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Roger Sciammas

TitleRESEARCH ASSOCIATE (ASSISTANT PROFESSOR)
InstitutionUniversity of Chicago
DepartmentSurgery
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Cook SL, Sievert EP, Sciammas R. B Cell Intrinsic IRF4 Haploinsufficiency Impairs Affinity Maturation. J Immunol. 2021 Nov 10. PMID: 34759017.
      View in: PubMed
    2. Ochiai K, Shima H, Ikura T, Franke MC, Sievert EP, Sciammas R, Igarashi K. Protocol for in vitro BCR-mediated plasma cell differentiation and purification of chromatin-associated proteins. STAR Protoc. 2021 09 17; 2(3):100633. PMID: 34258594.
      View in: PubMed
    3. Ochiai K, Yamaoka M, Swaminathan A, Shima H, Hiura H, Matsumoto M, Kurotaki D, Nakabayashi J, Funayama R, Nakayama K, Arima T, Ikawa T, Tamura T, Sciammas R, Bouvet P, Kundu TK, Igarashi K. Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4. Cell Rep. 2020 12 22; 33(12):108517. PMID: 33357426.
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    4. Choi JW, Withers SS, Chang H, Spanier JA, De La Trinidad VL, Panesar H, Fife BT, Sciammas R, Sparger EE, Moore PF, Kent MS, Rebhun RB, McSorley SJ. Development of canine PD-1/PD-L1 specific monoclonal antibodies and amplification of canine T cell function. PLoS One. 2020; 15(7):e0235518. PMID: 32614928.
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    5. Khiew SH, Jain D, Chen J, Yang J, Yin D, Young JS, Dent A, Sciammas R, Alegre ML, Chong AS. Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells. J Clin Invest. 2020 07 01; 130(7):3453-3466. PMID: 32452834.
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    6. Cook SL, Franke MC, Sievert EP, Sciammas R. A Synchronous IRF4-Dependent Gene Regulatory Network in B and Helper T Cells Orchestrating the Antibody Response. Trends Immunol. 2020 07; 41(7):614-628. PMID: 32467029.
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    7. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 02 04; 9. PMID: 32014112.
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    8. Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze LJ, Wang J, Ghobrial RM, Xia J, Sciammas R, Li XC, Chen W. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017 12 19; 47(6):1114-1128.e6. PMID: 29221730.
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    9. Veselits M, Tanaka A, Chen Y, Hamel K, Mandal M, Kandasamy M, Manicassamy B, O'Neill SK, Wilson P, Sciammas R, Clark MR. Igß ubiquitination activates PI3K signals required for endosomal sorting. J Exp Med. 2017 Dec 04; 214(12):3775-3790. PMID: 29141870.
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    10. Young JS, Khiew SH, Yang J, Vannier A, Yin D, Sciammas R, Alegre ML, Chong AS. Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice. Front Immunol. 2017; 8:1169. PMID: 28970838.
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    11. Krishnamoorthy V, Kannanganat S, Maienschein-Cline M, Cook SL, Chen J, Bahroos N, Sievert E, Corse E, Chong A, Sciammas R. The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate. Immunity. 2017 09 19; 47(3):481-497.e7. PMID: 28930660.
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    12. Khiew SH, Yang J, Young JS, Chen J, Wang Q, Yin D, Vu V, Miller ML, Sciammas R, Alegre ML, Chong AS. CTLA4-Ig in combination with FTY720 promotes allograft survival in sensitized recipients. JCI Insight. 2017 May 04; 2(9). PMID: 28469082.
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    13. Yang J, Chen J, Young JS, Wang Q, Yin D, Sciammas R, Chong AS. Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation. Transplantation. 2016 08; 100(8):1683-91. PMID: 27362308.
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    14. Young JS, Chen J, Miller ML, Vu V, Tian C, Moon JJ, Alegre ML, Sciammas R, Chong AS. Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection. Am J Transplant. 2016 08; 16(8):2312-23. PMID: 26928966.
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    15. Chen J, Wang Q, Yin D, Vu V, Sciammas R, Chong AS. Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients. J Immunol. 2015 Nov 01; 195(9):4069-73. PMID: 26416270.
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    16. Chong AS, Sciammas R. Memory B cells in transplantation. Transplantation. 2015 Jan; 99(1):21-8. PMID: 25525921.
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    17. Cowan M, Chon WJ, Desai A, Andrews S, Bai Y, Veguilla V, Katz JM, Josephson MA, Wilson PC, Sciammas R, Chong AS. Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients. Transplantation. 2014 Apr 27; 97(8):846-53. PMID: 24366008.
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    18. Veselits M, Tanaka A, Lipkowitz S, O'Neill S, Sciammas R, Finnegan A, Zhang J, Clark MR. Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes. PLoS One. 2014; 9(3):e89792. PMID: 24651487.
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    19. Chen J, Pompano RR, Santiago FW, Maillat L, Sciammas R, Sun T, Han H, Topham DJ, Chong AS, Collier JH. The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation. Biomaterials. 2013 Nov; 34(34):8776-85. PMID: 23953841.
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    20. Chen J, Yin H, Xu J, Wang Q, Edelblum KL, Sciammas R, Chong AS. Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig. Am J Transplant. 2013 Sep; 13(9):2280-92. PMID: 23855587.
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    21. Yan W, Xu R, Ma LL, Han W, Geevarghese SK, Williams PE, Sciammas R, Chong AS, Yin DP. B cells assist allograft rejection in the deficiency of protein kinase c-theta. Transpl Int. 2013 Sep; 26(9):919-27. PMID: 23841454.
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    22. Ochiai K, Maienschein-Cline M, Simonetti G, Chen J, Rosenthal R, Brink R, Chong AS, Klein U, Dinner AR, Singh H, Sciammas R. Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity. 2013 May 23; 38(5):918-29. PMID: 23684984.
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    23. Williams JW, Tjota MY, Clay BS, Vander Lugt B, Bandukwala HS, Hrusch CL, Decker DC, Blaine KM, Fixsen BR, Singh H, Sciammas R, Sperling AI. Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun. 2013; 4:2990. PMID: 24356538.
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    24. Chang A, Moore JM, Cowan ML, Josephson MA, Chon WJ, Sciammas R, Du Z, Marino SR, Meehan SM, Millis M, David MZ, Williams JW, Chong AS. Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection. Transpl Int. 2012 Oct; 25(10):1050-8. PMID: 22805456.
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    25. Ochiai K, Maienschein-Cline M, Mandal M, Triggs JR, Bertolino E, Sciammas R, Dinner AR, Clark MR, Singh H. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nat Immunol. 2012 Jan 22; 13(3):300-7. PMID: 22267219.
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    26. Becker AM, Michael DG, Satpathy AT, Sciammas R, Singh H, Bhattacharya D. IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors. Blood. 2012 Mar 01; 119(9):2003-12. PMID: 22238324.
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    27. Maienschein-Cline M, Zhou J, White KP, Sciammas R, Dinner AR. Discovering transcription factor regulatory targets using gene expression and binding data. Bioinformatics. 2012 Jan 15; 28(2):206-13. PMID: 22084256.
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    28. Chong AS, Sciammas R. Matchmaking the B-cell signature of tolerance to regulatory B cells. Am J Transplant. 2011 Dec; 11(12):2555-60. PMID: 21967001.
      View in: PubMed
    29. Cowan ML, Sciammas R, Chong AS. Experimental models of B cell tolerance in transplantation. Semin Immunol. 2012 Apr; 24(2):77-85. PMID: 21925896.
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    30. Sciammas R, Li Y, Warmflash A, Song Y, Dinner AR, Singh H. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling. Mol Syst Biol. 2011 May 24; 7:495. PMID: 21613984.
      View in: PubMed
    31. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell. 2006 Aug 25; 126(4):755-66. PMID: 16923394.
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    32. Sciammas R, Shaffer AL, Schatz JH, Zhao H, Staudt LM, Singh H. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 2006 Aug; 25(2):225-36. PMID: 16919487.
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    33. Singh H, Sciammas R. Shedding B cell identity. Immunity. 2006 Mar; 24(3):239-40. PMID: 16546090.
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    34. Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ. The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development. 2005 Mar; 132(6):1315-25. PMID: 15750184.
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    35. Sciammas R, Davis MM. Blimp-1; immunoglobulin secretion and the switch to plasma cells. Curr Top Microbiol Immunol. 2005; 290:201-24. PMID: 16480044.
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    36. Sciammas R, Davis MM. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol. 2004 May 01; 172(9):5427-40. PMID: 15100284.
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    37. Sciammas R, Bluestone JA. TCRgammadelta cells and viruses. Microbes Infect. 1999 Mar; 1(3):203-12. PMID: 10801231.
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    38. Sciammas R, Bluestone JA. HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner. J Immunol. 1998 Nov 15; 161(10):5187-92. PMID: 9820489.
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    39. Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. J Exp Med. 1997 Jun 02; 185(11):1969-75. PMID: 9166426.
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    40. Bluestone JA, Khattri R, Sciammas R, Sperling AI. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annu Rev Cell Dev Biol. 1995; 11:307-53. PMID: 8689560.
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    41. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA. Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell. J Immunol. 1994 Jun 01; 152(11):5392-7. PMID: 8189058.
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    42. Sciammas R, Tatsumi Y, Sperling AI, Arunan K, Bluestone JA. TCR gamma delta cells: mysterious cells of the immune system. Immunol Res. 1994; 13(4):268-79. PMID: 7616054.
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