakov K, Roos RP. Molecular mechanisms of attenuation of the Sabin strain of poliovirus type 3. J Virol. 2004 Oct; 78(20):11097-107. PMID: 15452230; PMCID: PMC521805.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    55. Lin X, Ma X, Rodriguez M, Roos RP. CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice. Int Immunol. 2004 Sep; 16(9):1237-40. PMID: 15262897.
      Citations: 7     Fields:    Translation:AnimalsCells
    56. Nix WA, Berger MM, Oberste MS, Brooks BR, McKenna-Yasek DM, Brown RH, Roos RP, Pallansch MA. Failure to detect enterovirus in the spinal cord of ALS patients using a sensitive RT-PCR method. Neurology. 2004 Apr 27; 62(8):1372-7. PMID: 15111676.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    57. Mathiasen JR, McKenna BA, Saporito MS, Ghadge GD, Roos RP, Holskin BP, Wu ZL, Trusko SP, Connors TC, Maroney AC, Thomas BA, Thomas JC, Bozyczko-Coyne D. Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Res. 2004 Apr 02; 1003(1-2):86-97. PMID: 15019567.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    58. Mastrianni JA, Roos RP. Wrinkles and folds of the prion protein. Neurology. 2003 Nov 11; 61(9):1168-9. PMID: 14610113.
      Citations:    Fields:    Translation:HumansAnimals
    59. Rezania K, Yan J, Dellefave L, Deng HX, Siddique N, Pascuzzi RT, Siddique T, Roos RP. A rare Cu/Zn superoxide dismutase mutation causing familial amyotrophic lateral sclerosis with variable age of onset, incomplete penetrance and a sensory neuropathy. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Sep; 4(3):162-6. PMID: 13129803.
      Citations: 13     Fields:    Translation:Humans
    60. Lin X, Ma X, Rodriguez M, Feng X, Zoecklein L, Fu YX, Roos RP. Membrane lymphotoxin is required for resistance to Theiler's virus infection. Int Immunol. 2003 Aug; 15(8):955-62. PMID: 12882833.
      Citations: 9     Fields:    Translation:AnimalsCells
    61. Ghadge GD, Slusher BS, Bodner A, Canto MD, Wozniak K, Thomas AG, Rojas C, Tsukamoto T, Majer P, Miller RJ, Monti AL, Roos RP. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9554-9. PMID: 12876198; PMCID: PMC170956.
      Citations: 42     Fields:    Translation:AnimalsCells
    62. Bodner A, Maroney AC, Finn JP, Ghadge G, Roos R, Miller RJ, Bodner A, Maroney AC, Finn JP, Ghadge G, Roos R, Miller RJ. Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity. J Neurochem. 2002 Sep; 82(6):1424-34. PMID: 12354290.
      Citations: 17     Fields:    Translation:AnimalsCells
    63. Lee JP, Gerin C, Bindokas VP, Miller R, Ghadge G, Roos RP, Lee JP, Gerin C, Bindokas VP, Miller R, Ghadge G, Roos RP. No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis. J Neurochem. 2002 Sep; 82(5):1229-38. PMID: 12358770.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    64. Mastrianni J, Roos RP, Mastrianni J, Roos RP. "Out, damned spot! out, I say!...": issues related to prion decontamination. Neurology. 2002 Aug 27; 59(4):488-9. PMID: 12196639.
      Citations:    Fields:    Translation:HumansPHPublic Health
    65. Maat-Kievit A, Helderman-van den Enden P, Losekoot M, de Knijff P, Belfroid R, Vegter-van der Vlis M, Roos R, Breuning M. Using a roster and haplotyping is useful in risk assessment for persons with intermediate and reduced penetrance alleles in Huntington disease. Am J Med Genet. 2001 Dec 08; 105(8):737-44. PMID: 11803522.
      Citations: 4     Fields:    Translation:HumansCells
    66. Pilipenko EV, Viktorova EG, Guest ST, Agol VI, Roos RP. Cell-specific proteins regulate viral RNA translation and virus-induced disease. EMBO J. 2001 Dec 03; 20(23):6899-908. PMID: 11726525; PMCID: PMC125770.
      Citations: 55     Fields:    Translation:AnimalsCells
    67. Roos RP. Controlling new prion diseases. N Engl J Med. 2001 May 17; 344(20):1548-51. PMID: 11357162.
      Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
    68. Hentati A, Deng HX, Zhai H, Chen W, Yang Y, Hung WY, Azim AC, Bohlega S, Tandan R, Warner C, Laing NG, Cambi F, Mitsumoto H, Roos RP, Boustany RM, Ben Hamida M, Hentati F, Siddique T. Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology. 2000 Nov 14; 55(9):1388-90. PMID: 11087788.
      Citations: 12     Fields:    Translation:Humans
    69. Weihl CC, Lin G, Ghadge G, Stoodley M, Roos RP, Macdonald RL, Lüders JC. Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Neurosurgery. 2000 Nov; 47(5):1206-14; discussion 1214-5. PMID: 11063115.
      Citations: 6     Fields:    Translation:AnimalsCells
    70. Rodriguez M, Roos RP, McGavern D, Zoecklein L, Pavelko K, Sang H, Lin X. The CD4-mediated immune response is critical in determining the outcome of infection using Theiler's viruses with VP1 capsid protein point mutations. Virology. 2000 Sep 15; 275(1):9-19. PMID: 11017783.
      Citations: 6     Fields:    Translation:AnimalsCells
    71. Stoodley M, Weihl CC, Zhang ZD, Lin G, Johns LM, Kowalczuk A, Ghadge G, Roos RP, Macdonald RL. Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery. 2000 May; 46(5):1193-202; discussion 1202-3. PMID: 10807252.
      Citations: 9     Fields:    Translation:AnimalsCells
    72. Miller RJ, Roos RP. What happens when mutant neuroserpins get into bad shape. Lancet. 2000 Feb 19; 355(9204):590-1. PMID: 10696974.
      Citations:    Fields:    Translation:HumansCells
    73. Mastrianni JA, Roos RP. The prion diseases. Semin Neurol. 2000; 20(3):337-52. PMID: 11051298.
      Citations: 5     Fields:    Translation:Humans
    74. Weihl CC, Roos RP. Creutzfeldt-Jakob disease, new variant creutzfeldt-jakob disease, and bovine spongiform encephalopathy. Neurol Clin. 1999 Nov; 17(4):835-59. PMID: 10517931.
      Citations: 3     Fields:    Translation:HumansAnimals
    75. Yamasaki K, Weihl CC, Roos RP. Alternative translation initiation of Theiler's murine encephalomyelitis virus. J Virol. 1999 Oct; 73(10):8519-26. PMID: 10482605; PMCID: PMC112872.
      Citations: 5     Fields:    Translation:AnimalsCells
    76. Weihl CC, Miller RJ, Roos RP. The role of beta-catenin stability in mutant PS1-associated apoptosis. Neuroreport. 1999 Aug 20; 10(12):2527-32. PMID: 10574364.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    77. Weihl CC, Ghadge GD, Miller RJ, Roos RP. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons. J Neurochem. 1999 Jul; 73(1):31-40. PMID: 10386952.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    78. Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J Neurosci. 1999 Jul 01; 19(13):5360-9. PMID: 10377346; PMCID: PMC6782321.
      Citations: 44     Fields:    Translation:AnimalsCells
    79. Lee JP, Palfrey HC, Bindokas VP, Ghadge GD, Ma L, Miller RJ, Roos RP. The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3251-6. PMID: 10077670; PMCID: PMC15928.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    80. Lin X, Roos RP, Pease LR, Wettstein P, Rodriguez M. A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity. J Immunol. 1999 Jan 01; 162(1):17-24. PMID: 9886365.
      Citations: 9     Fields:    Translation:AnimalsCells
    81. Ghadge GD, Ma L, Sato S, Kim J, Roos RP. A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence. J Virol. 1998 Nov; 72(11):8605-12. PMID: 9765399; PMCID: PMC110271.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    82. Takata H, Obuchi M, Yamamoto J, Odagiri T, Roos RP, Iizuka H, Ohara Y. L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line. J Virol. 1998 Jun; 72(6):4950-5. PMID: 9573263; PMCID: PMC110056.
      Citations: 19     Fields:    Translation:AnimalsCells
    83. Lin X, Sato S, Patick AK, Pease LR, Roos RP, Rodriguez M. Molecular characterization of a nondemyelinating variant of Daniel's strain of Theiler's virus isolated from a persistently infected glioma cell line. J Virol. 1998 Feb; 72(2):1262-9. PMID: 9445026; PMCID: PMC124604.
      Citations: 9     Fields:    Translation:AnimalsCells
    84. Ghadge GD, Lee JP, Bindokas VP, Jordan J, Ma L, Miller RJ, Roos RP. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection. J Neurosci. 1997 Nov 15; 17(22):8756-66. PMID: 9348345; PMCID: PMC6573090.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    85. Sato S, Reiner SL, Jensen MA, Roos RP. Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection. J Neuroimmunol. 1997 Jun; 76(1-2):213-23. PMID: 9184653.
      Citations: 14     Fields:    Translation:AnimalsCells
    86. Roos RP. The regulation of gene expression in neurotrophic viruses. J Neurovirol. 1997 May; 3 Suppl 1:S25-7. PMID: 9179786.
      Citations:    Fields:    Translation:HumansAnimalsCells
    87. Rinehart JE, Roos RP, Gómez RM. Molecular determinants for virulence in coxsackievirus B1 infection. J Virol. 1997 May; 71(5):3986-91. PMID: 9094675; PMCID: PMC191550.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    88. Prehn JH, Ghadge GD, Preis E, Galindo MF, Roos RP, Krieglstein J, Miller RJ, Jordán J. Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis. J Neurochem. 1997 Apr; 68(4):1679-85. PMID: 9084441.
      Citations: 25     Fields:    Translation:AnimalsCells
    89. Galindo MF, Prehn JH, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ, Jordán J. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J Neurosci. 1997 Feb 15; 17(4):1397-405. PMID: 9006981; PMCID: PMC6793734.
      Citations: 39     Fields:    Translation:AnimalsCells
    90. Sato S, Zhang L, Kim J, Jakob J, Grant RA, Wollmann R, Roos RP. A neutralization site of DA strain of Theiler's murine encephalomyelitis virus important for disease phenotype. Virology. 1996 Dec 15; 226(2):327-37. PMID: 8955052.
      Citations: 15     Fields:    Translation:AnimalsCells
    91. Piccone ME, Chen HH, Roos RP, Grubman MJ. Construction of a chimeric Theiler's murine encephalomyelitis virus containing the leader gene of foot-and-mouth disease virus. Virology. 1996 Dec 01; 226(1):135-9. PMID: 8941332.
      Citations: 5     Fields:    Translation:AnimalsCells
    92. Rinehart JE, Wollmann R, Roos RP, Gómez RM. Theiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease. J Virol. 1996 Dec; 70(12):8926-33. PMID: 8971022; PMCID: PMC190990.
      Citations: 15     Fields:    Translation:AnimalsCells
    93. Hackett J, Swanson P, Leahy D, Anderson EL, Sato S, Roos RP, Decker R, Devare SG. Search for retrovirus in patients with multiple sclerosis. Ann Neurol. 1996 Nov; 40(5):805-9. PMID: 8957025.
      Citations: 2     Fields:    Translation:HumansCells
    94. Moss AH, Oppenheimer EA, Casey P, Cazzolli PA, Roos RP, Stocking CB, Siegler M. Patients with amyotrophic lateral sclerosis receiving long-term mechanical ventilation. Advance care planning and outcomes. Chest. 1996 Jul; 110(1):249-55. PMID: 8681635.
      Citations: 26     Fields:    Translation:Humans
    95. Furlan R, Salazar-Grueso EF, Martino G, Roos RP, Brambilla E, Castellano M, Cao J, Lillo F, Terreni MR, Bacellar H, Dorigatti F, Grimaldi LM. Human T-cell lymphotropic virus type-I infection in the severe combined immunodeficiency mouse. J Med Virol. 1996 Jun; 49(2):77-82. PMID: 8991939.
      Citations:    Fields:    Translation:HumansAnimalsCells
    96. Jakob J, Roos RP. Molecular determinants of Theiler's murine encephalomyelitis-induced disease. J Neurovirol. 1996 Apr; 2(2):70-7. PMID: 8799198.
      Citations: 7     Fields:    Translation:AnimalsCells
    97. Prehn JH, Bindokas VP, Galindo MF, Ghadge GD, Roos RP, Boise LH, Thompson CB, Krajewski S, Reed JC, Miller RJ, Jordán J. Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons. Mol Pharmacol. 1996 Feb; 49(2):319-28. PMID: 8632765.
      Citations: 41     Fields:    Translation:AnimalsCells
    98. Chen HH, Kong WP, Roos RP. The leader peptide of Theiler's murine encephalomyelitis virus is a zinc-binding protein. J Virol. 1995 Dec; 69(12):8076-8. PMID: 7494325; PMCID: PMC189757.
      Citations: 32     Fields:    Translation:AnimalsCells
    99. Chen HH, Kong WP, Zhang L, Ward PL, Roos RP. A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease. Nat Med. 1995 Sep; 1(9):927-31. PMID: 7585219.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    100. Tateishi J, Brown P, Kitamoto T, Hoque ZM, Roos R, Wollman R, Gajdusek DC, Cervenáková L. First experimental transmission of fatal familial insomnia. Nature. 1995 Aug 03; 376(6539):434-5. PMID: 7630420.
      Citations: 34     Fields:    Translation:HumansAnimals
    101. Brown P, Kenney K, Little B, Ironside J, Will R, Bjork RJ, San Martin RA, Safar J, Roos R, Cervenáková L, et al. Intracerebral distribution of infectious amyloid protein in spongiform encephalopathy. Ann Neurol. 1995 Aug; 38(2):245-53. PMID: 7654073.
      Citations: 13     Fields:    Translation:Humans
    102. Jordan J, Ghadge GD, Prehn JH, Toth PT, Roos RP, Miller RJ. Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor. Mol Pharmacol. 1995 Jun; 47(6):1095-1100. PMID: 7603446.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    103. Maselli RA, Wollmann R, Roos R. Function and ultrastructure of the neuromuscular junction in post-polio syndrome. Ann N Y Acad Sci. 1995 May 25; 753:129-37. PMID: 7611622.
      Citations: 2     Fields:    Translation:HumansCells
    104. Jubelt B, Salazar-Grueso EF, Roos RP, Cashman NR. Antibody titer to the poliovirus in blood and cerebrospinal fluid of patients with post-polio syndrome. Ann N Y Acad Sci. 1995 May 25; 753:201-7. PMID: 7611629.
      Citations: 1     Fields:    Translation:HumansCells
    105. Chard PS, Marcuccilli CJ, Miller RJ, Leiden JM, Roos RP, Ghadge GD, Jordán J. Regulation of excitatory transmission at hippocampal synapses by calbindin D28k. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5144-8. PMID: 7761464; PMCID: PMC41865.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    106. Zhang L, Sato S, Kim JI, Roos RP. Theiler's virus as a vector for foreign gene delivery. J Virol. 1995 May; 69(5):3171-5. PMID: 7707546; PMCID: PMC189020.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    107. Senkowski A, Shim B, Roos RP. The effect of Theiler's murine encephalomyelitis virus (TMEV) VP1 carboxyl region on the virus-induced central nervous system disease. J Neurovirol. 1995 Mar; 1(1):101-10. PMID: 9222346.
      Citations: 5     Fields:    Translation:AnimalsCells
    108. Ghadge GD, Roos RP, Kang UJ, Wollmann R, Fishman PS, Kalynych AM, Barr E, Leiden JM. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. Gene Ther. 1995 Mar; 2(2):132-7. PMID: 7536617.
      Citations: 21     Fields:    Translation:AnimalsCells
    109. Salazar-Grueso EF, Roos RP. Amyotrophic lateral sclerosis and viruses. Clin Neurosci. 1995-1996; 3(6):360-7. PMID: 9021257.
      Citations: 4     Fields:    Translation:HumansCells
    110. Furlan R, Salazar-Grueso EF, Martino G, Lillo F, Kotulski M, Brambilla E, Castellano M, Terreni MR, Roos RP, Grimaldi LM. HTLV-I hu-SCID mouse in the study of HTLV-I neurotropism. Ann N Y Acad Sci. 1994 Jun 06; 724:422-5. PMID: 8030969.
      Citations:    Fields:    Translation:HumansAnimalsCells
    111. Grant RA, Hogle JM, Zhang L, Senkowski A, Roos RP, Michiels T, Brahic M, McAllister A, Jarousse N. A single amino acid change determines persistence of a chimeric Theiler's virus. J Virol. 1994 May; 68(5):3364-8. PMID: 7512164; PMCID: PMC236827.
      Citations: 32     Fields:    Translation:AnimalsCells
    112. Kong WP, Ghadge GD, Roos RP. Involvement of cardiovirus leader in host cell-restricted virus expression. Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1796-800. PMID: 8127884; PMCID: PMC43250.
      Citations: 32     Fields:    Translation:AnimalsCells
    113. Appelbaum JS, Roos RP. Coexistence of amyotrophic lateral sclerosis and Werdnig-Hoffmann disease within a family. Muscle Nerve. 1993 Dec; 16(12):1416. PMID: 8232401.
      Citations:    Fields:    Translation:Humans
    114. Maselli RA, Wollman RL, Leung C, Distad B, Palombi S, Richman DP, Salazar-Grueso EF, Roos RP. Neuromuscular transmission in amyotrophic lateral sclerosis. Muscle Nerve. 1993 Nov; 16(11):1193-203. PMID: 8105377.
      Citations: 43     Fields:    Translation:HumansCells
    115. Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science. 1993 Aug 20; 261(5124):1047-51. PMID: 8351519.
      Citations: 342     Fields:    Translation:HumansCells
    116. Zhang L, Senkowski A, Shim B, Roos RP. Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence. J Virol. 1993 Jul; 67(7):4404-8. PMID: 8510228; PMCID: PMC237815.
      Citations: 8     Fields:    Translation:AnimalsCells
    117. Moss AH, Casey P, Stocking CB, Roos RP, Brooks BR, Siegler M. Home ventilation for amyotrophic lateral sclerosis patients: outcomes, costs, and patient, family, and physician attitudes. Neurology. 1993 Feb; 43(2):438-43. PMID: 8437718.
      Citations: 24     Fields:    Translation:Humans
    118. Rubeiz H, Roos RP. Viral meningitis and encephalitis. Semin Neurol. 1992 Sep; 12(3):165-77. PMID: 1455104.
      Citations: 2     Fields:    Translation:HumansAnimals
    119. Appelbaum JS, Roos RP, Salazar-Grueso EF, Buchman A, Iannaccone S, Glantz R, Siddique T, Maselli R. Intrafamilial heterogeneity in hereditary motor neuron disease. Neurology. 1992 Aug; 42(8):1488-92. PMID: 1641141.
      Citations: 5     Fields:    Translation:Humans
    120. Stein SB, Zhang L, Roos RP. Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence. J Virol. 1992 Jul; 66(7):4508-17. PMID: 1602556; PMCID: PMC241260.
      Citations: 17     Fields:    Translation:AnimalsCells
    121. Maselli RA, Cashman NR, Wollman RL, Salazar-Grueso EF, Roos R. Neuromuscular transmission as a function of motor unit size in patients with prior poliomyelitis. Muscle Nerve. 1992 Jun; 15(6):648-55. PMID: 1324424.
      Citations: 3     Fields:    Translation:HumansCells
    122. Salazar-Grueso EF, Roos RP, Jubelt B, Cashman NR. Immune responses in the post-polio syndrome. N Engl J Med. 1992 Feb 27; 326(9):641; author reply 642. PMID: 1370858.
      Citations:    Fields:    Translation:HumansCells
    123. Rodriguez M, Roos RP. Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses. J Virol. 1992 Jan; 66(1):217-25. PMID: 1727485; PMCID: PMC238278.
      Citations: 18     Fields:    Translation:AnimalsCells
    124. Silverstein MD, Stocking CB, Antel JP, Beckwith J, Roos RP, Siegler M. Amyotrophic lateral sclerosis and life-sustaining therapy: patients' desires for information, participation in decision making, and life-sustaining therapy. Mayo Clin Proc. 1991 Sep; 66(9):906-13. PMID: 1921500.
      Citations: 19     Fields:    Translation:Humans
    125. Castagna A, Maimone D, Martino GV, Dolci A, Pristera R, Lazzarin A, Roos RP, Grimaldi LM. Kappa light chain predominance in serum and cerebrospinal fluid from human immunodeficiency virus type 1 (HIV-1)-infected patients. J Neuroimmunol. 1991 Jun; 32(3):259-68. PMID: 1903402.
      Citations: 4     Fields:    Translation:HumansCells
    126. Kong WP, Roos RP. Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus. J Virol. 1991 Jun; 65(6):3395-9. PMID: 2033677; PMCID: PMC241004.
      Citations: 39     Fields:    Translation:Cells
    127. Zurbriggen A, Thomas C, Yamada M, Roos RP, Fujinami RS. Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. J Virol. 1991 Apr; 65(4):1929-37. PMID: 1705992; PMCID: PMC240018.
      Citations: 29     Fields:    Translation:AnimalsCells
    128. Kremer B, Swaab D, Bots G, Fisser B, Ravid R, Roos R. The hypothalamic lateral tuberal nucleus in Alzheimer's disease. Ann Neurol. 1991 Mar; 29(3):279-84. PMID: 1710433.
      Citations: 2     Fields:    Translation:HumansCells
    129. Fu J, Rodriguez M, Roos RP. Strains from both Theiler's virus subgroups encode a determinant for demyelination. J Virol. 1990 Dec; 64(12):6345-8. PMID: 2243399; PMCID: PMC248818.
      Citations: 26     Fields:    Translation:AnimalsCells
    130. Salazar-Grueso EF, Holzer TJ, Gutierrez RA, Casey JM, Desai SM, Devare SG, Dawson G, Roos RP. Familial spastic paraparesis syndrome associated with HTLV-I infection. N Engl J Med. 1990 Sep 13; 323(11):732-7. PMID: 2388670.
      Citations: 3     Fields:    Translation:HumansCells
    131. Fu JL, Stein S, Rosenstein L, Bodwell T, Routbort M, Semler BL, Roos RP. Neurovirulence determinants of genetically engineered Theiler viruses. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4125-9. PMID: 2161533; PMCID: PMC54060.
      Citations: 43     Fields:    Translation:AnimalsCells
    132. Salazar-Grueso EF, Routbort MJ, Martin J, Dawson G, Roos RP. Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants. Ann Neurol. 1990 May; 27(5):558-63. PMID: 2113790.
      Citations: 17     Fields:    Translation:HumansCells
    133. Salazar-Grueso EF, Siegel I, Roos RP. The post-polio syndrome: evaluation and treatment. Compr Ther. 1990 Feb; 16(2):24-30. PMID: 2178859.
      Citations:    Fields:    Translation:Humans
    134. Salazar-Grueso EF, Grimaldi LM, Roos RP, Variakojis R, Jubelt B, Cashman NR. Isoelectric focusing studies of serum and cerebrospinal fluid in patients with antecedent poliomyelitis. Ann Neurol. 1989 Dec; 26(6):709-13. PMID: 2513770.
      Citations: 3     Fields:    Translation:Humans
    135. Roos RP, Kong WP, Semler BL. Polyprotein processing of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5344-53. PMID: 2555559; PMCID: PMC251201.
      Citations: 22     Fields:    Translation:AnimalsCells
    136. Roos RP, Stein S, Ohara Y, Fu JL, Semler BL. Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5492-6. PMID: 2555569; PMCID: PMC251223.
      Citations: 49     Fields:    Translation:AnimalsCells
    137. Roos RP, Stein S, Routbort M, Senkowski A, Bodwell T, Wollmann R. Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype. J Virol. 1989 Oct; 63(10):4469-73. PMID: 2476574; PMCID: PMC251072.
      Citations: 25     Fields:    Translation:AnimalsCells
    138. Siddique T, Pericak-Vance MA, Brooks BR, Roos RP, Hung WY, Antel JP, Munsat TL, Phillips K, Warner K, Speer M, et al. Linkage analysis in familial amyotrophic lateral sclerosis. Neurology. 1989 Jul; 39(7):919-25. PMID: 2739919.
      Citations: 11     Fields:    Translation:Humans
    139. Ohara Y, Roos RP. Viral infectious complementary-DNA studies may identify nonviral genes critical to central nervous system disease. Ann Neurol. 1989 Mar; 25(3):305-9. PMID: 2543264.
      Citations: 4     Fields:    Translation:HumansCells
    140. Grimaldi LM, Roos RP, Devare SG, Casey JM, Maruo Y, Hamada T, Tashiro K. HTLV-I-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-I p24 antibody. Ann Neurol. 1988 Dec; 24(6):727-31. PMID: 3207356.
      Citations: 13     Fields:    Translation:Humans
    141. Ohara Y, Senkowski A, Fu JL, Klaman L, Goodall J, Toth M, Roos RP. Trypsin-sensitive neutralization site on VP1 of Theiler's murine encephalomyelitis viruses. J Virol. 1988 Sep; 62(9):3527-9. PMID: 2457118; PMCID: PMC253483.
      Citations: 13     Fields:    Translation:AnimalsCells
    142. Grimaldi LM, Roos RP, Manservigi R, Spear PG, Lakeman FD, Whitley RJ. An isoelectric focusing study in herpes simplex virus encephalitis. Ann Neurol. 1988 Aug; 24(2):227-32. PMID: 3140713.
      Citations: 3     Fields:    Translation:Humans
    143. Grimaldi LM, Castagna A, Lazzarin A, Bianchi G, Moroni M, Roos RP, Pristerá R. Oligoclonal IgG bands in cerebrospinal fluid and serum during asymptomatic human immunodeficiency virus infection. Ann Neurol. 1988 Aug; 24(2):277-9. PMID: 3140714.
      Citations: 3     Fields:    Translation:Humans
    144. Grimaldi LM, Roos RP, Devare SG, Robey WG, Casey JM, Gurney ME, Apatoff BR, Lazzarin D. Restricted heterogeneity of antibody to gp120 and p24 in AIDS. J Immunol. 1988 Jul 01; 141(1):114-7. PMID: 2837506.
      Citations: 6     Fields:    Translation:HumansCells
    145. Liebert UG, Cattaneo R, Billeter MA, Roos RP, ter Meulen V, Baczko K. Restriction of measles virus gene expression in measles inclusion body encephalitis. J Infect Dis. 1988 Jul; 158(1):144-50. PMID: 3164746.
      Citations: 17     Fields:    Translation:HumansCells
    146. Ohara Y, Stein S, Fu JL, Stillman L, Klaman L, Roos RP. Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology. 1988 May; 164(1):245-55. PMID: 2834872.
      Citations: 72     Fields:    Translation:Cells
    147. Salazar-Grueso EF, Rosenberg RS, Roos RP. Sleep apnea in olivopontocerebellar degeneration: treatment with trazodone. Ann Neurol. 1988 Apr; 23(4):399-401. PMID: 3164175.
      Citations: 4     Fields:    Translation:Humans
    148. Grimaldi LM, Roos RP, Lazzarin A, Moroni M, Casey JM, Devare SG. Human immunodeficiency virus gp120 and p24 oligoclonal antibody in acquired immunodeficiency syndrome cerebrospinal fluid and sera. Ann N Y Acad Sci. 1988; 540:611-4. PMID: 3207289.
      Citations: 1     Fields:    Translation:HumansCells
    149. Clatch RJ, Pevear DC, Rozhon E, Roos RP, Miller SD, Lipton HL. Characterization and specificity of humoral immune responses to Theiler's murine encephalomyelitis virus capsid proteins. J Gen Virol. 1987 Dec; 68 ( Pt 12):3191-6. PMID: 2826657.
      Citations: 10     Fields:    Translation:AnimalsCells
    150. Cashman NR, Maselli R, Wollmann RL, Roos R, Simon R, Antel JP. Late denervation in patients with antecedent paralytic poliomyelitis. N Engl J Med. 1987 Jul 02; 317(1):7-12. PMID: 3587319.
      Citations: 12     Fields:    Translation:HumansCells
    151. Cashman NR, Maselli R, Wollmann RL, Roos R, Simon R, Antel JP. Post-poliomyelitis syndrome: evidence of ongoing denervation in symptomatic and asymptomatic patients. Birth Defects Orig Artic Ser. 1987; 23(4):237-9. PMID: 3620621.
      Citations:    Fields:    Translation:Humans
    152. Ohara Y, Roos R. The antibody response in Theiler's virus infection: new perspectives on multiple sclerosis. Prog Med Virol. 1987; 34:156-79. PMID: 2821576.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    153. Roos RP, Nalefski EA, Nitayaphan S, Variakojis R, Singh KK. An isoelectric focusing overlay study of the humoral immune response in Theiler's virus demyelinating disease. J Neuroimmunol. 1987 Jan; 13(3):305-14. PMID: 3540007.
      Citations: 12     Fields:    Translation:AnimalsCells
    154. Salazar-Grueso E, Roos R. Sciatic endometriosis: a treatable sensorimotor mononeuropathy. Neurology. 1986 Oct; 36(10):1360-3. PMID: 3762945.
      Citations: 5     Fields:    Translation:Humans
    155. Huttenlocher PR, Picchietti DL, Roos RP, Cashman NR, Horowitz B, Horowitz MS. Intrathecal interferon in subacute sclerosing panencephalitis. Ann Neurol. 1986 Mar; 19(3):303-5. PMID: 2421637.
      Citations: 5     Fields:    Translation:HumansCells
    156. Nitayaphan S, Omilianowski D, Toth MM, Parks GD, Rueckert RR, Palmenberg AC, Roos RP. Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses. Intervirology. 1986; 26(3):140-8. PMID: 3034822.
      Citations: 13     Fields:    Translation:Cells
    157. Nitayaphan S, Toth MM, Roos RP. Localization of a neutralization site of Theiler's murine encephalomyelitis viruses. J Virol. 1985 Dec; 56(3):887-95. PMID: 2415718; PMCID: PMC252661.
      Citations: 13     Fields:    Translation:AnimalsCells
    158. Grimaldi LM, Roos RP, Nalefski EA, Arnason BG. Oligoclonal IgA bands in multiple sclerosis and subacute sclerosing panencephalitis. Neurology. 1985 Jun; 35(6):813-7. PMID: 3889705.
      Citations: 4     Fields:    Translation:Humans
    159. Stowring L, Haase AT, Petursson G, Georgsson G, Palsson P, Lutley R, Roos R, Szuchet S. Detection of visna virus antigens and RNA in glial cells in foci of demyelination. Virology. 1985 Mar; 141(2):311-8. PMID: 3002020.
      Citations: 20     Fields:    Translation:AnimalsCells
    160. Nitayaphan S, Toth MM, Roos RP. Neutralizing monoclonal antibodies to Theiler's murine encephalomyelitis viruses. J Virol. 1985 Feb; 53(2):651-7. PMID: 2578578; PMCID: PMC254681.
      Citations: 23     Fields:    Translation:AnimalsCells
    161. Roos RP, Davis K, Meltzer HY. Immunoglobulin studies in patients with psychiatric diseases. Arch Gen Psychiatry. 1985 Feb; 42(2):124-8. PMID: 3977540.
      Citations: 12     Fields:    Translation:Humans
    162. Roos RP. B-cell abnormalities in multiple sclerosis. A hypothesis. Arch Neurol. 1985 Jan; 42(1):73-5. PMID: 3871325.
      Citations: 1     Fields:    Translation:HumansCells
    163. Roos RP. Genetically controlled resistance to virus infections of the central nervous system. Prog Med Genet. 1985; 6:241-76. PMID: 3014607.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    164. Roos RP, Whitelaw PJ. Biochemical analysis of DA strain of Theiler's murine encephalomyelitis virus obtained directly from acutely infected mouse brain. Infect Immun. 1984 Jun; 44(3):642-9. PMID: 6327529; PMCID: PMC263655.
      Citations: 6     Fields:    Translation:AnimalsCells
    165. Roos RP, Wollmann R. DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice. Ann Neurol. 1984 May; 15(5):494-9. PMID: 6732198.
      Citations: 42     Fields:    Translation:AnimalsCells
    166. Roos RP, Lichter M. Silver staining of cerebrospinal fluid IgG in isoelectric focusing gels. J Neurosci Methods. 1983 Aug; 8(4):375-80. PMID: 6194384.
      Citations: 2     Fields:    Translation:Humans
    167. Oger J, Roos R, Antel JP. Immunology of multiple sclerosis. Neurol Clin. 1983 Aug; 1(3):655-79. PMID: 6209537.
      Citations: 8     Fields:    Translation:HumansCells
    168. Roos RP. Viruses and demyelinating disease of the central nervous system. Neurol Clin. 1983 Aug; 1(3):681-700. PMID: 6209538; PMCID: PMC7135343.
      Citations: 2     Fields:    Translation:HumansCells
    169. Roos RP, Richards OC, Ehrenfeld E. Analysis of Theiler's virus isolates from persistently infected mouse nervous tissue. J Gen Virol. 1983 Mar; 64 Pt 3:701-6. PMID: 6298351.
      Citations: 7     Fields:    Translation:AnimalsCells
    170. Stefansson K, Marton L, Antel JP, Wollmann RL, Roos RP, Chejfec G, Arnason BG. Neuropathy accompanying IgM lambda monoclonal gammopathy. Acta Neuropathol. 1983; 59(4):255-61. PMID: 6306978.
      Citations: 16     Fields:    Translation:HumansCells
    171. Whitacre CC, Mattson DH, Day ED, Peterson DJ, Paterson PY, Roos RP, Arnason BG. Oligoclonal IgG in rabbits with experimental allergic encephalomyelitis: non-reactivity of the bands with sensitizing neural antigens. Neurochem Res. 1982 Oct; 7(10):1209-21. PMID: 6185858.
      Citations: 2     Fields:    Translation:Animals
    172. Roos RP, Richards OC, Green J, Ehrenfeld E. Characterization of a cell culture persistently infected with the DA strain of Theiler's murine encephalomyelitis virus. J Virol. 1982 Sep; 43(3):1118-22. PMID: 6292455; PMCID: PMC256224.
      Citations: 20     Fields:    Translation:AnimalsCells
    173. Mattson DH, Roos RP, Hopper JE, Arnason BG. Light chain composition of CSF oligoclonal IgG bands in multiple sclerosis and subacute sclerosing panencephalitis. J Neuroimmunol. 1982 Aug; 3(1):63-76. PMID: 6808024.
      Citations: 4     Fields:    Translation:Humans
    174. Roos RP, Firestone S, Wollmann R, Variakojis D, Arnason BG. The effect of short-term and chronic immunosuppression on Theiler's virus demyelination. J Neuroimmunol. 1982 Jun; 2(3-4):223-34. PMID: 6282927.
      Citations: 37     Fields:    Translation:AnimalsCells
    175. Mattson DH, Roos RP, Arnason BG. Oligoclonal IgG in multiple sclerosis and subacute sclerosing panencephalitis brains. J Neuroimmunol. 1982 Jun; 2(3-4):261-76. PMID: 7085864.
      Citations: 7     Fields:    Translation:Humans
    176. Viola MV, Lazarus M, Antel J, Roos R. Nucleic acid probes in the study of amyotrophic lateral sclerosis. Adv Neurol. 1982; 36:317-29. PMID: 6295102.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    177. Noronha AB, Antel JP, Roos RP, Medof ME. Circulating immune complexes in neurologic disease. Neurology. 1981 Nov; 31(11):1402-7. PMID: 7198188.
      Citations: 9     Fields:    Translation:Humans
    178. Roos RP, Graves MC, Wollmann RL, Chilcote RR, Nixon J. Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host: the relationship to subacute sclerosing panencephalitis. Neurology. 1981 Oct; 31(10):1263-70. PMID: 7202137.
      Citations: 14     Fields:    Translation:HumansCells
    179. Mattson DH, Roos RP, Arnason BG. Comparison of agar gel electrophoresis and isoelectric focusing in multiple sclerosis and subacute sclerosing panencephalitis. Ann Neurol. 1981 Jan; 9(1):34-41. PMID: 6163394.
      Citations: 18     Fields:    Translation:Humans
    180. Whitacre CC, Mattson DH, Paterson PY, Roos RP, Peterson DJ, Arnason BG. Cerebrospinal fluid and serum oligoclonal IgG bands in rabbits with experiment allergic encephalomyelitis. Neurochem Res. 1981 Jan; 6(1):87-96. PMID: 6164000.
      Citations: 5     Fields:    Translation:Animals
    181. Mattson DH, Roos RP, Arnason BG. Immunoperoxidase staining of cerebrospinal fluid IgG in isoelectric focusing gels: a sensitive new technique. J Neurosci Methods. 1980 Oct; 3(1):67-75. PMID: 6164880.
      Citations: 2     Fields:    Translation:Humans
    182. Mattson DH, Roos RP, Arnason BG. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature. 1980 Sep 25; 287(5780):335-7. PMID: 7421992.
      Citations: 33     Fields:    Translation:HumansCells
    183. Stefansson K, Antel JP, Oger J, Burns J, Noronha AB, Roos RP, Arnason BG, Gudmundsson G. Autosomal dominant cerebrovascular amyloidosis: properties of peripheral blood lymphocytes. Ann Neurol. 1980 May; 7(5):436-40. PMID: 7396423.
      Citations: 2     Fields:    Translation:HumansCells
    184. Roos RP, Viola MV, Wollmann R, Hatch MH, Antel JP. Amyotrophic lateral sclerosis with antecedent poliomyelitis. Arch Neurol. 1980 May; 37(5):312-3. PMID: 6247998.
      Citations: 6     Fields:    Translation:HumansCells
    185. Noronha AB, Antel JP, Roos RP, Arnason BG. Changes in concanavalin A capping of human lymphocytes with age. Mech Ageing Dev. 1980 Apr; 12(4):331-7. PMID: 7392675.
      Citations: 5     Fields:    Translation:HumansCells
    186. Noronha AB, Roos RP, Antel JP, Arnason BG. Huntington's disease: abnormality of lymphocyte capping. Ann Neurol. 1979 Nov; 6(5):447-50. PMID: 160212.
      Citations: 2     Fields:    Translation:HumansCells
    187. Viola MV, Myers JC, Gann KL, Gibbs JC, Roos RP. Failure to detect poliovirus genetic information in amyotrophic lateral sclerosis. Ann Neurol. 1979 Apr; 5(4):402-3. PMID: 220904.
      Citations: 3     Fields:    Translation:HumansCells
    188. Papathanasios B, Dendrinos C, Mposinakos M. [Osteogenesis imperfecta associated with dentinogenesis imperfecta]. Stomatologia (Athenai). 1979 Mar-Apr; 36(2):90-4. PMID: 288222.
      Citations:    Translation:Humans
    189. Roos RP, Wollmann R. Non-productive paramyxovirus infection: Nariva virus infection in hamsters. Arch Virol. 1979; 62(3):229-40. PMID: 518307.
      Citations:    Fields:    Translation:AnimalsCells
    190. Roos RP, Griffin DE, Johnson RT. Determinants of measles virus (hamster neurotropic strain) replication in mouse brain. J Infect Dis. 1978 Jun; 137(6):722-7. PMID: 207790.
      Citations: 6     Fields:    Translation:AnimalsCells
    191. Pericak-Vance MA, Conneally PM, Merritt AD, Roos R, Norton JA, Vance JM. Genetic linkage studies in Huntington disease. Cytogenet Cell Genet. 1978; 22(1-6):640-5. PMID: 156628.
      Citations: 3     Fields:    Translation:Humans
    192. Roos RP, Kirkpatrick C, Gadoth N, Berman W, Rary J. An immunological and cytogenetic investigation of tuberous sclerosis. Ann Neurol. 1977 Feb; 1(2):192-4. PMID: 889305.
      Citations:    Fields:    Translation:Humans
    193. Roos RP, Johnson RT, Roos RP, Johnson RT. Viruses and dementia. Contemp Neurol Ser. 1977; 15:93-112. PMID: 336275.
      Citations:    Fields:    Translation:HumansAnimals
    194. Bobowick AR, Brody JA, Matthews MR, Roos R, Gajdusek DC. Creutzfeldt-Jakob disease: a case-control study. Am J Epidemiol. 1973 Nov; 98(5):381-94. PMID: 4583406.
      Citations: 14     Fields:    Translation:HumansAnimals
    195. Roos R, Gajdusek DC, Gibbs CJ. The clinical characteristics of transmissible Creutzfeldt-Jakob disease. Brain. 1973; 96(1):1-20. PMID: 4633062.
      Citations: 31     Fields:    Translation:HumansAnimals
    196. Brown P, Hooks J, Roos R, Gajdusek DC, Gibbs CJ. Attempt to identify the agent for Creutzfeldt-Jakob disease by CF antibody relationship to known viruses. Nat New Biol. 1972 Feb 02; 235(57):149-52. PMID: 4333969.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    197. Roos R, Chou SM, Rogers NG, Basnight M, Gajdusek DC. Isolation of an adenovirus 32 strain from human brain in a case of subacute encephalitis. Proc Soc Exp Biol Med. 1972 Feb; 139(2):636-40. PMID: 4333787.
      Citations: 10     Fields:    Translation:HumansCells
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