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Chong-Zhi Wang

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentAnesthesia & Critical Care
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    China Pharmaceutical University, Nanjing, ChinaB.S.07/1990Pharmaceutical Sciences
    China Pharmaceutical University, Nanjing, ChinaM.S.06/1999Natural Medicine
    China Pharmaceutical University, Nanjing, ChinaPh.D.06/2003Pharmacognosy
    University of Chicago, Chicago, ILPostdoc10/2007Phytomedicine
    University of Chicago, Chicago, ILNIH Career Development Training12/2015Pharmacology

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Luo Y, Wang CZ, Hesse-Fong J, Lin JG, Yuan CS. Application of Chinese Medicine in Acute and Critical Medical Conditions. Am J Chin Med. 2019; 47(6):1223-1235. PMID: 31505937.
      View in: PubMed
    2. Yu L, Wei F, Liang J, Ren G, Liu X, Wang CZ, Yuan J, Zeng J, Luo Y, Bi Y, Yuan CS. Target Molecular-Based Neuroactivity Screening and Analysis of Panax ginseng by Affinity Ultrafiltration, UPLC-QTOF-MS and Molecular Docking. Am J Chin Med. 2019; 47(6):1345-1363. PMID: 31495181.
      View in: PubMed
    3. Gan L, Ji J, Wang L, Li QY, Zhang CF, Wang CZ, Yuan CS. Identification of the metabolites in normal and AA rat plasma, urine and feces after oral administration of Daphne genkwa flavonoids by LC-Q-TOF-MS spectrometry. J Pharm Biomed Anal. 2020 Jan 05; 177:112856. PMID: 31521020.
      View in: PubMed
    4. Liu Z, Li JX, Wang CZ, Zhang DL, Wen X, Ruan CC, Li Y, Yuan CS. Microbial Conversion of Protopanaxadiol-Type Ginsenosides by the Edible and Medicinal Mushroom Schizophyllum commune: A Green Biotransformation Strategy. ACS Omega. 2019 Aug 20; 4(8):13114-13123. PMID: 31460439.
      View in: PubMed
    5. Bao Y, Sun YW, Ji J, Gan L, Zhang CF, Wang CZ, Yuan CS. Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-?B signaling pathways. Phytomedicine. 2019 Oct; 63:153036. PMID: 31401534.
      View in: PubMed
    6. Jin HR, Du CH, Wang CZ, Yuan CS, Du W. Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK. Cell Death Dis. 2019 Apr 05; 10(4):311. PMID: 30952841.
      View in: PubMed
    7. Jin HR, Du CH, Wang CZ, Yuan CS, Du W. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death. Phytother Res. 2019 Mar; 33(3):610-617. PMID: 30537241.
      View in: PubMed
    8. Zhang JW, Tan L, Zhang YZ, Zheng GC, Xia ZN, Wang CZ, Zhou LD, Zhang QH, Yuan CS. Debittering of lemon juice using surface molecularly imprinted polymers and the utilization of limonin. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 01; 1104:205-211. PMID: 30529494.
      View in: PubMed
    9. Wang J, Shao L, Wang CZ, Zhou HH, Yuan CS, Huang WH. Synergetic Inhibition of Human Colorectal Cancer Cells by Combining Polyyne-Enriched Fraction from Oplopanax elatus and Irinotecan. Nutr Cancer. 2019; 71(3):472-482. PMID: 30372160.
      View in: PubMed
    10. Wang CZ, Zhang CF, Zhang QH, Hesse-Fong J, Lager M, Du W, Xu M, Yuan CS. Fecal metabolomic dataset of American ginseng-treated DSS mice: Correlation between ginseng enteric inflammation inhibition and its biological signatures. Data Brief. 2018 Dec; 21:1403-1408. PMID: 30456264.
      View in: PubMed
    11. Bao Y, Li H, Li QY, Li Y, Li F, Zhang CF, Wang CZ, Yuan CS. Therapeutic effects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model. Biomed Pharmacother. 2018 Dec; 108:309-315. PMID: 30227323.
      View in: PubMed
    12. Wu K, Wang CZ, Yuan CS, Huang WH. Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects. Evid Based Complement Alternat Med. 2018; 2018:9186926. PMID: 30302120.
      View in: PubMed
    13. Wang CZ, Yao H, Zhang CF, Chen L, Wan JY, Huang WH, Zeng J, Zhang QH, Liu Z, Yuan J, Bi Y, Sava-Segal C, Du W, Xu M, Yuan CS. American ginseng microbial metabolites attenuate DSS-induced colitis and abdominal pain. Int Immunopharmacol. 2018 Nov; 64:246-251. PMID: 30212750.
      View in: PubMed
    14. Wang CZ, Wan JY, Zhang CF, Lu F, Chen L, Yuan CS. Deglycosylation of wogonoside enhances its anticancer potential. J Cancer Res Ther. 2018 Sep; 14(Supplement):S594-S599. PMID: 30249874.
      View in: PubMed
    15. Liu SM, Li XZ, Zhang SN, Yang ZM, Wang KX, Lu F, Wang CZ, Yuan CS. Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Model of Parkinson's Disease. Chin J Integr Med. 2018 Nov; 24(11):835-843. PMID: 30090975.
      View in: PubMed
    16. Sun ZL, Zhang YZ, Zhang F, Zhang JW, Zheng GC, Tan L, Wang CZ, Zhou LD, Zhang QH, Yuan CS. Quality assessment of Penthorum chinense Pursh through multicomponent qualification and fingerprint, chemometric, and antihepatocarcinoma analyses. Food Funct. 2018 Jul 17; 9(7):3807-3814. PMID: 29932194.
      View in: PubMed
    17. Zhang YZ, Zhang J, Tan L, Xia Z, Wang CZ, Zhou LD, Zhang Q, Yuan CS. Preparation and evaluation of temperature and magnetic dual-responsive molecularly imprinted polymers for the specific enrichment of formononetin. J Sep Sci. 2018 Aug; 41(15):3060-3068. PMID: 29878532.
      View in: PubMed
    18. Yao H, Wan JY, Wang CZ, Li L, Wang J, Li Y, Huang WH, Zeng J, Wang Q, Yuan CS. Bibliometric analysis of research on the role of intestinal microbiota in obesity. PeerJ. 2018; 6:e5091. PMID: 29967745.
      View in: PubMed
    19. Wan JY, Yao H, Zhang CF, Huang WH, Zhang Q, Liu Z, Bi Y, Williams S, Wang CZ, Yuan CS. Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways. J Appl Biomed. 2018 Nov; 16(4):311-319. PMID: 30976156.
      View in: PubMed
    20. Zhang QH, Tan L, Gou Q, Zhou LD, Wang CZ, Yuan CS. 6,8-di-C-glycosyl flavones with ß-furanoarabinose from Scutellaria baicalensis and their anti-inflammatory activities. Nat Prod Res. 2019 May; 33(9):1243-1250. PMID: 29683359.
      View in: PubMed
    21. Wang L, Lan XY, Ji J, Zhang CF, Li F, Wang CZ, Yuan CS. Anti-inflammatory and anti-angiogenic activities in vitro of eight diterpenes from Daphne genkwa based on hierarchical cluster and principal component analysis. J Nat Med. 2018 Jun; 72(3):675-685. PMID: 29680963.
      View in: PubMed
    22. Yao H, Wan JY, Zeng J, Huang WH, Sava-Segal C, Li L, Niu X, Wang Q, Wang CZ, Yuan CS. Effects of compound K, an enteric microbiome metabolite of ginseng, in the treatment of inflammation associated colon cancer. Oncol Lett. 2018 Jun; 15(6):8339-8348. PMID: 29805567.
      View in: PubMed
    23. Yao D, Zhang L, Huang J, Sun C, Zhang Y, Gu X, Wang CZ, Li F, Chen L, Yuan CS. A surface magnetic imprinted polymers as artificial receptors for selective and efficient capturing of new neuronal nitric oxide synthase-post synaptic density protein-95 uncouplers. J Pharm Biomed Anal. 2018 May 30; 154:180-190. PMID: 29550707.
      View in: PubMed
    24. Yao H, Mo S, Wang J, Li Y, Wang CZ, Wan JY, Zhang Z, Chen Y, Sun R, Yuan CS, Liu X, Li L, Wang Q. Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution. Cell Physiol Biochem. 2018; 45(5):1999-2008. PMID: 29518789.
      View in: PubMed
    25. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice. Clin Transl Oncol. 2018 03; 20(3):425. PMID: 29027650.
      View in: PubMed
    26. Zeng JX, Wang J, Zhang SW, Zhu JX, Li M, Huang WH, Wan JY, Yao HQ, Wang CZ, Yuan CS. Antigout Effects of Plantago asiatica: Xanthine Oxidase Inhibitory Activities Assessed by Electrochemical Biosensing Method. Evid Based Complement Alternat Med. 2018; 2018:1364617. PMID: 29681967.
      View in: PubMed
    27. Zhang YZ, Zhang JW, Wang CZ, Zhou LD, Zhang QH, Yuan CS. Polydopamine-Coated Magnetic Molecularly Imprinted Polymers with Fragment Template for Identification of Pulsatilla Saponin Metabolites in Rat Feces with UPLC-Q-TOF-MS. J Agric Food Chem. 2018 Jan 24; 66(3):653-660. PMID: 29260546.
      View in: PubMed
    28. Chen MY, Shao L, Zhang W, Wang CZ, Zhou HH, Huang WH, Yuan CS. Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS. J Pharm Biomed Anal. 2018 Feb 20; 150:199-207. PMID: 29245089.
      View in: PubMed
    29. Sun C, Wang J, Huang J, Yao D, Wang CZ, Zhang L, Hou S, Chen L, Yuan CS. The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples. Polymers (Basel). 2017 Nov 28; 9(12). PMID: 30965954.
      View in: PubMed
    30. Gu X, Huang J, Zhang L, Zhang Y, Wang CZ, Sun C, Yao D, Li F, Chen L, Yuan CS. Efficient discovery and capture of new neuronal nitric oxide synthase-postsynaptic density protein-95 uncouplers from herbal medicines using magnetic molecularly imprinted polymers as artificial antibodies. J Sep Sci. 2017 Sep; 40(17):3522-3534. PMID: 28704580.
      View in: PubMed
    31. Wan JY, Huang WH, Zheng W, Park CW, Kim SH, Seo DB, Shin KS, Zeng J, Yao H, Sava-Segal C, Wang CZ, Yuan CS. Multiple Effects of Ginseng Berry Polysaccharides: Plasma Cholesterol Level Reduction and Enteric Neoplasm Prevention. Am J Chin Med. 2017; 45(6):1293-1307. PMID: 28830208.
      View in: PubMed
    32. Wang CZ, Huang WH, Zhang CF, Wan JY, Wang Y, Yu C, Williams S, He TC, Du W, Musch MW, Chang EB, Yuan CS. Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected]. Clin Transl Oncol. 2018 03; 20(3):302-312. PMID: 28808878.
      View in: PubMed
    33. Du WJ, Ji J, Wang L, Lan XY, Li J, Lei JQ, He X, Zhang CF, Huang WZ, Wang ZZ, Xiao W, Wang CZ, Yuan CS. Relationship between the UPLC-Q-TOF-MS fingerprinted constituents from Daphne genkwa and their anti-inflammatory, anti-oxidant activities. Biomed Chromatogr. 2017 Dec; 31(12). PMID: 28543360.
      View in: PubMed
    34. Sun YY, Zhang WJ, Dong CL, Zhang XF, Ji J, Wang X, Wang L, Hu WL, Du WJ, Cui CL, Zhang CF, Li F, Wang CZ, Yuan CS. Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System. Phytother Res. 2017 Jun; 31(6):899-905. PMID: 28488307.
      View in: PubMed
    35. Liu Z, Wang CZ, Zhu XY, Wan JY, Zhang J, Li W, Ruan CC, Yuan CS. Dynamic Changes in Neutral and Acidic Ginsenosides with Different Cultivation Ages and Harvest Seasons: Identification of Chemical Characteristics for Panax ginseng Quality Control. Molecules. 2017 May 04; 22(5). PMID: 28471389.
      View in: PubMed
    36. Cui CL, He X, Dong CL, Song ZJ, Ji J, Wang X, Wang L, Wang JY, Du WJ, Wang CZ, Yuan CS, Guo CR, Zhang CF. The enhancement mechanism of wine-processed Radix Scutellaria on NTG-induced migraine rats. Biomed Pharmacother. 2017 Jul; 91:138-146. PMID: 28456113.
      View in: PubMed
    37. Bi Y, Liu XX, Zhang HY, Yang X, Liu ZY, Lu J, Lewis PJ, Wang CZ, Xu JY, Meng QG, Ma C, Yuan CS. Synthesis and Antibacterial Evaluation of Novel 3-Substituted Ocotillol-Type Derivatives as Leads. Molecules. 2017 Apr 07; 22(4). PMID: 28387737.
      View in: PubMed
    38. Zhang XF, Zhang WJ, Dong CL, Hu WL, Sun YY, Bao Y, Zhang CF, Guo CR, Wang CZ, Yuan CS. Analgesia effect of baicalein against NTG-induced migraine in rats. Biomed Pharmacother. 2017 Jun; 90:116-121. PMID: 28343071.
      View in: PubMed
    39. Wang X, He X, Zhang CF, Guo CR, Wang CZ, Yuan CS. Anti-arthritic effect of berberine on adjuvant-induced rheumatoid arthritis in rats. Biomed Pharmacother. 2017 May; 89:887-893. PMID: 28282791.
      View in: PubMed
    40. Tang YJ, Hu K, Huang WH, Wang CZ, Liu Z, Chen Y, Ouyang DS, Tan ZR, Zhou HH, Yuan CS. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers. Biomed Res Int. 2017; 2017:4189678. PMID: 28331852.
      View in: PubMed
    41. Yuan J, Ren G, Liang J, Wang CZ, Yan Z, Huang Q, Li J, Chen Y, Tang Y, Liu X, Yuan CS. Comparative studies on the multi-component pharmacokinetics of Aristolochiae Fructus and honey-fried Aristolochiae Fructus extracts after oral administration in rats. BMC Complement Altern Med. 2017 Feb 10; 17(1):107. PMID: 28187732.
      View in: PubMed
    42. Liu ZY, Zhang HY, Bi Y, Liu XX, Lu J, Zhang XC, Xu JY, Wang CZ, Yuan CS. Design and synthesis of 28-hydroxy protopanaxadiol as a novel probe template. Nat Prod Res. 2017 Jul; 31(13):1523-1528. PMID: 28107791.
      View in: PubMed
    43. Dai D, Zhang CF, Williams S, Yuan CS, Wang CZ. Ginseng on Cancer: Potential Role in Modulating Inflammation-Mediated Angiogenesis. Am J Chin Med. 2017; 45(1):13-22. PMID: 28068835.
      View in: PubMed
    44. Wang L, Wang X, Zhang SL, Zhu XM, Liu YQ, Song ZJ, Du WJ, Ji J, Cui CL, He X, Zhang CF, Guo CR, Wang CZ, Yuan CS. Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats. J Nat Med. 2017 Jan; 71(1):257-264. PMID: 27858308.
      View in: PubMed
    45. Shao L, Nie MK, Chen MY, Wang J, Wang CZ, Huang WH, Yuan CS, Zhou HH. Screening and identifying antioxidants from Oplopanax elatus using 2,2'-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry. J Sep Sci. 2016 Nov; 39(22):4269-4280. PMID: 27624907.
      View in: PubMed
    46. Yuan J, Chen Y, Liang J, Wang CZ, Liu X, Yan Z, Tang Y, Li J, Yuan CS. Component analysis and target cell-based neuroactivity screening of Panax ginseng by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Dec 01; 1038:1-11. PMID: 27776327.
      View in: PubMed
    47. Wan JY, Wang CZ, Zhang QH, Liu Z, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota. Biomed Chromatogr. 2017 Apr; 31(4). PMID: 27606833.
      View in: PubMed
    48. Hasebe T, Matsukawa J, Ringus D, Miyoshi J, Hart J, Kaneko A, Yamamoto M, Kono T, Fujiya M, Kohgo Y, Wang CZ, Yuan CS, Bissonnette M, Musch MW, Chang EB. Daikenchuto (TU-100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer. Phytother Res. 2017 Jan; 31(1):90-99. PMID: 27730672.
      View in: PubMed
    49. Wang L, Wang X, Zhu XM, Liu YQ, Du WJ, Ji J, He X, Zhang CF, Li F, Guo CR, Wang CZ, Yuan CS. Gastroprotective Effect of Alkaloids from Cortex Phellodendri on Gastric Ulcers in Rats through Neurohumoral Regulation. Planta Med. 2017 Feb; 83(3-04):277-284. PMID: 27648555.
      View in: PubMed
    50. Wang CZ, Yu C, Wen XD, Chen L, Zhang CF, Calway T, Qiu Y, Wang Y, Zhang Z, Anderson S, Wang Y, Jia W, Yuan CS. American Ginseng Attenuates Colitis-Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics. Cancer Prev Res (Phila). 2016 Oct; 9(10):803-811. PMID: 27443884.
      View in: PubMed
    51. Liu Z, Xia J, Wang CZ, Zhang JQ, Ruan CC, Sun GZ, Yuan CS. Remarkable Impact of Acidic Ginsenosides and Organic Acids on Ginsenoside Transformation from Fresh Ginseng to Red Ginseng. J Agric Food Chem. 2016 Jul 06; 64(26):5389-99. PMID: 27295137.
      View in: PubMed
    52. Wang J, Dong C, Song Z, Zhang W, He X, Zhang R, Guo C, Zhang C, Li F, Wang C, Yuan C. Monocyclic monoterpenes as penetration enhancers of ligustrazine hydrochloride for dermal delivery. Pharm Dev Technol. 2017 Jun; 22(4):571-577. PMID: 27269134.
      View in: PubMed
    53. Zhang Q, Zhou L, Chen H, Wang CZ, Xia Z, Yuan CS. Solid-phase microextraction technology for in vitro and in vivo metabolite analysis. Trends Analyt Chem. 2016 Jun; 80:57-65. PMID: 27695152.
      View in: PubMed
    54. Ma WK, Li H, Dong CL, He X, Guo CR, Zhang CF, Yu CH, Wang CZ, Yuan CS. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines. Mol Med Rep. 2016 Jul; 14(1):491-8. PMID: 27175745.
      View in: PubMed
    55. Chen MY, Tang YJ, Wang YC, Wang CZ, Yuan CS, Chen Y, Tan ZR, Huang WH, Zhou HH. Quantitative determination of betamethasone sodium phosphate and betamethasone dipropionate in human plasma by UPLC-MS/MS and a bioequivalence study. Anal Methods. 2016 May 07; 8(17):3550-3563. PMID: 27695531.
      View in: PubMed
    56. Wang J, Ji J, Song Z, Zhang W, He X, Li F, Zhang C, Guo C, Wang C, Yuan C. Hypocholesterolemic effect of emodin by simultaneous determination of in vitro and in vivo bile salts binding. Fitoterapia. 2016 Apr; 110:116-22. PMID: 26964768.
      View in: PubMed
    57. Wan JY, Wang CZ, Liu Z, Zhang QH, Musch MW, Bissonnette M, Chang EB, Li P, Qi LW, Yuan CS. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15; 1015-1016:62-73. PMID: 26896573.
      View in: PubMed
    58. Wang CZ, Anderson S, Yuan CS. Phytochemistry and Anticancer Potential of Notoginseng. Am J Chin Med. 2016; 44(1):23-34. PMID: 26916912.
      View in: PubMed
    59. Wang CZ, Anderson S, DU W, He TC, Yuan CS. Red ginseng and cancer treatment. Chin J Nat Med. 2016 Jan; 14(1):7-16. PMID: 26850342.
      View in: PubMed
    60. Du WJ, Yang XL, Song ZJ, Wang JY, Zhang WJ, He X, Zhang RQ, Zhang CF, Li F, Yu CH, Wang CZ, Yuan CS. Antitumor Activity of Total Flavonoids from Daphne genkwa in Colorectal Cancer. Phytother Res. 2016 Feb; 30(2):323-30. PMID: 26646778.
      View in: PubMed
    61. Wang CZ, Qi LW, Yuan CS. Cancer Chemoprevention Effects of Ginger and its Active Constituents: Potential for New Drug Discovery. Am J Chin Med. 2015; 43(7):1351-63. PMID: 26477795.
      View in: PubMed
    62. Wang CZ, Zhang CF, Chen L, Anderson S, Lu F, Yuan CS. Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin. Int J Oncol. 2015 Nov; 47(5):1749-58. PMID: 26398706.
      View in: PubMed
    63. Wang X, Song ZJ, He X, Zhang RQ, Zhang CF, Li F, Wang CZ, Yuan CS. Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APC(Min/+) mice. Int Immunopharmacol. 2015 Dec; 29(2):701-707. PMID: 26388189.
      View in: PubMed
    64. Wang CZ, Cai Y, Anderson S, Yuan CS. Ginseng Metabolites on Cancer Chemoprevention: An Angiogenesis Link? Diseases. 2015 Sep; 3(3):193-204. PMID: 26941993.
      View in: PubMed
    65. Wang CZ, Moss J, Yuan CS. Commonly Used Dietary Supplements on Coagulation Function during Surgery. Medicines (Basel). 2015 Sep; 2(3):157-185. PMID: 26949700.
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    66. Li H, He H, Huang J, Wang CZ, Gu X, Gao Y, Zhang H, Du S, Chen L, Yuan CS. A novel molecularly imprinted method with computational simulation for the affinity isolation and knockout of baicalein from Scutellaria baicalensis. Biomed Chromatogr. 2016 Feb; 30(2):117-25. PMID: 26037609.
      View in: PubMed
    67. Xie G, Wang CZ, Yu C, Qiu Y, Wen XD, Zhang CF, Yuan CS, Jia W. Metabonomic Profiling Reveals Cancer Chemopreventive Effects of American Ginseng on Colon Carcinogenesis in Apc(Min/+) Mice. J Proteome Res. 2015 Aug 07; 14(8):3336-47. PMID: 26136108.
      View in: PubMed
    68. Qi LW, Zhang Z, Zhang CF, Anderson S, Liu Q, Yuan CS, Wang CZ. Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk. Am J Chin Med. 2015; 43(4):743-56. PMID: 26119958.
      View in: PubMed
    69. Lian F, Tian J, Chen X, Li Z, Piao C, Guo J, Ma L, Zhao L, Xia C, Wang CZ, Yuan CS, Tong X. The Efficacy and Safety of Chinese Herbal Medicine Jinlida as Add-On Medication in Type 2 Diabetes Patients Ineffectively Managed by Metformin Monotherapy: A Double-Blind, Randomized, Placebo-Controlled, Multicenter Trial. PLoS One. 2015; 10(6):e0130550. PMID: 26098833.
      View in: PubMed
    70. Li H, Song ZJ, Dai YP, Zhang SL, He X, Guo CR, Zhang WJ, Wang JY, Zhang CF, Wang CZ, Yuan CS. Antioxidative Activity of Flavonoids from Abrus cantoniensis against Ethanol-Induced Gastric Ulcer in Mice. Planta Med. 2015 Jul; 81(10):784-90. PMID: 26039267.
      View in: PubMed
    71. Meng LZ, Huang WH, Wang CZ, Yuan CS, Li SP. Correction: Huang, W.-H., et al. Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives. Molecules 2014, 19, 6142-6162. Molecules. 2015 Mar 26; 20(4):5438-9. PMID: 25822082.
      View in: PubMed
    72. Huang WH, Zhang QW, Wang CZ, Yuan CS, Li SP. Phenolic Derivatives from the Root Bark of Oplopanax horridus. Helv Chim Acta. 2015 Feb; 98(2):201-209. PMID: 27284207.
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    73. Wang CZ, Zhang Z, Wan JY, Zhang CF, Anderson S, He X, Yu C, He TC, Qi LW, Yuan CS. Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer. Nutrients. 2015 Jan 23; 7(2):799-814. PMID: 25625815.
      View in: PubMed
    74. Wu XH, Wang CZ, Wang SQ, Mi C, He Y, Zhang J, Zhang YW, Anderson S, Yuan CS. Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. J Ethnopharmacol. 2015 Mar 13; 162:362-8. PMID: 25617746.
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    75. Yu C, Wen XD, Zhang Z, Zhang CF, Wu X, He X, Liao Y, Wu N, Wang CZ, Du W, He TC, Yuan CS. American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice. J Ginseng Res. 2015 Jul; 39(3):230-7. PMID: 26199554.
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    76. Gu X, He H, Wang CZ, Gao Y, Zhang H, Hong J, Du S, Chen L, Yuan CS. Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection from biological samples. RSC Adv. 2015 Jan 01; 5(52):41377-41384. PMID: 26257892.
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    77. Zhang WJ, Wang JY, Li H, He X, Zhang RQ, Zhang CF, Li F, Yang ZL, Wang CZ, Yuan CS. Novel Application of Natural Anisole Compounds as Enhancers for Transdermal Delivery of Ligustrazine. Am J Chin Med. 2015; 43(6):1231-46. PMID: 26446204.
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    78. Shao L, Bao MH, Ouyang DS, Wang CZ, Yuan CS, Zhou HH, Huang WH. Unstable simple volatiles and gas chromatography-tandem mass spectrometry analysis of essential oil from the roots bark of Oplopanax horridus extracted by supercritical fluid extraction. Molecules. 2014 Nov 27; 19(12):19708-17. PMID: 25438081.
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    79. Zhang Z, Li Z, Wu X, Zhang CF, Calway T, He TC, Du W, Chen J, Wang CZ, Yuan CS. TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol. J Pharmacol Sci. 2015 Jan; 127(1):83-91. PMID: 25704023.
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    80. He YS, Sun W, Wang CZ, Qi LW, Yang J, Li P, Wen XD, Yuan CS. Effects of American ginseng on pharmacokinetics of 5-fluorouracil in rats. Biomed Chromatogr. 2015 May; 29(5):762-7. PMID: 25339249.
      View in: PubMed
    81. Yang ZM, Zhao J, Lao KM, Chen XJ, Leong F, Wang CZ, Yuan CS, Li SP. Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography. Electrophoresis. 2014 Oct; 35(20):2959-64. PMID: 25070635.
      View in: PubMed
    82. Zhang SL, Li H, He X, Zhang RQ, Sun YH, Zhang CF, Wang CZ, Yuan CS. Alkaloids from Mahonia bealei posses anti-H?/K?-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats. Phytomedicine. 2014 Sep 25; 21(11):1356-63. PMID: 25172799.
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    83. Wu XH, Wang CZ, Zhang J, Wang SQ, Han L, Zhang YW, Yuan CS. Effects of Smilaxchinoside A and Smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model. Phytother Res. 2014 Dec; 28(12):1822-8. PMID: 25098402.
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    84. Zhang Z, Yu C, Zhang CF, Wu XH, Wen XD, Anderson S, Du W, Huang WH, Li SP, Wang CZ, Yuan CS. Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on colorectal cancer. Nutrients. 2014 Jul 18; 6(7):2668-80. PMID: 25045937.
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    85. Yu C, Wen XD, Zhang Z, Zhang CF, Wu XH, Martin A, Du W, He TC, Wang CZ, Yuan CS. American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice. J Ginseng Res. 2015 Jan; 39(1):14-21. PMID: 25535472.
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    86. Yu C, Wang CZ, Zhou CJ, Wang B, Han L, Zhang CF, Wu XH, Yuan CS. Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis. J Pharm Biomed Anal. 2014 Oct; 99:8-15. PMID: 25044150.
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    87. Ueno N, Hasebe T, Kaneko A, Yamamoto M, Fujiya M, Kohgo Y, Kono T, Wang CZ, Yuan CS, Bissonnette M, Chang EB, Musch MW. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: microbe-independent effects involving Akt and NF-?B suppression. PLoS One. 2014; 9(5):e97456. PMID: 24857966.
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    88. Huang WH, Shao L, Wang CZ, Yuan CS, Zhou HH. Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives. Molecules. 2014 May 14; 19(5):6142-62. PMID: 24830715.
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    89. Huang WH, Luo W, Wang CZ, Yuan CS, Nie MK, Shi SY, Zhou HH, Ouyang DS. [Phenolic constituents from Oplopanax horridus]. Zhongguo Zhong Yao Za Zhi. 2014 May; 39(10):1852-7. PMID: 25282894.
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    90. Jin HR, Liao Y, Li X, Zhang Z, Zhao J, Wang CZ, Huang WH, Li SP, Yuan CS, Du W. Anticancer compound Oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis. 2014 Apr 24; 5:e1190. PMID: 24763047.
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    91. Zhang CF, Zhang SL, He X, Yang XL, Wu HT, Lin BQ, Jiang CP, Wang J, Yu CH, Yang ZL, Wang CZ, Li P, Yuan CS. Antioxidant effects of Genkwa flos flavonoids on Freund?s adjuvant-induced rheumatoid arthritis in rats. J Ethnopharmacol. 2014 May 14; 153(3):793-800. PMID: 24685587.
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    92. Jiang CP, He X, Yang XL, Zhang SL, Li H, Song ZJ, Zhang CF, Yang ZL, Li P, Wang CZ, Yuan CS. Anti-rheumatoid arthritic activity of flavonoids from Daphne genkwa. Phytomedicine. 2014 May 15; 21(6):830-7. PMID: 24561028.
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    93. Huang WH, Zhang QW, Yuan CS, Wang CZ, Li SP, Zhou HH. Chemical constituents of the plants from the genus Oplopanax. Chem Biodivers. 2014 Feb; 11(2):181-96. PMID: 24591310.
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    94. Lian F, Li G, Chen X, Wang X, Piao C, Wang J, Hong Y, Ba Z, Wu S, Zhou X, Lang J, Liu Y, Zhang R, Hao J, Zhu Z, Li H, Fang Liu H, Cao A, Yan Z, An Y, Bai Y, Wang Q, Zhen Z, Yu C, Wang CZ, Yuan CS, Tong X. Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: a double-blind, randomized, placebo-controlled, multicenter trial. J Clin Endocrinol Metab. 2014 Feb; 99(2):648-55. PMID: 24432995.
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    95. Wang CZ, Zhang Z, Anderson S, Yuan CS. Natural products and chemotherapeutic agents on cancer: prevention vs. treatment. Am J Chin Med. 2014; 42(6):1555-8. PMID: 25482675.
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    96. Tung NH, Du GJ, Yuan CS, Shoyama Y, Wang CZ. Isolation and chemopreventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria. Anticancer Drugs. 2013 Nov; 24(10):1058-68. PMID: 24025561.
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    97. Wen XD, Wang CZ, Yu C, Zhao L, Zhang Z, Matin A, Wang Y, Li P, Xiao SY, Du W, He TC, Yuan CS. Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model. Phytother Res. 2014 Jun; 28(6):892-8. PMID: 24142591.
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    98. Yu C, Zhang Z, Zhang H, Zhen Z, Calway T, Wang Y, Yuan CS, Wang CZ. Pretreatment of baicalin and wogonoside with glycoside hydrolase: a promising approach to enhance anticancer potential. Oncol Rep. 2013 Nov; 30(5):2411-8. PMID: 24026776.
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    99. Wang CZ, Yuan CS. Pharmacologic treatment of opioid-induced constipation. Expert Opin Investig Drugs. 2013 Oct; 22(10):1225-7. PMID: 23834367.
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    100. Yu CH, Wang CZ, Yuan CS. [Progress in anti-cancer research of American ginseng: with an example of colorectal cancer]. Yao Xue Xue Bao. 2013 Jul; 48(7):986-92. PMID: 24133965.
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    101. Wang CZ, Zhang Z, Huang WH, Du GJ, Wen XD, Calway T, Yu C, Nass R, Zhao J, Du W, Li SP, Yuan CS. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine. 2013 Aug 15; 20(11):999-1006. PMID: 23746754.
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    102. Zhang Z, Wang CZ, Du GJ, Qi LW, Calway T, He TC, Du W, Yuan CS. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol. 2013 Jul; 43(1):289-96. PMID: 23686257.
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    103. Zhang Z, Wang CZ, Wen XD, Shoyama Y, Yuan CS. Role of saffron and its constituents on cancer chemoprevention. Pharm Biol. 2013 Jul; 51(7):920-4. PMID: 23570520.
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    104. Zhang Z, Du GJ, Wang CZ, Wen XD, Calway T, Li Z, He TC, Du W, Bissonnette M, Musch MW, Chang EB, Yuan CS. Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. Int J Mol Sci. 2013 Jan 31; 14(2):2980-95. PMID: 23434653.
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    105. Wang CZ, Calway TD, Wen XD, Smith J, Yu C, Wang Y, Mehendale SR, Yuan CS. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int J Oncol. 2013 Mar; 42(3):1018-26. PMID: 23337959.
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    106. Wang CZ, Li B, Wen XD, Zhang Z, Yu C, Calway TD, He TC, Du W, Yuan CS. Paraptosis and NF-?B activation are associated with protopanaxadiol-induced cancer chemoprevention. BMC Complement Altern Med. 2013 Jan 03; 13:2. PMID: 23281928.
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    107. Wen XD, Wang CZ, Yu C, Zhang Z, Calway T, Wang Y, Li P, Yuan CS. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis. Am J Chin Med. 2013; 41(5):1097-108. PMID: 24117071.
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    108. Li Z, Zhang Z, Li Y, Arnovitz S, Chen P, Huang H, Jiang X, Hong GM, Kunjamma RB, Ren H, He C, Wang CZ, Elkahloun AG, Valk PJ, Döhner K, Neilly MB, Bullinger L, Delwel R, Löwenberg B, Liu PP, Morgan R, Rowley JD, Yuan CS, Chen J. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013 Feb 21; 121(8):1422-31. PMID: 23264595.
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    109. Du GJ, Zhang Z, Wen XD, Yu C, Calway T, Yuan CS, Wang CZ. Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients. 2012 Nov 08; 4(11):1679-91. PMID: 23201840.
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    110. Li J, Shao ZH, Xie JT, Wang CZ, Ramachandran S, Yin JJ, Aung H, Li CQ, Qin G, Vanden Hoek T, Yuan CS. The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes. Arch Pharm Res. 2012 Jul; 35(7):1259-67. PMID: 22864749.
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    111. Du GJ, Wang CZ, Qi LW, Zhang ZY, Calway T, He TC, Du W, Yuan CS. The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res. 2013 Feb; 27(2):272-7. PMID: 22566066.
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    112. Wen XD, Yang J, Ma RH, Gao W, Qi LW, Li P, Bauer BA, Du GJ, Zhang Z, Somogyi J, Wang CZ, Yuan CS. Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 01; 895-896:162-8. PMID: 22465198.
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    113. Wang CZ, Du GJ, Zhang Z, Wen XD, Calway T, Zhen Z, Musch MW, Bissonnette M, Chang EB, Yuan CS. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int J Oncol. 2012 Jun; 40(6):1970-6. PMID: 22426808.
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    114. Du GJ, Wang CZ, Zhang ZY, Wen XD, Somogyi J, Calway T, He TC, Du W, Yuan CS. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. J Pharm Pharmacol. 2012 May; 64(5):727-34. PMID: 22471369.
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    115. Wang CZ, Li P, Yuan CS. Traditional Chinese herbal therapy as a treatment option for H1N1 influenza. Ann Intern Med. 2012 Jan 17; 156(2):166; author reply 166-7. PMID: 22250153.
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    116. Wang CZ, Calway T, Yuan CS. Herbal medicines as adjuvants for cancer therapeutics. Am J Chin Med. 2012; 40(4):657-69. PMID: 22809022.
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    117. Wang CZ, He H, Wang X, Yuan CS. Trends in scientific publications of Chinese medicine. Am J Chin Med. 2012; 40(6):1099-108. PMID: 23227784.
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    118. Calway T, Du GJ, Wang CZ, Huang WH, Zhao J, Li SP, Yuan CS. Chemical and pharmacological studies of Oplopanax horridus, a North American botanical. J Nat Med. 2012 Apr; 66(2):249-56. PMID: 22101399.
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    119. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. PMID: 22070864.
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    120. Qi LW, Wang CZ, Du GJ, Zhang ZY, Calway T, Yuan CS. Metabolism of ginseng and its interactions with drugs. Curr Drug Metab. 2011 Nov; 12(9):818-22. PMID: 21619519.
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    121. Wang CZ, Du GJ, Zhen Z, Calway T, Yuan CS. Significant dose differences in donepezil purchased from the United States and Canada. Ann Intern Med. 2011 Aug 16; 155(4):279-80. PMID: 21844564.
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    122. Sun S, Qi LW, Du GJ, Mehendale SR, Wang CZ, Yuan CS. Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem. 2011 Apr 15; 125(4):1299-1305. PMID: 21344064.
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    123. Xie JT, Du GJ, McEntee E, Aung HH, He H, Mehendale SR, Wang CZ, Yuan CS. Effects of Triterpenoid Glycosides from Fresh Ginseng Berry on SW480 Human Colorectal Cancer Cell Line. Cancer Res Treat. 2011 Mar; 43(1):49-55. PMID: 21509163.
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    124. Qi LW, Wang CZ, Yuan CS. Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry. 2011 Jun; 72(8):689-99. PMID: 21396670.
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    125. Qi LW, Wang CZ, Yuan CS. Isolation and analysis of ginseng: advances and challenges. Nat Prod Rep. 2011 Mar; 28(3):467-95. PMID: 21258738.
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    126. Wang CZ, Mehendale SR, Calway T, Yuan CS. Botanical flavonoids on coronary heart disease. Am J Chin Med. 2011; 39(4):661-71. PMID: 21721147.
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    127. Du GJ, Dai Q, Williams S, Wang CZ, Yuan CS. Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities. Anticancer Drugs. 2011 Jan; 22(1):35-45. PMID: 20926945.
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    128. Wang CZ, Kim KE, Du GJ, Qi LW, Wen XD, Li P, Bauer BA, Bissonnette MB, Musch MW, Chang EB, Yuan CS. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am J Chin Med. 2011; 39(6):1161-71. PMID: 22083988.
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    129. Wang HY, Qi LW, Wang CZ, Li P. Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides. Am J Chin Med. 2011; 39(6):1103-15. PMID: 22083984.
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    130. Li B, Zhao J, Wang CZ, Searle J, He TC, Yuan CS, Du W. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 2011 Feb 28; 301(2):185-92. PMID: 21194832.
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    131. Yuan CS, Wang CZ, Wicks SM, Qi LW. Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res. 2010 Sep 01; 34(3):160-7. PMID: 21359120.
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    132. Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS. Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). J Ethnopharmacol. 2010 Oct 28; 132(1):280-5. PMID: 20723598.
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    133. Sun S, Li XL, Wang CZ, Williams S, Yuan CS. Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. Phytother Res. 2010 Aug; 24(8):1166-74. PMID: 20077432.
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    134. Qi LW, Wang CZ, Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol. 2010 Oct 01; 80(7):947-54. PMID: 20599804.
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    135. Li XL, Sun S, Du GJ, Qi LW, Williams S, Wang CZ, Yuan CS. Effects of Oplopanax horridus on human colorectal cancer cells. Anticancer Res. 2010 Feb; 30(2):295-302. PMID: 20332432.
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    136. Wang CZ, Li XL, Wang QF, Mehendale SR, Yuan CS. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine. 2010 Jan; 17(1):63-8. PMID: 19836937.
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    137. Yuan CS, Sun S, Attele A, Wang CZ, Tong R, Israel RJ. Methylnaltrexone potentiates body weight and fat reduction with leptin. J Opioid Manag. 2009 Nov-Dec; 5(6):373-8. PMID: 20073411.
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    138. Li XL, Wang CZ, Sun S, Mehendale SR, Du W, He TC, Yuan CS. American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells. Oncol Rep. 2009 Oct; 22(4):943-52. PMID: 19724877.
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    139. Xie JT, Wang CZ, Zhang B, Mehendale SR, Li XL, Sun S, Han AH, Du W, He TC, Yuan CS. In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds. Biol Pharm Bull. 2009 Sep; 32(9):1552-8. PMID: 19721231.
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    140. Li B, Wang CZ, He TC, Yuan CS, Du W. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett. 2010 Mar 01; 289(1):62-70. PMID: 19716228.
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    141. Yuan CS, Wang CZ, Mehendale SR, Aung HH, Foo A, Israel RJ. Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model. AIDS Res Ther. 2009 Aug 21; 6:19. PMID: 19698111.
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    142. Wang CZ, Aung HH, Mehendale SR, Shoyama Y, Yuan CS. High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: comparison of stem and berry extracts. Fitoterapia. 2010 Mar; 81(2):132-9. PMID: 19686820.
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    143. Wang CZ, Li XL, Sun S, Xie JT, Aung HH, Tong R, McEntee E, Yuan CS. Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-Fu on human carcinoma cells. Anticancer Res. 2009 Aug; 29(8):2927-32. PMID: 19661297.
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    144. Yuan CS, Wang CZ, Attele A, Zhang L. Methylnaltrexone reduced body weight gain in ob/ob mice. J Opioid Manag. 2009 Jul-Aug; 5(4):213-8. PMID: 19736901.
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    145. Fishbein AB, Wang CZ, Li XL, Mehendale SR, Sun S, Aung HH, Yuan CS. Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: comparison between white and red ginseng. Arch Pharm Res. 2009 Apr; 32(4):505-13. PMID: 19407967.
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    146. Xie JT, Wang CZ, Li XL, Ni M, Fishbein A, Yuan CS. Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model. Fitoterapia. 2009 Jul; 80(5):306-11. PMID: 19358881.
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    147. Wang CZ, Ni M, Sun S, Li XL, He H, Mehendale SR, Yuan CS. Detection of adulteration of notoginseng root extract with other panax species by quantitative HPLC coupled with PCA. J Agric Food Chem. 2009 Mar 25; 57(6):2363-7. PMID: 19256509.
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    148. Li XL, Wang CZ, Mehendale SR, Sun S, Wang Q, Yuan CS. Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells. Cancer Chemother Pharmacol. 2009 Nov; 64(6):1097-104. PMID: 19277659.
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    149. Wang CZ, Li XL, Wang QF, Mehendale SR, Fishbein AB, Han AH, Sun S, Yuan CS. The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. Oncol Rep. 2009 Mar; 21(3):577-84. PMID: 19212614.
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    150. Wang CZ, Xie JT, Fishbein A, Aung HH, He H, Mehendale SR, He TC, Du W, Yuan CS. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother Res. 2009 Jan; 23(1):6-13. PMID: 19048608.
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    151. Wang CZ, Aung HH, Zhang B, Sun S, Li XL, He H, Xie JT, He TC, Du W, Yuan CS. Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res. 2008 Sep-Oct; 28(5A):2545-51. PMID: 19035277.
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    152. Luo X, Wang CZ, Chen J, Song WX, Luo J, Tang N, He BC, Kang Q, Wang Y, Du W, He TC, Yuan CS. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int J Oncol. 2008 May; 32(5):975-83. PMID: 18425323.
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    153. Lin E, Wang Y, Mehendale S, Sun S, Wang CZ, Xie JT, Aung HH, Yuan CS. Antioxidant protection by American ginseng in pancreatic beta-cells. Am J Chin Med. 2008; 36(5):981-8. PMID: 19051362.
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    154. Wang CZ, Yuan CS. Potential role of ginseng in the treatment of colorectal cancer. Am J Chin Med. 2008; 36(6):1019-28. PMID: 19051332.
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    155. Mehendale S, Aung H, Wang CZ, Tong R, Foo A, Xie JT, Yuan CS. Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects. J Pharm Pharmacol. 2007 Nov; 59(11):1567-72. PMID: 17976269.
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    156. Wang CZ, Xie JT, Zhang B, Ni M, Fishbein A, Aung HH, Mehendale SR, Du W, He TC, Yuan CS. Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells. Int J Oncol. 2007 Nov; 31(5):1149-56. PMID: 17912442.
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    157. Wang CZ, Aung HH, Ni M, Wu JA, Tong R, Wicks S, He TC, Yuan CS. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med. 2007 Jun; 73(7):669-74. PMID: 17538869.
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    158. Chang WT, Shao ZH, Yin JJ, Mehendale S, Wang CZ, Qin Y, Li J, Chen WJ, Chien CT, Becker LB, Vanden Hoek TL, Yuan CS. Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes. Eur J Pharmacol. 2007 Jul 02; 566(1-3):58-66. PMID: 17475241.
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    159. Wang CZ, Mehendale SR, Yuan CS. Commonly used antioxidant botanicals: active constituents and their potential role in cardiovascular illness. Am J Chin Med. 2007; 35(4):543-58. PMID: 17708622.
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    160. Wicks SM, Tong R, Wang CZ, O'Connor M, Karrison T, Li S, Moss J, Yuan CS. Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial. Am J Chin Med. 2007; 35(3):407-14. PMID: 17597499.
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    161. Wang CZ, Zhang B, Song WX, Wang A, Ni M, Luo X, Aung HH, Xie JT, Tong R, He TC, Yuan CS. Steamed American ginseng berry: ginsenoside analyses and anticancer activities. J Agric Food Chem. 2006 Dec 27; 54(26):9936-42. PMID: 17177524.
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    162. Mehendale SR, Wang CZ, Shao ZH, Li CQ, Xie JT, Aung HH, Yuan CS. Chronic pretreatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes. Eur J Pharmacol. 2006 Dec 28; 553(1-3):209-14. PMID: 17092497.
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    163. Wang CZ, Luo X, Zhang B, Song WX, Ni M, Mehendale S, Xie JT, Aung HH, He TC, Yuan CS. Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. Cancer Chemother Pharmacol. 2007 Jun; 60(1):69-79. PMID: 17009031.
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    164. Aung HH, Mehendale SR, Wang CZ, Xie JT, McEntee E, Yuan CS. Cisplatin's tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. Cancer Chemother Pharmacol. 2007 Feb; 59(3):369-74. PMID: 16799811.
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    165. Wang CZ, Wu JA, McEntee E, Yuan CS. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J Agric Food Chem. 2006 Mar 22; 54(6):2261-6. PMID: 16536605.
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    166. Xie JT, Shao ZH, Vanden Hoek TL, Chang WT, Li J, Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ, Yuan CS. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J Pharmacol. 2006 Feb 27; 532(3):201-7. PMID: 16497296.
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    167. Xie JT, Chang WT, Wang CZ, Mehendale SR, Li J, Ambihaipahar R, Ambihaipahar U, Fong HH, Yuan CS. Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/ob mice. Am J Chin Med. 2006; 34(2):279-84. PMID: 16552838.
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    168. Aung H, Mehendale S, Chang WT, Wang CZ, Xie JT, Yuan CS. Scutellaria baicalensis decreases ritonavir-induced nausea. AIDS Res Ther. 2005 Dec 20; 2:12. PMID: 16368007.
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    169. Wang CZ, Fishbein A, Aung HH, Mehendale SR, Chang WT, Xie JT, Li J, Yuan CS. Polyphenol contents in grape-seed extracts correlate with antipica effects in cisplatin-treated rats. J Altern Complement Med. 2005 Dec; 11(6):1059-65. PMID: 16398598.
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    170. Xie JT, Wang CZ, Wang AB, Wu J, Basila D, Yuan CS. Antihyperglycemic effects of total ginsenosides from leaves and stem of Panax ginseng. Acta Pharmacol Sin. 2005 Sep; 26(9):1104-10. PMID: 16115378.
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    171. Wang A, Wang CZ, Wu JA, Osinski J, Yuan CS. Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography. Phytochem Anal. 2005 Jul-Aug; 16(4):272-7. PMID: 16042154.
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    172. Wang CZ, Li P, Ding JY, Jin GQ, Yuan CS. Identification of Fritillaria pallidiflora using diagnostic PCR and PCR-RFLP based on nuclear ribosomal DNA internal transcribed spacer sequences. Planta Med. 2005 Apr; 71(4):384-6. PMID: 15856423.
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    173. Mehendale S, Aung H, Wang A, Yin JJ, Wang CZ, Xie JT, Yuan CS. American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats. Cancer Chemother Pharmacol. 2005 Jul; 56(1):63-9. PMID: 15791456.
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    174. Wang CZ, Basila D, Aung HH, Mehendale SR, Chang WT, McEntee E, Guan X, Yuan CS. Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. Am J Chin Med. 2005; 33(5):807-15. PMID: 16265993.
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    175. Xie JT, Mehendale SR, Li X, Quigg R, Wang X, Wang CZ, Wu JA, Aung HH, A Rue P, Bell GI, Yuan CS. Anti-diabetic effect of ginsenoside Re in ob/ob mice. Biochim Biophys Acta. 2005 Jun 10; 1740(3):319-25. PMID: 15949698.
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    176. Yuan CS, Mehendale SR, Wang CZ, Aung HH, Jiang T, Guan X, Shoyama Y. Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial. J Clin Pharmacol. 2004 Nov; 44(11):1323-7. PMID: 15496650.
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    177. Mehendale SR, Aung HH, Yin JJ, Lin E, Fishbein A, Wang CZ, Xie JT, Yuan CS. Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model. Am J Chin Med. 2004; 32(6):897-905. PMID: 15673195.
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