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Daniel Appelbaum

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Daniel Appelbaum, MD, is both a radiologist and nuclear medicine physician. He has expertise in the full spectrum of nuclear/molecular imaging, specializing in oncologic, neurologic, cardiac and positron emission tomographic (PET and PET/CT) applications. Dr. Appelbaum and his colleagues offer a full array of both diagnostic and therapeutic nuclear exams and procedures for adults and children at the University of Chicago Medicine.

    Dr. Appelbaum conducts nuclear and molecular imaging research in the basic science and clinical settings. His current work involves development of a novel brain imaging agent for multiple sclerosis, as well as a metabolic catalyst to augment tumor detection with PET imaging. Other interests include developing new strategies for using computer-aided diagnosis (CAD) in nuclear medicine, work for which he has been awarded a patent in artificial intelligence (AI). The section he leads is involved in several oncology PET/CT clinical trials that monitor how patients respond to therapy. Dr. Appelbaum chairs the University of Chicago Radioactive Drug Research Advisory Committee (RADRAC).

    An active educator, Dr. Appelbaum accepts many lecture invitations on nuclear and PET imaging at hospitals and medical meetings worldwide. He is a longstanding member of the national Society of Nuclear Medicine Committee on Education. He has also published a textbook (Nuclear Medicine RadCases) designed as a comprehensive review of his field.

    Collapse Biography 
    Collapse education and training
    Mallinckrodt Institute of Radiology at Washington University, St. Louis, MO2000Fellowship- Nuclear Medicine
    University of Chicago, Chicago, IL 1999Residency- Diagnostic Radiology
    Mount Sinai School of Medicine, New York, NYMD1995
    Cornell University, Ithaca, NYBA1991English Literature
    American Board of Radiology1999 Certification
    American Board of Nuclear Medicine2000Certification
    Collapse awards and honors
    2014 - now"America's Top Doctor", Castle Connolly
    2012 - now“Chicago’s Top Doctor”, Chicago Magazine
    2006 - 2007Marc Tetalman "Teacher of the Year" Award , The University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rojek AE, Kline JP, Feinberg N, Appelbaum DE, Pu Y, Derman BA, Jakubowiak A, Kosuri S, Liu H, Nawas MT, Smith SM, Bishop MR, Riedell PA. Optimization of Metabolic Tumor Volume as a Prognostic Marker in CAR T-Cell Therapy for Aggressive Large B-cell NHL. Clin Lymphoma Myeloma Leuk. 2024 02; 24(2):83-93. PMID: 37827881.
      Citations:    Fields:    Translation:Humans
    2. Wlodarski R, Seibert K, Issa NP, O'Brien-Penney B, Soliven B, Sarswat N, Appelbaum D, Rezania K. 99m Technetium-pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study. Muscle Nerve. 2023 Feb; 67(2):111-116. PMID: 36222831; PMCID: PMC10092886.
      Citations: 2     Fields:    Translation:Humans
    3. Seibert K, Wlodarski R, Sarswat N, Appelbaum D, Issa NP, Soliven B, Rezania K. Progressive Multiple Mononeuropathy in a Patient With Familial Transthyretin Amyloidosis After Liver Transplantation. J Clin Neuromuscul Dis. 2022 Mar 01; 23(3):143-147. PMID: 35188911.
      Citations:    Fields:    Translation:Humans
    4. Trujillo JA, Godfrey J, Hu Y, Huang J, Smith SM, Frigault MJ, DeFilipp Z, Appelbaum D, Pu Y, Feinberg N, Althaus T, Bishop MR, Riedell PA, Kline J. Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 06 17; 137(24):3454-3459. PMID: 33881502; PMCID: PMC8212512.
      Citations: 4     Fields:    Translation:HumansCells
    5. Kebed KY, Carter SV, Flatley E, Ward RP, Moss JD, Appelbaum DE, Singh A, Lang RM, Tung R, Patel AR. Prevalence of newly diagnosed sarcoidosis in patients with ventricular arrhythmias: a cardiac magnetic resonance and 18F-FDG cardiac PET study. Int J Cardiovasc Imaging. 2021 Apr; 37(4):1361-1369. PMID: 33225427; PMCID: PMC8035303.
      Citations: 3     Fields:    Translation:Humans
    6. Sokol EA, Engelmann R, Kang W, Pinto N, Starkey A, Lai H, Nadel H, Shulkin BL, Pu Y, Appelbaum D, Yanik GA, Cohn SL, Armato SG, Volchenboum S. Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma. Pediatr Blood Cancer. 2018 12; 65(12):e27417. PMID: 30198643; PMCID: PMC6317352.
      Citations: 2     Fields:    Translation:Humans
    7. Pu Y, Zhang JX, Liu H, Appelbaum D, Meng J, Penney BC. Developing and validating a novel metabolic tumor volume risk stratification system for supplementing non-small cell lung cancer staging. Eur J Nucl Med Mol Imaging. 2018 11; 45(12):2079-2092. PMID: 29882161; PMCID: PMC6286257.
      Citations: 7     Fields:    Translation:Humans
    8. Xie T, Appelbaum D, Bernard J, Padmanaban M, Pu Y, Gomez C. Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6. J Neurol. 2016 Nov; 263(11):2302-2307. PMID: 27544504.
      Citations: 2     Fields:    Translation:HumansCells
    9. Zhang H, Wroblewski K, Jiang Y, Penney BC, Appelbaum D, Simon CA, Salgia R, Pu Y. A new PET/CT volumetric prognostic index for non-small cell lung cancer. Lung Cancer. 2015 Jul; 89(1):43-9. PMID: 25936471; PMCID: PMC4457565.
      Citations: 9     Fields:    Translation:Humans
    10. Zhang C, Liao C, Penney BC, Appelbaum DE, Simon CA, Pu Y. Relationship between Overall Survival of Patients with Non-Small Cell Lung Cancer and Whole-Body Metabolic Tumor Burden Seen on Postsurgical Fluorodeoxyglucose PET Images. Radiology. 2015 Jun; 275(3):862-9. PMID: 25584710; PMCID: PMC4441545.
      Citations: 15     Fields:    Translation:Humans
    11. Yacoub JH, Yousuf A, Agrawal G, Thomas S, Appelbaum DE, Oto A. Evaluation of the gallbladder and cystic duct patency with gadoxetate disodium enhanced MR cholangiography: prospective comparison of patients with normal gallbladder function and acute cholecystitis. Acta Radiol. 2015 Jul; 56(7):782-9. PMID: 25009279.
      Citations: 2     Fields:    Translation:Humans
    12. Chen JL, Appelbaum DE, Kocherginsky M, Cowey CL, Rathmell WK, McDermott DF, Stadler WM. FDG-PET as a predictive biomarker for therapy with everolimus in metastatic renal cell cancer. Cancer Med. 2013 Aug; 2(4):545-52. PMID: 24156027; PMCID: PMC3799289.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    13. Choi YJ, Gabikian P, Zhu F, Appelbaum DE, Wollmann R, Lukas RV. Advanced neuroimaging studies in a patient with brain metastases from transitional cell carcinoma of the bladder. J Neuroimaging. 2014 Jul-Aug; 24(4):429-31. PMID: 23551927.
      Citations: 1     Fields:    Translation:Humans
    14. Solanki AA, Weichselbaum RR, Appelbaum D, Farrey K, Yenice KM, Chmura SJ, Salama JK. The utility of FDG-PET for assessing outcomes in oligometastatic cancer patients treated with stereotactic body radiotherapy: a cohort study. Radiat Oncol. 2012 Dec 18; 7:216. PMID: 23244066; PMCID: PMC3551831.
      Citations: 12     Fields:    Translation:Humans
    15. Shiraishi J, Li Q, Appelbaum D, Doi K. Computer-aided diagnosis and artificial intelligence in clinical imaging. Semin Nucl Med. 2011 Nov; 41(6):449-62. PMID: 21978447.
      Citations: 43     Fields:    Translation:Humans
    16. Liao S, Penney BC, Wroblewski K, Zhang H, Simon CA, Kampalath R, Shih MC, Shimada N, Chen S, Salgia R, Appelbaum DE, Suzuki K, Chen CT, Pu Y. Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging. 2012 Jan; 39(1):27-38. PMID: 21946983.
      Citations: 140     Fields:    Translation:Humans
    17. Huang YE, Pu YL, Huang YJ, Chen CF, Pu QH, Konda SD, Appelbaum DE. The utility of the nonattenuation corrected 18F-FDG PET images in the characterization of solitary pulmonary lesions. Nucl Med Commun. 2010 Nov; 31(11):945-51. PMID: 20739905.
      Citations: 4     Fields:    Translation:Humans
    18. Huang YE, Chen CF, Huang YJ, Konda SD, Appelbaum DE, Pu Y. Interobserver variability among measurements of the maximum and mean standardized uptake values on (18)F-FDG PET/CT and measurements of tumor size on diagnostic CT in patients with pulmonary tumors. Acta Radiol. 2010 Sep; 51(7):782-8. PMID: 20707663.
      Citations: 14     Fields:    Translation:Humans
    19. Brown RL, Segu VB, Appelbaum DE. What is the diagnosis? Gastrointestinal duplication cyst. Endocr Pract. 2010 May-Jun; 16(3):530. PMID: 20061277.
      Citations:    Fields:    Translation:Humans
    20. Ilkhchoui Y, Appelbaum DE, Pu Y. FDG-PET/CT findings of a metastatic pituitary tumor. Cancer Imaging. 2010 Mar 18; 10:114-6. PMID: 20299302; PMCID: PMC2842182.
      Citations: 3     Fields:    Translation:Humans
    21. Rubin DT, Surma BL, Gavzy SJ, Schnell KM, Bunnag AP, Huo D, Appelbaum DE. Positron emission tomography (PET) used to image subclinical inflammation associated with ulcerative colitis (UC) in remission. Inflamm Bowel Dis. 2009 May; 15(5):750-5. PMID: 19090558.
      Citations: 11     Fields:    Translation:Humans
    22. Pu Y, Mahankali S, Hou J, Li J, Lancaster JL, Gao JH, Appelbaum DE, Fox PT. High prevalence of pineal cysts in healthy adults demonstrated by high-resolution, noncontrast brain MR imaging. AJNR Am J Neuroradiol. 2007 Oct; 28(9):1706-9. PMID: 17885233; PMCID: PMC8134222.
      Citations: 26     Fields:    Translation:Humans
    23. Shiraishi J, Appelbaum D, Pu Y, Li Q, Pesce L, Doi K. Usefulness of temporal subtraction images for identification of interval changes in successive whole-body bone scans: JAFROC analysis of radiologists' performance. Acad Radiol. 2007 Aug; 14(8):959-66. PMID: 17659242.
      Citations: 7     Fields:    Translation:Humans
    24. Shiraishi J, Li Q, Appelbaum D, Pu Y, Doi K. Development of a computer-aided diagnostic scheme for detection of interval changes in successive whole-body bone scans. Med Phys. 2007 Jan; 34(1):25-36. PMID: 17278486.
      Citations: 11     Fields:    Translation:Humans
    25. Nie Y, Li Q, Li F, Pu Y, Appelbaum D, Doi K. Integrating PET and CT information to improve diagnostic accuracy for lung nodules: A semiautomatic computer-aided method. J Nucl Med. 2006 Jul; 47(7):1075-80. PMID: 16818939.
      Citations: 13     Fields:    Translation:Humans
    26. Kan JH, Funaki B, O'Rourke BD, Ward MB, Appelbaum DE. Delayed 99mTc-labeled erythrocyte scintigraphy in patients with lower gastrointestinal tract hemorrhage: effect of positive findings on clinical management. Acad Radiol. 2003 May; 10(5):497-501. PMID: 12755537.
      Citations: 2     Fields:    Translation:HumansCells
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