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Tao Xie

TitleProfessor
InstitutionUniversity of Chicago
DepartmentNeurology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Tao Xie, MD, PhD, specializes in the diagnosis and treatment of various movement disorders, including Parkinson's disease, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), cortical basal ganglionic degeneration (CBGD), Huntington's disease (HD) and chorea, tremor, dystonia, hemifacial spasm, blepharospasm, tics, and Tourette syndrome. He uses medications, botulinum toxin injection and deep brain stimulation surgery for treatment of these neurological conditions.

    In his clinical research, Dr. Xie studies the effectiveness of deep brain stimulation for the treatment of various movement disorders. He is also actively involved in clinical trials and research in Parkinson’s disease, PSP, MSA and tremor, and also the role of the DatScan in movement disorders.

    Dr. Xie is a physician in the University of Chicago Center for Parkinson's Disease and Movement Disorders. Dedicated as a Center for Advanced Research by the American Parkinson Disease Association, this multidisciplinary center combines clinical expertise with state-of-the-art therapies and groundbreaking research.

    Collapse Biography 
    Collapse education and training
    Columbia University Medical Center, NYFellowshipMovement Disorders
    Emory University School of Medicine, GAResidencyNeurology
    Emory University School of Medicine, GAInternshipMedicine
    Johns Hopkins School of Medicine, MDResearchNeurology
    The University of Hong KongPh.D.Parkinson's Disease
    Zhejiang University School of Medicine, ChinaMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xie T, Wills AM, Liao C, Dale ML, Ramsden DB, Padmanaban M, Abou Chaar W, Pantelyat A, Golbe LI, Xie T, Wills AM, Liao C, Dale ML, Ramsden DB, Padmanaban M, Abou Chaar W, Pantelyat A, Golbe LI. Using Downgaze Palsy Progression Rate to Model Survival in Progressive Supranuclear Palsy-Richardson Syndrome. Mov Disord. 2023 02; 38(2):304-312. PMID: 36573662.
      Citations:    Fields:    Translation:Humans
    2. Dam T, Boxer AL, Golbe LI, H?glinger GU, Morris HR, Litvan I, Lang AE, Corvol JC, Aiba I, Grundman M, Yang L, Tidemann-Miller B, Kupferman J, Harper K, Kamisoglu K, Wald MJ, Graham DL, Gedney L, O'Gorman J, Haeberlein SB, Dam T, Boxer AL, Golbe LI, H?glinger GU, Morris HR, Litvan I, Lang AE, Corvol JC, Aiba I, Grundman M, Yang L, Tidemann-Miller B, Kupferman J, Harper K, Kamisoglu K, Wald MJ, Graham DL, Gedney L, O'Gorman J, Haeberlein SB, PASSPORT Study Group. Author Correction: Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial. Nat Med. 2022 Oct 17. PMID: 36253611.
      Citations:    Fields:    
    3. Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, H?llerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Mart? MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matej R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, M?ller U, Schellenberg GD, Herms J, Kuhlenb?umer G, H?glinger G, Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, H?llerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Mart? MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matej R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, Alzheimer's Disease Genetics Consortium, M?ller U, Schellenberg GD, Herms J, Kuhlenb?umer G, H?glinger G. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Mov Disord. 2022 10; 37(10):2110-2121. PMID: 35997131.
      Citations: 3     Fields:    Translation:Humans
    4. Wills AM, Golbe LI, Lang AE, Xie T, Dale ML, Espay A, Tartaglia MC, Fox SH, Parashos SA, McFarland NR, Schneider RB, Rodriguez-Porcel F, Gunzler SA, Pantelyat A, Wills AM, Golbe LI, Lang AE, Xie T, Dale ML, Espay A, Tartaglia MC, Fox SH, Parashos SA, McFarland NR, Schneider RB, Rodriguez-Porcel F, Gunzler SA, Pantelyat A. Recommendations for Virtual Administration of the PSP Rating Scale. Mov Disord. 2022 09; 37(9):1960-1961. PMID: 35810447; PMCID: PMC9541138.
      Citations:    Fields:    Translation:Humans
    5. Wills AM, Pantelyat A, Espay A, Chan J, Litvan I, Xie T, Dale ML, Gunzler SA, Tartaglia MC, Fox SH, Rodriguez-Porcel F, Sharma M, Lang AE, Boxer AL, Golbe LI, Wills AM, Pantelyat A, Espay A, Chan J, Litvan I, Xie T, Dale ML, Gunzler SA, Tartaglia MC, Fox SH, Rodriguez-Porcel F, Sharma M, Lang AE, Boxer AL, AL-108-231 Study Group, Golbe LI. A Modified Progressive Supranuclear Palsy Rating Scale for Virtual Assessments. Mov Disord. 2022 06; 37(6):1265-1271. PMID: 35363932; PMCID: PMC9232989.
      Citations: 1     Fields:    Translation:Humans
    6. Xie T, Padmanaban M, Javed A, Satzer D, Towle TE, Warnke P, Towle VL, Xie T, Padmanaban M, Javed A, Satzer D, Towle TE, Warnke P, Towle VL. Effect of Deep Brain Stimulation on Cerebellar Tremor Compared to Non-Cerebellar Tremor Using a Wearable Device in a Patient With Multiple Sclerosis: Case Report. Front Hum Neurosci. 2021; 15:754091. PMID: 35095448; PMCID: PMC8792598.
      Citations:    
    7. Xie T, Yuen CA, Kang W, Padmanaban M, Hain TC, Nichols J, Xie T, Yuen CA, Kang W, Padmanaban M, Hain TC, Nichols J. Severity of Downgaze Palsy in the Context of Disease Duration Could Estimate Survival Duration in Patients With Progressive Supranuclear Palsy. Front Neurol. 2021; 12:736784. PMID: 34650511; PMCID: PMC8505535.
      Citations:    
    8. Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, Reiter RJ, Cen B, Yuan Y, Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, Reiter RJ, Cen B, Yuan Y. Pan-cancer analyses reveal genomics and clinical characteristics of the melatonergic regulators in cancer. J Pineal Res. 2021 Oct; 71(3):e12758. PMID: 34289167.
      Citations: 13     Fields:    Translation:Humans
    9. Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, Cen B, Yuan Y, Ye J, Zhang J, Jiang H, Du K, Xie T, Wang B, Chen C, Cen B, Yuan Y, Ye J. Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators. Front Med (Lausanne). 2021; 8:662460. PMID: 34458283; PMCID: PMC8385656.
      Citations: 2     
    10. Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R, Duquette A, Fernandez HH, Fleisher JE, Grossman M, Howell M, Kerwin DR, Leegwater-Kim J, Lepage C, Ljubenkov PA, Mancini M, McFarland NR, Moretti P, Myrick E, Patel P, Plummer LS, Rodriguez-Porcel F, Rojas J, Sidiropoulos C, Sklerov M, Sokol LL, Tuite PJ, VandeVrede L, Wilhelm J, Wills AA, Xie T, Golbe LI, Bluett B, Pantelyat AY, Litvan I, Ali F, Apetauerova D, Bega D, Bloom L, Bower J, Boxer AL, Dale ML, Dhall R, Duquette A, Fernandez HH, Fleisher JE, Grossman M, Howell M, Kerwin DR, Leegwater-Kim J, Lepage C, Ljubenkov PA, Mancini M, McFarland NR, Moretti P, Myrick E, Patel P, Plummer LS, Rodriguez-Porcel F, Rojas J, Sidiropoulos C, Sklerov M, Sokol LL, Tuite PJ, VandeVrede L, Wilhelm J, Wills AA, Xie T, Golbe LI. Best Practices in the Clinical Management of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Consensus Statement of the CurePSP Centers of Care. Front Neurol. 2021; 12:694872. PMID: 34276544; PMCID: PMC8284317.
      Citations: 2     
    11. Xie T, Christoforidis GA, Xie T, Christoforidis GA. Position-Related Paroxysmal Facial Twitching. Mov Disord Clin Pract. 2021 Jul; 8(5):807-808. PMID: 34307759; PMCID: PMC8287172.
      Citations:    
    12. Xie T, Liao C, Lee D, Yu H, Padmanaban M, Kang W, Johnson J, Alshaikh J, Yuen C, Burns M, Chiu BC, Xie T, Liao C, Lee D, Yu H, Padmanaban M, Kang W, Johnson J, Alshaikh J, Yuen C, Burns M, Chiu BC. Disparities in diagnosis, treatment and survival between Black and White Parkinson patients. Parkinsonism Relat Disord. 2021 06; 87:7-12. PMID: 33905958.
      Citations: 1     Fields:    Translation:Humans
    13. Morgan JC, Ye X, Mellor JA, Golden KJ, Zamudio J, Chiodo LA, Bao Y, Xie T, Morgan JC, Ye X, Mellor JA, Golden KJ, Zamudio J, Chiodo LA, Bao Y, Xie T. Disease course and treatment patterns in progressive supranuclear palsy: A real-world study. J Neurol Sci. 2021 Feb 15; 421:117293. PMID: 33385754.
      Citations: 5     Fields:    Translation:Humans
    14. Xie T, Bloom L, Padmanaban M, Takahashi K, Kang W, Dachman A, MacCracken E, Warnke P, Xie T, Bloom L, Padmanaban M, Takahashi K, Kang W, Dachman A, MacCracken E, Warnke P. Impact of oral textures on aspiration and changes in swallow dynamics in patients with PD with DBS. J Neurol Neurosurg Psychiatry. 2020 Nov 26. PMID: 33243856.
      Citations:    Fields:    
    15. Satzer D, Yu H, Wells M, Padmanaban M, Burns MR, Warnke PC, Xie T, Satzer D, Yu H, Wells M, Padmanaban M, Burns MR, Warnke PC, Xie T. Deep Brain Stimulation Impedance Decreases Over Time Even When Stimulation Settings Are Held Constant. Front Hum Neurosci. 2020; 14:584005. PMID: 33240066; PMCID: PMC7680729.
      Citations: 4     
    16. Nayak HM, Sauser E, Xie T, Nayak HM, Sauser E, Xie T. Interference of subcutaneous implantable cardioverter defibrillator by deep brain stimulation. Parkinsonism Relat Disord. 2020 12; 81:75-77. PMID: 33075699.
      Citations: 1     Fields:    Translation:Humans
    17. Yu H, Takahashi K, Bloom L, Quaynor SD, Xie T, Yu H, Takahashi K, Bloom L, Quaynor SD, Xie T. Effect of Deep Brain Stimulation on Swallowing Function: A Systematic Review. Front Neurol. 2020; 11:547. PMID: 32765388; PMCID: PMC7380112.
      Citations: 3     
    18. Singh S, Cotts KG, Maroof KA, Dhaliwal U, Singh N, Xie T, Singh S, Cotts KG, Maroof KA, Dhaliwal U, Singh N, Xie T. Disability-inclusive compassionate care: Disability competencies for an Indian Medical Graduate. J Family Med Prim Care. 2020 Mar; 9(3):1719-1727. PMID: 32509678; PMCID: PMC7266227.
      Citations: 4     
    19. Zhang J, Xie T, Zhong X, Jiang HL, Li R, Wang BY, Huang XT, Cen BH, Yuan YW, Zhang J, Xie T, Zhong X, Jiang HL, Li R, Wang BY, Huang XT, Cen BH, Yuan YW. Melatonin reverses nasopharyngeal carcinoma cisplatin chemoresistance by inhibiting the Wnt/?-catenin signaling pathway. Aging (Albany NY). 2020 03 23; 12(6):5423-5438. PMID: 32203052; PMCID: PMC7138577.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    20. Zhong Y, Sun R, Geng Y, Zhou Q, Piao Y, Xie T, Zhou R, Shen Y, Zhong Y, Sun R, Geng Y, Zhou Q, Piao Y, Xie T, Zhou R, Shen Y. N-Oxide polymer-cupric ion nanogels potentiate disulfiram for cancer therapy. Biomater Sci. 2020 Mar 17; 8(6):1726-1733. PMID: 31995039.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Zhang J, Luo J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y, Zhang J, Luo J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y. Corrigendum: The Tumor Suppressor Role of Zinc Finger Protein 671 (ZNF671) in Multiple Tumors Based on Cancer Single-Cell Sequencing. Front Oncol. 2020; 10:339. PMID: 32211338; PMCID: PMC7076908.
      Citations:    
    22. Zhang J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y, Zhang J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y. Differential Expression and Alternative Splicing of Transcripts Associated With Cisplatin-Induced Chemoresistance in Nasopharyngeal Carcinoma. Front Genet. 2020; 11:52. PMID: 32161615; PMCID: PMC7052373.
      Citations: 3     
    23. Zhou Q, Dong C, Fan W, Jiang H, Xiang J, Qiu N, Piao Y, Xie T, Luo Y, Li Z, Liu F, Shen Y, Zhou Q, Dong C, Fan W, Jiang H, Xiang J, Qiu N, Piao Y, Xie T, Luo Y, Li Z, Liu F, Shen Y. Tumor extravasation and infiltration as barriers of nanomedicine for high efficacy: The current status and transcytosis strategy. Biomaterials. 2020 05; 240:119902. PMID: 32105817.
      Citations: 24     Fields:    Translation:HumansAnimals
    24. Metz PJ, Ching KA, Xie T, Delgado Cuenca P, Niessen S, Tatlock JH, Jensen-Pergakes K, Murray BW, Metz PJ, Ching KA, Xie T, Delgado Cuenca P, Niessen S, Tatlock JH, Jensen-Pergakes K, Murray BW. Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling. Cell Rep. 2020 02 11; 30(6):1935-1950.e8. PMID: 32049022.
      Citations: 15     Fields:    Translation:HumansCells
    25. Miterko LN, Baker KB, Beckinghausen J, Bradnam LV, Cheng MY, Cooperrider J, DeLong MR, Gornati SV, Hallett M, Heck DH, Hoebeek FE, Kouzani AZ, Kuo SH, Louis ED, Machado A, Manto M, McCambridge AB, Nitsche MA, Taib NOB, Popa T, Tanaka M, Timmann D, Steinberg GK, Wang EH, Wichmann T, Xie T, Sillitoe RV, Miterko LN, Baker KB, Beckinghausen J, Bradnam LV, Cheng MY, Cooperrider J, DeLong MR, Gornati SV, Hallett M, Heck DH, Hoebeek FE, Kouzani AZ, Kuo SH, Louis ED, Machado A, Manto M, McCambridge AB, Nitsche MA, Taib NOB, Popa T, Tanaka M, Timmann D, Steinberg GK, Wang EH, Wichmann T, Xie T, Sillitoe RV. Consensus Paper: Experimental Neurostimulation of the Cerebellum. Cerebellum. 2019 Dec; 18(6):1064-1097. PMID: 31165428; PMCID: PMC6867990.
      Citations: 56     Fields:    Translation:HumansAnimals
    26. Park JK, Nan K, Luan H, Zheng N, Zhao S, Zhang H, Cheng X, Wang H, Li K, Xie T, Huang Y, Zhang Y, Kim S, Rogers JA, Park JK, Nan K, Luan H, Zheng N, Zhao S, Zhang H, Cheng X, Wang H, Li K, Xie T, Huang Y, Zhang Y, Kim S, Rogers JA. Remotely Triggered Assembly of 3D Mesostructures Through Shape-Memory Effects. Adv Mater. 2019 Dec; 31(52):e1905715. PMID: 31721341.
      Citations: 6     Fields:    
    27. Zhang J, Luo J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y, Zhang J, Luo J, Jiang H, Xie T, Zheng J, Tian Y, Li R, Wang B, Lin J, Xu A, Huang X, Yuan Y. The Tumor Suppressor Role of Zinc Finger Protein 671 (ZNF671) in Multiple Tumors Based on Cancer Single-Cell Sequencing. Front Oncol. 2019; 9:1214. PMID: 31781507; PMCID: PMC6857622.
      Citations: 5     
    28. Archer DB, Bricker JT, Chu WT, Burciu RG, McCracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, Parrish TB, Comella C, Xie T, Seppi K, Bohnen NI, M?ller ML, Albin RL, Krismer F, Du G, Lewis MM, Huang X, Li H, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE, Archer DB, Bricker JT, Chu WT, Burciu RG, McCracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, Parrish TB, Comella C, Xie T, Seppi K, Bohnen NI, M?ller ML, Albin RL, Krismer F, Du G, Lewis MM, Huang X, Li H, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE. Development and validation of the automated imaging differentiation in parkinsonism (AID-P): a multicentre machine learning study. Lancet Digit Health. 2019 09; 1(5):e222-e231. PMID: 33323270.
      Citations: 8     Fields:    Translation:Humans
    29. Archer DB, Bricker JT, Chu WT, Burciu RG, Mccracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, Parrish TB, Comella C, Xie T, Seppi K, Bohnen NI, M?ller MLTM, Albin RL, Krismer F, Du G, Lewis MM, Huang X, Li H, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE, Archer DB, Bricker JT, Chu WT, Burciu RG, Mccracken JL, Lai S, Coombes SA, Fang R, Barmpoutis A, Corcos DM, Kurani AS, Mitchell T, Black ML, Herschel E, Simuni T, Parrish TB, Comella C, Xie T, Seppi K, Bohnen NI, M?ller MLTM, Albin RL, Krismer F, Du G, Lewis MM, Huang X, Li H, Pasternak O, McFarland NR, Okun MS, Vaillancourt DE. Development and Validation of the Automated Imaging Differentiation in Parkinsonism (AID-P): A Multi-Site Machine Learning Study. Lancet Digit Health. 2019 09; 1(5):e222-e231. PMID: 32259098; PMCID: PMC7111208.
      Citations: 15     Fields:    Translation:Humans
    30. Mitchell T, Archer DB, Chu WT, Coombes SA, Lai S, Wilkes BJ, McFarland NR, Okun MS, Black ML, Herschel E, Simuni T, Comella C, Xie T, Li H, Parrish TB, Kurani AS, Corcos DM, Vaillancourt DE, Mitchell T, Archer DB, Chu WT, Coombes SA, Lai S, Wilkes BJ, McFarland NR, Okun MS, Black ML, Herschel E, Simuni T, Comella C, Xie T, Li H, Parrish TB, Kurani AS, Corcos DM, Vaillancourt DE. Neurite orientation dispersion and density imaging (NODDI) and free-water imaging in Parkinsonism. Hum Brain Mapp. 2019 12 01; 40(17):5094-5107. PMID: 31403737; PMCID: PMC6865390.
      Citations: 23     Fields:    Translation:HumansCells
    31. Vollstedt EJ, Kasten M, Klein C, Vollstedt EJ, Kasten M, Klein C, MJFF Global Genetic Parkinson's Disease Study Group. Using global team science to identify genetic parkinson's disease worldwide. Ann Neurol. 2019 08; 86(2):153-157. PMID: 31155756; PMCID: PMC7410260.
      Citations: 11     Fields:    Translation:Humans
    32. Luo L, Andrews H, Alcalay RN, Poyraz FC, Boehme AK, Goldman JG, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Sutherland M, Kopil C, Naito A, Kang UJ, Luo L, Andrews H, Alcalay RN, Poyraz FC, Boehme AK, Goldman JG, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Sutherland M, Kopil C, Naito A, Kang UJ. Motor phenotype classification in moderate to advanced PD in BioFIND study. Parkinsonism Relat Disord. 2019 08; 65:178-183. PMID: 31255537; PMCID: PMC6774826.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    33. Boxer AL, Qureshi I, Ahlijanian M, Grundman M, Golbe LI, Litvan I, Honig LS, Tuite P, McFarland NR, O'Suilleabhain P, Xie T, Tirucherai GS, Bechtold C, Bordelon Y, Geldmacher DS, Grossman M, Isaacson S, Zesiewicz T, Olsson T, Muralidharan KK, Graham DL, O'Gorman J, Haeberlein SB, Dam T, Boxer AL, Qureshi I, Ahlijanian M, Grundman M, Golbe LI, Litvan I, Honig LS, Tuite P, McFarland NR, O'Suilleabhain P, Xie T, Tirucherai GS, Bechtold C, Bordelon Y, Geldmacher DS, Grossman M, Isaacson S, Zesiewicz T, Olsson T, Muralidharan KK, Graham DL, O'Gorman J, Haeberlein SB, Dam T. Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial. Lancet Neurol. 2019 06; 18(6):549-558. PMID: 31122495.
      Citations: 50     Fields:    Translation:HumansCTClinical Trials
    34. Brittain C, McCarthy A, Irizarry MC, McDermott D, Biglan K, H?glinger GU, Lorenzl S, Del Ser T, Boxer AL, Brittain C, McCarthy A, Irizarry MC, McDermott D, Biglan K, H?glinger GU, Lorenzl S, Del Ser T, Boxer AL, AL-108-231 Study Group, PROPSPERA investigators, 4RNTI-1authors, Tau Restoration on PSP (TAUROS) Investigators. Severity dependent distribution of impairments in PSP and CBS: Interactive visualizations. Parkinsonism Relat Disord. 2019 03; 60:138-145. PMID: 30201421; PMCID: PMC6399076.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    35. Xie T, Bloom L, Padmanaban M, Bertacchi B, Kang W, MacCracken E, Dachman A, Vigil J, Satzer D, Zadikoff C, Markopoulou K, Warnke P, Kang UJ, Xie T, Bloom L, Padmanaban M, Bertacchi B, Kang W, MacCracken E, Dachman A, Vigil J, Satzer D, Zadikoff C, Markopoulou K, Warnke P, Kang UJ. Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD. J Neurol Neurosurg Psychiatry. 2018 09; 89(9):989-994. PMID: 29654112.
      Citations: 19     Fields:    Translation:Humans
    36. Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL, Rojas JC, Bang J, Lobach IV, Tsai RM, Rabinovici GD, Miller BL, Boxer AL, AL-108-231 Investigators. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 2018 01 23; 90(4):e273-e281. PMID: 29282336; PMCID: PMC5798651.
      Citations: 36     Fields:    Translation:HumansCellsCTClinical Trials
    37. Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Saint-Hilaire MH, Frasier M, Arnedo V, Reimer AN, Sutherland M, Swanson-Fischer C, Gwinn K, Kang UJ, Goldman JG, Andrews H, Amara A, Naito A, Alcalay RN, Shaw LM, Taylor P, Xie T, Tuite P, Henchcliffe C, Hogarth P, Frank S, Saint-Hilaire MH, Frasier M, Arnedo V, Reimer AN, Sutherland M, Swanson-Fischer C, Gwinn K, Fox Investigation of New Biomarker Discovery, Kang UJ. Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features. Mov Disord. 2018 02; 33(2):282-288. PMID: 29205509; PMCID: PMC5836918.
      Citations: 61     Fields:    Translation:Humans
    38. Xie T, Padmanaban M, Bloom L, MacCracken E, Bertacchi B, Dachman A, Warnke P, Xie T, Padmanaban M, Bloom L, MacCracken E, Bertacchi B, Dachman A, Warnke P. Effect of low versus high frequency stimulation on freezing of gait and other axial symptoms in Parkinson patients with bilateral STN DBS: a mini-review. Transl Neurodegener. 2017; 6:13. PMID: 28529730; PMCID: PMC5437495.
      Citations: 21     Fields:    
    39. Pirio Richardson S, Wegele AR, Skipper B, Deligtisch A, Jinnah HA, Pirio Richardson S, Wegele AR, Skipper B, Deligtisch A, Jinnah HA, Dystonia Coalition Investigators. Dystonia treatment: Patterns of medication use in an international cohort. Neurology. 2017 Feb 07; 88(6):543-550. PMID: 28077492; PMCID: PMC5304465.
      Citations: 19     Fields:    Translation:Humans
    40. Xie T, Kang UJ, Xie T, Kang UJ. Comments on the recent viewpoint article on low-frequency deep brain stimulation for Parkinson's disease. Mov Disord. 2017 01; 32(1):176. PMID: 27862290.
      Citations: 4     Fields:    Translation:Humans
    41. Norris SA, Jinnah HA, Espay AJ, Klein C, Br?ggemann N, Barbano RL, Malaty IA, Rodriguez RL, Vidailhet M, Roze E, Reich SG, Berman BD, LeDoux MS, Richardson SP, Agarwal P, Mari Z, Ondo WG, Shih LC, Fox SH, Berardelli A, Testa CM, Cheng FC, Truong D, Nahab FB, Xie T, Hallett M, Rosen AR, Wright LJ, Perlmutter JS, Norris SA, Jinnah HA, Espay AJ, Klein C, Br?ggemann N, Barbano RL, Malaty IA, Rodriguez RL, Vidailhet M, Roze E, Reich SG, Berman BD, LeDoux MS, Richardson SP, Agarwal P, Mari Z, Ondo WG, Shih LC, Fox SH, Berardelli A, Testa CM, Cheng FC, Truong D, Nahab FB, Xie T, Hallett M, Rosen AR, Wright LJ, Perlmutter JS. Clinical and demographic characteristics related to onset site and spread of cervical dystonia. Mov Disord. 2016 12; 31(12):1874-1882. PMID: 27753188; PMCID: PMC5154862.
      Citations: 15     Fields:    Translation:Humans
    42. Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR, Miller BL, Rosen HJ, Boxer AL, Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR, Miller BL, Rosen HJ, Boxer AL, AL-108-231 investigators. Progression of brain atrophy in PSP and CBS over 6 months and 1 year. Neurology. 2016 Nov 08; 87(19):2016-2025. PMID: 27742814; PMCID: PMC5109951.
      Citations: 29     Fields:    Translation:Humans
    43. Xie T, Appelbaum D, Bernard J, Padmanaban M, Pu Y, Gomez C, Xie T, Appelbaum D, Bernard J, Padmanaban M, Pu Y, Gomez C. Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6. J Neurol. 2016 Nov; 263(11):2302-2307. PMID: 27544504.
      Citations: 2     Fields:    Translation:HumansCells
    44. Kang UJ, Goldman JG, Alcalay RN, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Rudolph A, Casaceli C, Andrews H, Gwinn K, Sutherland M, Kopil C, Vincent L, Frasier M, Kang UJ, Goldman JG, Alcalay RN, Xie T, Tuite P, Henchcliffe C, Hogarth P, Amara AW, Frank S, Rudolph A, Casaceli C, Andrews H, Gwinn K, Sutherland M, Kopil C, Vincent L, Frasier M. The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort. Mov Disord. 2016 06; 31(6):924-32. PMID: 27113479; PMCID: PMC5021110.
      Citations: 26     Fields:    Translation:Humans
    45. Xie T, Vigil J, MacCracken E, Warnke P, Kang UJ, Xie T, Vigil J, MacCracken E, Warnke P, Kang UJ. Author Response. Neurology. 2015 Aug 11; 85(6):557. PMID: 26484368.
      Citations:    Fields:    Translation:Humans
    46. Xie T, Guan R, Staisch J, Towle VL, Warnke P, Xie T, Guan R, Staisch J, Towle VL, Warnke P. Respiratory dyskinesia in a patient with Parkinson disease successfully treated with STN DBS. Neurology. 2015 Aug 04; 85(5):479-80. PMID: 26138944; PMCID: PMC4534072.
      Citations: 5     Fields:    Translation:Humans
    47. Xie T, Kang UJ, Kuo SH, Poulopoulos M, Greene P, Fahn S, Xie T, Kang UJ, Kuo SH, Poulopoulos M, Greene P, Fahn S. Comparison of clinical features in pathologically confirmed PSP and MSA patients followed at a tertiary center. NPJ Parkinsons Dis. 2015; 1:15007. PMID: 28725681; PMCID: PMC5516563.
      Citations: 15     
    48. Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W, Bernard J, Warnke P, Kang UJ, Xie T, Vigil J, MacCracken E, Gasparaitis A, Young J, Kang W, Bernard J, Warnke P, Kang UJ. Low-frequency stimulation of STN-DBS reduces aspiration and freezing of gait in patients with PD. Neurology. 2015 Jan 27; 84(4):415-20. PMID: 25540305; PMCID: PMC4336001.
      Citations: 54     Fields:    Translation:Humans
    49. Rydz D, Lin CY, Xie T, Cortes E, Vonsattel JP, Kuo SH, Rydz D, Lin CY, Xie T, Cortes E, Vonsattel JP, Kuo SH. Pathological findings of anti-Yo cerebellar degeneration with Holmes tremor. J Neurol Neurosurg Psychiatry. 2015 Jan; 86(1):121-2. PMID: 24876186; PMCID: PMC4247802.
      Citations: 3     Fields:    Translation:Humans
    50. Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, H?glinger GU, Koestler M, Jack CR, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH, Boxer AL, Lang AE, Grossman M, Knopman DS, Miller BL, Schneider LS, Doody RS, Lees A, Golbe LI, Williams DR, Corvol JC, Ludolph A, Burn D, Lorenzl S, Litvan I, Roberson ED, H?glinger GU, Koestler M, Jack CR, Van Deerlin V, Randolph C, Lobach IV, Heuer HW, Gozes I, Parker L, Whitaker S, Hirman J, Stewart AJ, Gold M, Morimoto BH, AL-108-231 Investigators. Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2/3 trial. Lancet Neurol. 2014 Jul; 13(7):676-85. PMID: 24873720; PMCID: PMC4129545.
      Citations: 113     Fields:    Translation:HumansCTClinical Trials
    51. Xie T, Awad I, Kang UJ, Warnke P, Xie T, Awad I, Kang UJ, Warnke P. DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN. Neurology. 2014 Feb 18; 82(7):636-7. PMID: 24384639; PMCID: PMC3963417.
      Citations: 2     Fields:    Translation:Humans
    52. Kuo SH, Xie T, Fahn S, Kuo SH, Xie T, Fahn S. Anticholinergic responsive cyclic myoclonus. Mov Disord. 2013 Mar; 28(3):401-2. PMID: 23404345; PMCID: PMC6158792.
      Citations: 1     Fields:    Translation:Humans
    53. Xie T, Bernard J, Warnke P, Xie T, Bernard J, Warnke P. Post subthalamic area deep brain stimulation for tremors: a mini-review. Transl Neurodegener. 2012 Oct 29; 1(1):20. PMID: 23210767; PMCID: PMC3534556.
      Citations: 23     Fields:    
    54. Xie T, Warnke P, Kang UJ, de la Fuente-Fernandez R, Xie T, Warnke P, Kang UJ, de la Fuente-Fernandez R. Role of DaTSCAN and clinical diagnosis in Parkinson disease. Neurology. 2012 Oct 16; 79(16):1744; author reply 1744. PMID: 23071169.
      Citations: 4     Fields:    Translation:Humans
    55. Kang UJ, Xie T, Kang UJ, Xie T. Diagnostic biomarkers of Parkinson's disease: what gain at what cost? J Neurol Neurosurg Psychiatry. 2012 Aug; 83(8):769. PMID: 22733084.
      Citations: 2     Fields:    Translation:Humans
    56. Xie T, Kang UJ, Warnke P, Xie T, Kang UJ, Warnke P. Effect of stimulation frequency on immediate freezing of gait in newly activated STN DBS in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2012 Oct; 83(10):1015-7. PMID: 22696586.
      Citations: 34     Fields:    Translation:Humans
    57. Xie T, Goodman R, Browner N, Haberfeld E, Winfield L, Goldman J, Ford B, Xie T, Goodman R, Browner N, Haberfeld E, Winfield L, Goldman J, Ford B. Treatment of fragile X-associated tremor/ataxia syndrome with unilateral deep brain stimulation. Mov Disord. 2012 May; 27(6):799-800. PMID: 22344717.
      Citations: 11     Fields:    Translation:Humans
    58. Xie T, Tong L, McLane MW, Hatzidimitriou G, Yuan J, McCann U, Ricaurte G, Xie T, Tong L, McLane MW, Hatzidimitriou G, Yuan J, McCann U, Ricaurte G. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology. 2006 Dec; 31(12):2639-51. PMID: 16452989.
      Citations: 31     Fields:    Translation:AnimalsCells
    59. Liu J, Huang Q, Higdon J, Liu W, Xie T, Yamashita T, Cheon K, Cheng C, Zuo J, Liu J, Huang Q, Higdon J, Liu W, Xie T, Yamashita T, Cheon K, Cheng C, Zuo J. Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations. Hum Mol Genet. 2005 Oct 01; 14(19):2945-58. PMID: 16126734.
      Citations: 7     Fields:    Translation:AnimalsCells
    60. Ricaurte GA, Mechan AO, Yuan J, Hatzidimitriou G, Xie T, Mayne AH, McCann UD, Ricaurte GA, Mechan AO, Yuan J, Hatzidimitriou G, Xie T, Mayne AH, McCann UD. Amphetamine treatment similar to that used in the treatment of adult attention-deficit/hyperactivity disorder damages dopaminergic nerve endings in the striatum of adult nonhuman primates. J Pharmacol Exp Ther. 2005 Oct; 315(1):91-8. PMID: 16014752.
      Citations: 24     Fields:    Translation:Animals
    61. Xie T, Tong L, McCann UD, Yuan J, Becker KG, Mechan AO, Cheadle C, Donovan DM, Ricaurte GA, Xie T, Tong L, McCann UD, Yuan J, Becker KG, Mechan AO, Cheadle C, Donovan DM, Ricaurte GA. Identification and characterization of metallothionein-1 and -2 gene expression in the context of (+/-)3,4-methylenedioxymethamphetamine-induced toxicity to brain dopaminergic neurons. J Neurosci. 2004 Aug 11; 24(32):7043-50. PMID: 15306638; PMCID: PMC6729169.
      Citations: 8     Fields:    Translation:AnimalsCells
    62. Jiang H, Xie T, Ramsden DB, Ho SL, Jiang H, Xie T, Ramsden DB, Ho SL. Human catechol-O-methyltransferase down-regulation by estradiol. Neuropharmacology. 2003 Dec; 45(7):1011-8. PMID: 14573393.
      Citations: 59     Fields:    Translation:HumansCells
    63. Xie T, Tong L, Barrett T, Yuan J, Hatzidimitriou G, McCann UD, Becker KG, Donovan DM, Ricaurte GA, Xie T, Tong L, Barrett T, Yuan J, Hatzidimitriou G, McCann UD, Becker KG, Donovan DM, Ricaurte GA. Changes in gene expression linked to methamphetamine-induced dopaminergic neurotoxicity. J Neurosci. 2002 Jan 01; 22(1):274-83. PMID: 11756511; PMCID: PMC6757595.
      Citations: 15     Fields:    Translation:AnimalsCells
    64. Barrett T, Xie T, Piao Y, Dillon-Carter O, Kargul GJ, Lim MK, Chrest FJ, Wersto R, Rowley DL, Juhaszova M, Zhou L, Vawter MP, Becker KG, Cheadle C, Wood WH, McCann UD, Freed WJ, Ko MS, Ricaurte GA, Donovan DM, Barrett T, Xie T, Piao Y, Dillon-Carter O, Kargul GJ, Lim MK, Chrest FJ, Wersto R, Rowley DL, Juhaszova M, Zhou L, Vawter MP, Becker KG, Cheadle C, Wood WH, McCann UD, Freed WJ, Ko MS, Ricaurte GA, Donovan DM. A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity. Neurobiol Dis. 2001 Oct; 8(5):822-33. PMID: 11592851.
      Citations: 10     Fields:    Translation:AnimalsCells
    65. Ramsden DB, Parsons RB, Ho SL, Xie T, Waring RH, Williams AC, Ramsden DB, Parsons RB, Ho SL, Xie T, Waring RH, Williams AC. Further studies in xenobiotic metabolism and Parkinson's disease. Adv Neurol. 2001; 86:105-13. PMID: 11553967.
      Citations: 3     Fields:    Translation:Humans
    66. Xie T, McCann UD, Kim S, Yuan J, Ricaurte GA, Xie T, McCann UD, Kim S, Yuan J, Ricaurte GA. Effect of temperature on dopamine transporter function and intracellular accumulation of methamphetamine: implications for methamphetamine-induced dopaminergic neurotoxicity. J Neurosci. 2000 Oct 15; 20(20):7838-45. PMID: 11027249; PMCID: PMC6772867.
      Citations: 37     Fields:    Translation:AnimalsCells
    67. Xie T, Ho SL, Ramsden D, Xie T, Ho SL, Ramsden D. Characterization and implications of estrogenic down-regulation of human catechol-O-methyltransferase gene transcription. Mol Pharmacol. 1999 Jul; 56(1):31-8. PMID: 10385681.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    68. Hong J, Shu-Leong H, Tao X, Lap-Ping Y, Hong J, Shu-Leong H, Tao X, Lap-Ping Y. Distribution of catechol-O-methyltransferase expression in human central nervous system. Neuroreport. 1998 Aug 24; 9(12):2861-4. PMID: 9760135.
      Citations: 39     Fields:    Translation:Humans
    69. Xie T, Ho SL, Ramsden D, Xie T, Ho SL, Ramsden D. Catechol-O-methyltransferase inhibitors in Parkinson's disease. Lancet. 1998 Jun 27; 351(9120):1966. PMID: 9654300.
      Citations:    Fields:    Translation:Humans
    70. Xie T, Ho SL, Ma OC, Xie T, Ho SL, Ma OC. High resolution single strand conformation polymorphism analysis using formamide and ethidium bromide staining. Mol Pathol. 1997 Oct; 50(5):276-8. PMID: 9497922; PMCID: PMC379648.
      Citations: 8     Fields:    Translation:HumansCells
    71. Xie T, Ho SL, Li LS, Ma OC, Xie T, Ho SL, Li LS, Ma OC. G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease. Mov Disord. 1997 May; 12(3):426-7. PMID: 9159741.
      Citations: 9     Fields:    Translation:HumansCells
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