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Carole Ober

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBSD Academic Admin
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.


    Collapse Biography 
    Collapse education and training
    Northwestern University, Evanston, ILPhDBiological Anthropology
    George Washington University, Washington, D.C.BAAnthropology
    Collapse awards and honors
    2018Distinguished Service Professor, University of Chicago
    2017Jonas Salk Health Leadership Award for Research, March of Dimes
    2017Top 10 Clinical Research Achievement Award , Clinical Research Forum
    2015John E. Salvaggio Memorial Lectureship, American Association of Asthma, Allergy and Clinical Immunology
    2015Reuben M. Cherniak Lecturer, Petty Aspen Lung Conference
    2014Fellow, American Association for the Advancement of Science (AAAS)
    2010Named Blum-Riese Professor, University of Chicago
    2005Northwestern Obstetrics and Gynecology Award, Northwestern University Medical School
    2005Charles Reed Lectureship, American Association of Asthma, Allergy, and Immunology (AAAAI)
    1996J. Christian Herr Award for Excellence in Basic or Applied Research in Reproductive Immunology, American Society of Reproductive Immunology (ASRI)

    Collapse ORNG Applications 
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    Collapse Research 
    Collapse research activities and funding
    P01HL070831     (JACKSON, DANIEL J)Jul 1, 2002 - Jun 30, 2018
    NIH
    Rhinovirus Infections and Asthma in Children and Adolescents
    Role: Co-Investigator

    U19AI106683     (SCHLEIMER, ROBERT P)Aug 5, 2013 - Jul 31, 2018
    NIH
    Chronic Rhinosinusitis Integrative Studies Program (CRISP)
    Role: Principal Investigator

         (OBER, CAROLE)Jul 1, 2015 - Sep 30, 2020
    March of Dimes
    Cellular and Molecular Systems Biology of Pregnancy
    Role: Principal Inverstigator

    R01HL129735     (OBER, CAROLE)Sep 1, 2015 - May 31, 2019
    NIH
    Prenatal Origins of Asthma
    Role: Principal Investigator

    R01HL122712     (SOLWAY, JULIAN)Sep 1, 2015 - Jun 30, 2019
    NIH
    Mendelian Disease - Asthma Comorbidity to Find Subgroup-Specific Asthma Genes
    Role: Co-Investigator

    UG3OD023282     (GERN, JAMES E.)Sep 21, 2016 - Aug 31, 2018
    NIH
    Children's Respiratory and Environmental Workgroup (CREW)
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai JF, Corre T, Cousminer DL, Dekker AM, Eccles DA, van Eijk KR, Fuchsberger C, Gao H, Germain M, Gordon SD, de Haan HG, Harris SE, Hofer E, Huerta-Chagoya A, Igartua C, Jansen IE, Jia Y, Kacprowski T, Karlsson T, Kleber ME, Li SA, Li-Gao R, Mahajan A, Matsuda K, Meidtner K, Meng W, Montasser ME, van der Most PJ, Munz M, Nutile T, Palviainen T, Prasad G, Prasad RB, Priyanka TDS, Rizzi F, Salvi E, Sapkota BR, Shriner D, Skotte L, Smart MC, Smith AV, van der Spek A, Spracklen CN, Strawbridge RJ, Tajuddin SM, Trompet S, Turman C, Verweij N, Viberti C, Wang L, Warren HR, Wootton RE, Yanek LR, Yao J, Yousri NA, Zhao W, Adeyemo AA, Afaq S, Aguilar-Salinas CA, Akiyama M, Albert ML, Allison MA, Alver M, Aung T, Azizi F, Bentley AR, Boeing H, Boerwinkle E, Borja JB, de Borst GJ, Bottinger EP, Broer L, Campbell H, Chanock S, Chee ML, Chen G, Chen YI, Chen Z, Chiu YF, Cocca M, Collins FS, Concas MP, Corley J, Cugliari G, van Dam RM, Damulina A, Daneshpour MS, Day FR, Delgado GE, Dhana K, Doney ASF, Dörr M, Doumatey AP, Dzimiri N, Ebenesersdóttir SS, Elliott J, Elliott P, Ewert R, Felix JF, Fischer K, Freedman BI, Girotto G, Goel A, Gögele M, Goodarzi MO, Graff M, Granot-Hershkovitz E, Grodstein F, Guarrera S, Gudbjartsson DF, Guity K, Gunnarsson B, Guo Y, Hagenaars SP, Haiman CA, Halevy A, Harris TB, Hedayati M, van Heel DA, Hirata M, Höfer I, Hsiung CA, Huang J, Hung YJ, Ikram MA, Jagadeesan A, Jousilahti P, Kamatani Y, Kanai M, Kerrison ND, Kessler T, Khaw KT, Khor CC, de Kleijn DPV, Koh WP, Kolcic I, Kraft P, Krämer BK, Kutalik Z, Kuusisto J, Langenberg C, Launer LJ, Lawlor DA, Lee IT, Lee WJ, Lerch MM, Li L, Liu J, Loh M, London SJ, Loomis S, Lu Y, Luan J, Mägi R, Manichaikul AW, Manunta P, Másson G, Matoba N, Mei XW, Meisinger C, Meitinger T, Mezzavilla M, Milani L, Millwood IY, Momozawa Y, Moore A, Morange PE, Moreno-Macías H, Mori TA, Morrison AC, Muka T, Murakami Y, Murray AD, de Mutsert R, Mychaleckyj JC, Nalls MA, Nauck M, Neville MJ, Nolte IM, Ong KK, Orozco L, Padmanabhan S, Pálsson G, Pankow JS, Pattaro C, Pattie A, Polasek O, Poulter N, Pramstaller PP, Quintana-Murci L, Räikkönen K, Ralhan S, Rao DC, van Rheenen W, Rich SS, Ridker PM, Rietveld CA, Robino A, van Rooij FJA, Ruggiero D, Saba Y, Sabanayagam C, Sabater-Lleal M, Sala CF, Salomaa V, Sandow K, Schmidt H, Scott LJ, Scott WR, Sedaghati-Khayat B, Sennblad B, van Setten J, Sever PJ, Sheu WH, Shi Y, Shrestha S, Shukla SR, Sigurdsson JK, Sikka TT, Singh JR, Smith BH, Stancáková A, Stanton A, Starr JM, Stefansdottir L, Straker L, Sulem P, Sveinbjornsson G, Swertz MA, Taylor AM, Taylor KD, Terzikhan N, Tham YC, Thorleifsson G, Thorsteinsdottir U, Tillander A, Tracy RP, Tusié-Luna T, Tzoulaki I, Vaccargiu S, Vangipurapu J, Veldink JH, Vitart V, Völker U, Vuoksimaa E, Wakil SM, Waldenberger M, Wander GS, Wang YX, Wareham NJ, Wild S, Yajnik CS, Yuan JM, Zeng L, Zhang L, Zhou J, Amin N, Asselbergs FW, Bakker SJL, Becker DM, Lehne B, Bennett DA, van den Berg LH, Berndt SI, Bharadwaj D, Bielak LF, Bochud M, Boehnke M, Bouchard C, Bradfield JP, Brody JA, Campbell A, Carmi S, Caulfield MJ, Cesarini D, Chambers JC, Chandak GR, Cheng CY, Ciullo M, Cornelis M, Cusi D, Smith GD, Deary IJ, Dorajoo R, van Duijn CM, Ellinghaus D, Erdmann J, Eriksson JG, Evangelou E, Evans MK, Faul JD, Feenstra B, Feitosa M, Foisy S, Franke A, Friedlander Y, Gasparini P, Gieger C, Gonzalez C, Goyette P, Grant SFA, Griffiths LR, Groop L, Gudnason V, Gyllensten U, Hakonarson H, Hamsten A, van der Harst P, Heng CK, Hicks AA, Hochner H, Huikuri H, Hunt SC, Jaddoe VWV, De Jager PL, Johannesson M, Johansson Å, Jonas JB, Jukema JW, Junttila J, Kaprio J, Kardia SLR, Karpe F, Kumari M, Laakso M, van der Laan SW, Lahti J, Laudes M, Lea RA, Lieb W, Lumley T, et al. Associations of autozygosity with a broad range of human phenotypes. Nat Commun. 2019 Oct 31; 10(1):4957. PMID: 31673082.
      View in: PubMed
    2. Schoettler N, Rodríguez E, Weidinger S, Ober C. Advances in Asthma and Allergic Disease Genetics - Is Bigger Always Better? J Allergy Clin Immunol. 2019 Oct 30. PMID: 31677964.
      View in: PubMed
    3. Hrusch CL, Stein MM, Gozdz J, Holbreich M, von Mutius E, Vercelli D, Ober C, Sperling AI. T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children. J Allergy Clin Immunol. 2019 Nov; 144(5):1391-1401.e10. PMID: 31401285.
      View in: PubMed
    4. Sharma A, Laxman B, Naureckas ET, Hogarth DK, Sperling AI, Solway J, Ober C, Gilbert JA, White SR. Associations between fungal and bacterial microbiota of airways and asthma endotypes. J Allergy Clin Immunol. 2019 Nov; 144(5):1214-1227.e7. PMID: 31279011.
      View in: PubMed
    5. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019 Jun; 7(6):509-522. PMID: 31036433.
      View in: PubMed
    6. Mozaffari SV, DeCara JM, Shah SJ, Sidore C, Fiorillo E, Cucca F, Lang RM, Nicolae DL, Ober C. Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree. Commun Biol. 2019; 2:28. PMID: 30675526.
      View in: PubMed
    7. Mozaffari SV, Stein MM, Magnaye KM, Nicolae DL, Ober C. Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions. PLoS One. 2018; 13(9):e0203906. PMID: 30204804.
      View in: PubMed
    8. Stein MM, Hrusch CL, Sperling AI, Ober C. Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies. Genes Immun. 2019 07; 20(6):462-472. PMID: 29977032.
      View in: PubMed
    9. Thompson EE, Nicodemus-Johnson J, Kim KW, Gern JE, Jackson DJ, Lemanske RF, Ober C. Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes. Clin Epigenetics. 2018; 10:62. PMID: 29760811.
      View in: PubMed
    10. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Morin A, Washington C, Nicolae D, Bønnelykke K, Ober C. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018 09; 142(3):749-764.e3. PMID: 29307657.
      View in: PubMed
    11. Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018 01; 50(1):42-53. PMID: 29273806.
      View in: PubMed
    12. Igartua C, Mozaffari SV, Nicolae DL, Ober C. Rare non-coding variants are associated with plasma lipid traits in a founder population. Sci Rep. 2017 11 27; 7(1):16415. PMID: 29180722.
      View in: PubMed
    13. Ober C, Sperling AI, von Mutius E, Vercelli D. Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol. 2017 Oct; 48:51-60. PMID: 28843541.
      View in: PubMed
    14. Igartua C, Davenport ER, Gilad Y, Nicolae DL, Pinto J, Ober C. Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome. 2017 02 01; 5(1):16. PMID: 28143570.
      View in: PubMed
    15. Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. JCI Insight. 2016 12 08; 1(20):e90151. PMID: 27942592.
      View in: PubMed
    16. Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children. N Engl J Med. 2016 Aug 04; 375(5):411-421. PMID: 27518660.
      View in: PubMed
    17. Burrows CK, Kosova G, Herman C, Patterson K, Hartmann KE, Velez Edwards DR, Stephenson MD, Lynch VJ, Ober C. Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes. PLoS Genet. 2016 07; 12(7):e1005858. PMID: 27447835.
      View in: PubMed
    18. Bønnelykke K, Ober C. Leveraging gene-environment interactions and endotypes for asthma gene discovery. J Allergy Clin Immunol. 2016 Mar; 137(3):667-79. PMID: 26947980.
      View in: PubMed
    19. Ober C. Asthma Genetics in the Post-GWAS Era. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S85-90. PMID: 27027959.
      View in: PubMed
    20. Cusanovich DA, Caliskan M, Billstrand C, Michelini K, Chavarria C, De Leon S, Mitrano A, Lewellyn N, Elias JA, Chupp GL, Lang RM, Shah SJ, Decara JM, Gilad Y, Ober C. Integrated analyses of gene expression and genetic association studies in a founder population. Hum Mol Genet. 2016 05 15; 25(10):2104-2112. PMID: 26931462.
      View in: PubMed
    21. Nicodemus-Johnson J, Naughton KA, Sudi J, Hogarth K, Naurekas ET, Nicolae DL, Sperling AI, Solway J, White SR, Ober C. Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):376-85. PMID: 26474238.
      View in: PubMed
    22. Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. 2015; 10(11):e0140301. PMID: 26528553.
      View in: PubMed
    23. Çaliskan M, Baker SW, Gilad Y, Ober C. Host genetic variation influences gene expression response to rhinovirus infection. PLoS Genet. 2015 Apr; 11(4):e1005111. PMID: 25874939.
      View in: PubMed
    24. Livne OE, Han L, Alkorta-Aranburu G, Wentworth-Sheilds W, Abney M, Ober C, Nicolae DL. PRIMAL: Fast and accurate pedigree-based imputation from sequence data in a founder population. PLoS Comput Biol. 2015 Mar; 11(3):e1004139. PMID: 25735005.
      View in: PubMed
    25. Gao Z, Waggoner D, Stephens M, Ober C, Przeworski M. An estimate of the average number of recessive lethal mutations carried by humans. Genetics. 2015 Apr; 199(4):1243-54. PMID: 25697177.
      View in: PubMed
    26. Igartua C, Myers RA, Mathias RA, Pino-Yanes M, Eng C, Graves PE, Levin AM, Del-Rio-Navarro BE, Jackson DJ, Livne OE, Rafaels N, Edlund CK, Yang JJ, Huntsman S, Salam MT, Romieu I, Mourad R, Gern JE, Lemanske RF, Wyss A, Hoppin JA, Barnes KC, Burchard EG, Gauderman WJ, Martinez FD, Raby BA, Weiss ST, Williams LK, London SJ, Gilliland FD, Nicolae DL, Ober C. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. Nat Commun. 2015 Jan 16; 6:5965. PMID: 25591454.
      View in: PubMed
    27. Kosova G, Stephenson MD, Lynch VJ, Ober C. Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss. Hum Reprod. 2015 Mar; 30(3):519-29. PMID: 25586782.
      View in: PubMed
    28. Çaliskan M, Pritchard JK, Ober C, Gilad Y. The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines. PLoS One. 2014; 9(9):e107166. PMID: 25192014.
      View in: PubMed
    29. Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, Patterson KM, Eng C, Torgerson DG, Hu D, Herman C, Chong JX, Ko A, O'Roak BJ, Krumm N, Vives L, Lee C, Roth LA, Rodriguez-Cintron W, Rodriguez-Santana J, Brigino-Buenaventura E, Davis A, Meade K, LeNoir MA, Thyne S, Jackson DJ, Gern JE, Lemanske RF, Shendure J, Abney M, Burchard EG, Ober C, Eichler EE. Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PLoS One. 2014; 9(8):e104396. PMID: 25116239.
      View in: PubMed
    30. Myers RA, Scott NM, Gauderman WJ, Qiu W, Mathias RA, Romieu I, Levin AM, Pino-Yanes M, Graves PE, Villarreal AB, Beaty TH, Carey VJ, Croteau-Chonka DC, del Rio Navarro B, Edlund C, Hernandez-Cadena L, Navarro-Olivos E, Padhukasahasram B, Salam MT, Torgerson DG, Van den Berg DJ, Vora H, Bleecker ER, Meyers DA, Williams LK, Martinez FD, Burchard EG, Barnes KC, Gilliland FD, Weiss ST, London SJ, Raby BA, Ober C, Nicolae DL. Genome-wide interaction studies reveal sex-specific asthma risk alleles. Hum Mol Genet. 2014 Oct 01; 23(19):5251-9. PMID: 24824216.
      View in: PubMed
    31. Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. Seasonal variation in human gut microbiome composition. PLoS One. 2014; 9(3):e90731. PMID: 24618913.
      View in: PubMed
    32. Yao TC, Du G, Han L, Sun Y, Hu D, Yang JJ, Mathias R, Roth LA, Rafaels N, Thompson EE, Loisel DA, Anderson R, Eng C, Arruabarrena Orbegozo M, Young M, Klocksieben JM, Anderson E, Shanovich K, Lester LA, Williams LK, Barnes KC, Burchard EG, Nicolae DL, Abney M, Ober C. Genome-wide association study of lung function phenotypes in a founder population. J Allergy Clin Immunol. 2014 Jan; 133(1):248-55.e1-10. PMID: 23932459.
      View in: PubMed
    33. Caliskan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF, Nicolae DL, Ober C. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013 Apr 11; 368(15):1398-407. PMID: 23534543.
      View in: PubMed
    34. Nicodemus-Johnson J, Laxman B, Stern RK, Sudi J, Tierney CN, Norwick L, Hogarth DK, McConville JF, Naureckas ET, Sperling AI, Solway J, Krishnan JA, Nicolae DL, White SR, Ober C. Maternal asthma and microRNA regulation of soluble HLA-G in the airway. J Allergy Clin Immunol. 2013 Jun; 131(6):1496-503. PMID: 23534973.
      View in: PubMed
    35. Thompson EE, Myers RA, Du G, Aydelotte TM, Tisler CJ, Stern DA, Evans MD, Graves PE, Jackson DJ, Martinez FD, Gern JE, Wright AL, Lemanske RF, Ober C. Maternal microchimerism protects against the development of asthma. J Allergy Clin Immunol. 2013 Jul; 132(1):39-44. PMID: 23434286.
      View in: PubMed
    36. Levin AM, Mathias RA, Huang L, Roth LA, Daley D, Myers RA, Himes BE, Romieu I, Yang M, Eng C, Park JE, Zoratti K, Gignoux CR, Torgerson DG, Galanter JM, Huntsman S, Nguyen EA, Becker AB, Chan-Yeung M, Kozyrskyj AL, Kwok PY, Gilliland FD, Gauderman WJ, Bleecker ER, Raby BA, Meyers DA, London SJ, Martinez FD, Weiss ST, Burchard EG, Nicolae DL, Ober C, Barnes KC, Williams LK. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol. 2013 Apr; 131(4):1176-84. PMID: 23146381.
      View in: PubMed
    37. Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, LeNoir MA, Soto-Quiros M, Liu J, Celedón JC, Galanter JM, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012 Dec; 130(6):1294-301. PMID: 23040885.
      View in: PubMed
    38. Campbell CD, Chong JX, Malig M, Ko A, Dumont BL, Han L, Vives L, O'Roak BJ, Sudmant PH, Shendure J, Abney M, Ober C, Eichler EE. Estimating the human mutation rate using autozygosity in a founder population. Nat Genet. 2012 Nov; 44(11):1277-81. PMID: 23001126.
      View in: PubMed
    39. Loisel DA, Billstrand C, Murray K, Patterson K, Chaiworapongsa T, Romero R, Ober C. The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women. Mol Hum Reprod. 2013 Mar; 19(3):144-52. PMID: 23002110.
      View in: PubMed
    40. Chong JX, Ouwenga R, Anderson RL, Waggoner DJ, Ober C. A population-based study of autosomal-recessive disease-causing mutations in a founder population. Am J Hum Genet. 2012 Oct 05; 91(4):608-20. PMID: 22981120.
      View in: PubMed
    41. Ding D, Scott NM, Thompson EE, Chaiworapongsa T, Torres R, Billstrand C, Murray K, Dexheimer PJ, Ismail M, Kay H, Levy S, Romero R, Lindheimer MD, Nicolae DL, Ober C. Increased protein-coding mutations in the mitochondrial genome of African American women with preeclampsia. Reprod Sci. 2012 Dec; 19(12):1343-51. PMID: 22902742.
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    42. Li X, Ampleford EJ, Howard TD, Moore WC, Torgerson DG, Li H, Busse WW, Castro M, Erzurum SC, Israel E, Nicolae DL, Ober C, Wenzel SE, Hawkins GA, Bleecker ER, Meyers DA. Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. J Allergy Clin Immunol. 2012 Oct; 130(4):861-8.e7. PMID: 22694930.
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    43. Kosova G, Scott NM, Niederberger C, Prins GS, Ober C. Genome-wide association study identifies candidate genes for male fertility traits in humans. Am J Hum Genet. 2012 Jun 08; 90(6):950-61. PMID: 22633400.
      View in: PubMed
    44. Torgerson DG, Capurso D, Ampleford EJ, Li X, Moore WC, Gignoux CR, Hu D, Eng C, Mathias RA, Busse WW, Castro M, Erzurum SC, Fitzpatrick AM, Gaston B, Israel E, Jarjour NN, Teague WG, Wenzel SE, Rodríguez-Santana JR, Rodríguez-Cintrón W, Avila PC, Ford JG, Barnes KC, Burchard EG, Howard TD, Bleecker ER, Meyers DA, Cox NJ, Ober C, Nicolae DL. Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects. J Allergy Clin Immunol. 2012 Sep; 130(3):622-629.e9. PMID: 22607992.
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    45. Uricchio LH, Chong JX, Ross KD, Ober C, Nicolae DL. Accurate imputation of rare and common variants in a founder population from a small number of sequenced individuals. Genet Epidemiol. 2012 May; 36(4):312-9. PMID: 22460724.
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    46. Meyer WK, Arbeithuber B, Ober C, Ebner T, Tiemann-Boege I, Hudson RR, Przeworski M. Evaluating the evidence for transmission distortion in human pedigrees. Genetics. 2012 May; 191(1):215-32. PMID: 22377632.
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    47. Torgerson DG, Capurso D, Mathias RA, Graves PE, Hernandez RD, Beaty TH, Bleecker ER, Raby BA, Meyers DA, Barnes KC, Weiss ST, Martinez FD, Nicolae DL, Ober C. Resequencing candidate genes implicates rare variants in asthma susceptibility. Am J Hum Genet. 2012 Feb 10; 90(2):273-81. PMID: 22325360.
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    48. Cusanovich DA, Billstrand C, Zhou X, Chavarria C, De Leon S, Michelini K, Pai AA, Ober C, Gilad Y. The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. Hum Mol Genet. 2012 May 01; 21(9):2111-23. PMID: 22286170.
      View in: PubMed
    49. Motika CA, Papachristou C, Abney M, Lester LA, Ober C. Rising prevalence of asthma is sex-specific in a US farming population. J Allergy Clin Immunol. 2011 Oct; 128(4):774-9. PMID: 21840584.
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    50. Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31; 43(9):887-92. PMID: 21804549.
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    51. Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF, Ober C. IFNG genotype and sex interact to influence the risk of childhood asthma. J Allergy Clin Immunol. 2011 Sep; 128(3):524-31. PMID: 21798578.
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    52. Ober C, Yao TC. The genetics of asthma and allergic disease: a 21st century perspective. Immunol Rev. 2011 Jul; 242(1):10-30. PMID: 21682736.
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    53. Chong JX, Oktay AA, Dai Z, Swoboda KJ, Prior TW, Ober C. A common spinal muscular atrophy deletion mutation is present on a single founder haplotype in the US Hutterites. Eur J Hum Genet. 2011 Oct; 19(10):1045-51. PMID: 21610747.
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    54. Caliskan M, Cusanovich DA, Ober C, Gilad Y. The effects of EBV transformation on gene expression levels and methylation profiles. Hum Mol Genet. 2011 Apr 15; 20(8):1643-52. PMID: 21289059.
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    55. Ober C, Vercelli D. Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet. 2011 Mar; 27(3):107-15. PMID: 21216485.
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    56. Çaliskan M, Chong JX, Uricchio L, Anderson R, Chen P, Sougnez C, Garimella K, Gabriel SB, dePristo MA, Shakir K, Matern D, Das S, Waggoner D, Nicolae DL, Ober C. Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13. Hum Mol Genet. 2011 Apr 01; 20(7):1285-9. PMID: 21212097.
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    57. Kosova G, Pickrell JK, Kelley JL, McArdle PF, Shuldiner AR, Abney M, Ober C. The CFTR Met 470 allele is associated with lower birth rates in fertile men from a population isolate. PLoS Genet. 2010 Jun 03; 6(6):e1000974. PMID: 20532200.
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    58. Thompson EE, Sun Y, Nicolae D, Ober C. Shades of gray: a comparison of linkage disequilibrium between Hutterites and Europeans. Genet Epidemiol. 2010 Feb; 34(2):133-9. PMID: 19697328.
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    59. Thompson EE, Haller G, Pinto JM, Sun Y, Zelano B, Jacob S, McClintock MK, Nicolae DL, Ober C. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. Hum Immunol. 2010 Jan; 71(1):100-3. PMID: 19833159.
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    60. Haller G, Torgerson DG, Ober C, Thompson EE. Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility. J Allergy Clin Immunol. 2009 Dec; 124(6):1204-9.e9. PMID: 19910025.
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    61. Pichler I, Fuchsberger C, Platzer C, Caliskan M, Marroni F, Pramstaller PP, Ober C. Drawing the history of the Hutterite population on a genetic landscape: inference from Y-chromosome and mtDNA genotypes. Eur J Hum Genet. 2010 Apr; 18(4):463-70. PMID: 19844259.
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    62. Kosova G, Abney M, Ober C. Colloquium papers: Heritability of reproductive fitness traits in a human population. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 Suppl 1:1772-8. PMID: 19822755.
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    63. Ober C, Nord AS, Thompson EE, Pan L, Tan Z, Cusanovich D, Sun Y, Nicolae R, Edelstein C, Schneider DH, Billstrand C, Pfaffinger D, Phillips N, Anderson RL, Philips B, Rajagopalan R, Hatsukami TS, Rieder MJ, Heagerty PJ, Nickerson DA, Abney M, Marcovina S, Jarvik GP, Scanu AM, Nicolae DL. Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q. J Lipid Res. 2009 May; 50(5):798-806. PMID: 19124843.
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    64. Ober C, Loisel DA, Gilad Y. Sex-specific genetic architecture of human disease. Nat Rev Genet. 2008 Dec; 9(12):911-22. PMID: 19002143.
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    65. Pinto JM, Hayes MG, Schneider D, Naclerio RM, Ober C. A genomewide screen for chronic rhinosinusitis genes identifies a locus on chromosome 7q. Laryngoscope. 2008 Nov; 118(11):2067-72. PMID: 18622306.
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    66. Nolan DK, Chen P, Das S, Ober C, Waggoner D. Fine mapping of a locus for nonsyndromic mental retardation on chromosome 19p13. Am J Med Genet A. 2008 Jun 01; 146A(11):1414-22. PMID: 18446860.
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    67. Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF, Nicolae DL, Elias JA, Chupp GL. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med. 2008 Apr 17; 358(16):1682-91. PMID: 18403759.
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    68. Pinto JM, Thanaviratananich S, Hayes MG, Naclerio RM, Ober C. A genome-wide screen for hyposmia susceptibility Loci. Chem Senses. 2008 Apr; 33(4):319-29. PMID: 18245794.
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    69. Coop G, Wen X, Ober C, Pritchard JK, Przeworski M. High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science. 2008 Mar 07; 319(5868):1395-8. PMID: 18239090.
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    70. Gallego Romero I, Ober C. CFTR mutations and reproductive outcomes in a population isolate. Hum Genet. 2008 Jan; 122(6):583-8. PMID: 17901983.
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    71. Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C. Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet. 2007 Oct; 81(4):829-34. PMID: 17847008.
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    72. Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF, Nicolae DL, Ober C. Integrin beta 3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007 Jun; 119(6):1423-9. PMID: 17556058.
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    73. Pluzhnikov A, Nolan DK, Tan Z, McPeek MS, Ober C. Correlation of intergenerational family sizes suggests a genetic component of reproductive fitness. Am J Hum Genet. 2007 Jul; 81(1):165-9. PMID: 17564973.
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    74. Pan L, Ober C, Abney M. Heritability estimation of sex-specific effects on human quantitative traits. Genet Epidemiol. 2007 May; 31(4):338-47. PMID: 17323368.
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    75. Kurz T, Hoffjan S, Hayes MG, Schneider D, Nicolae R, Heinzmann A, Jerkic SP, Parry R, Cox NJ, Deichmann KA, Ober C. Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci. J Allergy Clin Immunol. 2006 Aug; 118(2):396-402. PMID: 16890764.
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    76. Weiss LA, Ober C, Cook EH. ITGB3 shows genetic and expression interaction with SLC6A4. Hum Genet. 2006 Aug; 120(1):93-100. PMID: 16721604.
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    77. Weiss LA, Kosova G, Delahanty RJ, Jiang L, Cook EH, Ober C, Sutcliffe JS. Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility. Eur J Hum Genet. 2006 Aug; 14(8):923-31. PMID: 16724005.
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    78. Ober C, Pan L, Phillips N, Parry R, Kurina LM. Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population. Curr Allergy Asthma Rep. 2006 May; 6(3):241-6. PMID: 16579875.
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    79. Ober C, Billstrand C, Kuldanek S, Tan Z. The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells. Hum Reprod. 2006 Jul; 21(7):1743-8. PMID: 16501035.
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    80. Weiss LA, Pan L, Abney M, Ober C. The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006 Feb; 38(2):218-22. PMID: 16429159.
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    81. Donfack J, Schneider DH, Tan Z, Kurz T, Dubchak I, Frazer KA, Ober C. Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy. Respir Res. 2005 Dec 10; 6:145. PMID: 16336695.
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    82. Tan Z, Shon AM, Ober C. Evidence of balancing selection at the HLA-G promoter region. Hum Mol Genet. 2005 Dec 01; 14(23):3619-28. PMID: 16236759.
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    83. Ober C, Thompson EE. Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol. 2005 Dec; 17(6):670-8. PMID: 16214315.
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    84. Zhang J, Schneider D, Ober C, McPeek MS. Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals. Genet Epidemiol. 2005 Sep; 29(2):128-40. PMID: 16049966.
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    85. Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI. Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production. J Immunol. 2005 Aug 15; 175(4):2061-5. PMID: 16081771.
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    86. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J. 2005 May; 19(7):681-93. PMID: 15857883.
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    87. Weiss LA, Abney M, Parry R, Scanu AM, Cook EH, Ober C. Variation in ITGB3 has sex-specific associations with plasma lipoprotein(a) and whole blood serotonin levels in a population-based sample. Hum Genet. 2005 Jun; 117(1):81-7. PMID: 15834589.
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    88. Weiss LA, Lester LA, Gern JE, Wolf RL, Parry R, Lemanske RF, Solway J, Ober C. Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations. Am J Respir Crit Care Med. 2005 Jul 01; 172(1):67-73. PMID: 15817799.
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    89. Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel DB, Steiner L, Walker K, Shult P, Gangnon RE, Gern JE, Martinez FD, Lemanske RF, Ober C. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet. 2005 Apr; 76(4):696-704. PMID: 15726497.
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    90. McClintock MK, Bullivant S, Jacob S, Spencer N, Zelano B, Ober C. Human body scents: conscious perceptions and biological effects. Chem Senses. 2005 Jan; 30 Suppl 1:i135-7. PMID: 15738077.
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    91. Nicolae D, Cox NJ, Lester LA, Schneider D, Tan Z, Billstrand C, Kuldanek S, Donfack J, Kogut P, Patel NM, Goodenbour J, Howard T, Wolf R, Koppelman GH, White SR, Parry R, Postma DS, Meyers D, Bleecker ER, Hunt JS, Solway J, Ober C. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21. Am J Hum Genet. 2005 Feb; 76(2):349-57. PMID: 15611928.
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    92. Weiss LA, Abney M, Cook EH, Ober C. Sex-specific genetic architecture of whole blood serotonin levels. Am J Hum Genet. 2005 Jan; 76(1):33-41. PMID: 15526234.
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    93. Weiss LA, Veenstra-Vanderweele J, Newman DL, Kim SJ, Dytch H, McPeek MS, Cheng S, Ober C, Cook EH, Abney M. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet. 2004 Nov; 12(11):949-54. PMID: 15292919.
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    94. Bourgain C, Abney M, Schneider D, Ober C, McPeek MS. Testing for Hardy-Weinberg equilibrium in samples with related individuals. Genetics. 2004 Dec; 168(4):2349-61. PMID: 15371359.
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    95. Newman DL, Hoffjan S, Bourgain C, Abney M, Nicolae RI, Profits ET, Grow MA, Walker K, Steiner L, Parry R, Reynolds R, McPeek MS, Cheng S, Ober C. Are common disease susceptibility alleles the same in outbred and founder populations? Eur J Hum Genet. 2004 Jul; 12(7):584-90. PMID: 15100713.
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    96. McPeek MS, Wu X, Ober C. Best linear unbiased allele-frequency estimation in complex pedigrees. Biometrics. 2004 Jun; 60(2):359-67. PMID: 15180661.
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    97. Reed AM, McNallan K, Wettstein P, Vehe R, Ober C. Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis? J Immunol. 2004 Apr 15; 172(8):5041-6. PMID: 15067086.
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    98. Hoffjan S, Ostrovnaja I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004 Mar; 113(3):511-8. PMID: 15007355.
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    99. Gern JE, Reardon CL, Hoffjan S, Nicolae D, Li Z, Roberg KA, Neaville WA, Carlson-Dakes K, Adler K, Hamilton R, Anderson E, Gilbertson-White S, Tisler C, Dasilva D, Anklam K, Mikus LD, Rosenthal LA, Ober C, Gangnon R, Lemanske RF. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol. 2004 Feb; 113(2):307-14. PMID: 14767447.
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    100. Zöllner S, Wen X, Hanchard NA, Herbert MA, Ober C, Pritchard JK. Evidence for extensive transmission distortion in the human genome. Am J Hum Genet. 2004 Jan; 74(1):62-72. PMID: 14681832.
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    101. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res. 2003; 4:14. PMID: 14748924.
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    102. Bourgain C, Hoffjan S, Nicolae R, Newman D, Steiner L, Walker K, Reynolds R, Ober C, McPeek MS. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet. 2003 Sep; 73(3):612-26. PMID: 12929084.
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    103. Ober C, Aldrich CL, Chervoneva I, Billstrand C, Rahimov F, Gray HL, Hyslop T. Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet. 2003 Jun; 72(6):1425-35. PMID: 12721954.
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    104. Donfack J, Kogut P, Forsythe S, Solway J, Ober C. Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy. J Allergy Clin Immunol. 2003 Mar; 111(3):527-32. PMID: 12642833.
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    105. Newman DL, Abney M, Dytch H, Parry R, McPeek MS, Ober C. Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree. Hum Mol Genet. 2003 Jan 15; 12(2):137-44. PMID: 12499394.
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    106. Aldrich C, Wambebe C, Odama L, Di Rienzo A, Ober C. Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution. Hum Immunol. 2002 May; 63(5):405-12. PMID: 11975984.
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    107. Abney M, Ober C, McPeek MS. Quantitative-trait homozygosity and association mapping and empirical genomewide significance in large, complex pedigrees: fasting serum-insulin level in the Hutterites. Am J Hum Genet. 2002 Apr; 70(4):920-34. PMID: 11880950.
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    108. Jacob S, McClintock MK, Zelano B, Ober C. Paternally inherited HLA alleles are associated with women's choice of male odor. Nat Genet. 2002 Feb; 30(2):175-9. PMID: 11799397.
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    109. Aldrich CL, Stephenson MD, Karrison T, Odem RR, Branch DW, Scott JR, Schreiber JR, Ober C. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Reprod. 2001 Dec; 7(12):1167-72. PMID: 11719594.
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    110. Ober C, Abney M, McPeek MS. The genetic dissection of complex traits in a founder population. Am J Hum Genet. 2001 Nov; 69(5):1068-79. PMID: 11590547.
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    111. Abney M, McPeek MS, Ober C. Broad and narrow heritabilities of quantitative traits in a founder population. Am J Hum Genet. 2001 May; 68(5):1302-7. PMID: 11309690.
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    112. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet. 2000 Nov; 67(5):1154-62. PMID: 11022011.
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    113. Aldrich C, Verp MS, Walker MA, Ober C. A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation. J Reprod Immunol. 2000 May; 47(1):41-8. PMID: 10779589.
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    114. Abney M, McPeek MS, Ober C. Estimation of variance components of quantitative traits in inbred populations. Am J Hum Genet. 2000 Feb; 66(2):629-50. PMID: 10677322.
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    115. Ober C, Karrison T, Odem RR, Barnes RB, Branch DW, Stephenson MD, Baron B, Walker MA, Scott JR, Schreiber JR. Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial. Lancet. 1999 Jul 31; 354(9176):365-9. PMID: 10437864.
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    116. Robertson A, Charlesworth D, Ober C. Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci. Genet Epidemiol. 1999; 17(3):165-73. PMID: 10446464.
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    117. Kaufman KA, Bowen JA, Tsai AF, Bluestone JA, Hunt JS, Ober C. The CTLA-4 gene is expressed in placental fibroblasts. Mol Hum Reprod. 1999 Jan; 5(1):84-7. PMID: 10050667.
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    118. Ober C, Hyslop T, Hauck WW. Inbreeding effects on fertility in humans: evidence for reproductive compensation. Am J Hum Genet. 1999 Jan; 64(1):225-31. PMID: 9915962.
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    119. Tsai AF, Kaufman KA, Walker MA, Karrison TG, Odem RR, Barnes RB, Scott JR, Schreiber JR, Stephenson MD, Ober C. Transmission disequilibrium of maternally-inherited CTLA-4 microsatellite alleles in idiopathic recurrent miscarriage. J Reprod Immunol. 1998 Nov; 40(2):147-57. PMID: 9881742.
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    120. Ober C, Aldrich C, Rosinsky B, Robertson A, Walker MA, Willadsen S, Verp MS, Geraghty DE, Hunt JS. HLA-G1 protein expression is not essential for fetal survival. Placenta. 1998 Mar-Apr; 19(2-3):127-32. PMID: 9548178.
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    121. Ober C, Hyslop T, Elias S, Weitkamp LR, Hauck WW. Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study. Hum Reprod. 1998 Jan; 13(1):33-8. PMID: 9512225.
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    122. Ober C. HLA and pregnancy: the paradox of the fetal allograft. Am J Hum Genet. 1998 Jan; 62(1):1-5. PMID: 9443885.
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    123. Ober C, Aldrich CL. HLA-G polymorphisms: neutral evolution or novel function? J Reprod Immunol. 1997 Nov 30; 36(1-2):1-21. PMID: 9430736.
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    124. Ober C, Weitkamp LR, Cox N, Dytch H, Kostyu D, Elias S. HLA and mate choice in humans. Am J Hum Genet. 1997 Sep; 61(3):497-504. PMID: 9326314.
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    125. Grimsley C, Ober C. Population genetic studies of HLA-E: evidence for selection. Hum Immunol. 1997 Jan; 52(1):33-40. PMID: 9021407.
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    126. Ober C, Rosinsky B, Grimsley C, van der Ven K, Robertson A, Runge A. Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1. J Reprod Immunol. 1996 Dec; 32(2):111-23. PMID: 9023816.
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    127. Steck T, van der Ven K, Kwak J, Beer A, Ober C. HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion. J Reprod Immunol. 1995 Jul; 29(2):95-104. PMID: 7500323.
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    128. Ober C, Steck T, van der Ven K, Billstrand C, Messer L, Kwak J, Beaman K, Beer A. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion. J Reprod Immunol. 1993 Dec; 25(3):195-207. PMID: 8207709.
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    129. Kostyu DD, Ober CL, Dawson DV, Ghanayem M, Elias S, Martin AO. Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites. Am J Hum Genet. 1989 Aug; 45(2):261-9. PMID: 2757031.
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    130. Simpson JL, Mills JL, Holmes LB, Ober CL, Aarons J, Jovanovic L, Knopp RH. Low fetal loss rates after ultrasound-proved viability in early pregnancy. JAMA. 1987 Nov 13; 258(18):2555-7. PMID: 3312659.
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    131. Ober CL, Hauck WW, Kostyu DD, O'Brien E, Elias S, Simpson JL, Martin AO. Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort study in a human isolate. Fertil Steril. 1985 Aug; 44(2):227-32. PMID: 3860403.
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    132. Ober CL, Martin AO, Simpson JL, Hauck WW, Amos DB, Kostyu DD, Fotino M, Allen FH. Shared HLA antigens and reproductive performance among Hutterites. Am J Hum Genet. 1983 Sep; 35(5):994-1004. PMID: 6577788.
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