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Olga Y. Zaborina

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentSurgery-General Surgery
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023 08 04; 381(6657):502-508. PMID: 37535745; PMCID: PMC10876062.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    2. Vigneswaran J, Keskey RC, Morgan RB, Alverdy JC, Alpert L, Chang E, Weichselbaum R, Zaborina O, Shogan BD. Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery. Ann Surg. 2023 12 01; 278(6):954-960. PMID: 37522222; PMCID: PMC10775465.
      Citations:    Fields:    Translation:HumansAnimals
    3. Hyoju SK, Keskey R, Castillo G, Machutta K, Zaborin A, Zaborina O, Alverdy JC. A Novel Nonantibiotic Gut-directed Strategy to Prevent Surgical Site Infections. Ann Surg. 2022 09 01; 276(3):472-481. PMID: 35749750; PMCID: PMC9869400.
      Citations: 2     Fields:    Translation:Animals
    4. Williamson AJ, Jacobson R, van Praagh JB, Gaines S, Koo HY, Lee B, Chan WC, Weichselbaum R, Alverdy JC, Zaborina O, Shogan BD. Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells. Neoplasia. 2022 05; 27:100787. PMID: 35366466; PMCID: PMC8971311.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    5. Jacobson RA, Williamson AJ, Wienholts K, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC. Prevention of Anastomotic Leak Via Local Application of Tranexamic Acid to Target Bacterial-mediated Plasminogen Activation: A Practical Solution to a Complex Problem. Ann Surg. 2021 12 01; 274(6):e1038-e1046. PMID: 31851007; PMCID: PMC7875208.
      Citations: 8     Fields:    Translation:AnimalsCells
    6. van den Berg FF, Hugenholtz F, Boermeester MA, Zaborina O, Alverdy JC. Spatioregional assessment of the gut microbiota in experimental necrotizing pancreatitis. BJS Open. 2021 09 06; 5(5). PMID: 34518874; PMCID: PMC8438261.
      Citations: 7     Translation:HumansAnimals
    7. Anderson DI, Keskey R, Ackerman MT, Zaborina O, Hyman N, Alverdy JC, Shogan BD. Enterococcus faecalis Is Associated with Anastomotic Leak in Patients Undergoing Colorectal Surgery. Surg Infect (Larchmt). 2021 Dec; 22(10):1047-1051. PMID: 34255574; PMCID: PMC8851212.
      Citations: 8     Fields:    Translation:HumansCells
    8. Guyton K, Belogortseva N, Levine Z, Kaiser BD, Sangwan N, Hyman N, Shogan BD, Zaborina O, Alverdy JC. Patient Acceptance of Routine Serial Postoperative Endoscopy Following Low Anterior Resection (LAR) and Its Ability to Detect Biomarkers in Anastomotic Lavage Fluid. World J Surg. 2021 07; 45(7):2227-2234. PMID: 33742231; PMCID: PMC8516158.
      Citations: 6     Fields:    Translation:HumansAnimals
    9. Keskey R, Papazian E, Lam A, Toni T, Hyoju S, Thewissen R, Zaborin A, Zaborina O, Alverdy JC. Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome. Ann Surg. 2022 11 01; 276(5):e361-e369. PMID: 33156068; PMCID: PMC8812511.
      Citations: 11     Fields:    Translation:HumansAnimals
    10. van den Berg FF, van Dalen D, Hyoju SK, van Santvoort HC, Besselink MG, Wiersinga WJ, Zaborina O, Boermeester MA, Alverdy J. Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. Gut. 2021 05; 70(5):915-927. PMID: 32873697; PMCID: PMC7917160.
      Citations: 40     Fields:    Translation:HumansAnimals
    11. Hyoju SK, Zaborina O, van Goor H. SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol). Med Hypotheses. 2020 Nov; 144:110039. PMID: 32758881; PMCID: PMC7834242.
      Citations: 7     Fields:    Translation:Humans
    12. Zaborin A, Penalver Bernabe B, Keskey R, Sangwan N, Hyoju S, Gottel N, Gilbert JA, Zaborina O, Alverdy JC. Spatial Compartmentalization of the Microbiome between the Lumen and Crypts Is Lost in the Murine Cecum following the Process of Surgery, Including Overnight Fasting and Exposure to Antibiotics. mSystems. 2020 Jun 09; 5(3). PMID: 32518197; PMCID: PMC7289591.
      Citations: 10     Fields:    
    13. Kim SM, DeFazio JR, Hyoju SK, Sangani K, Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris KG, Malik A, Zaborin A, Bouziat R, Ranoa DR, Wiegerinck M, Ernest JD, Shakhsheer BA, Fleming ID, Weichselbaum RR, Antonopoulos DA, Gilbert JA, Barreiro LB, Zaborina O, Jabri B, Alverdy JC. Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nat Commun. 2020 05 11; 11(1):2354. PMID: 32393794; PMCID: PMC7214422.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    14. Christley S, Shogan B, Levine Z, Koo H, Guyton K, Owens S, Gilbert J, Zaborina O, Alverdy JC. Comparative genetics of Enterococcus faecalis intestinal tissue isolates before and after surgery in a rat model of colon anastomosis. PLoS One. 2020; 15(4):e0232165. PMID: 32343730; PMCID: PMC7188289.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. van Praagh JB, Luo JN, Zaborina O, Alverdy JC. Involvement of the Commensal Organism Bacillus subtilis in the Pathogenesis of Anastomotic Leak. Surg Infect (Larchmt). 2020 Dec; 21(10):865-870. PMID: 32310731; PMCID: PMC7703376.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    16. Pimentel MB, Borges FTP, Teymour F, Zaborina OY, Alverdy JC, Fang K, Hong SH, Staneviciute A, He YJ, Papavasiliou G. An in vitro tissue model for screening sustained release of phosphate-based therapeutic attenuation of pathogen-induced proteolytic matrix degradation. J Mater Chem B. 2020 03 25; 8(12):2454-2465. PMID: 32108210; PMCID: PMC7183213.
      Citations:    Fields:    Translation:HumansCells
    17. Gaines S, Hyoju S, Williamson AJ, van Praagh JB, Zaborina O, Rubin DT, Alverdy JC, Shogan BD, Hyman N. Infliximab Does Not Promote the Presence of Collagenolytic Bacteria in a Mouse Model of Colorectal Anastomosis. J Gastrointest Surg. 2020 11; 24(11):2637-2642. PMID: 31898107; PMCID: PMC7931774.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    18. Hyoju SK, Adriaansens C, Wienholts K, Sharma A, Keskey R, Arnold W, van Dalen D, Gottel N, Hyman N, Zaborin A, Gilbert J, van Goor H, Zaborina O, Alverdy JC. Low-fat/high-fibre diet prehabilitation improves anastomotic healing via the microbiome: an experimental model. Br J Surg. 2020 05; 107(6):743-755. PMID: 31879948; PMCID: PMC7875206.
      Citations: 29     Fields:    Translation:Animals
    19. Gaines S, van Praagh JB, Williamson AJ, Jacobson RA, Hyoju S, Zaborin A, Mao J, Koo HY, Alpert L, Bissonnette M, Weichselbaum R, Gilbert J, Chang E, Hyman N, Zaborina O, Shogan BD, Alverdy JC. Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery. Gastroenterology. 2020 03; 158(4):958-970.e2. PMID: 31655031; PMCID: PMC7062578.
      Citations: 26     Fields:    Translation:AnimalsCells
    20. Jacobson RA, Wienholts K, Williamson AJ, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC. Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G1-G9. PMID: 31604031; PMCID: PMC6985841.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    21. Guyton KL, Levine ZC, Lowry AC, Lambert L, Gribovskaja-Rupp I, Hyman N, Zaborina O, Alverdy J. Identification of Collagenolytic Bacteria in Human Samples: Screening Methods and Clinical Implications for Resolving and Preventing Anastomotic Leaks and Wound Complications. Dis Colon Rectum. 2019 08; 62(8):972-979. PMID: 31283593; PMCID: PMC6624086.
      Citations: 12     Fields:    Translation:HumansCells
    22. Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC. Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts. mBio. 2019 07 30; 10(4). PMID: 31363025; PMCID: PMC6667615.
      Citations: 20     Fields:    Translation:Animals
    23. Nichols D, Pimentel MB, Borges FTP, Hyoju SK, Teymour F, Hong SH, Zaborina OY, Alverdy JC, Papavasiliou G. Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro. Front Bioeng Biotechnol. 2019; 7:153. PMID: 31297368; PMCID: PMC6607000.
      Citations: 4     
    24. Urbaniak C, van Dam P, Zaborin A, Zaborina O, Gilbert JA, Torok T, Wang CCC, Venkateswaran K. Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station. mSystems. 2019 Mar-Apr; 4(2). PMID: 30944876; PMCID: PMC6426649.
      Citations: 17     Fields:    
    25. Hyoju SK, Klabbers RE, Aaron M, Krezalek MA, Zaborin A, Wiegerinck M, Hyman NH, Zaborina O, Van Goor H, Alverdy JC. Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa. Ann Surg. 2018 06; 267(6):1112-1118. PMID: 28166091; PMCID: PMC5540820.
      Citations: 32     Fields:    Translation:AnimalsCells
    26. Wiegerinck M, Hyoju SK, Mao J, Zaborin A, Adriaansens C, Salzman E, Hyman NH, Zaborina O, van Goor H, Alverdy JC. Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model. Br J Surg. 2018 09; 105(10):1368-1376. PMID: 29658991; PMCID: PMC6827486.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    27. Krezalek MA, Hyoju S, Zaborin A, Okafor E, Chandrasekar L, Bindokas V, Guyton K, Montgomery CP, Daum RS, Zaborina O, Boyle-Vavra S, Alverdy JC. Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis". Ann Surg. 2018 04; 267(4):749-758. PMID: 28187042.
      Citations: 38     Fields:    Translation:AnimalsCells
    28. Belogortseva N, Krezalek M, Guyton K, Labno C, Poroyko V, Zaborina O, Alverdy JC. Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology. PLoS One. 2017; 12(8):e0182825. PMID: 28793333; PMCID: PMC5549984.
      Citations: 6     Fields:    Translation:AnimalsCells
    29. Mao J, Zaborin A, Poroyko V, Goldfeld D, Lynd NA, Chen W, Tirrell MV, Zaborina O, Alverdy JC. De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):2076-2085. PMID: 29372179; PMCID: PMC5779099.
      Citations: 5     Fields:    
    30. Gaines S, Luo JN, Gilbert J, Zaborina O, Alverdy JC. Optimum Operating Room Environment for the Prevention of Surgical Site Infections. Surg Infect (Larchmt). 2017 May/Jun; 18(4):503-507. PMID: 28402706; PMCID: PMC5972753.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    31. Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, Defazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC. Modeling Acinetobacter baumannii wound infections: The critical role of iron. J Trauma Acute Care Surg. 2017 03; 82(3):557-565. PMID: 28030490; PMCID: PMC5322184.
      Citations: 9     Fields:    Translation:AnimalsCells
    32. Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J. Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats. Int J Colorectal Dis. 2017 Apr; 32(4):539-547. PMID: 27999936.
      Citations: 9     Fields:    Translation:Animals
    33. Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC. Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 01; 312(2):G112-G122. PMID: 27979825; PMCID: PMC5338606.
      Citations: 15     Fields:    Translation:Animals
    34. Yin Y, Papavasiliou G, Zaborina OY, Alverdy JC, Teymour F. De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen. Ann Biomed Eng. 2017 04; 45(4):1058-1068. PMID: 27761766; PMCID: PMC5364061.
      Citations: 6     Fields:    Translation:Cells
    35. Shakhsheer BA, Versten LA, Luo JN, Defazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami NJ, Petrosino JF, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC. Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak. J Gastrointest Surg. 2016 10; 20(10):1744-51. PMID: 27530446; PMCID: PMC10314329.
      Citations: 27     Fields:    Translation:AnimalsCells
    36. Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC. The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury. Shock. 2016 May; 45(5):475-82. PMID: 26863118; PMCID: PMC4833524.
      Citations: 63     Fields:    Translation:Humans
    37. Kanteti R, Dhanasingh I, El-Hashani E, Riehm JJ, Stricker T, Nagy S, Zaborin A, Zaborina O, Biron D, Alverdy JC, Im HK, Siddiqui S, Padilla PA, Salgia R. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther. 2016; 17(1):91-103. PMID: 26574927; PMCID: PMC6093410.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    38. Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. 2015 May 06; 7(286):286ra68. PMID: 25947163; PMCID: PMC5027898.
      Citations: 167     Fields:    Translation:HumansAnimalsCells
    39. Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC. Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. J Trauma Acute Care Surg. 2015 Apr; 78(4):823-9. PMID: 25807409; PMCID: PMC4376013.
      Citations: 13     Fields:    Translation:AnimalsCells
    40. Defazio J, Fleming ID, Shakhsheer B, Zaborina O, Alverdy JC. The opposing forces of the intestinal microbiome and the emerging pathobiome. Surg Clin North Am. 2014 Dec; 94(6):1151-61. PMID: 25440116; PMCID: PMC4254556.
      Citations: 25     Fields:    Translation:Humans
    41. Zaborin A, Smith D, Garfield K, Quensen J, Shakhsheer B, Kade M, Tirrell M, Tiedje J, Gilbert JA, Zaborina O, Alverdy JC. Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. mBio. 2014 Sep 23; 5(5):e01361-14. PMID: 25249279; PMCID: PMC4173762.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    42. Shogan BD, Smith DP, Christley S, Gilbert JA, Zaborina O, Alverdy JC. Intestinal anastomotic injury alters spatially defined microbiome composition and function. Microbiome. 2014; 2:35. PMID: 25250176; PMCID: PMC4171717.
      Citations: 76     Fields:    
    43. Shah M, Zaborin A, Alverdy JC, Scott K, Zaborina O. Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa. FEMS Microbiol Lett. 2014 Mar; 352(1):54-61. PMID: 24372739; PMCID: PMC3949141.
      Citations: 4     Fields:    Translation:HumansCells
    44. Zaborina O, Alverdy J, Shah M, Chen Y. Microscopic analysis: morphotypes and cellular appendages. Methods Mol Biol. 2014; 1149:99-107. PMID: 24818901.
      Citations:    Fields:    Translation:Cells
    45. Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp DG, Smith RD, Adkins JN, Kim SM, Alverdy A, Goldfeld D, Firestone MA, Collier JH, Jabri B, Tirrell M, Zaborina O, Alverdy JC. Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. Antimicrob Agents Chemother. 2014; 58(2):966-77. PMID: 24277029; PMCID: PMC3910877.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    46. Luong PM, Shogan BD, Zaborin A, Belogortseva N, Shrout JD, Zaborina O, Alverdy JC. Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF. J Bacteriol. 2014 Jan; 196(2):504-13. PMID: 24244000; PMCID: PMC3911258.
      Citations: 24     Fields:    Translation:AnimalsCells
    47. Valuckaite V, Seal J, Zaborina O, Tretiakova M, Testa G, Alverdy JC. High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation. J Surg Res. 2013 Aug; 183(2):869-75. PMID: 23522457; PMCID: PMC3713159.
      Citations: 11     Fields:    Translation:AnimalsCells
    48. Stern JR, Olivas AD, Valuckaite V, Zaborina O, Alverdy JC, An G. Agent-based model of epithelial host-pathogen interactions in anastomotic leak. J Surg Res. 2013 Oct; 184(2):730-8. PMID: 23290531; PMCID: PMC4184143.
      Citations: 10     Fields:    Translation:AnimalsCells
    49. Stern JR, Christley S, Zaborina O, Alverdy JC, An G. Integration of TGF-ß- and EGFR-based signaling pathways using an agent-based model of epithelial restitution. Wound Repair Regen. 2012 Nov-Dec; 20(6):862-71. PMID: 23110640; PMCID: PMC3841986.
      Citations: 13     Fields:    Translation:HumansCells
    50. Olivas AD, Shogan BD, Valuckaite V, Zaborin A, Belogortseva N, Musch M, Meyer F, Trimble WL, An G, Gilbert J, Zaborina O, Alverdy JC. Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak. PLoS One. 2012; 7(8):e44326. PMID: 22952955; PMCID: PMC3432121.
      Citations: 94     Fields:    Translation:AnimalsCells
    51. Babrowski T, Romanowski K, Fink D, Kim M, Gopalakrishnan V, Zaborina O, Alverdy JC. The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis. Surgery. 2013 Jan; 153(1):36-43. PMID: 22862900; PMCID: PMC3521093.
      Citations: 26     Fields:    Translation:AnimalsCells
    52. Carlisle EM, Liu D, Zaborina O, Alverdy JC. Novel model to study combined effects of microorganisms and oxidants on development of intestinal necrosis. Surg Infect (Larchmt). 2012 Aug; 13(4):238-44. PMID: 22789034.
      Citations:    Fields:    Translation:AnimalsCells
    53. Zaborin A, Gerdes S, Holbrook C, Liu DC, Zaborina OY, Alverdy JC. Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate. PLoS One. 2012; 7(4):e34883. PMID: 22514685; PMCID: PMC3325935.
      Citations: 38     Fields:    Translation:AnimalsCells
    54. Babrowski T, Holbrook C, Moss J, Gottlieb L, Valuckaite V, Zaborin A, Poroyko V, Liu DC, Zaborina O, Alverdy JC. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration. Ann Surg. 2012 Feb; 255(2):386-93. PMID: 21989372; PMCID: PMC3258463.
      Citations: 60     Fields:    Translation:AnimalsCells
    55. Romanowski K, Zaborin A, Valuckaite V, Rolfes RJ, Babrowski T, Bethel C, Olivas A, Zaborina O, Alverdy JC. Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype. PLoS One. 2012; 7(1):e30119. PMID: 22253901; PMCID: PMC3258262.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    56. Fink D, Romanowski K, Valuckaite V, Babrowski T, Kim M, Matthews JB, Liu D, Zaborina O, Alverdy JC. Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: the role of in vivo virulence activation. J Trauma. 2011 Dec; 71(6):1575-82. PMID: 22002612; PMCID: PMC3245766.
      Citations: 17     Fields:    Translation:AnimalsCells
    57. Edelstein A, Fink D, Musch M, Valuckaite V, Zaborina O, Grubjesic S, Firestone MA, Matthews JB, Alverdy JC. Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption. Shock. 2011 Nov; 36(5):451-7. PMID: 21937955; PMCID: PMC3196772.
      Citations: 5     Fields:    Translation:HumansCells
    58. Romanowski K, Zaborin A, Fernandez H, Poroyko V, Valuckaite V, Gerdes S, Liu DC, Zaborina OY, Alverdy JC. Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH. BMC Microbiol. 2011 Sep 26; 11:212. PMID: 21943078; PMCID: PMC3195088.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    59. Seal JB, Alverdy JC, Zaborina O, An G. Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis. Theor Biol Med Model. 2011 Sep 19; 8:33. PMID: 21929759; PMCID: PMC3184268.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    60. Zaborina O, Zaborin A, Romanowski K, Babrowski T, Alverdy J. Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans. Curr Pharm Des. 2011; 17(13):1254-60. PMID: 21470113; PMCID: PMC4862579.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    61. Seal JB, Morowitz M, Zaborina O, An G, Alverdy JC. The molecular Koch's postulates and surgical infection: a view forward. Surgery. 2010 Jun; 147(6):757-65. PMID: 20494210.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    62. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1041-52. PMID: 19833862; PMCID: PMC2850088.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    63. Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K, Morozova I, Babrowski T, Liu DC, Zaborina O, Alverdy JC. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6327-32. PMID: 19369215; PMCID: PMC2669342.
      Citations: 109     Fields:    Translation:AnimalsCells
    64. Chiang ET, Camp SM, Dudek SM, Brown ME, Usatyuk PV, Zaborina O, Alverdy JC, Garcia JG. Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement. Microvasc Res. 2009 Mar; 77(2):174-86. PMID: 19121327; PMCID: PMC3736723.
      Citations: 26     Fields:    Translation:HumansCells
    65. Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J. Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis. Surgery. 2008 Aug; 144(2):189-97. PMID: 18656625; PMCID: PMC2601706.
      Citations: 56     Fields:    Translation:AnimalsCells
    66. Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa. PLoS Pathog. 2008 Feb 08; 4(2):e43. PMID: 18282104; PMCID: PMC2242829.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    67. Kolli BK, Kostal J, Zaborina O, Chakrabarty AM, Chang KP. Leishmania-released nucleoside diphosphate kinase prevents ATP-mediated cytolysis of macrophages. Mol Biochem Parasitol. 2008 Apr; 158(2):163-75. PMID: 18242727; PMCID: PMC2277215.
      Citations: 30     Fields:    Translation:AnimalsCells
    68. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. PMID: 17367209; PMCID: PMC1828698.
      Citations: 93     Fields:    Translation:AnimalsCells
    69. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. PMID: 16901993; PMCID: PMC2694754.
      Citations: 39     Fields:    Translation:HumansCells
    70. Zaborina O, Kohler JE, Wang Y, Bethel C, Shevchenko O, Wu L, Turner JR, Alverdy JC. Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier. Ann Clin Microbiol Antimicrob. 2006 Jun 08; 5:14. PMID: 16762075; PMCID: PMC1513249.
      Citations: 25     Fields:    Translation:HumansCells
    71. Wu L, Kohler JE, Zaborina O, Akash G, Musch MW, Chang EB, Alverdy JC. Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa. Curr Issues Intest Microbiol. 2006 Mar; 7(1):19-28. PMID: 16570696.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    72. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7. PMID: 16051797.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    73. Alverdy J, Zaborina O, Wu L. The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface. Curr Opin Clin Nutr Metab Care. 2005 Mar; 8(2):205-9. PMID: 15716801.
      Citations: 26     Fields:    Translation:Humans
    74. Wu LR, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Turner JR, Alverdy JC. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg Infect (Larchmt). 2005; 6(2):185-95. PMID: 16128625.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    75. Kohler JE, Zaborina O, Wu L, Wang Y, Bethel C, Chen Y, Shapiro J, Turner JR, Alverdy JC. Components of intestinal epithelial hypoxia activate the virulence circuitry of Pseudomonas. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G1048-54. PMID: 15550562.
      Citations: 20     Fields:    Translation:HumansCells
    76. Wu L, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Shapiro J, Turner JR, Wu G, Lee KY, Alverdy JC. High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa. Gastroenterology. 2004 Feb; 126(2):488-98. PMID: 14762786.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    77. Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Ann Surg. 2003 Nov; 238(5):754-64. PMID: 14578740; PMCID: PMC1356156.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    78. Punj V, Sharma R, Zaborina O, Chakrabarty AM. Energy-generating enzymes of Burkholderia cepacia and their interactions with macrophages. J Bacteriol. 2003 May; 185(10):3167-78. PMID: 12730177; PMCID: PMC154058.
      Citations: 2     Fields:    Translation:AnimalsCells
    79. Yamada T, Goto M, Punj V, Zaborina O, Kimbara K, Das Gupta TK, Chakrabarty AM, Yamada T, Goto M, Punj V, Zaborina O, Kimbara K, Das Gupta TK, Chakrabarty AM. The bacterial redox protein azurin induces apoptosis in J774 macrophages through complex formation and stabilization of the tumor suppressor protein p53. Infect Immun. 2002 Dec; 70(12):7054-62. PMID: 12438386; PMCID: PMC133031.
      Citations: 32     Fields:    Translation:AnimalsCells
    80. Yamada T, Goto M, Punj V, Zaborina O, Chen ML, Kimbara K, Majumdar D, Cunningham E, Das Gupta TK, Chakrabarty AM, Yamada T, Goto M, Punj V, Zaborina O, Chen ML, Kimbara K, Majumdar D, Cunningham E, Das Gupta TK, Chakrabarty AM. Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14098-103. PMID: 12393814; PMCID: PMC137843.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    81. Markaryan A, Zaborina O, Punj V, Chakrabarty AM. Adenylate kinase as a virulence factor of Pseudomonas aeruginosa. J Bacteriol. 2001 Jun; 183(11):3345-52. PMID: 11344142; PMCID: PMC99632.
      Citations: 13     Fields:    Translation:HumansCells
    82. Zaborina O, Dhiman N, Ling Chen M, Kostal J, Holder IA, Chakrabarty AM. Secreted products of a nonmucoid Pseudomonas aeruginosa strain induce two modes of macrophage killing: external-ATP-dependent, P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis. Microbiology (Reading). 2000 Oct; 146 ( Pt 10):2521-2530. PMID: 11021927.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    83. Punj V, Zaborina O, Dhiman N, Falzari K, Bagdasarian M, Chakrabarty AM. Phagocytic cell killing mediated by secreted cytotoxic factors of Vibrio cholerae. Infect Immun. 2000 Sep; 68(9):4930-7. PMID: 10948107; PMCID: PMC101703.
      Citations: 23     Fields:    Translation:AnimalsCells
    84. Melnikov A, Zaborina O, Dhiman N, Prabhakar BS, Chakrabarty AM, Hendrickson W. Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells. Mol Microbiol. 2000 Jun; 36(6):1481-93. PMID: 10931297.
      Citations: 17     Fields:    Translation:AnimalsCells
    85. Zaborina O, Misra N, Kostal J, Kamath S, Kapatral V, El-Idrissi ME, Prabhakar BS, Chakrabarty AM. P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients. Infect Immun. 1999 Oct; 67(10):5231-42. PMID: 10496900; PMCID: PMC96875.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    86. Zaborina O, Li X, Cheng G, Kapatral V, Chakrabarty AM. Secretion of ATP-utilizing enzymes, nucleoside diphosphate kinase and ATPase, by Mycobacterium bovis BCG: sequestration of ATP from macrophage P2Z receptors? Mol Microbiol. 1999 Mar; 31(5):1333-43. PMID: 10200955.
      Citations: 34     Fields:    Translation:AnimalsCells
    87. Zaborina O, Daubaras DL, Zago A, Xun L, Saido K, Klem T, Nikolic D, Chakrabarty AM. Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100. J Bacteriol. 1998 Sep; 180(17):4667-75. PMID: 9721310; PMCID: PMC107482.
      Citations: 13     Fields:    Translation:Cells
    88. Zaborina O, Latus M, Golovleva LA, Lingens F, Eberspächer J. Purification and characterization of 6-chlorohydroxyquinol 1,2-dioxygenase from Streptomyces rochei 303: comparison with an analogous enzyme from Azotobacter sp. strain GP1. J Bacteriol. 1995 Jan; 177(1):229-34. PMID: 7798136; PMCID: PMC176577.
      Citations: 17     Fields:    Translation:CellsPHPublic Health
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