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Carole Ober

TitleProfessor
InstitutionUniversity of Chicago
DepartmentHuman Genetics
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    The research goals of my laboratory are to parse the roles of genetic variation and environmental exposures in the development of asthma and allergic diseases using genetic, transcriptomic and epigenomic markers and integrated omic and systems level analyses. We focus our studies on freshly isolated (ex vivo) blood and airway cells and in vitro cell culture models of gene-environment interactions. Our studies are in diverse U.S. populations of children and adults who have been followed longitudinally and have detailed phenotypes and environmental assessments.
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    Collapse Biography 
    Collapse education and training
    Northwestern University, Evanston, ILPhDBiological Anthropology
    George Washington University, Washington, D.C.BAAnthropology
    Collapse awards and honors
    2018Distinguished Service Professor, University of Chicago
    2017Jonas Salk Health Leadership Award for Research, March of Dimes
    2017Top 10 Clinical Research Achievement Award , Clinical Research Forum
    2015John E. Salvaggio Memorial Lectureship, American Association of Asthma, Allergy and Clinical Immunology
    2015Reuben M. Cherniak Lecturer, Petty Aspen Lung Conference
    2014Fellow, American Association for the Advancement of Science (AAAS)
    2010Named Blum-Riese Professor, University of Chicago
    2005Northwestern Obstetrics and Gynecology Award, Northwestern University Medical School
    2005Charles Reed Lectureship, American Association of Asthma, Allergy, and Immunology (AAAAI)
    1996J. Christian Herr Award for Excellence in Basic or Applied Research in Reproductive Immunology, American Society of Reproductive Immunology (ASRI)

    Collapse Research 
    Collapse research activities and funding
    U19AI162310     (OBER, CAROLE)Jul 19, 2021 - Apr 30, 2026
    NIH
    Integrated genetic, omic, and immunologic studies to identify endotypes and novel drug targets for asthma and allergic diseases
    Role: Principal Investigator
    UG3OD023282     (GERN, JAMES E.)Sep 21, 2016 - Aug 31, 2018
    NIH
    Children's Respiratory and Environmental Workgroup (CREW)
    Role: Co-Investigator
    R01HL129735     (OBER, CAROLE)Sep 1, 2015 - May 31, 2021
    NIH
    Prenatal Origins of Asthma
    Role: Principal Investigator
    R01HL122712     (SOLWAY, JULIAN)Sep 1, 2015 - Jun 30, 2020
    NIH
    Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
    Role: Co-Investigator
         (OBER, CAROLE)Jul 1, 2015 - Sep 30, 2020
    March of Dimes
    Cellular and Molecular Systems Biology of Pregnancy
    Role: Principal Inverstigator
    K12HL119995     (SOLWAY, JULIAN)Sep 1, 2013 - May 31, 2018
    NIH
    Training of Junior Faculty for Careers in Omics of Lung Diseases
    Role: Co-Principal Investigator
    U19AI106683     (SCHLEIMER, ROBERT P)Aug 5, 2013 - Jul 31, 2018
    NIH
    Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Role: Principal Investigator
    U19AI095230     (WHITE, STEVEN R)Jul 25, 2011 - Dec 31, 2017
    NIH
    Airway inflammation and HLA-G in asthma
    Role: Co-Principal Investigator
    RC2HL101651     (OBER, CAROLE)Sep 30, 2009 - Jun 30, 2013
    NIH
    The EVE Asthma Genetics Consortium: Building Upon GWAS
    Role: Principal Investigator
    R01HL085197     (OBER, CAROLE)Jul 1, 2006 - Dec 31, 2017
    NIH
    Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
    Role: Principal Investigator
    R01HL072414     (OBER, CAROLE)Jan 3, 2003 - Dec 31, 2008
    NIH
    Positional Cloning of a 6p-linked Asthma Gene
    Role: Principal Investigator
    P01HL070831     (JACKSON, DANIEL J)Jul 1, 2002 - Jun 30, 2018
    NIH
    Rhinovirus Infections and Asthma in Children and Adolescents
    Role: Co-Investigator
    R01HL066533     (OBER, CAROLE)Sep 30, 2000 - Aug 31, 2005
    NIH
    CHARACTERIZING A 5P-LINKED BHR SUSCEPTIBILITY LOCUS
    Role: Principal Investigator
    U01HL049596     (OBER, CAROLE)Sep 30, 1992 - Aug 31, 2003
    NIH
    COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
    Role: Principal Investigator
    R01HD027686     (OBER, CAROLE)Aug 1, 1992 - Nov 30, 1999
    NIH
    THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
    Role: Principal Investigator
    R01HD021244     (OBER, CAROLE)Jan 1, 1986 - Jun 30, 2013
    NIH
    Molecular Genetic Studies of Fertility in the Hutterites
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Szczesny B, Boorgula MP, Chavan S, Campbell M, Johnson RK, Kammers K, Thompson EE, Cox MS, Shankar G, Cox C, Morin A, Lorizio W, Daya M, Kelada SNP, Beaty TH, Doumatey AP, Cruz AA, Watson H, Naureckas ET, Giles BL, Arinola GA, Sogaolu O, Falade AG, Hansel NN, Yang IV, Olopade CO, Rotimi CN, Landis RC, Figueiredo CA, Altman MC, Kenny E, Ruczinski I, Liu AH, Ober C, Taub MA, Barnes KC, Mathias RA. Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations. Nat Commun. 2024 May 28; 15(1):4546. PMID: 38806494; PMCID: PMC11133339.
      Citations:    Fields:    Translation:HumansCells
    2. Kharitonova EV, Sun Q, Ockerman F, Chen B, Zhou LY, Cao H, Mathias RA, Auer PL, Ober C, Raffield LM, Reiner AP, Cox NJ, Kelada S, Tao R, Li Y. EndoPRS: Incorporating Endophenotype Information to Improve Polygenic Risk Scores for Clinical Endpoints. medRxiv. 2024 May 24. PMID: 38826253; PMCID: PMC11142285.
      Citations:    
    3. Ober C, Joseph CLM, Novembre J. Population descriptors in asthma and allergy research: Time to regroup. J Allergy Clin Immunol. 2024 Jul; 154(1):79-81. PMID: 38642714.
      Citations:    Fields:    Translation:Humans
    4. Bunyavanich S, Becker PM, Altman MC, Lasky-Su J, Ober C, Zengler K, Berdyshev E, Bonneau R, Chatila T, Chatterjee N, Chung KF, Cutcliffe C, Davidson W, Dong G, Fang G, Fulkerson P, Himes BE, Liang L, Mathias RA, Ogino S, Petrosino J, Price ND, Schadt E, Schofield J, Seibold MA, Steen H, Wheatley L, Zhang H, Togias A, Hasegawa K. Analytical challenges in omics research on asthma and allergy: A National Institute of Allergy and Infectious Diseases workshop. J Allergy Clin Immunol. 2024 Apr; 153(4):954-968. PMID: 38295882; PMCID: PMC10999353.
      Citations: 1     Fields:    Translation:Humans
    5. Clay S, Alladina J, Smith NP, Visness CM, Wood RA, O'Connor GT, Cohen RT, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Rivera-Spoljaric K, Robison RG, Gergen PJ, Busse WW, Villani AC, Cho JL, Medoff BD, Gern JE, Jackson DJ, Ober C, Dapas M. Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma. J Allergy Clin Immunol. 2024 Mar; 153(3):809-820. PMID: 37944567; PMCID: PMC10939893.
      Citations:    Fields:    Translation:HumansAnimals
    6. Dapas M, Lee YL, Wentworth-Sheilds W, Im HK, Ober C, Schoettler N. Revealing polygenic pleiotropy using genetic risk scores for asthma. HGG Adv. 2023 10 12; 4(4):100233. PMID: 37663543; PMCID: PMC10474095.
      Citations: 3     Fields:    Translation:Humans
    7. Soliai MM, Kato A, Naughton KA, Norton JE, Klinger AI, Kern RC, Tan BK, Nicolae DL, Schleimer RP, Ober C, Pinto JM. Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis. Allergy. 2023 10; 78(10):2698-2711. PMID: 37571876; PMCID: PMC10614423.
      Citations:    Fields:    Translation:HumansCells
    8. Marques Dos Santos M, Pivniouk V, Rankl B, Walker A, Pagani G, Hertkorn N, Schmitt-Kopplin P, Müller C, Bracher F, Merl-Pham J, Hauck SM, Schloter M, Michael AN, Anderson D, Honeker L, Gozdz J, Pivniouk O, Ober C, Holbreich M, Martinez FD, Snyder SA, von Mutius E, Vercelli D. Asthma-protective agents in dust from traditional farm environments. J Allergy Clin Immunol. 2023 09; 152(3):610-621. PMID: 37271318; PMCID: PMC10680491.
      Citations: 1     Fields:    Translation:Animals
    9. Liu X, Aneas I, Sakabe N, Anderson RL, Billstrand C, Paz C, Kaur H, Furner B, Choi S, Prichina AY, Enninga EAL, Dong H, Murtha A, Crawford GE, Kessler JA, Grobman W, Nobrega MA, Rana S, Ober C. Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor. Sci Rep. 2023 05 16; 13(1):7903. PMID: 37193763; PMCID: PMC10188528.
      Citations: 1     Fields:    Translation:HumansCells
    10. Thompson EE, Helling BA, Shorey-Kendrick LE, Faber P, Gebretsadik T, Bacharier LB, Kattan M, O'Connor GT, Rivera-Spoljaric K, Wood RA, Barnes KC, Mathias RA, Altman MC, Hansen K, McEvoy CT, Spindel ER, Hartert T, Jackson DJ, Gern JE, McKennan CG, Ober C, Morin A, program collaborators for Environmental Influences on Child Health Outcomes and Children’s Respirato. A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome. J Allergy Clin Immunol. 2023 06; 151(6):1609-1621. PMID: 36754293; PMCID: PMC10859971.
      Citations: 5     Fields:    Translation:HumansCells
    11. Dapas M, Thompson EE, Wentworth-Sheilds W, Clay S, Visness CM, Calatroni A, Sordillo JE, Gold DR, Wood RA, Makhija M, Khurana Hershey GK, Sherenian MG, Gruchalla RS, Gill MA, Liu AH, Kim H, Kattan M, Bacharier LB, Rastogi D, Altman MC, Busse WW, Becker PM, Nicolae D, O'Connor GT, Gern JE, Jackson DJ, Ober C. Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings. PLoS Genet. 2023 01; 19(1):e1010594. PMID: 36638096; PMCID: PMC9879483.
      Citations: 2     Fields:    Translation:HumansCells
    12. Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway J. Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712. PMID: 36344522; PMCID: PMC9640644.
      Citations: 7     Fields:    Translation:Humans
    13. Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, Lemanske RF, Ober C, Gern JE. New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am J Respir Cell Mol Biol. 2022 Oct; 67(4):430-437. PMID: 35580164; PMCID: PMC9564923.
      Citations: 4     Fields:    Translation:Humans
    14. Washington C, Dapas M, Biddanda A, Magnaye KM, Aneas I, Helling BA, Szczesny B, Boorgula MP, Taub MA, Kenny E, Mathias RA, Barnes KC, CAAPA, Khurana Hershey GK, Kercsmar CM, Gereige JD, Makhija M, Gruchalla RS, Gill MA, Liu AH, Rastogi D, Busse W, Gergen PJ, Visness CM, Gold DR, Hartert T, Johnson CC, Lemanske RF, Martinez FD, Miller RL, Ownby D, Seroogy CM, Wright AL, Zoratti EM, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Nobrega MA, Altman MC, Jackson DJ, Gern JE, McKennan CG, Ober C. African-specific alleles modify risk for asthma at the 17q12-q21 locus in African Americans. Genome Med. 2022 09 29; 14(1):112. PMID: 36175932; PMCID: PMC9520885.
      Citations: 2     Fields:    Translation:Humans
    15. Tingskov Pedersen CE, Eliasen AU, Ketzel M, Brandt J, Loft S, Frohn LM, Khan J, Brix S, Rasmussen MA, Stokholm J, Chawes B, Morin A, Ober C, Bisgaard H, Pedersen M, Bønnelykke K. Prenatal exposure to ambient air pollution is associated with early life immune perturbations. J Allergy Clin Immunol. 2023 01; 151(1):212-221. PMID: 36075322.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    16. Chung J, Das A, Sun X, Leung YY, Igartua C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X, Jun GR, Stein TD, Kunkle BW, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, Nobrega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA, Sobreira DR. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women. Alzheimers Dement. 2023 03; 19(3):896-908. PMID: 35770850; PMCID: PMC9800643.
      Citations: 20     Fields:    Translation:Humans
    17. Magnaye KM, Clay SM, Nicodemus-Johnson J, Naughton KA, Huffman J, Altman MC, Jackson DJ, Gern JE, Hogarth DK, Naureckas ET, White SR, Ober C. DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma. Proc Natl Acad Sci U S A. 2022 06 14; 119(24):e2116467119. PMID: 35666868; PMCID: PMC9214527.
      Citations: 6     Fields:    Translation:HumansCells
    18. Clay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C. Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55. PMID: 35606880; PMCID: PMC9128203.
      Citations: 2     Fields:    Translation:HumansCells
    19. Jackman JK, Stockwell A, Choy DF, Xie MM, Lu P, Jia G, Li H, Abbas AR, Bronson PG, Lin WY, Chiu CPC, Maun HR, Roose-Girma M, Tam L, Zhang J, Modrusan Z, Graham RR, Behrens TW, White SR, Naureckas T, Ober C, Ferreira M, Sedlacek R, Wu J, Lee WP, Lazarus RA, Koerber JT, Arron JR, Yaspan BL, Yi T. Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma. J Allergy Clin Immunol. 2022 10; 150(4):972-978.e7. PMID: 35487308.
      Citations: 4     Fields:    Translation:Humans
    20. Eliasen AU, Pedersen CET, Rasmussen MA, Wang N, Soverini M, Fritz A, Stokholm J, Chawes BL, Bork-Jensen J, Grarup N, Pedersen O, Hansen T, Linneberg A, Mortensen PB, Hougaard DM, Bybjerg-Grauholm J, Mors O, Nordentoft M, Werge T, Agerbo E, Altman MC, Thysen AH, McKennan CG, Brix S, Gern JE, Ober C, Ahluwalia TS, Bisgaard H, Pedersen AG, Morin A, Bækvad-Hansen M, Børglum AD, Söderhall C, Bønnelykke K. Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB. J Allergy Clin Immunol. 2022 09; 150(3):622-630. PMID: 35381269.
      Citations: 3     Fields:    Translation:Humans
    21. Aneas I, Decker DC, Howard CL, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Schoetler N, Ober C, Sperling AI, Sobreira DR, Tena J, Gomez-Skarmeta JL, Nóbrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. PMID: 34675193; PMCID: PMC8531453.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    22. Soliai MM, Kato A, Helling BA, Stanhope CT, Norton JE, Naughton KA, Klinger AI, Thompson EE, Clay SM, Kim S, Gern JE, Jackson DJ, Altman MC, Kern RC, Tan BK, Schleimer RP, Nicolae DL, Pinto JM, Ober C, Celedón JC. Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. Genome Med. 2021 10 10; 13(1):157. PMID: 34629083; PMCID: PMC8504130.
      Citations: 18     Fields:    Translation:HumansCells
    23. Daya M, Cox C, Acevedo N, Boorgula MP, Campbell M, Chavan S, Cho MH, David GL, Kachroo P, Lasky-Su J, Li X, McHugh CP, Qiao D, Rafaels N, Beck LA, Bleecker ER, Caraballo L, Cupples AL, Gallo RL, Hanifin J, Hansel NN, Hata TR, Hersh CP, Knight-Madden J, Leung DYM, Guttman-Yassky E, Meyers DA, O'Connor G, Ober C, Ong PY, Ortega VE, Paller AS, Putcha N, Reed RM, Schneider LC, Silverman EK, Slifka MK, Spergel JM, Vasan RS, Viaud-Martinez KA, Watson H, Weiss ST, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ruczinski I, Beaty TH, Mathias RA, Barnes KC, Figueiredo CA. Multiethnic genome-wide and HLA association study of total serum IgE level. J Allergy Clin Immunol. 2021 12; 148(6):1589-1595. PMID: 34536413; PMCID: PMC8665111.
      Citations: 9     Fields:    Translation:Humans
    24. Joslin AC, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Sobreira DR, Nóbrega MA. A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nat Commun. 2021 09 06; 12(1):5253. PMID: 34489471; PMCID: PMC8421397.
      Citations: 16     Fields:    Translation:HumansCells
    25. Bai T, Peng CY, Aneas I, Sakabe N, Requena DF, Billstrand C, Nobrega M, Ober C, Parast M, Kessler JA. Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts. Stem Cell Res. 2021 10; 56:102507. PMID: 34454392; PMCID: PMC8551050.
      Citations: 11     Fields:    Translation:HumansCells
    26. Magnaye KM, Naughton KA, Huffman J, Hogarth DK, Naureckas ET, White SR, Ober C. A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma. Eur Respir J. 2021 07; 58(1). PMID: 33446603.
      Citations: 9     Fields:    Translation:HumansCells
    27. Kim KW, Kim DY, Yoon D, Kim KK, Jang H, Schoettler N, Kim EG, Kim MN, Hong JY, Lee JK, Kim S, Ober C, Gee HY, Sohn MH. Genome-wide association study identifies TNFSF15 associated with childhood asthma. Allergy. 2022 01; 77(1):218-229. PMID: 34022066; PMCID: PMC8606614.
      Citations: 7     Fields:    Translation:Humans
    28. Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Sobreira DR, Nóbrega MA. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Science. 2021 06 04; 372(6546):1085-1091. PMID: 34083488; PMCID: PMC8386003.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    29. Altman MC, Flynn K, Rosasco MG, Dapas M, Kattan M, Lovinsky-Desir S, O'Connor GT, Gill MA, Gruchalla RS, Liu AH, Pongracic JA, Khurana Hershey GK, Zoratti EM, Teach SJ, Rastrogi D, Wood RA, Bacharier LB, LeBeau P, Gergen PJ, Togias A, Busse WW, Presnell S, Gern JE, Ober C, Jackson DJ, NIAID Inner City Asthma Consortium. Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children. J Allergy Clin Immunol. 2021 12; 148(6):1505-1514. PMID: 34019912; PMCID: PMC8599524.
      Citations: 7     Fields:    Translation:Humans
    30. Hallmark B, Wegienka G, Havstad S, Billheimer D, Ownby D, Mendonca EA, Gress L, Stern DA, Myers JB, Khurana Hershey GK, Hoepner L, Miller RL, Lemanske RF, Jackson DJ, Gold DR, O'Connor GT, Nicolae DL, Gern JE, Ober C, Wright AL, Martinez FD. Chromosome 17q12-21 Variants Are Associated with Multiple Wheezing Phenotypes in Childhood. Am J Respir Crit Care Med. 2021 04 01; 203(7):864-870. PMID: 33535024; PMCID: PMC8017591.
      Citations: 13     Fields:    Translation:HumansCells
    31. Stein MM, Conery M, Magnaye KM, Clay SM, Billstrand C, Nicolae R, Naughton K, Ober C, Thompson EE. Sex-specific differences in peripheral blood leukocyte transcriptional response to LPS are enriched for HLA region and X chromosome genes. Sci Rep. 2021 01 13; 11(1):1107. PMID: 33441806; PMCID: PMC7806814.
      Citations: 8     Fields:    Translation:HumansCells
    32. Turi KN, McKennan C, Gebretsadik T, Snyder B, Seroogy CM, Lemanske RF, Zoratti E, Havstad S, Ober C, Lynch S, McCauley K, Yu C, Jackson DJ, Gern JE, Hartert TV, ECHO-CREW investigators. Unconjugated bilirubin is associated with protection from early-life wheeze and childhood asthma. J Allergy Clin Immunol. 2021 07; 148(1):128-138. PMID: 33434532; PMCID: PMC8271087.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    33. Soliai M, Sundaresan AS, Hirsch AG, Stanhope C, Kuiper J, Schwartz BS, Ober C, Pinto JM, Morin A. Two-stage genome-wide association study of chronic rhinosinusitis and disease subphenotypes highlights mucosal immunity contributing to risk. Int Forum Allergy Rhinol. 2021 04; 11(4):814-817. PMID: 33393196; PMCID: PMC8048969.
      Citations: 2     Fields:    Translation:Humans
    34. Ahluwalia TS, Eliasen AU, Sevelsted A, Pedersen CT, Stokholm J, Chawes B, Bork-Jensen J, Grarup N, Pedersen O, Hansen T, Linneberg A, Sharma A, Weiss ST, Evans MD, Jackson DJ, Morin A, Krogfelt KA, Mortensen PB, Hougaard DM, Bybjerg-Grauholm J, Mors O, Nordentoft M, Werge T, Agerbo E, Gern JE, Lemanske RF, Ober C, Pedersen AG, Bisgaard H, Schjørring S, Bækvad-Hansen M, Børglum AD, Bønnelykke K. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses. Nat Commun. 2020 12 16; 11(1):6398. PMID: 33328473; PMCID: PMC7744576.
      Citations: 10     Fields:    Translation:HumansCells
    35. Sakabe NJ, Aneas I, Knoblauch N, Sobreira DR, Clark N, Paz C, Horth C, Ziffra R, Kaur H, Liu X, Anderson R, Morrison J, Cheung VC, Grotegut C, Reddy TE, Jacobsson B, Hallman M, Teramo K, Murtha A, Kessler J, Grobman W, Zhang G, Muglia LJ, Rana S, Lynch VJ, Crawford GE, Ober C, He X, Nóbrega MA. Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. Sci Adv. 2020 12; 6(49). PMID: 33268355; PMCID: PMC7710387.
      Citations: 20     Fields:    Translation:HumansCells
    36. Helling BA, Hansen GT, Sakabe NJ, Luo K, Billstrand C, Laxman B, Nicolae RI, Nicolae DL, Bochkov YA, Gern JE, Nobrega MA, White SR, Ober C, Sobreira DR. Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma. Commun Biol. 2020 11 13; 3(1):678. PMID: 33188283; PMCID: PMC7666152.
      Citations: 14     Translation:HumansCells
    37. McKennan C, Naughton K, Stanhope C, Kattan M, O'Connor GT, Sandel MT, Visness CM, Wood RA, Bacharier LB, Beigelman A, Lovinsky-Desir S, Togias A, Gern JE, Nicolae D, Ober C. Longitudinal data reveal strong genetic and weak non-genetic components of ethnicity-dependent blood DNA methylation levels. Epigenetics. 2021 06; 16(6):662-676. PMID: 32997571; PMCID: PMC8143220.
      Citations: 13     Fields:    Translation:HumansCells
    38. Hoang TT, Sikdar S, Xu CJ, Lee MK, Cardwell J, Forno E, Imboden M, Jeong A, Qi C, Wang T, Bennett BD, Ward JM, Parks CG, Beane-Freeman LE, King D, Motsinger-Reif A, Umbach DM, Wyss AB, Schwartz DA, Ober C, Probst-Hensch N, Yang IV, Koppelman GH, London SJ, Madore AM, Celedón JC, Laprise C. Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study. Eur Respir J. 2020 09; 56(3). PMID: 32381493; PMCID: PMC7469973.
      Citations: 28     Fields:    Translation:HumansCells
    39. Thompson EE, Dang Q, Mitchell-Handley B, Rajendran K, Ram-Mohan S, Solway J, Ober C, Krishnan R. Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma. Genome Med. 2020 07 20; 12(1):64. PMID: 32690065; PMCID: PMC7370514.
      Citations: 8     Fields:    Translation:HumansCells
    40. McKennan CG, Pedersen CT, Stokholm J, Chawes BL, Malby Schoos AM, Naughton KA, Thorsen J, Mortensen MS, Vercelli D, Trivedi U, Bisgaard H, Nicolae DL, Ober C, Morin A, Sørensen SJ, Bønnelykke K. Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age. J Allergy Clin Immunol. 2020 12; 146(6):1358-1366. PMID: 32693091; PMCID: PMC7821422.
      Citations: 27     Fields:    Translation:HumansCellsCTClinical Trials
    41. McKennan C, Ober C, Nicolae D. ESTIMATION AND INFERENCE IN METABOLOMICS WITH NON-RANDOM MISSING DATA AND LATENT FACTORS. Ann Appl Stat. 2020 Jun; 14(2):789-808. PMID: 34221212; PMCID: PMC8248477.
      Citations: 6     
    42. Ober C, McKennan CG, Magnaye KM, Altman MC, Washington C, Stanhope C, Naughton KA, Rosasco MG, Bacharier LB, Billheimer D, Gold DR, Gress L, Hartert T, Havstad S, Khurana Hershey GK, Hallmark B, Hogarth DK, Jackson DJ, Johnson CC, Kattan M, Lemanske RF, Lynch SV, Mendonca EA, Miller RL, Naureckas ET, O'Connor GT, Seroogy CM, Wegienka G, White SR, Wood RA, Wright AL, Zoratti EM, Martinez FD, Ownby D, Nicolae DL, Levin AM, Gern JE, Environmental Influences on Child Health Outcomes-Children's Respiratory Research Workgroup. Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. Lancet Respir Med. 2020 05; 8(5):482-492. PMID: 32380068; PMCID: PMC7335429.
      Citations: 24     Fields:    Translation:HumansCells
    43. Jackson DJ, Busse WW, Bacharier LB, Kattan M, O'Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2. J Allergy Clin Immunol. 2020 Jul; 146(1):203-206.e3. PMID: 32333915; PMCID: PMC7175851.
      Citations: 291     Fields:    Translation:HumansCellsPHPublic Health
    44. Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 04 08; 27(4):614-628.e6. PMID: 32130954; PMCID: PMC7305569.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    45. Daya M, Morii W, Rafaels N, Boorgula MP, Chavan S, Vergara C, Ortega VE, Wilson JG, Lange LA, Watson H, Nicolae DL, Meyers DA, Hansel NN, Ford JG, Faruque MU, Bleecker ER, Campbell M, Beaty TH, Ruczinski I, Mathias RA, Taub MA, Ober C, Noguchi E, Barnes KC, CAAPA, Torgerson D, Vince N, Limou S, Geffard E, Douillard V, Walencik A, Gourraud PA. Association of HLA-DRB1*09:01 with tIgE levels among African-ancestry individuals with asthma. J Allergy Clin Immunol. 2020 07; 146(1):147-155. PMID: 31981624.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    46. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019 Nov 13; 2(1):411. PMID: 31925217.
      Citations:    
    47. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019; 2:411. PMID: 31754641; PMCID: PMC6853923.
      Citations: 10     Translation:HumansCells
    48. Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Gao H, Gordon SD, de Haan HG, Harris SE, Hofer E, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Nutile T, Palviainen T, Prasad G, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Doumatey AP, Dzimiri N, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Manichaikul AW, Matoba N, Mei XW, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Padmanabhan S, Pankow JS, Pattie A, Polasek O, Poulter N, Quintana-Murci L, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Vuoksimaa E, Wakil SM, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan JM, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, Martin NG, Matullo G, McCarthy MI, Medland SE, Merriman TR, Metspalu A, Meyer BF, Mohlke KL, Montgomery GW, Mook-Kanamori D, Munroe PB, North KE, Nyholt DR, O'connell JR, Ober C, Oldehinkel AJ, Palmas W, Palmer C, Pasterkamp GG, Patin E, Pennell CE, Perusse L, Peyser PA, Pirastu M, Polderman TJC, Porteous DJ, Posthuma D, Psaty BM, Rioux JD, Rivadeneira F, Rotimi C, Rotter JI, Rudan I, Den Ruijter HM, Sanghera DK, Sattar N, et al. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 2019 10 31; 10(1):4957. PMID: 31673082; PMCID: PMC6823371.
      Citations: 57     Fields:    Translation:Humans
    49. Schoettler N, Weidinger S, Ober C, Rodríguez E. Advances in asthma and allergic disease genetics: Is bigger always better? J Allergy Clin Immunol. 2019 12; 144(6):1495-1506. PMID: 31677964; PMCID: PMC6900451.
      Citations: 36     Fields:    Translation:Humans
    50. Schoettler N, Ober C. Genetic architecture of moderate-to-severe asthma mirrors that of mild asthma. J Allergy Clin Immunol. 2019 12; 144(6):1521-1523. PMID: 31541629.
      Citations: 3     Fields:    Translation:Humans
    51. Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Hansel NN, Hernandez RD, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O'Connor TD, Olopade CO, Olopade O, Qin ZS, Rotimi C, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, Mathias RA, Barnes KC, CAAPA, Gourraud PA, Herrera-Paz EF, Jiménez S, Lizee A, Oliveira RR, Vince N. Author Correction: Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019 Sep 04; 10(1):4082. PMID: 31484942; PMCID: PMC6726619.
      Citations: 1     Fields:    
    52. Hrusch CL, Stein MM, Gozdz J, Holbreich M, Vercelli D, Ober C, Sperling AI, von Mutius E. T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children. J Allergy Clin Immunol. 2019 11; 144(5):1391-1401.e10. PMID: 31401285; PMCID: PMC6842432.
      Citations: 17     Fields:    Translation:HumansCellsPHPublic Health
    53. Sharma A, Laxman B, Naureckas ET, Hogarth DK, Sperling AI, Solway J, Ober C, Gilbert JA, White SR. Associations between fungal and bacterial microbiota of airways and asthma endotypes. J Allergy Clin Immunol. 2019 11; 144(5):1214-1227.e7. PMID: 31279011; PMCID: PMC6842419.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    54. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019 06; 7(6):509-522. PMID: 31036433; PMCID: PMC6534440.
      Citations: 125     Fields:    Translation:HumansCells
    55. Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C. Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree. Commun Biol. 2019; 2:28. PMID: 30675526; PMCID: PMC6338666.
      Citations: 14     Translation:Humans
    56. Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C. Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree. Commun Biol. 2019 Jan 18; 2(1):28. PMID: 31924898.
      Citations:    
    57. Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C. Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions. PLoS One. 2018; 13(9):e0203906. PMID: 30204804; PMCID: PMC6133383.
      Citations: 5     Fields:    Translation:HumansCells
    58. Stein MM, Hrusch CL, Sperling AI, Ober C. Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies. Genes Immun. 2019 07; 20(6):462-472. PMID: 29977032; PMCID: PMC8026236.
      Citations: 6     Fields:    Translation:HumansCells
    59. Thompson EE, Nicodemus-Johnson J, Kim KW, Gern JE, Jackson DJ, Lemanske RF, Ober C. Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes. Clin Epigenetics. 2018; 10:62. PMID: 29760811; PMCID: PMC5941468.
      Citations: 29     Fields:    Translation:HumansCells
    60. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Washington C, Nicolae D, Ober C, Morin A, Bønnelykke K. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018 09; 142(3):749-764.e3. PMID: 29307657; PMCID: PMC6172038.
      Citations: 83     Fields:    Translation:HumansCells
    61. Barnes KC, Cookson WOC, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Boomsma DI, Brightling CE, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA, Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Meyers D, Michel S, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Smith LJ, Solodilova M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Torgerson DG, Tsunoda T, van der Valk RJP, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL, Demenais F, Margaritte-Jeannin P, Altmüller J, Bønnelykke K, Bouzigon E, Brossard M, Heliövaara M, Kähönen M, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Marenholz I, Melén E, Mohamdi H, Pershagen G, Schlünssen V, Siroux V, Standl M, Tiesler CMT, Uitterlinden AG, Vaysse A, Widén E. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 01; 50(1):42-53. PMID: 29273806; PMCID: PMC5901974.
      Citations: 239     Fields:    Translation:HumansCells
    62. Igartua C, Mozaffari SV, Nicolae DL, Ober C. Rare non-coding variants are associated with plasma lipid traits in a founder population. Sci Rep. 2017 11 27; 7(1):16415. PMID: 29180722; PMCID: PMC5704019.
      Citations: 13     Fields:    Translation:Humans
    63. Ober C, Sperling AI, von Mutius E, Vercelli D. Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol. 2017 Oct; 48:51-60. PMID: 28843541; PMCID: PMC5682224.
      Citations: 30     Fields:    Translation:Humans
    64. Igartua C, Davenport ER, Gilad Y, Nicolae DL, Pinto J, Ober C. Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome. 2017 02 01; 5(1):16. PMID: 28143570; PMCID: PMC5286564.
      Citations: 39     Fields:    Translation:HumansCells
    65. Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight. 2016 12 08; 1(20):e90151. PMID: 27942592; PMCID: PMC5139904.
      Citations: 76     Fields:    Translation:HumansCells
    66. Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med. 2016 Aug 04; 375(5):411-421. PMID: 27518660; PMCID: PMC5137793.
      Citations: 375     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    67. Burrows CK, Herman C, Patterson K, Hartmann KE, Velez Edwards DR, Stephenson MD, Lynch VJ, Ober C, Kosova G. Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes. PLoS Genet. 2016 07; 12(7):e1005858. PMID: 27447835; PMCID: PMC4957750.
      Citations: 17     Fields:    Translation:HumansCells
    68. Ober C, Bønnelykke K. Leveraging gene-environment interactions and endotypes for asthma gene discovery. J Allergy Clin Immunol. 2016 Mar; 137(3):667-79. PMID: 26947980; PMCID: PMC5004762.
      Citations: 53     Fields:    Translation:HumansAnimals
    69. Ober C. Asthma Genetics in the Post-GWAS Era. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S85-90. PMID: 27027959; PMCID: PMC5015734.
      Citations: 47     Fields:    Translation:Humans
    70. Elias JA, Chupp GL, Lang RM, Shah SJ, Decara JM, Cusanovich DA, Caliskan M, Billstrand C, Michelini K, Chavarria C, De Leon S, Mitrano A, Lewellyn N, Gilad Y, Ober C. Integrated analyses of gene expression and genetic association studies in a founder population. Hum Mol Genet. 2016 05 15; 25(10):2104-2112. PMID: 26931462; PMCID: PMC5062579.
      Citations: 13     Fields:    Translation:Humans
    71. Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C. Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):376-85. PMID: 26474238; PMCID: PMC4803084.
      Citations: 54     Fields:    Translation:HumansCells
    72. Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. 2015; 10(11):e0140301. PMID: 26528553; PMCID: PMC4631601.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    73. Baker SW, Gilad Y, Ober C, Çaliskan M. Host genetic variation influences gene expression response to rhinovirus infection. PLoS Genet. 2015 Apr; 11(4):e1005111. PMID: 25874939; PMCID: PMC4395341.
      Citations: 40     Fields:    Translation:HumansCells
    74. Livne OE, Han L, Alkorta-Aranburu G, Wentworth-Sheilds W, Abney M, Ober C, Nicolae DL. PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population. PLoS Comput Biol. 2015 Mar; 11(3):e1004139. PMID: 25735005; PMCID: PMC4348507.
      Citations: 22     Fields:    Translation:Humans
    75. Gao Z, Waggoner D, Stephens M, Ober C, Przeworski M. An estimate of the average number of recessive lethal mutations carried by humans. Genetics. 2015 Apr; 199(4):1243-54. PMID: 25697177; PMCID: PMC4391560.
      Citations: 34     Fields:    Translation:Humans
    76. Igartua C, Myers RA, Mathias RA, Pino-Yanes M, Eng C, Graves PE, Levin AM, Del-Rio-Navarro BE, Jackson DJ, Livne OE, Rafaels N, Edlund CK, Yang JJ, Huntsman S, Salam MT, Romieu I, Mourad R, Gern JE, Lemanske RF, Wyss A, Hoppin JA, Barnes KC, Burchard EG, Gauderman WJ, Martinez FD, Raby BA, Weiss ST, Williams LK, London SJ, Gilliland FD, Nicolae DL, Ober C. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. Nat Commun. 2015 Jan 16; 6:5965. PMID: 25591454; PMCID: PMC4309441.
      Citations: 43     Fields:    Translation:Humans
    77. Stephenson MD, Lynch VJ, Ober C, Kosova G. Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss. Hum Reprod. 2015 Mar; 30(3):519-29. PMID: 25586782; PMCID: PMC4325674.
      Citations: 15     Fields:    Translation:HumansCells
    78. Pritchard JK, Ober C, Gilad Y, Çaliskan M. The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines. PLoS One. 2014; 9(9):e107166. PMID: 25192014; PMCID: PMC4156430.
      Citations: 14     Fields:    Translation:HumansCells
    79. Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, Patterson KM, Eng C, Torgerson DG, Hu D, Herman C, Chong JX, Ko A, O'Roak BJ, Krumm N, Vives L, Lee C, Roth LA, Rodriguez-Cintron W, Brigino-Buenaventura E, Davis A, Meade K, LeNoir MA, Thyne S, Jackson DJ, Gern JE, Lemanske RF, Shendure J, Abney M, Burchard EG, Ober C, Eichler EE, Rodriguez-Santana J. Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One. 2014; 9(8):e104396. PMID: 25116239; PMCID: PMC4130548.
      Citations: 21     Fields:    Translation:Humans
    80. Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL, GRAAD, del Rio Navarro B. Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014 Oct 01; 23(19):5251-9. PMID: 24824216; PMCID: PMC4159149.
      Citations: 40     Fields:    Translation:Humans
    81. Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. Seasonal variation in human gut microbiome composition. PLoS One. 2014; 9(3):e90731. PMID: 24618913; PMCID: PMC3949691.
      Citations: 138     Fields:    Translation:Humans
    82. Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE, Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM, Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL, Abney M, Ober C. Genome-wide association study of lung function phenotypes in a founder population. J Allergy Clin Immunol. 2014 Jan; 133(1):248-55.e1-10. PMID: 23932459; PMCID: PMC4270121.
      Citations: 40     Fields:    Translation:Humans
    83. Caliskan M, Bochkov YA, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF, Nicolae DL, Ober C, Kreiner-Møller E, Bønnelykke K. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013 Apr 11; 368(15):1398-407. PMID: 23534543; PMCID: PMC3755952.
      Citations: 241     Fields:    Translation:HumansCells
    84. Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C. Maternal asthma and microRNA regulation of soluble HLA-G in the airway. J Allergy Clin Immunol. 2013 Jun; 131(6):1496-503. PMID: 23534973; PMCID: PMC3779062.
      Citations: 26     Fields:    Translation:HumansPHPublic Health
    85. Thompson EE, Myers RA, Du G, Aydelotte TM, Tisler CJ, Stern DA, Evans MD, Graves PE, Jackson DJ, Martinez FD, Gern JE, Wright AL, Lemanske RF, Ober C. Maternal microchimerism protects against the development of asthma. J Allergy Clin Immunol. 2013 Jul; 132(1):39-44. PMID: 23434286; PMCID: PMC3700564.
      Citations: 12     Fields:    Translation:Humans
    86. Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. PMID: 23146381; PMCID: PMC3596497.
      Citations: 34     Fields:    Translation:Humans
    87. Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Galanter JM, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C, Celedón JC. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. PMID: 23040885; PMCID: PMC3666859.
      Citations: 12     Fields:    Translation:HumansCells
    88. Campbell CD, Chong JX, Malig M, Ko A, Dumont BL, Han L, Vives L, O'Roak BJ, Sudmant PH, Shendure J, Abney M, Ober C, Eichler EE. Estimating the human mutation rate using autozygosity in a founder population. Nat Genet. 2012 Nov; 44(11):1277-81. PMID: 23001126; PMCID: PMC3483378.
      Citations: 115     Fields:    Translation:Humans
    89. Loisel DA, Billstrand C, Murray K, Patterson K, Chaiworapongsa T, Romero R, Ober C. The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women. Mol Hum Reprod. 2013 Mar; 19(3):144-52. PMID: 23002110; PMCID: PMC3579410.
      Citations: 23     Fields:    Translation:Humans
    90. Chong JX, Ouwenga R, Anderson RL, Waggoner DJ, Ober C. A population-based study of autosomal-recessive disease-causing mutations in a founder population. Am J Hum Genet. 2012 Oct 05; 91(4):608-20. PMID: 22981120; PMCID: PMC3484657.
      Citations: 29     Fields:    Translation:Humans
    91. Ding D, Scott NM, Thompson EE, Chaiworapongsa T, Torres R, Billstrand C, Murray K, Dexheimer PJ, Ismail M, Kay H, Levy S, Romero R, Lindheimer MD, Nicolae DL, Ober C. Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia. Reprod Sci. 2012 Dec; 19(12):1343-51. PMID: 22902742; PMCID: PMC4046444.
      Citations: 7     Fields:    Translation:HumansCells
    92. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012 Oct; 130(4):861-8.e7. PMID: 22694930; PMCID: PMC3579216.
      Citations: 71     Fields:    Translation:Humans
    93. Scott NM, Niederberger C, Prins GS, Ober C, Kosova G. Genome-wide association study identifies candidate genes for male fertility traits in humans. Am J Hum Genet. 2012 Jun 08; 90(6):950-61. PMID: 22633400; PMCID: PMC3370277.
      Citations: 64     Fields:    Translation:Humans
    94. Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Avila PC, Ford JG, Barnes KC, Burchard EG, Howard TD, Bleecker ER, Meyers DA, Cox NJ, Ober C, Nicolae DL, Rodríguez-Santana JR, Rodríguez-Cintrón W. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012 Sep; 130(3):622-629.e9. PMID: 22607992; PMCID: PMC3503456.
      Citations: 21     Fields:    Translation:HumansCells
    95. Uricchio LH, Chong JX, Ross KD, Ober C, Nicolae DL. Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals. Genet Epidemiol. 2012 May; 36(4):312-9. PMID: 22460724; PMCID: PMC3794468.
      Citations: 15     Fields:    Translation:Humans
    96. Meyer WK, Arbeithuber B, Ober C, Ebner T, Tiemann-Boege I, Hudson RR, Przeworski M. Evaluating the evidence for transmission distortion in human pedigrees. Genetics. 2012 May; 191(1):215-32. PMID: 22377632; PMCID: PMC3338262.
      Citations: 27     Fields:    Translation:HumansCells
    97. Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012 Feb 10; 90(2):273-81. PMID: 22325360; PMCID: PMC3276672.
      Citations: 35     Fields:    Translation:Humans
    98. Cusanovich DA, Billstrand C, Zhou X, Chavarria C, De Leon S, Michelini K, Pai AA, Ober C, Gilad Y. The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. Hum Mol Genet. 2012 May 01; 21(9):2111-23. PMID: 22286170; PMCID: PMC3315207.
      Citations: 35     Fields:    Translation:HumansCells
    99. Motika CA, Papachristou C, Abney M, Lester LA, Ober C. Rising prevalence of asthma is sex-specific in a US farming population. J Allergy Clin Immunol. 2011 Oct; 128(4):774-9. PMID: 21840584; PMCID: PMC3401412.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    100. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ, Mexico City Childhood Asthma Study (MCAAS), Gilliland FD, Children's Health Study (CHS) and HARBORS study, Burchard EG, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Lat, Martinez FD, Childhood Asthma Research and Education (CARE) Network, Weiss ST, Childhood Asthma Management Program (CAMP), Williams LK, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes KC, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober C, Nicolae DL, Celedón JC. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31; 43(9):887-92. PMID: 21804549; PMCID: PMC3445408.
      Citations: 407     Fields:    Translation:Humans
    101. Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF, Ober C. IFNG genotype and sex interact to influence the risk of childhood asthma. J Allergy Clin Immunol. 2011 Sep; 128(3):524-31. PMID: 21798578; PMCID: PMC3548570.
      Citations: 21     Fields:    Translation:Humans
    102. Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev. 2011 Jul; 242(1):10-30. PMID: 21682736; PMCID: PMC3151648.
      Citations: 244     Fields:    Translation:HumansCells
    103. Chong JX, Oktay AA, Dai Z, Swoboda KJ, Prior TW, Ober C. A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites. Eur J Hum Genet. 2011 Oct; 19(10):1045-51. PMID: 21610747; PMCID: PMC3190247.
      Citations: 13     Fields:    Translation:Humans
    104. Caliskan M, Cusanovich DA, Ober C, Gilad Y. The effects of EBV transformation on gene expression levels and methylation profiles. Hum Mol Genet. 2011 Apr 15; 20(8):1643-52. PMID: 21289059; PMCID: PMC3063990.
      Citations: 83     Fields:    Translation:HumansCells
    105. Ober C, Vercelli D. Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet. 2011 Mar; 27(3):107-15. PMID: 21216485; PMCID: PMC3073697.
      Citations: 79     Fields:    Translation:Humans
    106. Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C, Çaliskan M. Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13. Hum Mol Genet. 2011 Apr 01; 20(7):1285-9. PMID: 21212097; PMCID: PMC3115579.
      Citations: 49     Fields:    Translation:HumansCells
    107. Pickrell JK, Kelley JL, McArdle PF, Shuldiner AR, Abney M, Ober C, Kosova G. The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate. PLoS Genet. 2010 Jun 03; 6(6):e1000974. PMID: 20532200; PMCID: PMC2880556.
      Citations: 13     Fields:    Translation:Humans
    108. Thompson EE, Sun Y, Nicolae D, Ober C. Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans. Genet Epidemiol. 2010 Feb; 34(2):133-9. PMID: 19697328; PMCID: PMC4238926.
      Citations: 5     Fields:    Translation:Humans
    109. Thompson EE, Haller G, Pinto JM, Sun Y, Zelano B, Jacob S, McClintock MK, Nicolae DL, Ober C. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. Hum Immunol. 2010 Jan; 71(1):100-3. PMID: 19833159; PMCID: PMC3631539.
      Citations: 6     Fields:    Translation:HumansCells
    110. Haller G, Torgerson DG, Ober C, Thompson EE. Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility. J Allergy Clin Immunol. 2009 Dec; 124(6):1204-9.e9. PMID: 19910025; PMCID: PMC3984460.
      Citations: 20     Fields:    Translation:Humans
    111. Fuchsberger C, Platzer C, Caliskan M, Marroni F, Pramstaller PP, Ober C, Pichler I. Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes. Eur J Hum Genet. 2010 Apr; 18(4):463-70. PMID: 19844259; PMCID: PMC2987252.
      Citations: 15     Fields:    Translation:HumansCells
    112. Abney M, Ober C, Kosova G. Colloquium papers: Heritability of reproductive fitness traits in a human population. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 Suppl 1:1772-8. PMID: 19822755; PMCID: PMC2868280.
      Citations: 42     Fields:    Translation:Humans
    113. Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J Lipid Res. 2009 May; 50(5):798-806. PMID: 19124843; PMCID: PMC2666166.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    114. Ober C, Loisel DA, Gilad Y. Sex-specific genetic architecture of human disease. Nat Rev Genet. 2008 Dec; 9(12):911-22. PMID: 19002143; PMCID: PMC2694620.
      Citations: 361     Fields:    Translation:HumansAnimals
    115. Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C. A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q. Laryngoscope. 2008 Nov; 118(11):2067-72. PMID: 18622306; PMCID: PMC4288474.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    116. Nolan DK, Chen P, Das S, Ober C, Waggoner D. Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13. Am J Med Genet A. 2008 Jun 01; 146A(11):1414-22. PMID: 18446860.
      Citations: 3     Fields:    Translation:HumansCells
    117. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med. 2008 Apr 17; 358(16):1682-91. PMID: 18403759; PMCID: PMC2629486.
      Citations: 224     Fields:    Translation:Humans
    118. Pinto JM, Thanaviratananich S, Hayes MG, Naclerio RM, Ober C. A genome-wide screen for hyposmia susceptibility Loci. Chem Senses. 2008 Apr; 33(4):319-29. PMID: 18245794.
      Citations: 5     Fields:    Translation:HumansCells
    119. Coop G, Wen X, Ober C, Pritchard JK, Przeworski M. High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science. 2008 Mar 07; 319(5868):1395-8. PMID: 18239090.
      Citations: 219     Fields:    Translation:Humans
    120. Gallego Romero I, Ober C. CFTR mutations and reproductive outcomes in a population isolate. Hum Genet. 2008 Jan; 122(6):583-8. PMID: 17901983.
      Citations: 9     Fields:    Translation:Humans
    121. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet. 2007 Oct; 81(4):829-34. PMID: 17847008; PMCID: PMC2227932.
      Citations: 175     Fields:    Translation:HumansCells
    122. Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF, Nicolae DL, Ober C. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007 Jun; 119(6):1423-9. PMID: 17556058.
      Citations: 11     Fields:    Translation:Humans
    123. Pluzhnikov A, Nolan DK, Tan Z, McPeek MS, Ober C. Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Am J Hum Genet. 2007 Jul; 81(1):165-9. PMID: 17564973; PMCID: PMC1950912.
      Citations: 12     Fields:    Translation:Humans
    124. Pan L, Ober C, Abney M. Heritability estimation of sex-specific effects on human quantitative traits. Genet Epidemiol. 2007 May; 31(4):338-47. PMID: 17323368.
      Citations: 22     Fields:    Translation:HumansCells
    125. Kurz T, Hoffjan S, Hayes MG, Schneider D, Nicolae R, Heinzmann A, Jerkic SP, Parry R, Cox NJ, Deichmann KA, Ober C. Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci. J Allergy Clin Immunol. 2006 Aug; 118(2):396-402. PMID: 16890764.
      Citations: 29     Fields:    Translation:HumansCells
    126. Weiss LA, Ober C, Cook EH. ITGB3 shows genetic and expression interaction with SLC6A4. Hum Genet. 2006 Aug; 120(1):93-100. PMID: 16721604.
      Citations: 20     Fields:    Translation:HumansAnimals
    127. Weiss LA, Delahanty RJ, Jiang L, Cook EH, Ober C, Sutcliffe JS, Kosova G. Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. Eur J Hum Genet. 2006 Aug; 14(8):923-31. PMID: 16724005.
      Citations: 40     Fields:    Translation:Humans
    128. Ober C, Pan L, Phillips N, Parry R, Kurina LM. Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population. Curr Allergy Asthma Rep. 2006 May; 6(3):241-6. PMID: 16579875.
      Citations: 11     Fields:    Translation:Humans
    129. Ober C, Billstrand C, Kuldanek S, Tan Z. The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells. Hum Reprod. 2006 Jul; 21(7):1743-8. PMID: 16501035.
      Citations: 29     Fields:    Translation:HumansCells
    130. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006 Feb; 38(2):218-22. PMID: 16429159.
      Citations: 171     Fields:    Translation:Humans
    131. Donfack J, Schneider DH, Tan Z, Kurz T, Dubchak I, Frazer KA, Ober C. Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy. Respir Res. 2005 Dec 10; 6:145. PMID: 16336695; PMCID: PMC1325232.
      Citations: 17     Fields:    Translation:HumansCells
    132. Tan Z, Shon AM, Ober C. Evidence of balancing selection at the HLA-G promoter region. Hum Mol Genet. 2005 Dec 01; 14(23):3619-28. PMID: 16236759.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    133. Ober C, Thompson EE. Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol. 2005 Dec; 17(6):670-8. PMID: 16214315.
      Citations: 19     Fields:    Translation:Humans
    134. Zhang J, Schneider D, Ober C, McPeek MS. Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals. Genet Epidemiol. 2005 Sep; 29(2):128-40. PMID: 16049966.
      Citations: 3     Fields:    Translation:Humans
    135. Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol. 2005 Aug 15; 175(4):2061-5. PMID: 16081771.
      Citations: 14     Fields:    Translation:HumansCells
    136. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J. 2005 May; 19(7):681-93. PMID: 15857883.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    137. Weiss LA, Abney M, Parry R, Scanu AM, Cook EH, Ober C. Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. Hum Genet. 2005 Jun; 117(1):81-7. PMID: 15834589.
      Citations: 10     Fields:    Translation:Humans
    138. Weiss LA, Lester LA, Gern JE, Wolf RL, Parry R, Lemanske RF, Solway J, Ober C. Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Am J Respir Crit Care Med. 2005 Jul 01; 172(1):67-73. PMID: 15817799; PMCID: PMC2718448.
      Citations: 19     Fields:    Translation:HumansCells
    139. Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel DB, Steiner L, Walker K, Shult P, Gangnon RE, Gern JE, Martinez FD, Lemanske RF, Ober C. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet. 2005 Apr; 76(4):696-704. PMID: 15726497; PMCID: PMC1199307.
      Citations: 24     Fields:    Translation:Humans
    140. McClintock MK, Bullivant S, Jacob S, Spencer N, Zelano B, Ober C. Human body scents: conscious perceptions and biological effects. Chem Senses. 2005 Jan; 30 Suppl 1:i135-7. PMID: 15738077.
      Citations: 8     Fields:    Translation:Humans
    141. Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 Feb; 76(2):349-57. PMID: 15611928; PMCID: PMC1196380.
      Citations: 80     Fields:    Translation:HumansCells
    142. Weiss LA, Abney M, Cook EH, Ober C. Sex-specific genetic architecture of whole blood serotonin levels. Am J Hum Genet. 2005 Jan; 76(1):33-41. PMID: 15526234; PMCID: PMC1196431.
      Citations: 52     Fields:    Translation:HumansCells
    143. Weiss LA, Veenstra-Vanderweele J, Newman DL, Kim SJ, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH, Abney M. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet. 2004 Nov; 12(11):949-54. PMID: 15292919.
      Citations: 30     Fields:    Translation:HumansCells
    144. Bourgain C, Abney M, Schneider D, Ober C, McPeek MS. Testing for Hardy-Weinberg equilibrium in samples with related individuals. Genetics. 2004 Dec; 168(4):2349-61. PMID: 15371359; PMCID: PMC1448754.
      Citations: 26     Fields:    
    145. Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C. Are common disease susceptibility alleles the same in outbred and founder populations? Eur J Hum Genet. 2004 Jul; 12(7):584-90. PMID: 15100713.
      Citations: 17     Fields:    Translation:Humans
    146. McPeek MS, Wu X, Ober C. Best linear unbiased allele-frequency estimation in complex pedigrees. Biometrics. 2004 Jun; 60(2):359-67. PMID: 15180661.
      Citations: 55     Fields:    Translation:Humans
    147. Reed AM, McNallan K, Wettstein P, Vehe R, Ober C. Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis? J Immunol. 2004 Apr 15; 172(8):5041-6. PMID: 15067086.
      Citations: 31     Fields:    Translation:Humans
    148. Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004 Mar; 113(3):511-8. PMID: 15007355.
      Citations: 25     Fields:    Translation:Humans
    149. Gern JE, Reardon CL, Hoffjan S, Nicolae D, Li Z, Roberg KA, Neaville WA, Carlson-Dakes K, Adler K, Hamilton R, Anderson E, Gilbertson-White S, Tisler C, Dasilva D, Anklam K, Mikus LD, Rosenthal LA, Ober C, Gangnon R, Lemanske RF. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol. 2004 Feb; 113(2):307-14. PMID: 14767447.
      Citations: 62     Fields:    Translation:HumansAnimals
    150. Wen X, Hanchard NA, Herbert MA, Ober C, Pritchard JK, Zöllner S. Evidence for extensive transmission distortion in the human genome. Am J Hum Genet. 2004 Jan; 74(1):62-72. PMID: 14681832; PMCID: PMC1181913.
      Citations: 40     Fields:    Translation:HumansCells
    151. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res. 2003; 4:14. PMID: 14748924; PMCID: PMC314398.
      Citations: 49     Fields:    Translation:Humans
    152. Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K, Reynolds R, Ober C, McPeek MS. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet. 2003 Sep; 73(3):612-26. PMID: 12929084; PMCID: PMC1180685.
      Citations: 81     Fields:    Translation:Humans
    153. Ober C, Aldrich CL, Chervoneva I, Billstrand C, Rahimov F, Gray HL, Hyslop T. Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet. 2003 Jun; 72(6):1425-35. PMID: 12721954; PMCID: PMC1180303.
      Citations: 60     Fields:    Translation:HumansCells
    154. Donfack J, Kogut P, Forsythe S, Solway J, Ober C. Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy. J Allergy Clin Immunol. 2003 Mar; 111(3):527-32. PMID: 12642833.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    155. Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C. Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet. 2003 Jan 15; 12(2):137-44. PMID: 12499394.
      Citations: 17     Fields:    Translation:HumansCells
    156. Aldrich C, Wambebe C, Odama L, Di Rienzo A, Ober C. Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution. Hum Immunol. 2002 May; 63(5):405-12. PMID: 11975984.
      Citations: 5     Fields:    Translation:Humans
    157. Abney M, Ober C, McPeek MS. Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. Am J Hum Genet. 2002 Apr; 70(4):920-34. PMID: 11880950; PMCID: PMC379120.
      Citations: 70     Fields:    Translation:HumansCells
    158. Jacob S, McClintock MK, Zelano B, Ober C. Paternally inherited HLA alleles are associated with women's choice of male odor. Nat Genet. 2002 Feb; 30(2):175-9. PMID: 11799397.
      Citations: 93     Fields:    Translation:HumansAnimals
    159. Aldrich CL, Stephenson MD, Karrison T, Odem RR, Branch DW, Scott JR, Schreiber JR, Ober C. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod. 2001 Dec; 7(12):1167-72. PMID: 11719594.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    160. Ober C, Abney M, McPeek MS. The genetic dissection of complex traits in a founder population. Am J Hum Genet. 2001 Nov; 69(5):1068-79. PMID: 11590547; PMCID: PMC1274354.
      Citations: 76     Fields:    Translation:HumansCells
    161. Abney M, McPeek MS, Ober C. Broad and narrow heritabilities of quantitative traits in a founder population. Am J Hum Genet. 2001 May; 68(5):1302-7. PMID: 11309690; PMCID: PMC1226113.
      Citations: 67     Fields:    Translation:Humans
    162. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet. 2000 Nov; 67(5):1154-62. PMID: 11022011; PMCID: PMC1288558.
      Citations: 90     Fields:    Translation:HumansCells
    163. Aldrich C, Verp MS, Walker MA, Ober C. A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation. J Reprod Immunol. 2000 May; 47(1):41-8. PMID: 10779589.
      Citations: 13     Fields:    Translation:Humans
    164. Abney M, McPeek MS, Ober C. Estimation of variance components of quantitative traits in inbred populations. Am J Hum Genet. 2000 Feb; 66(2):629-50. PMID: 10677322; PMCID: PMC1288115.
      Citations: 54     Fields:    Translation:Humans
    165. Ober C, Karrison T, Odem RR, Barnes RB, Branch DW, Stephenson MD, Baron B, Walker MA, Scott JR, Schreiber JR. Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial. Lancet. 1999 Jul 31; 354(9176):365-9. PMID: 10437864.
      Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
    166. Robertson A, Charlesworth D, Ober C. Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci. Genet Epidemiol. 1999; 17(3):165-73. PMID: 10446464.
      Citations: 3     Fields:    Translation:HumansCells
    167. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod. 1999 Jan; 5(1):84-7. PMID: 10050667.
      Citations: 26     Fields:    Translation:HumansCells
    168. Ober C, Hyslop T, Hauck WW. Inbreeding effects on fertility in humans: evidence for reproductive compensation. Am J Hum Genet. 1999 Jan; 64(1):225-31. PMID: 9915962; PMCID: PMC1377721.
      Citations: 35     Fields:    Translation:Humans
    169. Tsai AF, Kaufman KA, Walker MA, Karrison TG, Odem RR, Barnes RB, Scott JR, Schreiber JR, Stephenson MD, Ober C. Transmission disequilibrium of maternally-inherited CTLA-4 microsatellite alleles in idiopathic recurrent miscarriage. J Reprod Immunol. 1998 Nov; 40(2):147-57. PMID: 9881742.
      Citations: 9     Fields:    Translation:HumansCells
    170. Ober C, Aldrich C, Rosinsky B, Robertson A, Walker MA, Willadsen S, Verp MS, Geraghty DE, Hunt JS. HLA-G1 protein expression is not essential for fetal survival. Placenta. 1998 Mar-Apr; 19(2-3):127-32. PMID: 9548178.
      Citations: 24     Fields:    Translation:Humans
    171. Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW. Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. Hum Reprod. 1998 Jan; 13(1):33-8. PMID: 9512225.
      Citations: 40     Fields:    Translation:HumansCTClinical Trials
    172. Ober C. HLA and pregnancy: the paradox of the fetal allograft. Am J Hum Genet. 1998 Jan; 62(1):1-5. PMID: 9443885; PMCID: PMC1376816.
      Citations: 17     Fields:    Translation:Humans
    173. Ober C, Aldrich CL. HLA-G polymorphisms: neutral evolution or novel function? J Reprod Immunol. 1997 Nov 30; 36(1-2):1-21. PMID: 9430736.
      Citations: 8     Fields:    Translation:HumansCells
    174. Ober C, Weitkamp LR, Cox N, Dytch H, Kostyu D, Elias S. HLA and mate choice in humans. Am J Hum Genet. 1997 Sep; 61(3):497-504. PMID: 9326314; PMCID: PMC1715964.
      Citations: 81     Fields:    Translation:Humans
    175. Grimsley C, Ober C. Population genetic studies of HLA-E: evidence for selection. Hum Immunol. 1997 Jan; 52(1):33-40. PMID: 9021407.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    176. Ober C, Rosinsky B, Grimsley C, van der Ven K, Robertson A, Runge A. Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1. J Reprod Immunol. 1996 Dec; 32(2):111-23. PMID: 9023816.
      Citations: 10     Fields:    Translation:Humans
    177. Steck T, van der Ven K, Kwak J, Beer A, Ober C. HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion. J Reprod Immunol. 1995 Jul; 29(2):95-104. PMID: 7500323.
      Citations: 3     Fields:    Translation:Humans
    178. Ober C, Steck T, van der Ven K, Billstrand C, Messer L, Kwak J, Beaman K, Beer A. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. J Reprod Immunol. 1993 Dec; 25(3):195-207. PMID: 8207709.
      Citations: 4     Fields:    Translation:HumansCells
    179. Kostyu DD, Ober CL, Dawson DV, Ghanayem M, Elias S, Martin AO. Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites. Am J Hum Genet. 1989 Aug; 45(2):261-9. PMID: 2757031; PMCID: PMC1683340.
      Citations: 3     Fields:    Translation:HumansCells
    180. Simpson JL, Mills JL, Holmes LB, Ober CL, Aarons J, Jovanovic L, Knopp RH. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA. 1987 Nov 13; 258(18):2555-7. PMID: 3312659.
      Citations: 11     Fields:    Translation:Humans
    181. Ober CL, Hauck WW, Kostyu DD, O'Brien E, Elias S, Simpson JL, Martin AO. Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort study in a human isolate. Fertil Steril. 1985 Aug; 44(2):227-32. PMID: 3860403.
      Citations: 10     Fields:    Translation:Humans
    182. Ober CL, Martin AO, Simpson JL, Hauck WW, Amos DB, Kostyu DD, Fotino M, Allen FH. Shared HLA antigens and reproductive performance among Hutterites. Am J Hum Genet. 1983 Sep; 35(5):994-1004. PMID: 6577788; PMCID: PMC1685819.
      Citations: 22     Fields:    Translation:Humans
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