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Fotini Gounari

TitleAssociate Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
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    Fotini Gounari’s laboratory studies how transcription and epigenetic regulators cooperate to guide T cell development. The role of individual regulators is becoming increasingly clear in the development of T cells. However, much less is known on how these regulatory molecules are integrated into complex networks that drive the chromatin conformation and gene expression changes required at each stage of T-cell development. The objectives of the studies are to elucidate how the DNA-binding protein T-cell factor 1 (Tcf-1), coordinates the action of multiple epigenetic and transcription regulators to control gene expression events that instruct T cell differentiation. The long-term goal is to provide a blueprint of the interplay of molecular networks in the development of healthy T-cell immunity and to understand mechanisms underlying immune-related diseases and T cell malignancies.

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    R21AI176254     (GOUNARI, FOTINI)Mar 1, 2023 - Feb 28, 2025
    Tools for reversible short-term degradation of TCF-1 to address its molecular functions
    Role: Principal Investigator

    R01CA264048     (KHAZAIE, KHASHAYARSHA)Sep 13, 2021 - Aug 31, 2026
    Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
    Role: Co-Principal Investigator

    R01AI147652     (GOUNARI, FOTINI)Nov 22, 2019 - Oct 31, 2024
    Molecular functions of Tcf-1 in DP thymocytes
    Role: Principal Investigator

    R01AI108682     (GOUNARI, FOTINI)Jul 1, 2014 - Jun 30, 2025
    How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal
    Role: Principal Investigator

    R21CA175821     (GOUNARI, FOTINI)Dec 2, 2013 - Nov 30, 2015
    The role of b-catenin/Tcf-1 signaling in T-cell leukemia/lymphoma
    Role: Principal Investigator

    R21AI076720     (GOUNARI, FOTINI)May 1, 2008 - Apr 30, 2010
    Wnt/b-catenin signaling in T-cell transformation
    Role: Principal Investigator

    R56AI059676     (GOUNARI, FOTINI)Apr 1, 2004 - Aug 31, 2011
    Signaling in thymic selection
    Role: Principal Investigator

    R01AI059676     (GOUNARI, FOTINI)Apr 1, 2004 - Mar 31, 2010
    Signaling in the DN to DP thymocyte transition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pollard J, Hynes G, Yin D, Mandal M, Gounari F, Alegre ML, Chong A. Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells. Res Sq. 2023 Apr 05. PMID: 37066154; PMCID: PMC10104270.
    2. Arnovitz S, Mathur P, Tracy M, Mohsin A, Mondal S, Quandt J, Hernandez KM, Khazaie K, Dose M, Emmanuel AO, Gounari F. Tcf-1 promotes genomic instability and T cell transformation in response to aberrant ß-catenin activation. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2201493119. PMID: 35921443; PMCID: PMC9371646.
      Citations: 4     Fields:    Translation:AnimalsCells
    3. Gounari F, Khazaie K. TCF-1: a maverick in T cell development and function. Nat Immunol. 2022 05; 23(5):671-678. PMID: 35487986; PMCID: PMC9202512.
      Citations: 15     Fields:    Translation:Cells
    4. Osman A, Yan B, Li Y, Pavelko KD, Quandt J, Saadalla A, Singh MP, Kazemian M, Gounari F, Khazaie K. TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer. Nat Immunol. 2021 09; 22(9):1152-1162. PMID: 34385712; PMCID: PMC8428683.
      Citations: 24     Fields:    Translation:AnimalsCells
    5. Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484. PMID: 33664518; PMCID: PMC8262575.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    6. Gounari F. CRELD1 controls T cell homeostasis. Nat Immunol. 2020 12; 21(12):1480-1482. PMID: 33169012; PMCID: PMC8194060.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lyu A, Lazarus M, Breyer RM, Yu Y. DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation. 2020 02 25; 141(8):655-666. PMID: 31893939; PMCID: PMC8232565.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Saadalla A, Lima MM, Tsai F, Osman A, Singh MP, Linden DR, Dennis KL, Haeryfar SMM, Gurish MF, Gounari F, Khazaie K. Cell Intrinsic Deregulated ß-Catenin Signaling Promotes Expansion of Bone Marrow Derived Connective Tissue Type Mast Cells, Systemic Inflammation, and Colon Cancer. Front Immunol. 2019; 10:2777. PMID: 31849960; PMCID: PMC6902090.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR. CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Nat Immunol. 2019 10; 20(10):1393-1403. PMID: 31477919; PMCID: PMC6754289.
      Citations: 33     Fields:    Translation:AnimalsCells
    10. Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K. Chromatin restriction by the nucleosome remodeler Mi-2ß and functional interplay with lineage-specific transcription regulators control B-cell differentiation. Genes Dev. 2019 07 01; 33(13-14):763-781. PMID: 31123064; PMCID: PMC6601517.
      Citations: 18     Fields:    Translation:AnimalsCells
    11. Emmanuel AO, Arnovitz S, Haghi L, Mathur PS, Mondal S, Quandt J, Okoreeh MK, Maienschein-Cline M, Khazaie K, Dose M, Gounari F. TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes. Nat Immunol. 2018 12; 19(12):1366-1378. PMID: 30420627; PMCID: PMC6867931.
      Citations: 31     Fields:    Translation:AnimalsCells
    12. Saadalla AM, Osman A, Gurish MF, Dennis KL, Blatner NR, Pezeshki A, McNagny KM, Cheroutre H, Gounari F, Khazaie K. Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1588-1592. PMID: 29429965; PMCID: PMC5816178.
      Citations: 21     Fields:    Translation:AnimalsCells
    13. Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K. The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer Immunol Immunother. 2018 01; 67(1):13-23. PMID: 28875329; PMCID: PMC5783191.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    14. Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K. Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia. Genes Dev. 2016 09 01; 30(17):1971-90. PMID: 27664237; PMCID: PMC5066240.
      Citations: 43     Fields:    Translation:AnimalsCells
    15. Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Gounari F, Kee BL. Correction: Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the notch signaling pathway. J Immunol. 2015 Jun 15; 194(12):6191. PMID: 26048968; PMCID: PMC4891201.
      Citations: 1     Fields:    
    16. Phillips JD, Knab LM, Blatner NR, Haghi L, DeCamp MM, Meyerson SL, Heiferman MJ, Heiferman JR, Gounari F, Bentrem DJ, Khazaie K. Preferential expansion of pro-inflammatory Tregs in human non-small cell lung cancer. Cancer Immunol Immunother. 2015 Sep; 64(9):1185-91. PMID: 26047578; PMCID: PMC4891203.
      Citations: 16     Fields:    Translation:HumansCells
    17. Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K. T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res. 2015 Jul; 3(7):806-14. PMID: 25855122; PMCID: PMC4749132.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Krishnamoorthy V, Carr T, de Pooter RF, Emanuelle AO, Akinola EO, Gounari F, Kee BL. Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway. J Immunol. 2015 Apr 01; 194(7):3191-200. PMID: 25710912; PMCID: PMC4369417.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    19. Jeggo P, Gounari F. Robin Holliday 1932-2014. Nat Struct Mol Biol. 2014 Jun; 21(6):501-2. PMID: 24896809.
      Citations:    Fields:    
    20. Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28. PMID: 24574339; PMCID: PMC4020714.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    21. Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. ß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6. PMID: 24371308; PMCID: PMC3890837.
      Citations: 42     Fields:    Translation:AnimalsCells
    22. Dennis KL, Blatner NR, Gounari F, Khazaie K. Current status of interleukin-10 and regulatory T-cells in cancer. Curr Opin Oncol. 2013 Nov; 25(6):637-45. PMID: 24076584; PMCID: PMC4322764.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    23. Gounari F, Kee BL. Fingerprinting ikaros. Nat Immunol. 2013 Oct; 14(10):1034-5. PMID: 24048134; PMCID: PMC4197131.
      Citations: 1     Fields:    Translation:Animals
    24. Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K. Transcriptional regulation of the Ikzf1 locus. Blood. 2013 Oct 31; 122(18):3149-59. PMID: 24002445; PMCID: PMC3814732.
      Citations: 25     Fields:    Translation:AnimalsCells
    25. Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV. A far downstream enhancer for murine Bcl11b controls its T-cell specific expression. Blood. 2013 Aug 08; 122(6):902-11. PMID: 23741008; PMCID: PMC3739036.
      Citations: 81     Fields:    Translation:AnimalsCells
    26. Blatner NR, Gounari F, Khazaie K. The two faces of regulatory T cells in cancer. Oncoimmunology. 2013 May 01; 2(5):e23852. PMID: 23762787; PMCID: PMC3667893.
      Citations: 6     Fields:    
    27. Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, Ham S, Sandall BP, Khan MW, Mahvi DM, Halverson AL, Stryker SJ, Boller AM, Singal A, Sneed RK, Sarraj B, Ansari MJ, Oft M, Iwakura Y, Zhou L, Bonertz A, Beckhove P, Gounari F, Khazaie K. Expression of ROR?t marks a pathogenic regulatory T cell subset in human colon cancer. Sci Transl Med. 2012 Dec 12; 4(164):164ra159. PMID: 23241743; PMCID: PMC3762575.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    28. Aghajani K, Keerthivasan S, Yu Y, Gounari F. Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells. Genesis. 2012 Dec; 50(12):908-13. PMID: 22887772; PMCID: PMC3535561.
      Citations: 30     Fields:    Translation:AnimalsCells
    29. Khazaie K, Zadeh M, Khan MW, Bere P, Gounari F, Dennis K, Blatner NR, Owen JL, Klaenhammer TR, Mohamadzadeh M. Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10462-7. PMID: 22689992; PMCID: PMC3387103.
      Citations: 82     Fields:    Translation:AnimalsCells
    30. Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5. PMID: 22109558; PMCID: PMC3250146.
      Citations: 118     Fields:    Translation:AnimalsCells
    31. Zhang J, Jackson AF, Naito T, Dose M, Seavitt J, Liu F, Heller EJ, Kashiwagi M, Yoshida T, Gounari F, Petrie HT, Georgopoulos K. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nat Immunol. 2011 Nov 13; 13(1):86-94. PMID: 22080921; PMCID: PMC3868219.
      Citations: 110     Fields:    Translation:AnimalsCells
    32. Dose M, Gounari F. Sleeping beauty: does ETP-ALL awaken later? Blood. 2011 Oct 27; 118(17):4500-1. PMID: 22033941.
      Citations: 1     Fields:    Translation:HumansAnimals
    33. Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW. CDK6 kinase activity is required for thymocyte development. Blood. 2011 Jun 09; 117(23):6120-31. PMID: 21508411; PMCID: PMC3122937.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    34. Khazaie K, Blatner NR, Khan MW, Gounari F, Gounaris E, Dennis K, Bonertz A, Tsai FN, Strouch MJ, Cheon E, Phillips JD, Beckhove P, Bentrem DJ. The significant role of mast cells in cancer. Cancer Metastasis Rev. 2011 Mar; 30(1):45-60. PMID: 21287360.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    35. Driessens G, Zheng Y, Locke F, Cannon JL, Gounari F, Gajewski TF. Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation. J Immunol. 2011 Jan 15; 186(2):784-90. PMID: 21149602; PMCID: PMC4888792.
      Citations: 30     Fields:    Translation:AnimalsCells
    36. De Keersmaecker K, Real PJ, Gatta GD, Palomero T, Sulis ML, Tosello V, Van Vlierberghe P, Barnes K, Castillo M, Sole X, Hadler M, Lenz J, Aplan PD, Kelliher M, Kee BL, Pandolfi PP, Kappes D, Gounari F, Petrie H, Van der Meulen J, Speleman F, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Soulier J, Avran D, Dastugue N, Raimondi S, Meijerink JP, Cordon-Cardo C, Califano A, Ferrando AA, Cavé H. The TLX1 oncogene drives aneuploidy in T cell transformation. Nat Med. 2010 Nov; 16(11):1321-7. PMID: 20972433; PMCID: PMC2974790.
      Citations: 83     Fields:    Translation:AnimalsCells
    37. Dose M, Gounari F. The My(c)stery of iNKT cell ontogeny. Cell Cycle. 2009 Oct 01; 8(19):3082-5. PMID: 19738416.
      Citations: 2     Fields:    Translation:AnimalsCells
    38. Kovalovsky D, Yu Y, Dose M, Emmanouilidou A, Konstantinou T, Germar K, Aghajani K, Guo Z, Mandal M, Gounari F. Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol. 2009 Sep 15; 183(6):3873-84. PMID: 19717519; PMCID: PMC4695211.
      Citations: 16     Fields:    Translation:AnimalsCells
    39. Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12453-8. PMID: 19617548; PMCID: PMC2718370.
      Citations: 144     Fields:    Translation:AnimalsCells
    40. Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res. 2009 Jul 01; 69(13):5490-7. PMID: 19570783; PMCID: PMC2881579.
      Citations: 95     Fields:    Translation:AnimalsCells
    41. Dose M, Sleckman BP, Han J, Bredemeyer AL, Bendelac A, Gounari F. Intrathymic proliferation wave essential for Valpha14+ natural killer T cell development depends on c-Myc. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8641-6. PMID: 19423665; PMCID: PMC2689024.
      Citations: 73     Fields:    Translation:AnimalsCells
    42. Hu MG, Deshpande A, Enos M, Mao D, Hinds EA, Hu GF, Chang R, Guo Z, Dose M, Mao C, Tsichlis PN, Gounari F, Hinds PW. A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 2009 Feb 01; 69(3):810-8. PMID: 19155308; PMCID: PMC2636510.
      Citations: 71     Fields:    Translation:AnimalsCells
    43. Li X, Gounari F, Protopopov A, Khazaie K, von Boehmer H. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. J Exp Med. 2008 Nov 24; 205(12):2851-61. PMID: 18981238; PMCID: PMC2585834.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    44. Dose M, Gounari F. Fifty ways to Notch T-ALL. Blood. 2008 Aug 01; 112(3):457-8. PMID: 18650457; PMCID: PMC2481527.
      Citations:    Fields:    
    45. Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K. Mast cells are an essential hematopoietic component for polyp development. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19977-82. PMID: 18077429; PMCID: PMC2148408.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    46. Mao C, Tili EG, Dose M, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN, Haks MC. Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. J Immunol. 2007 May 01; 178(9):5443-53. PMID: 17442925.
      Citations: 69     Fields:    Translation:AnimalsCells
    47. Guo Z, Dose M, Kovalovsky D, Chang R, O'Neil J, Look AT, von Boehmer H, Khazaie K, Gounari F. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood. 2007 Jun 15; 109(12):5463-72. PMID: 17317856; PMCID: PMC1890819.
      Citations: 64     Fields:    Translation:AnimalsCells
    48. Dose M, Khan I, Guo Z, Kovalovsky D, Krueger A, von Boehmer H, Khazaie K, Gounari F. c-Myc mediates pre-TCR-induced proliferation but not developmental progression. Blood. 2006 Oct 15; 108(8):2669-77. PMID: 16788099; PMCID: PMC1895574.
      Citations: 63     Fields:    Translation:AnimalsCells
    49. Garbe AI, Krueger A, Gounari F, von Boehmer H, Zúñiga-Pflücker JC. Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med. 2006 Jun 12; 203(6):1579-90. PMID: 16754723; PMCID: PMC2118312.
      Citations: 43     Fields:    Translation:AnimalsCells
    50. Gounari F, Chang R, Cowan J, Guo Z, Dose M, Gounaris E, Khazaie K. Loss of adenomatous polyposis coli gene function disrupts thymic development. Nat Immunol. 2005 Aug; 6(8):800-9. PMID: 16025118; PMCID: PMC4662936.
      Citations: 59     Fields:    Translation:AnimalsCells
    51. Karagianni N, Ly MC, Psarras S, Chlichlia K, Schirrmacher V, Gounari F, Khazaie K. Novel adenomatous polyposis coli gene promoter is located 40 kb upstream of the initiating methionine. Genomics. 2005 Feb; 85(2):231-7. PMID: 15676281.
      Citations: 2     Fields:    Translation:AnimalsCells
    52. Borowski C, Li X, Aifantis I, Gounari F, von Boehmer H. Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development. J Exp Med. 2004 Mar 01; 199(5):607-15. PMID: 14993248; PMCID: PMC2213307.
      Citations: 26     Fields:    Translation:AnimalsCells
    53. Martin CH, Aifantis I, Scimone ML, von Andrian UH, Reizis B, von Boehmer H, Gounari F. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol. 2003 Sep; 4(9):866-73. PMID: 12925850.
      Citations: 60     Fields:    Translation:AnimalsCells
    54. von Boehmer H, Aifantis I, Gounari F, Azogui O, Haughn L, Apostolou I, Jaeckel E, Grassi F, Klein L. Thymic selection revisited: how essential is it? Immunol Rev. 2003 Feb; 191:62-78. PMID: 12614352.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    55. Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H, Khazaie K. Stabilization of beta-catenin induces lesions reminiscent of prostatic intraepithelial neoplasia, but terminal squamous transdifferentiation of other secretory epithelia. Oncogene. 2002 Jun 13; 21(26):4099-107. PMID: 12037666.
      Citations: 40     Fields:    Translation:AnimalsCells
    56. Borowski C, Martin C, Gounari F, Haughn L, Aifantis I, Grassi F, von Boehmer H. On the brink of becoming a T cell. Curr Opin Immunol. 2002 Apr; 14(2):200-6. PMID: 11869893.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    57. Aifantis I, Borowski C, Gounari F, Lacorazza HD, Nikolich-Zugich J, von Boehmer H. A critical role for the cytoplasmic tail of pTalpha in T lymphocyte development. Nat Immunol. 2002 May; 3(5):483-8. PMID: 11927911.
      Citations: 23     Fields:    Translation:AnimalsCells
    58. Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96. PMID: 11927910.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    59. Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L, Khazaie K. Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):219-24. PMID: 11773619; PMCID: PMC117542.
      Citations: 49     Fields:    Translation:AnimalsCells
    60. Gounari F, Aifantis I, Khazaie K, Hoeflinger S, Harada N, Taketo MM, von Boehmer H, Gounari F, Aifantis I, Khazaie K, Hoeflinger S, Harada N, Taketo MM, von Boehmer H. Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development. Nat Immunol. 2001 Sep; 2(9):863-9. PMID: 11526403.
      Citations: 57     Fields:    Translation:AnimalsCells
    61. Aifantis I, Gounari F, Scorrano L, Borowski C, von Boehmer H. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT. Nat Immunol. 2001 May; 2(5):403-9. PMID: 11323693.
      Citations: 58     Fields:    Translation:AnimalsCells
    62. Janosch P, Kieser A, Eulitz M, Lovric J, Sauer G, Reichert M, Gounari F, Baccarini M, Mischak H, Kolch W, Büscher D. The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments. FASEB J. 2000 Oct; 14(13):2008-21. PMID: 11023985.
      Citations: 20     Fields:    Translation:Cells
    63. Gounari F, Prifti S, Hacker HJ, Schirrmacher V, Khazaie K, Müller M. EblacZ tumor dormancy in bone marrow and lymph nodes: active control of proliferating tumor cells by CD8+ immune T cells. Cancer Res. 1998 Dec 01; 58(23):5439-46. PMID: 9850077.
      Citations: 29     Fields:    Translation:AnimalsCellsPHPublic Health
    64. King JA, Bridger JM, Gounari F, Lichter P, Schulz TF, Schirrmacher V, Khazaie K. The extended packaging sequence of MoMLV contains a constitutive mRNA nuclear export function. FEBS Lett. 1998 Sep 04; 434(3):367-71. PMID: 9742956.
      Citations: 6     Fields:    Translation:HumansCells
    65. Georgatos SD, Gounari F, Goulielmos G, Aebi U. To bead or not to bead? Lens-specific intermediate filaments revisited. J Cell Sci. 1997 Nov; 110 ( Pt 21):2629-34. PMID: 9427381.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    66. Gounari F, Karagianni N, Mincheva A, Lichter P, Georgatos SD, Schirrmacher V. The mouse filensin gene: structure and evolutionary relation to other intermediate filament genes. FEBS Lett. 1997 Aug 18; 413(2):371-8. PMID: 9280315.
      Citations: 3     Fields:    Translation:AnimalsCells
    67. Rehberger S, Gounari F, DucDodon M, Chlichlia K, Gazzolo L, Schirrmacher V, Khazaie K. The activation domain of a hormone inducible HTLV-1 Rex protein determines colocalization with the nuclear pore. Exp Cell Res. 1997 Jun 15; 233(2):363-71. PMID: 9194498.
      Citations: 5     Fields:    Translation:HumansCells
    68. Goulielmos G, Gounari F, Remington S, Aebi U, Georgatos SD, Müller S, Häner M. Filensin and phakinin form a novel type of beaded intermediate filaments and coassemble de novo in cultured cells. J Cell Biol. 1996 Feb; 132(4):643-55. PMID: 8647895; PMCID: PMC2199861.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    69. Goulielmos G, Remington S, Schwesinger F, Georgatos SD, Gounari F. Contributions of the structural domains of filensin in polymer formation and filament distribution. J Cell Sci. 1996 Feb; 109 ( Pt 2):447-56. PMID: 8838668.
      Citations: 6     Fields:    Translation:AnimalsCells
    70. Georgatos SD, Gounari F, Remington S. The beaded intermediate filaments and their potential functions in eye lens. Bioessays. 1994 Jun; 16(6):413-8. PMID: 8080431.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    71. Merdes A, Gounari F, Georgatos SD. The 47-kD lens-specific protein phakinin is a tailless intermediate filament protein and an assembly partner of filensin. J Cell Biol. 1993 Dec; 123(6 Pt 1):1507-16. PMID: 7504675; PMCID: PMC2290875.
      Citations: 22     Fields:    Translation:AnimalsCells
    72. Gounari F, Merdes A, Quinlan R, Hess J, FitzGerald PG, Ouzounis CA, Georgatos SD. Bovine filensin possesses primary and secondary structure similarity to intermediate filament proteins. J Cell Biol. 1993 May; 121(4):847-53. PMID: 8491777; PMCID: PMC2119801.
      Citations: 24     Fields:    Translation:AnimalsCells
    73. Abbott C, Piaggio G, Ammendola R, Solomon E, Povey S, Gounari F, De Simone V, Cortese R. Mapping of the gene TCF2 coding for the transcription factor LFB3 to human chromosome 17 by polymerase chain reaction. Genomics. 1990 Sep; 8(1):165-7. PMID: 2081590.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    74. Gounari F, De Francesco R, Schmitt J, van der Vliet P, Cortese R, Stunnenberg H. Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J. 1990 Feb; 9(2):559-66. PMID: 2303041; PMCID: PMC551701.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    75. Ammendola R, Gounari F, Piaggio G, De Simone V, Cortese R. Transcription of the promoter of the rat NF-1 gene depends on the integrity of an Sp1 recognition site. Mol Cell Biol. 1990 Jan; 10(1):387-90. PMID: 2403642; PMCID: PMC360762.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    76. Paonessa G, Gounari F, Frank R, Cortese R. Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J. 1988 Oct; 7(10):3115-23. PMID: 3053160; PMCID: PMC454701.
      Citations: 84     Fields:    Translation:Cells
    77. Gounari F, Banks GR, Khazaie K, Jeggo PA, Holliday R. Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants. Genes Dev. 1987 Nov; 1(9):899-912. PMID: 2448188.
      Citations: 3     Fields:    Translation:AnimalsCells
    78. Khazaie K, Gounari F, Antoniou M, deBoer E, Grosveld F. Beta-globin gene promoter generates 5' truncated transcripts in the embryonic/fetal erythroid environment. Nucleic Acids Res. 1986 Sep 25; 14(18):7199-212. PMID: 2429259; PMCID: PMC311746.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
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