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Noboru Sakabe

Title
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li J, Zhu J, Gray O, Sobreira DR, Wu D, Huang RT, Miao B, Sakabe NJ, Krause MD, Kaikkonen MU, Romanoski CE, Nobrega MA, Fang Y. Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells. J Cell Biol. 2024 03 04; 223(3). PMID: 38231044; PMCID: PMC10794123.
      Citations:    Fields:    Translation:HumansCells
    2. Liu X, Aneas I, Sakabe N, Anderson RL, Billstrand C, Paz C, Kaur H, Furner B, Choi S, Prichina AY, Enninga EAL, Dong H, Murtha A, Crawford GE, Kessler JA, Grobman W, Nobrega MA, Rana S, Ober C. Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor. Sci Rep. 2023 05 16; 13(1):7903. PMID: 37193763; PMCID: PMC10188528.
      Citations: 1     Fields:    Translation:HumansCells
    3. Hansen GT, Weber ZT, Thornburg AG, Aneas I, Zhang L, Sakabe NJ, Joslin AC, Haddad GA, Strobel SM, Laber S, Sultana F, Sahebdel F, Khan K, Li YI, Claussnitzer M, Ye L, Battaglino RA, Sobreira DR, Nóbrega MA. Genetics of sexually dimorphic adipose distribution in humans. Nat Genet. 2023 03; 55(3):461-470. PMID: 36797366; PMCID: PMC10375400.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    4. Gray OA, Yoo J, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Di Rienzo A, Sobreira DR, Nobréga MA. A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942. PMID: 36417539; PMCID: PMC9683707.
      Citations: 10     Fields:    
    5. Aneas I, Decker DC, Howard CL, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Schoetler N, Ober C, Sperling AI, Sobreira DR, Tena J, Gomez-Skarmeta JL, Nóbrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. PMID: 34675193; PMCID: PMC8531453.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    6. Joslin AC, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Sobreira DR, Nóbrega MA. A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nat Commun. 2021 09 06; 12(1):5253. PMID: 34489471; PMCID: PMC8421397.
      Citations: 15     Fields:    Translation:HumansCells
    7. Bai T, Peng CY, Aneas I, Sakabe N, Requena DF, Billstrand C, Nobrega M, Ober C, Parast M, Kessler JA. Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts. Stem Cell Res. 2021 10; 56:102507. PMID: 34454392; PMCID: PMC8551050.
      Citations: 12     Fields:    Translation:HumansCells
    8. Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Sobreira DR, Nóbrega MA. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Science. 2021 06 04; 372(6546):1085-1091. PMID: 34083488; PMCID: PMC8386003.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    9. Cheung VC, Peng CY, Marinic M, Sakabe NJ, Aneas I, Lynch VJ, Ober C, Nobrega MA, Kessler JA. Pluripotent stem cell-derived endometrial stromal fibroblasts in a cyclic, hormone-responsive, coculture model of human decidua. Cell Rep. 2021 05 18; 35(7):109138. PMID: 34010658.
      Citations: 19     Fields:    Translation:HumansCells
    10. Sakabe NJ, Aneas I, Knoblauch N, Sobreira DR, Clark N, Paz C, Horth C, Ziffra R, Kaur H, Liu X, Anderson R, Morrison J, Cheung VC, Grotegut C, Reddy TE, Jacobsson B, Hallman M, Teramo K, Murtha A, Kessler J, Grobman W, Zhang G, Muglia LJ, Rana S, Lynch VJ, Crawford GE, Ober C, He X, Nóbrega MA. Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth. Sci Adv. 2020 12; 6(49). PMID: 33268355; PMCID: PMC7710387.
      Citations: 19     Fields:    Translation:HumansCells
    11. Helling BA, Hansen GT, Sakabe NJ, Luo K, Billstrand C, Laxman B, Nicolae RI, Nicolae DL, Bochkov YA, Gern JE, Nobrega MA, White SR, Ober C, Sobreira DR. Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma. Commun Biol. 2020 11 13; 3(1):678. PMID: 33188283; PMCID: PMC7666152.
      Citations: 13     Translation:HumansCells
    12. El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Huang SC, Rao SSP, Pruett N, Chauss D, Sadler E, Lopez A, Aiden EL, Asturias FJ, Casellas R, Sobreira DR, Nóbrega MA. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. 2019 08 22; 178(5):1145-1158.e20. PMID: 31402173; PMCID: PMC7533040.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    13. Boogerd CJ, Zhu X, Aneas I, Sakabe N, Zhang L, Sobreira DR, Montefiori L, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega MA, Evans SM. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circ Res. 2018 08 03; 123(4):428-442. PMID: 29903739; PMCID: PMC6092109.
      Citations: 30     Fields:    Translation:AnimalsCells
    14. Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA. A promoter interaction map for cardiovascular disease genetics. Elife. 2018 07 10; 7. PMID: 29988018; PMCID: PMC6053306.
      Citations: 80     Fields:    Translation:HumansCells
    15. Boogerd CJ, Aneas I, Sakabe N, Dirschinger RJ, Cheng QJ, Zhou B, Chen J, Nobrega MA, Evans SM. Probing chromatin landscape reveals roles of endocardial TBX20 in septation. J Clin Invest. 2016 08 01; 126(8):3023-35. PMID: 27348591; PMCID: PMC4966318.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    16. Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC, Guimarães-Camboa N. HIF1a Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Dev Cell. 2015 Jun 08; 33(5):507-21. PMID: 26028220; PMCID: PMC4509618.
      Citations: 80     Fields:    Translation:AnimalsCells
    17. Smemo S, Kim KH, Gamazon ER, Sakabe NJ, Aneas I, Credidio FL, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Manzanares M, Nagy A, Cox NJ, Hui CC, Tena JJ, Gómez-Marín C, Sobreira DR, Naranjo S, Acemel RD, Gomez-Skarmeta JL, Nóbrega MA. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014 Mar 20; 507(7492):371-5. PMID: 24646999; PMCID: PMC4113484.
      Citations: 640     Fields:    Translation:HumansAnimalsCells
    18. Sakabe NJ, Nobrega MA. Beyond the ENCODE project: using genomics and epigenomics strategies to study enhancer evolution. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 19; 368(1632):20130022. PMID: 24218635; PMCID: PMC3826496.
      Citations: 12     Fields:    Translation:Cells
    19. Sakabe NJ, Aneas I, Shen T, Shokri L, Park SY, Bulyk ML, Evans SM, Nobrega MA. Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function. Hum Mol Genet. 2012 May 15; 21(10):2194-204. PMID: 22328084; PMCID: PMC3335310.
      Citations: 48     Fields:    Translation:AnimalsCells
    20. Sakabe NJ, Savic D, Nobrega MA. Transcriptional enhancers in development and disease. Genome Biol. 2012 Jan 23; 13(1):238. PMID: 22269347; PMCID: PMC3334578.
      Citations: 88     Fields:    Translation:HumansCells
    21. Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 2011 Dec; 121(12):4640-54. PMID: 22080862; PMCID: PMC3223071.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    22. Sakabe NJ, Nobrega MA. Genome-wide maps of transcription regulatory elements. Wiley Interdiscip Rev Syst Biol Med. 2010 Jul-Aug; 2(4):422-437. PMID: 20836039.
      Citations: 16     Fields:    Translation:Humans
    23. Narlikar L, Sakabe NJ, Blanski AA, Arimura FE, Westlund JM, Nobrega MA, Ovcharenko I. Genome-wide discovery of human heart enhancers. Genome Res. 2010 Mar; 20(3):381-92. PMID: 20075146; PMCID: PMC2840982.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    24. Sakabe NJ, deOliveira AR, Silva MC, Mundstein AS, Cohen T, Chen YT, Chua R, Gurung S, Gnjatic S, Jungbluth AA, Bairoch A, Kiesler E, White SL, Simpson AJ, Old LJ, Camargo AA, Vasconcelos AT, Almeida LG, Caballero OL. CTdatabase: a knowledge-base of high-throughput and curated data on cancer-testis antigens. Nucleic Acids Res. 2009 Jan; 37(Database issue):D816-9. PMID: 18838390; PMCID: PMC2686577.
      Citations: 222     Fields:    Translation:Humans
    25. Sakabe NJ, de Souza SJ. Sequence features responsible for intron retention in human. BMC Genomics. 2007 Feb 26; 8:59. PMID: 17324281; PMCID: PMC1831480.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    26. Sakabe NJ, Vibranovski MD, de Souza SJ. A possible role of exon-shuffling in the evolution of signal peptides of human proteins. FEBS Lett. 2006 Mar 06; 580(6):1621-4. PMID: 16487520.
      Citations: 6     Fields:    Translation:HumansCells
    27. Sakabe NJ, de Oliveira RS, Vibranovski MD, de Souza SJ. Signs of ancient and modern exon-shuffling are correlated to the distribution of ancient and modern domains along proteins. J Mol Evol. 2005 Sep; 61(3):341-50. PMID: 16034650.
      Citations: 13     Fields:    Translation:Cells
    28. Vibranovski MD, Sakabe NJ, de Souza SJ. A bioinformatics analysis of alternative exon usage in human genes coding for extracellular matrix proteins. Genet Mol Res. 2004 Dec 30; 3(4):532-44. PMID: 15688319.
      Citations: 4     Fields:    Translation:HumansCells
    29. Sakabe NJ, Kirschbaum-Slager N, Galante PA, de Souza SJ. Detection and evaluation of intron retention events in the human transcriptome. RNA. 2004 May; 10(5):757-65. PMID: 15100430; PMCID: PMC1370565.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    30. Sakabe NJ, de Souza JE, Galante PA, de Oliveira PS, Brentani H, Leerkes MR, Brentani RR, Strausberg RL, Simpson AJ, Passetti F, Osório EC, Zaiats AC, Kitajima JP, de Souza SJ. ORESTES are enriched in rare exon usage variants affecting the encoded proteins. C R Biol. 2003 Oct-Nov; 326(10-11):979-85. PMID: 14744104.
      Citations: 6     Fields:    Translation:HumansCells
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