The University of Chicago Header Logo
Last Name

Daniel Appelbaum

InstitutionUniversity of Chicago
AddressChicago IL 60637
vCardDownload vCard

    Collapse Overview 
    Collapse overview
    Daniel Appelbaum, MD, is both a radiologist and nuclear medicine physician. He has expertise in the full spectrum of nuclear/molecular imaging, specializing in oncologic, neurologic, cardiac and positron emission tomographic (PET and PET/CT) applications. Dr. Appelbaum and his colleagues offer a full array of both diagnostic and therapeutic nuclear exams and procedures for adults and children at the University of Chicago Medicine.

    Dr. Appelbaum conducts nuclear and molecular imaging research in the basic science and clinical settings. His current work involves development of a novel brain imaging agent for multiple sclerosis, as well as a metabolic catalyst to augment tumor detection with PET imaging. Other interests include developing new strategies for using computer-aided diagnosis (CAD) in nuclear medicine, work for which he has been awarded a patent in artificial intelligence (AI). The section he leads is involved in several oncology PET/CT clinical trials that monitor how patients respond to therapy. Dr. Appelbaum chairs the University of Chicago Radioactive Drug Research Advisory Committee (RADRAC).

    An active educator, Dr. Appelbaum accepts many lecture invitations on nuclear and PET imaging at hospitals and medical meetings worldwide. He is a longstanding member of the national Society of Nuclear Medicine Committee on Education. He has also published a textbook (Nuclear Medicine RadCases) designed as a comprehensive review of his field.

    Collapse Biography 
    Collapse education and training
    Mallinckrodt Institute of Radiology at Washington University, St. Louis, MO2000Fellowship- Nuclear Medicine
    University of Chicago, Chicago, IL 1999Residency- Diagnostic Radiology
    Mount Sinai School of Medicine, New York, NYMD1995
    Cornell University, Ithaca, NYBA1991English Literature
    American Board of Radiology1999 Certification
    American Board of Nuclear Medicine2000Certification
    Collapse awards and honors
    2014 - now"America's Top Doctor", Castle Connolly
    2012 - now“Chicago’s Top Doctor”, Chicago Magazine
    2006 - 2007Marc Tetalman "Teacher of the Year" Award , The University of Chicago

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Trujillo JA, Godfrey J, Hu Y, Huang J, Smith SM, Frigault MJ, DeFilipp Z, Appelbaum D, Pu Y, Feinberg N, Althaus T, Bishop MR, Riedell PA, Kline J. Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 06 17; 137(24):3454-3459. PMID: 33881502.
      View in: PubMed
    2. Kebed KY, Carter SV, Flatley E, Ward RP, Moss JD, Appelbaum DE, Singh A, Lang RM, Tung R, Patel AR. Prevalence of newly diagnosed sarcoidosis in patients with ventricular arrhythmias: a cardiac magnetic resonance and 18F-FDG cardiac PET study. Int J Cardiovasc Imaging. 2021 Apr; 37(4):1361-1369. PMID: 33225427.
      View in: PubMed
    3. Sokol EA, Engelmann R, Kang W, Pinto N, Starkey A, Lai H, Nadel H, Shulkin BL, Pu Y, Appelbaum D, Yanik GA, Cohn SL, Armato SG, Volchenboum S. Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma. Pediatr Blood Cancer. 2018 12; 65(12):e27417. PMID: 30198643.
      View in: PubMed
    4. Pu Y, Zhang JX, Liu H, Appelbaum D, Meng J, Penney BC. Developing and validating a novel metabolic tumor volume risk stratification system for supplementing non-small cell lung cancer staging. Eur J Nucl Med Mol Imaging. 2018 11; 45(12):2079-2092. PMID: 29882161.
      View in: PubMed
    5. Xie T, Appelbaum D, Bernard J, Padmanaban M, Pu Y, Gomez C. Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6. J Neurol. 2016 Nov; 263(11):2302-2307. PMID: 27544504.
      View in: PubMed
    6. Zhang H, Wroblewski K, Jiang Y, Penney BC, Appelbaum D, Simon CA, Salgia R, Pu Y. A new PET/CT volumetric prognostic index for non-small cell lung cancer. Lung Cancer. 2015 Jul; 89(1):43-9. PMID: 25936471.
      View in: PubMed
    7. Zhang C, Liao C, Penney BC, Appelbaum DE, Simon CA, Pu Y. Relationship between Overall Survival of Patients with Non-Small Cell Lung Cancer and Whole-Body Metabolic Tumor Burden Seen on Postsurgical Fluorodeoxyglucose PET Images. Radiology. 2015 Jun; 275(3):862-9. PMID: 25584710.
      View in: PubMed
    8. Yacoub JH, Yousuf A, Agrawal G, Thomas S, Appelbaum DE, Oto A. Evaluation of the gallbladder and cystic duct patency with gadoxetate disodium enhanced MR cholangiography: prospective comparison of patients with normal gallbladder function and acute cholecystitis. Acta Radiol. 2015 Jul; 56(7):782-9. PMID: 25009279.
      View in: PubMed
    9. Chen JL, Appelbaum DE, Kocherginsky M, Cowey CL, Rathmell WK, McDermott DF, Stadler WM. FDG-PET as a predictive biomarker for therapy with everolimus in metastatic renal cell cancer. Cancer Med. 2013 Aug; 2(4):545-52. PMID: 24156027.
      View in: PubMed
    10. Choi YJ, Gabikian P, Zhu F, Appelbaum DE, Wollmann R, Lukas RV. Advanced neuroimaging studies in a patient with brain metastases from transitional cell carcinoma of the bladder. J Neuroimaging. 2014 Jul-Aug; 24(4):429-31. PMID: 23551927.
      View in: PubMed
    11. Solanki AA, Weichselbaum RR, Appelbaum D, Farrey K, Yenice KM, Chmura SJ, Salama JK. The utility of FDG-PET for assessing outcomes in oligometastatic cancer patients treated with stereotactic body radiotherapy: a cohort study. Radiat Oncol. 2012 Dec 18; 7:216. PMID: 23244066.
      View in: PubMed
    12. Shiraishi J, Li Q, Appelbaum D, Doi K. Computer-aided diagnosis and artificial intelligence in clinical imaging. Semin Nucl Med. 2011 Nov; 41(6):449-62. PMID: 21978447.
      View in: PubMed
    13. Liao S, Penney BC, Wroblewski K, Zhang H, Simon CA, Kampalath R, Shih MC, Shimada N, Chen S, Salgia R, Appelbaum DE, Suzuki K, Chen CT, Pu Y. Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2012 Jan; 39(1):27-38. PMID: 21946983.
      View in: PubMed
    14. Huang YE, Pu YL, Huang YJ, Chen CF, Pu QH, Konda SD, Appelbaum DE. The utility of the nonattenuation corrected 18F-FDG PET images in the characterization of solitary pulmonary lesions. Nucl Med Commun. 2010 Nov; 31(11):945-51. PMID: 20739905.
      View in: PubMed
    15. Huang YE, Chen CF, Huang YJ, Konda SD, Appelbaum DE, Pu Y. Interobserver variability among measurements of the maximum and mean standardized uptake values on (18)F-FDG PET/CT and measurements of tumor size on diagnostic CT in patients with pulmonary tumors. Acta Radiol. 2010 Sep; 51(7):782-8. PMID: 20707663.
      View in: PubMed
    16. Brown RL, Segu VB, Appelbaum DE. What is the diagnosis? Gastrointestinal duplication cyst. Endocr Pract. 2010 May-Jun; 16(3):530. PMID: 20061277.
      View in: PubMed
    17. Ilkhchoui Y, Appelbaum DE, Pu Y. FDG-PET/CT findings of a metastatic pituitary tumor. Cancer Imaging. 2010 Mar 18; 10:114-6. PMID: 20299302.
      View in: PubMed
    18. Rubin DT, Surma BL, Gavzy SJ, Schnell KM, Bunnag AP, Huo D, Appelbaum DE. Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission. Inflamm Bowel Dis. 2009 May; 15(5):750-5. PMID: 19090558.
      View in: PubMed
    19. Pu Y, Mahankali S, Hou J, Li J, Lancaster JL, Gao JH, Appelbaum DE, Fox PT. High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol. 2007 Oct; 28(9):1706-9. PMID: 17885233.
      View in: PubMed
    20. Shiraishi J, Appelbaum D, Pu Y, Li Q, Pesce L, Doi K. Usefulness of temporal subtraction images for identification of interval changes in successive whole-body bone scans: JAFROC analysis of radiologists' performance. Acad Radiol. 2007 Aug; 14(8):959-66. PMID: 17659242.
      View in: PubMed
    21. Shiraishi J, Li Q, Appelbaum D, Pu Y, Doi K. Development of a computer-aided diagnostic scheme for detection of interval changes in successive whole-body bone scans. Med Phys. 2007 Jan; 34(1):25-36. PMID: 17278486.
      View in: PubMed
    22. Nie Y, Li Q, Li F, Pu Y, Appelbaum D, Doi K. Integrating PET and CT information to improve diagnostic accuracy for lung nodules: A semiautomatic computer-aided method. J Nucl Med. 2006 Jul; 47(7):1075-80. PMID: 16818939.
      View in: PubMed
    23. Kan JH, Funaki B, O'Rourke BD, Ward MB, Appelbaum DE. Delayed 99mTc-labeled erythrocyte scintigraphy in patients with lower gastrointestinal tract hemorrhage: effect of positive findings on clinical management. Acad Radiol. 2003 May; 10(5):497-501. PMID: 12755537.
      View in: PubMed
    Appelbaum's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description