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Kay L. Medina

AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J, Tümpel S, Rudolph KL. Author Correction: Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2019 Aug; 572(7769):E11-E15. PMID: 31363230.
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    2. Manso BA, Zhang H, Mikkelson MG, Gwin KA, Secreto CR, Ding W, Parikh SA, Kay NE, Medina KL. Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients. Leukemia. 2019 03; 33(3):638-652. PMID: 30291337.
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    3. Schwörer S, Becker F, Feller C, Baig AH, Köber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J, Tümpel S, Rudolph KL. Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals. Nature. 2016 12 15; 540(7633):428-432. PMID: 27919074.
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    4. Xu Z, Gwin KA, Li Y, Medina KL. Developmental stage-specific effects of Pim-1 dysregulation on murine bone marrow B cell development. BMC Immunol. 2016 06 10; 17(1):16. PMID: 27287229.
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    5. Medina KL. Overview of the immune system. Handb Clin Neurol. 2016; 133:61-76. PMID: 27112671.
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    6. Dolence JJ, Gwin KA, Shapiro MB, Hsu FC, Shapiro VS, Medina KL. Cell extrinsic alterations in splenic B cell maturation in Flt3-ligand knockout mice. Immun Inflamm Dis. 2015 Jun; 3(2):103-17. PMID: 26029370.
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    7. Iida R, Welner RS, Zhao W, Alberola-lla J, Medina KL, Zhao ZJ, Kincade PW. Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry. PLoS One. 2014; 9(4):e93643. PMID: 24699465.
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    8. Dolence JJ, Gwin KA, Shapiro MB, Medina KL. Flt3 signaling regulates the proliferation, survival, and maintenance of multipotent hematopoietic progenitors that generate B cell precursors. Exp Hematol. 2014 May; 42(5):380-393.e3. PMID: 24444745.
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    9. Medina KL, Tangen SN, Seaburg LM, Thapa P, Gwin KA, Shapiro VS. Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1. PLoS One. 2013; 8(10):e78408. PMID: 24205225.
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    10. Zhang Q, Esplin BL, Iida R, Garrett KP, Huang ZL, Medina KL, Kincade PW. RAG-1 and Ly6D independently reflect progression in the B lymphoid lineage. PLoS One. 2013; 8(8):e72397. PMID: 24023617.
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    11. Gwin KA, Shapiro MB, Dolence JJ, Huang ZL, Medina KL. Hoxa9 and Flt3 signaling synergistically regulate an early checkpoint in lymphopoiesis. J Immunol. 2013 Jul 15; 191(2):745-54. PMID: 23772038.
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    12. Gwin K, Dolence JJ, Shapiro MB, Medina KL. Differential requirement for Hoxa9 in the development and differentiation of B, NK, and DC-lineage cells from Flt3+ multipotential progenitors. BMC Immunol. 2013 Jan 30; 14:5. PMID: 23363389.
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    13. Luckey D, Medina K, Taneja V. B cells as effectors and regulators of sex-biased arthritis. Autoimmunity. 2012 Aug; 45(5):364-76. PMID: 22429183.
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    14. Shimazu T, Iida R, Zhang Q, Welner RS, Medina KL, Alberola-Lla J, Kincade PW. CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential. Blood. 2012 May 24; 119(21):4889-97. PMID: 22371880.
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    15. Dolence JJ, Gwin K, Frank E, Medina KL. Threshold levels of Flt3-ligand are required for the generation and survival of lymphoid progenitors and B-cell precursors. Eur J Immunol. 2011 Feb; 41(2):324-34. PMID: 21268003.
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    16. Gwin K, Frank E, Bossou A, Medina KL. Hoxa9 regulates Flt3 in lymphohematopoietic progenitors. J Immunol. 2010 Dec 01; 185(11):6572-83. PMID: 20971928.
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    17. Pajerowski AG, Shapiro MJ, Gwin K, Sundsbak R, Nelson-Holte M, Medina K, Shapiro VS. Adult hematopoietic stem cells require NKAP for maintenance and survival. Blood. 2010 Oct 14; 116(15):2684-93. PMID: 20610818.
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    18. Cataldo G, Bernal SY, Rozengurtel S, Medina K, Bodnar RJ. Neonatal and adult gonadal hormone manipulations enhance morphine analgesia elicited from the ventrolateral periaqueductal gray in female rats. Int J Neurosci. 2010 Apr; 120(4):265-72. PMID: 20374074.
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    19. Ding W, Nowakowski GS, Knox TR, Boysen JC, Maas ML, Schwager SM, Wu W, Wellik LE, Dietz AB, Ghosh AK, Secreto CR, Medina KL, Shanafelt TD, Zent CS, Call TG, Kay NE. Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol. 2009 Nov; 147(4):471-83. PMID: 19751240.
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    20. Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, Bertolino E, Thomas M, Grosschedl R, Allman D, Singh H. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol. 2008 Feb; 9(2):203-15. PMID: 18176567.
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    21. Singh H, Pongubala JM, Medina KL. Gene regulatory networks that orchestrate the development of B lymphocyte precursors. Adv Exp Med Biol. 2007; 596:57-62. PMID: 17338175.
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    22. Bertolino E, Reddy K, Medina KL, Parganas E, Ihle J, Singh H. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nat Immunol. 2005 Aug; 6(8):836-43. PMID: 16025120.
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    23. Medina KL, Singh H. Genetic networks that regulate B lymphopoiesis. Curr Opin Hematol. 2005 May; 12(3):203-9. PMID: 15867576.
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    24. Singh H, Medina KL, Pongubala JM. Contingent gene regulatory networks and B cell fate specification. Proc Natl Acad Sci U S A. 2005 Apr 05; 102(14):4949-53. PMID: 15788530.
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    25. Igarashi H, Medina KL, Yokota T, Rossi MI, Sakaguchi N, Comp PC, Kincade PW. Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids. Int Immunol. 2005 May; 17(5):501-11. PMID: 15746243.
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    26. Medina KL, Singh H. Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation. Curr Top Microbiol Immunol. 2005; 290:1-14. PMID: 16480036.
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    27. Medina KL, Pongubala JM, Reddy KL, Lancki DW, Dekoter R, Kieslinger M, Grosschedl R, Singh H. Assembling a gene regulatory network for specification of the B cell fate. Dev Cell. 2004 Oct; 7(4):607-17. PMID: 15469848.
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    28. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
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    29. Yokota T, Meka CS, Kouro T, Medina KL, Igarashi H, Takahashi M, Oritani K, Funahashi T, Tomiyama Y, Matsuzawa Y, Kincade PW. Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J Immunol. 2003 Nov 15; 171(10):5091-9. PMID: 14607907.
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    30. Lu R, Medina KL, Lancki DW, Singh H. IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development. Genes Dev. 2003 Jul 15; 17(14):1703-8. PMID: 12832394.
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    31. Kincade PW, Igarashi H, Medina KL, Kouro T, Yokota T, Rossi MI, Owen JJ, Garrett KP, Sun XH, Sakaguchi N. Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage. Semin Immunol. 2002 Dec; 14(6):385-94. PMID: 12457611.
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    32. Rossi MI, Yokota T, Medina KL, Garrett KP, Comp PC, Schipul AH, Kincade PW. B lymphopoiesis is active throughout human life, but there are developmental age-related changes. Blood. 2003 Jan 15; 101(2):576-84. PMID: 12393702.
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    33. Yokota T, Meka CS, Medina KL, Igarashi H, Comp PC, Takahashi M, Nishida M, Oritani K, Miyagawa J, Funahashi T, Tomiyama Y, Matsuzawa Y, Kincade PW. Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest. 2002 May; 109(10):1303-10. PMID: 12021245.
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    34. Kosak ST, Skok JA, Medina KL, Riblet R, Le Beau MM, Fisher AG, Singh H. Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science. 2002 Apr 05; 296(5565):158-62. PMID: 11935030.
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    35. Rossi MI, Medina KL, Garrett K, Kolar G, Comp PC, Shultz LD, Capra JD, Wilson P, Schipul A, Kincade PW. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol. 2001 Sep 15; 167(6):3033-42. PMID: 11544286.
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    36. Medina KL, Garrett KP, Thompson LF, Rossi MI, Payne KJ, Kincade PW. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat Immunol. 2001 Aug; 2(8):718-24. PMID: 11477408.
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    37. Kouro T, Medina KL, Oritani K, Kincade PW. Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators. Blood. 2001 May 01; 97(9):2708-15. PMID: 11313262.
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    38. Nadon NL, Doersen CJ, Lade DA, Medina K, Thompson L, Rohrer M, Gimble JM. Multiple cellular phenotypes in an insertional mutation in mouse affecting bone development. Calcif Tissue Int. 2000 Dec; 67(6):449-54. PMID: 11289693.
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    39. Kincade PW, Medina KL, Payne KJ, Rossi MI, Tudor KS, Yamashita Y, Kouro T. Early B-lymphocyte precursors and their regulation by sex steroids. Immunol Rev. 2000 Jun; 175:128-37. PMID: 10933598.
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    40. Oritani K, Medina KL, Tomiyama Y, Ishikawa J, Okajima Y, Ogawa M, Yokota T, Aoyama K, Takahashi I, Kincade PW, Matsuzawa Y. Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors. Nat Med. 2000 Jun; 6(6):659-66. PMID: 10835682.
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    41. Medina KL, Strasser A, Kincade PW. Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood. 2000 Mar 15; 95(6):2059-67. PMID: 10706875.
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    42. Kincade PW, Payne KJ, Tudor KS, Yamashita Y, Medina KL, Rossi MI, Kouro T. Re-evaluation of B lymphocyte lineage differentiation schemes. Curr Top Microbiol Immunol. 2000; 251:67-72. PMID: 11036760.
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    43. Payne KJ, Medina KL, Kincade PW. Loss of c-kit accompanies B-lineage commitment and acquisition of CD45R by most murine B-lymphocyte precursors. Blood. 1999 Jul 15; 94(2):713-23. PMID: 10397738.
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    44. Webb CF, Smith EA, Medina KL, Buchanan KL, Smithson G, Dou S. Expression of bright at two distinct stages of B lymphocyte development. J Immunol. 1998 May 15; 160(10):4747-54. PMID: 9590220.
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    45. Kincade PW, Yamashita Y, Borghesi L, Medina K, Oritani K. Blood cell precursors in context. Composition of the bone marrow microenvironment that supports B lymphopoiesis. Vox Sang. 1998; 74 Suppl 2:265-8. PMID: 9704455.
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    46. Oritani K, Wu X, Medina K, Hudson J, Miyake K, Gimble JM, Burstein SA, Kincade PW. Antibody ligation of CD9 modifies production of myeloid cells in long-term cultures. Blood. 1996 Mar 15; 87(6):2252-61. PMID: 8630385.
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    47. Smithson G, Medina K, Ponting I, Kincade PW. Estrogen suppresses stromal cell-dependent lymphopoiesis in culture. J Immunol. 1995 Oct 01; 155(7):3409-17. PMID: 7561035.
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    48. Kincade PW, Medina KL, Smithson G, Scott DC. Pregnancy: a clue to normal regulation of B lymphopoiesis. Immunol Today. 1994 Nov; 15(11):539-44. PMID: 7802925.
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    49. Wu X, Miyake K, Medina KL, Kincade PW, Gimble JM. Recognition of murine integrin beta 1 by a rat anti-stromal cell monoclonal antibody. Hybridoma. 1994 Oct; 13(5):409-16. PMID: 7532155.
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    50. Medina KL, Kincade PW. Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5382-6. PMID: 8202495.
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    51. Kincade PW, Medina KL, Smithson G. Sex hormones as negative regulators of lymphopoiesis. Immunol Rev. 1994 Feb; 137:119-34. PMID: 8034331.
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    52. Medina KL, Smithson G, Kincade PW. Suppression of B lymphopoiesis during normal pregnancy. J Exp Med. 1993 Nov 01; 178(5):1507-15. PMID: 8228804.
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    53. Gimble JM, Medina K, Hudson J, Robinson M, Kincade PW. Modulation of lymphohematopoiesis in long-term cultures by gamma interferon: direct and indirect action on lymphoid and stromal cells. Exp Hematol. 1993 Feb; 21(2):224-30. PMID: 8425561.
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    54. Gimble JM, Youkhana K, Hua X, Bass H, Medina K, Sullivan M, Greenberger J, Wang CS. Adipogenesis in a myeloid supporting bone marrow stromal cell line. J Cell Biochem. 1992 Sep; 50(1):73-82. PMID: 1339460.
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    55. Miyake K, Medina K, Ishihara K, Kimoto M, Auerbach R, Kincade PW. A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture. J Cell Biol. 1991 Aug; 114(3):557-65. PMID: 1713592.
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    56. Ishihara K, Medina K, Hayashi S, Pietrangeli C, Namen AE, Miyake K, Kincade PW. Stromal-cell and cytokine-dependent lymphocyte clones which span the pre-B- to B-cell transition. Dev Immunol. 1991; 1(3):149-61. PMID: 1821694.
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    57. Kincade PW, Medina K, Pietrangeli CE, Hayashi SI, Namen AE. Stromal cell lines which support lymphocyte growth. II. Characteristics of a suppressive subclone. Adv Exp Med Biol. 1991; 292:227-34. PMID: 1950774.
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    58. Miyake K, Medina KL, Hayashi S, Ono S, Hamaoka T, Kincade PW. Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med. 1990 Feb 01; 171(2):477-88. PMID: 2406365.
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    59. Gimble JM, Dorheim MA, Cheng Q, Medina K, Wang CS, Jones R, Koren E, Pietrangeli C, Kincade PW. Adipogenesis in a murine bone marrow stromal cell line capable of supporting B lineage lymphocyte growth and proliferation: biochemical and molecular characterization. Eur J Immunol. 1990 Feb; 20(2):379-87. PMID: 2178944.
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    60. Lee G, Medina K, Kincade PW. Growth requirements of B lineage lymphocytes from scid and normal mice. Curr Top Microbiol Immunol. 1989; 152:33-7. PMID: 2680301.
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