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Malay Mandal

TitleResearch Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
Phone+1 (773) 7029719
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pollard JM, Hynes G, Yin D, Mandal M, Gounari F, Alegre ML, Chong AS, Pollard JM, Hynes G, Yin D, Mandal M, Gounari F, Alegre ML, Chong AS. Pregnancy dedifferentiates memory CD8+ T cells into hypofunctional cells with exhaustion-enriched programs. JCI Insight. 2024 May 21; 9(13). PMID: 38771643.
      Citations:    Fields:    Translation:AnimalsCells
    2. Wright NE, Kennedy DE, Ai J, Veselits ML, Attaway M, Yoon YM, Durkee MS, Veselits J, Maienschein-Cline M, Mandal M, Clark MR. BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function. bioRxiv. 2024 Apr 28. PMID: 38712068; PMCID: PMC11071454.
    3. Mandal M, Maienschein-Cline M, Hu Y, Mohsin A, Veselits ML, Wright NE, Okoreeh MK, Yoon YM, Veselits J, Georgopoulos K, Clark MR. BRWD1 orchestrates small pre-B?cell chromatin topology by converting static to dynamic cohesin. Nat Immunol. 2024 Jan; 25(1):129-141. PMID: 37985858.
      Citations:    Fields:    Translation:Cells
    4. Wright NE, Mandal M, Clark MR. Molecular mechanisms insulating proliferation from genotoxic stress in B lymphocytes. Trends Immunol. 2023 09; 44(9):668-677. PMID: 37573227; PMCID: PMC10530527.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Fike AJ, Chodisetti SB, Wright NE, Bricker KN, Domeier PP, Maienschein-Cline M, Rosenfeld AM, Luckenbill SA, Weber JL, Choi NM, Luning Prak ET, Mandal M, Clark MR, Rahman ZSM. STAT3 signaling in B cells controls germinal center zone organization and recycling. Cell Rep. 2023 05 30; 42(5):112512. PMID: 37200190; PMCID: PMC10311431.
      Citations: 3     Fields:    Translation:Cells
    6. Pollard J, Hynes G, Yin D, Mandal M, Gounari F, Alegre ML, Chong A. Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells. Res Sq. 2023 Apr 05. PMID: 37066154; PMCID: PMC10104270.
    7. Okoreeh MK, Kennedy DE, Emmanuel AO, Veselits M, Moshin A, Ladd RH, Erickson S, McLean KC, Madrigal B, Nemazee D, Maienschein-Cline M, Mandal M, Clark MR. Asymmetrical forward and reverse developmental trajectories determine molecular programs of B cell antigen receptor editing. Sci Immunol. 2022 08 05; 7(74):eabm1664. PMID: 35930652; PMCID: PMC9636592.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Zheng Z, Zhang L, Cui XL, Yu X, Hsu PJ, Lyu R, Tan H, Mandal M, Zhang M, Sun HL, Sanchez Castillo A, Peng J, Clark MR, He C, Huang H. Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation. Cell Rep. 2020 06 30; 31(13):107819. PMID: 32610122; PMCID: PMC7371152.
      Citations: 52     Fields:    Translation:AnimalsCells
    9. McLean KC, Mandal M. It Takes Three Receptors to Raise a B Cell. Trends Immunol. 2020 07; 41(7):629-642. PMID: 32451219; PMCID: PMC7331465.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    10. Kennedy DE, Okoreeh MK, Maienschein-Cline M, Ai J, Veselits M, McLean KC, Dhungana Y, Wang H, Peng J, Chi H, Mandal M, Clark MR. Novel specialized cell state and spatial compartments within the germinal center. Nat Immunol. 2020 06; 21(6):660-670. PMID: 32341509; PMCID: PMC7255947.
      Citations: 35     Fields:    Translation:AnimalsCells
    11. Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Koralov SB, Clark MR, Farrar MA, Skok JA, Rajewsky K. B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage. Nat Commun. 2019 10 18; 10(1):4768. PMID: 31628339; PMCID: PMC6802180.
      Citations: 23     Fields:    Translation:AnimalsCells
    12. Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR. CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis. Nat Immunol. 2019 10; 20(10):1393-1403. PMID: 31477919; PMCID: PMC6754289.
      Citations: 31     Fields:    Translation:AnimalsCells
    13. Mandal M, Maienschein-Cline M, Maffucci P, Veselits M, Kennedy DE, McLean KC, Okoreeh MK, Karki S, Cunningham-Rundles C, Clark MR. BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis. Nat Commun. 2018 09 24; 9(1):3888. PMID: 30250168; PMCID: PMC6155124.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Karki S, Kennedy DE, Mclean K, Grzybowski AT, Maienschein-Cline M, Banerjee S, Xu H, Davis E, Mandal M, Labno C, Powers SE, Le Beau MM, Dinner AR, Singh H, Ruthenburg AJ, Clark MR. Regulated Capture of V? Gene Topologically Associating Domains by Transcription Factories. Cell Rep. 2018 08 28; 24(9):2443-2456. PMID: 30157436; PMCID: PMC6310487.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. Publisher Correction: A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 11 30; 8(1):1933. PMID: 29192205; PMCID: PMC5709372.
      Citations:    Fields:    
    16. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR. Igß ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med. 2017 Dec 04; 214(12):3775-3790. PMID: 29141870; PMCID: PMC5716028.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Mao AP, Ishizuka IE, Kasal DN, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017 10 16; 8(1):863. PMID: 29038474; PMCID: PMC5643357.
      Citations: 32     Fields:    Translation:AnimalsCells
    18. Jacobsen JA, Woodard J, Mandal M, Clark MR, Bartom ET, Sigvardsson M, Kee BL. EZH2 Regulates the Developmental Timing of Effectors of the Pre-Antigen Receptor Checkpoints. J Immunol. 2017 06 15; 198(12):4682-4691. PMID: 28490575; PMCID: PMC5527689.
      Citations: 16     Fields:    Translation:AnimalsCells
    19. Mandal M, Hamel KM, Maienschein-Cline M, Tanaka A, Teng G, Tuteja JH, Bunker JJ, Bahroos N, Eppig JJ, Schatz DG, Clark MR. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Nat Immunol. 2015 Oct; 16(10):1094-103. PMID: 26301565; PMCID: PMC4575638.
      Citations: 23     Fields:    Translation:AnimalsCells
    20. Teng G, Maman Y, Resch W, Kim M, Yamane A, Qian J, Kieffer-Kwon KR, Mandal M, Meffre E, Clark MR, Cowell LG, Casellas R, Schatz DG, Ji Y. RAG Represents a Widespread Threat to the Lymphocyte Genome. Cell. 2015 Aug 13; 162(4):751-65. PMID: 26234156; PMCID: PMC4537821.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    21. Hamel KM, Mandal M, Karki S, Clark MR. Balancing Proliferation with Ig? Recombination during B-lymphopoiesis. Front Immunol. 2014; 5:139. PMID: 24765092; PMCID: PMC3980108.
      Citations: 7     Fields:    
    22. Clark MR, Mandal M, Ochiai K, Singh H. Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling. Nat Rev Immunol. 2014 Feb; 14(2):69-80. PMID: 24378843; PMCID: PMC4276135.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    23. Powers SE, Mandal M, Matsuda S, Miletic AV, Cato MH, Tanaka A, Rickert RC, Koyasu S, Clark MR. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J Exp Med. 2012 Nov 19; 209(12):2199-213. PMID: 23109711; PMCID: PMC3501354.
      Citations: 20     Fields:    Translation:AnimalsCells
    24. Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR, Singh H. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 2012 Jan 22; 13(3):300-7. PMID: 22267219; PMCID: PMC4028049.
      Citations: 88     Fields:    Translation:AnimalsCells
    25. Mandal M, Powers SE, Maienschein-Cline M, Bartom ET, Hamel KM, Kee BL, Dinner AR, Clark MR. Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nat Immunol. 2011 Oct 30; 12(12):1212-20. PMID: 22037603; PMCID: PMC3233979.
      Citations: 114     Fields:    Translation:AnimalsCells
    26. Ma S, Pathak S, Mandal M, Trinh L, Clark MR, Lu R. Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression. Mol Cell Biol. 2010 Sep; 30(17):4149-58. PMID: 20566697; PMCID: PMC2937562.
      Citations: 67     Fields:    Translation:AnimalsCells
    27. Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR. Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development. Nat Immunol. 2009 Oct; 10(10):1110-7. PMID: 19734904; PMCID: PMC3057509.
      Citations: 64     Fields:    Translation:AnimalsCells
    28. Kovalovsky D, Yu Y, Dose M, Emmanouilidou A, Konstantinou T, Germar K, Aghajani K, Guo Z, Mandal M, Gounari F. Beta-catenin/Tcf determines the outcome of thymic selection in response to alphabetaTCR signaling. J Immunol. 2009 Sep 15; 183(6):3873-84. PMID: 19717519; PMCID: PMC4695211.
      Citations: 16     Fields:    Translation:AnimalsCells
    29. Mandal M, Crusio KM, Meng F, Liu S, Kinsella M, Clark MR, Takeuchi O, Aifantis I. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20840-5. PMID: 19088189; PMCID: PMC2634950.
      Citations: 20     Fields:    Translation:AnimalsCells
    30. Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I, Thompson B. Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007 Jan; 13(1):70-7. PMID: 17173050.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    31. El Andaloussi A, Graves S, Meng F, Mandal M, Mashayekhi M, Aifantis I. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006 Apr; 7(4):418-26. PMID: 16518394.
      Citations: 38     Fields:    Translation:AnimalsCells
    32. Aifantis I, Mandal M, Sawai K, Ferrando A, Vilimas T. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol Rev. 2006 Feb; 209:159-69. PMID: 16448541.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    33. Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005 Feb 21; 201(4):603-14. PMID: 15728238; PMCID: PMC2213063.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    34. Mandal M, Das S, Chakraborti T, Mandal A, Chakraborti S. Identification, purification and partial characterization of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in bovine pulmonary artery smooth muscle. Mol Cell Biochem. 2003 Dec; 254(1-2):145-55. PMID: 14674693.
      Citations:    Fields:    Translation:HumansAnimalsCells
    35. Chiu NM, Chun T, Fay M, Mandal M, Wang CR. The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides. J Exp Med. 1999 Aug 02; 190(3):423-34. PMID: 10430630; PMCID: PMC2195588.
      Citations: 24     Fields:    Translation:AnimalsCells
    36. Mandal M, Chen XR, Alegre ML, Chiu NM, Chen YH, Wang CR, Castaño AR. Tissue distribution, regulation and intracellular localization of murine CD1 molecules. Mol Immunol. 1998 Jun; 35(9):525-36. PMID: 9809580.
      Citations: 28     Fields:    Translation:AnimalsCells
    37. Chen YH, Chiu NM, Mandal M, Wang N, Wang CR. Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity. 1997 Apr; 6(4):459-67. PMID: 9133425.
      Citations: 152     Fields:    Translation:AnimalsCells
    38. Mandal M, Beaman KD. Purification and characterization of a pregnancy-associated protein: TJ6s. Am J Reprod Immunol. 1995 Jan; 33(1):60-7. PMID: 7619235.
      Citations: 4     Fields:    Translation:AnimalsCells
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