 Ralph R. Weichselbaum
| Title | Professor |
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| Institution | University of Chicago |
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| Department | BSD Academic Admin |
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| Address | Chicago IL 60637
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| vCard | Download vCard |
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 Biography | University of Wisconsin, Madison WI | BS | 06/1967 | Liberal Arts | | University of Illinois, Chicago IL | MD | 06/1971 | Medicine |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Gutiontov SI, Weichselbaum RR. STING (or SRC) Like an ICB: Priming the Immune Response in Pancreatic Cancer. Cancer Res. 2019 Aug 01; 79(15):3815-3817. PMID: 31371279.
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Pitroda SP, Chmura SJ, Weichselbaum RR. Integration of radiotherapy and immunotherapy for treatment of oligometastases. Lancet Oncol. 2019 Aug; 20(8):e434-e442. PMID: 31364595.
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Foster CC, Pitroda SP, Weichselbaum RR. Beyond Palliation: The Rationale for Metastasis-Directed Therapy for Metastatic Non-Small Cell Lung Cancer. J Thorac Oncol. 2019 Jul 01. PMID: 31272814.
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Pitroda SP, Weichselbaum RR. Integrated molecular and clinical staging defines the spectrum of metastatic cancer. Nat Rev Clin Oncol. 2019 May 15. PMID: 31092903.
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Chan C, Guo N, Duan X, Han W, Xue L, Bryan D, Wightman SC, Khodarev NN, Weichselbaum RR, Lin W. Systemic miRNA delivery by nontoxic nanoscale coordination polymers limits epithelial-to-mesenchymal transition and suppresses liver metastases of colorectal cancer. Biomaterials. 2019 Jul; 210:94-104. PMID: 31060867.
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Duan X, Chan C, Han W, Guo N, Weichselbaum RR, Lin W. Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors. Nat Commun. 2019 04 23; 10(1):1899. PMID: 31015397.
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Foster CC, Pitroda SP, Weichselbaum RR. Staging the Metastatic Spectrum Through Integration of Clinical and Molecular Features. J Clin Oncol. 2019 May 20; 37(15):1270-1276. PMID: 30939093.
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Voce DJ, Bernal GM, Wu L, Crawley CD, Zhang W, Mansour NM, Cahill KE, Szymura SJ, Uppal A, Raleigh DR, Spretz R, Nunez L, Larsen G, Khodarev NN, Weichselbaum RR, Yamini B. Temozolomide Treatment Induces lncRNA MALAT1 in an NF-?B and p53 Codependent Manner in Glioblastoma. Cancer Res. 2019 May 15; 79(10):2536-2548. PMID: 30940658.
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Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C. Author Correction: Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature. 2019 Apr; 568(7751):E3. PMID: 30911170.
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Khan MK, Nasti TH, Buchwald ZS, Weichselbaum RR, Kron SJ. Repurposing Drugs for Cancer Radiotherapy: Early Successes and Emerging Opportunities. Cancer J. 2019 Mar/Apr; 25(2):106-115. PMID: 30896532.
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Han D, Liu J, Chen C, Dong L, Liu Y, Chang R, Huang X, Liu Y, Wang J, Dougherty U, Bissonnette MB, Shen B, Weichselbaum RR, Xu MM, He C. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells. Nature. 2019 02; 566(7743):270-274. PMID: 30728504.
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Foster CC, Sher DJ, Rusthoven CG, Verma V, Spiotto MT, Weichselbaum RR, Koshy M. Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis. Radiat Oncol. 2019 Jan 28; 14(1):18. PMID: 30691492.
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Huang L, David O, Cabay RJ, Valyi-Nagy K, Macias V, Zhong R, Wenig B, Feldman L, Weichselbaum R, Spiotto MT. Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer. Clin Cancer Res. 2019 Mar 15; 25(6):1795-1808. PMID: 30573692.
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Oshima G, Poli EC, Bolt MJ, Chlenski A, Forde M, Jutzy JMS, Biyani N, Posner MC, Pitroda SP, Weichselbaum RR, Khodarev NN. DNA Methylation Controls Metastasis-Suppressive 14q32-Encoded miRNAs. Cancer Res. 2019 02 01; 79(3):650-662. PMID: 30538122.
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Foster CC, Weichselbaum RR, Pitroda SP. Oligometastatic prostate cancer: Reality or figment of imagination? Cancer. 2019 Feb 01; 125(3):340-352. PMID: 30521067.
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Ranoa DRE, Widau RC, Mallon S, Parekh AD, Nicolae CM, Huang X, Bolt MJ, Arina A, Parry R, Kron SJ, Moldovan GL, Khodarev NN, Weichselbaum RR. STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability. Cancer Res. 2019 Apr 01; 79(7):1465-1479. PMID: 30482772.
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Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun. 2018 11 13; 9(1):4827. PMID: 30425251.
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Epel B, Maggio MC, Barth ED, Miller RC, Pelizzari CA, Krzykawska-Serda M, Sundramoorthy SV, Aydogan B, Weichselbaum RR, Tormyshev VM, Halpern HJ. Oxygen-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2019 Mar 15; 103(4):977-984. PMID: 30414912.
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Weichselbaum RR. The 46th David A. Karnofsky Memorial Award Lecture: Oligometastasis-From Conception to Treatment. J Clin Oncol. 2018 Sep 27; JCO1800847. PMID: 30260759.
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Romero-Calvo I, Weber CR, Ray M, Brown M, Kirby K, Nandi RK, Long TM, Sparrow SM, Ugolkov A, Qiang W, Zhang Y, Brunetti T, Kindler H, Segal JP, Rzhetsky A, Mazar AP, Buschmann MM, Weichselbaum R, Roggin K, White KP. Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors. Mol Cancer Res. 2019 01; 17(1):70-83. PMID: 30171177.
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Hou Y, Liang H, Rao E, Zheng W, Huang X, Deng L, Zhang Y, Yu X, Xu M, Mauceri H, Arina A, Weichselbaum RR, Fu YX. Non-canonical NF-?B Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Immunity. 2018 09 18; 49(3):490-503.e4. PMID: 30170810.
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Cai Y, Xue F, Quan C, Qu M, Liu N, Zhang Y, Fleming C, Hu X, Zhang HG, Weichselbaum R, Fu YX, Tieri D, Rouchka EC, Zheng J, Yan J. A Critical Role of the IL-1ß-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis. J Invest Dermatol. 2019 Jan; 139(1):146-156. PMID: 30120937.
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Lu K, Aung T, Guo N, Weichselbaum R, Lin W. Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. Adv Mater. 2018 Sep; 30(37):e1707634. PMID: 29971835.
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Wu L, Bernal GM, Cahill KE, Pytel P, Fitzpatrick CA, Mashek H, Weichselbaum RR, Yamini B. BCL3 expression promotes resistance to alkylating chemotherapy in gliomas. Sci Transl Med. 2018 Jul 04; 10(448). PMID: 29973405.
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Ni K, Lan G, Chan C, Quigley B, Lu K, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun. 2018 06 15; 9(1):2351. PMID: 29907739.
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Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun. 2018 05 04; 9(1):1793. PMID: 29728604.
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Murley JS, Arbiser JL, Weichselbaum RR, Grdina DJ. ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. Free Radic Biol Med. 2018 08 01; 123:39-52. PMID: 29660403.
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Hong JC, Ayala-Peacock DN, Lee J, Blackstock AW, Okunieff P, Sung MW, Weichselbaum RR, Kao J, Urbanic JJ, Milano MT, Chmura SJ, Salama JK. Classification for long-term survival in oligometastatic patients treated with ablative radiotherapy: A multi-institutional pooled analysis. PLoS One. 2018; 13(4):e0195149. PMID: 29649281.
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Chmura SJ, Connell PP, Weichselbaum RR. Retuning the Radio in Radiobiology. J Natl Cancer Inst. 2018 04 01; 110(4):325-326. PMID: 29126281.
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Lu K, He C, Guo N, Chan C, Ni K, Lan G, Tang H, Pelizzari C, Fu YX, Spiotto MT, Weichselbaum RR, Lin W. Low-dose X-ray radiotherapy-radiodynamic therapy via nanoscale metal-organic frameworks enhances checkpoint blockade immunotherapy. Nat Biomed Eng. 2018 Aug; 2(8):600-610. PMID: 31015630.
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Pitroda SP, Stack ME, Liu GF, Song SS, Chen L, Liang H, Parekh AD, Huang X, Roach P, Posner MC, Weichselbaum RR, Khodarev NN. JAK2 Inhibitor SAR302503 Abrogates PD-L1 Expression and Targets Therapy-Resistant Non-small Cell Lung Cancers. Mol Cancer Ther. 2018 04; 17(4):732-739. PMID: 29467274.
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Luke JJ, Lemons JM, Karrison TG, Pitroda SP, Melotek JM, Zha Y, Al-Hallaq HA, Arina A, Khodarev NN, Janisch L, Chang P, Patel JD, Fleming GF, Moroney J, Sharma MR, White JR, Ratain MJ, Gajewski TF, Weichselbaum RR, Chmura SJ. Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors. J Clin Oncol. 2018 06 01; 36(16):1611-1618. PMID: 29437535.
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Liang H, Deng L, Hou Y, Meng X, Huang X, Rao E, Zheng W, Mauceri H, Mack M, Xu M, Fu YX, Weichselbaum RR. Host STING-dependent MDSC mobilization drives extrinsic radiation resistance. Nat Commun. 2017 11 23; 8(1):1736. PMID: 29170400.
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Patel P, Oh AL, Koshy M, Sweiss K, Saraf SL, Quigley JG, Khan I, Mahmud N, Hacker E, Ozer H, Peace DJ, Weichselbaum RR, Aydogan B, Rondelli D. A phase 1 trial of autologous stem cell transplantation conditioned with melphalan 200?mg/m2 and total marrow irradiation (TMI) in patients with relapsed/refractory multiple myeloma. Leuk Lymphoma. 2018 07; 59(7):1666-1671. PMID: 29065747.
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Efimova EV, Ricco N, Labay E, Mauceri HJ, Flor AC, Ramamurthy A, Sutton HG, Weichselbaum RR, Kron SJ. HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Mol Cancer Ther. 2018 02; 17(2):407-418. PMID: 29030460.
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Spiotto MT, Jefferson GD, Wenig B, Markiewicz MR, Weichselbaum RR, Koshy M. Survival outcomes for postoperative chemoradiation in intermediate-risk oral tongue cancers. Head Neck. 2017 12; 39(12):2537-2548. PMID: 28960621.
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Koshy M, Sher DJ, Spiotto M, Husain Z, Engelhard H, Slavin K, Nicholas MK, Weichselbaum RR, Rusthoven C. Association between hospital volume and receipt of treatment and survival in patients with glioblastoma. J Neurooncol. 2017 Dec; 135(3):529-534. PMID: 28836140.
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Murley JS, Miller RC, Weichselbaum RR, Grdina DJ. TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response. Radiat Res. 2017 11; 188(5):579-590. PMID: 28813624.
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Xu MM, Pu Y, Han D, Shi Y, Cao X, Liang H, Chen X, Li XD, Deng L, Chen ZJ, Weichselbaum RR, Fu YX. Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein a Signaling. Immunity. 2017 08 15; 47(2):363-373.e5. PMID: 28801234.
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Chmura SJ, Weichselbaum RR. Rhythmic radiotherapy beats down TGF-ß. Cell Cycle. 2017 08 03; 16(15):1391. PMID: 28723240.
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Chmura SJ, Weichselbaum RR. Rhythmic radiotherapy beats down TGF-ß. Cell Cycle. 2017 Aug 03; 16(15):1391. PMID: 28727497.
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Spiotto MT, Jefferson G, Wenig B, Markiewicz M, Weichselbaum RR, Koshy M. Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis. JAMA Otolaryngol Head Neck Surg. 2017 07 01; 143(7):691-699. PMID: 28426848.
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Zhang Y, Kim TJ, Wroblewska JA, Tesic V, Upadhyay V, Weichselbaum RR, Tumanov AV, Tang H, Guo X, Tang H, Fu YX. Type 3 innate lymphoid cell-derived lymphotoxin prevents microbiota-dependent inflammation. Cell Mol Immunol. 2018 07; 15(7):697-709. PMID: 28579615.
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Oshima G, Guo N, He C, Stack ME, Poon C, Uppal A, Wightman SC, Parekh A, Skowron KB, Posner MC, Lin W, Khodarev NN, Weichselbaum RR. In Vivo Delivery and Therapeutic Effects of a MicroRNA on Colorectal Liver Metastases. Mol Ther. 2017 07 05; 25(7):1588-1595. PMID: 28457664.
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Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T. Tumour ischaemia by interferon-? resembles physiological blood vessel regression. Nature. 2017 05 04; 545(7652):98-102. PMID: 28445461.
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Pitroda SP, Bao R, Andrade J, Weichselbaum RR, Connell PP. Low Recombination Proficiency Score (RPS) Predicts Heightened Sensitivity to DNA-Damaging Chemotherapy in Breast Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4493-4500. PMID: 28341751.
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Shukla V, Dalela M, Vij M, Weichselbaum R, Kharbanda S, Ganguli M, Kufe D, Singh H. Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system. Nanomedicine. 2017 07; 13(5):1833-1839. PMID: 28343015.
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Rolle CE, Tan YC, Seiwert TY, Vora S, Kanteti R, Hasina R, Carey GB, Surati M, Weichselbaum RR, Lingen MW, Vokes EE, Salgia R. Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma. Oncotarget. 2017 Mar 21; 8(12):18726-18734. PMID: 27244893.
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Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME. CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response. Cell Rep. 2017 03 07; 18(10):2373-2386. PMID: 28273453.
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Weichselbaum RR, Liang H, Deng L, Fu YX. Radiotherapy and immunotherapy: a beneficial liaison? Nat Rev Clin Oncol. 2017 Jun; 14(6):365-379. PMID: 28094262.
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Arina A, Karrison T, Galka E, Schreiber K, Weichselbaum RR, Schreiber H. Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication. Cancer Immunol Res. 2017 02; 5(2):127-136. PMID: 28077434.
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Duan X, Chan C, Guo N, Han W, Weichselbaum RR, Lin W. Photodynamic Therapy Mediated by Nontoxic Core-Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer. J Am Chem Soc. 2016 12 28; 138(51):16686-16695. PMID: 27976881.
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Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR. Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-ß-Dependent Activation of Antigen-specific CD8+ T Cells. Mol Ther. 2010 May; 18(5):912-920. PMID: 28178556.
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Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp. 2016 11 30; (117). PMID: 27929457.
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Smith GL, Ganz PA, Bekelman JE, Chmura SJ, Dignam JJ, Efstathiou JA, Jagsi R, Johnstone PA, Steinberg ML, Williams SB, Yu JB, Zietman AL, Weichselbaum RR, Tina Shih YC. Promoting the Appropriate Use of Advanced Radiation Technologies in Oncology: Summary of a National Cancer Policy Forum Workshop. Int J Radiat Oncol Biol Phys. 2017 03 01; 97(3):450-461. PMID: 28011046.
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Skowron KB, Pitroda SP, Namm JP, Balogun O, Beckett MA, Zenner ML, Fayanju O, Huang X, Fernandez C, Zheng W, Qiao G, Chin R, Kron SJ, Khodarev NN, Posner MC, Steinberg GD, Weichselbaum RR. Basal Tumor Cell Isolation and Patient-Derived Xenograft Engraftment Identify High-Risk Clinical Bladder Cancers. Sci Rep. 2016 10 24; 6:35854. PMID: 27775025.
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Spiotto M, Fu YX, Weichselbaum RR. The intersection of radiotherapy and immunotherapy: mechanisms and clinical implications. Sci Immunol. 2016 Sep; 1(3). PMID: 28018989.
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Lu K, He C, Guo N, Chan C, Ni K, Weichselbaum RR, Lin W. Chlorin-Based Nanoscale Metal-Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J Am Chem Soc. 2016 09 28; 138(38):12502-10. PMID: 27575718.
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Appelbe OK, Zhang Q, Pelizzari CA, Weichselbaum RR, Kron SJ. Image-Guided Radiotherapy Targets Macromolecules through Altering the Tumor Microenvironment. Mol Pharm. 2016 10 03; 13(10):3457-3467. PMID: 27560921.
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He C, Duan X, Guo N, Chan C, Poon C, Weichselbaum RR, Lin W. Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy. Nat Commun. 2016 08 17; 7:12499. PMID: 27530650.
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Michelle Xu M, Pu Y, Weichselbaum RR, Fu YX. Integrating conventional and antibody-based targeted anticancer treatment into immunotherapy. Oncogene. 2017 02 02; 36(5):585-592. PMID: 27425593.
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Miller RC, Murley JS, Rademaker AW, Woloschak GE, Li JJ, Weichselbaum RR, Grdina DJ. Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity. Free Radic Biol Med. 2016 10; 99:110-119. PMID: 27427516.
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Zheng W, Skowron KB, Namm JP, Burnette B, Fernandez C, Arina A, Liang H, Spiotto MT, Posner MC, Fu YX, Weichselbaum RR. Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance. Oncotarget. 2016 Jul 12; 7(28):43039-43051. PMID: 27343548.
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Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7551-6. PMID: 27317748.
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Labay E, Mauceri HJ, Efimova EV, Flor AC, Sutton HG, Kron SJ, Weichselbaum RR. Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers. Oncotarget. 2016 Jun 07; 7(23):33919-33. PMID: 27129153.
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Liauw SL, Reddy AV, Weichselbaum RR, Smith ND, Steinberg GD. In Reply to Zaghloul. Int J Radiat Oncol Biol Phys. 2016 06 01; 95(2):855. PMID: 27131088.
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Wang T, Mathew B, Wu X, Shimizu Y, Rizzo AN, Dudek SM, Weichselbaum RR, Jacobson JR, Hecker L, Garcia JG. Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury. Pulm Circ. 2016 Jun; 6(2):234-9. PMID: 27252850.
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Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME, Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ. Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT). Cancer. 2016 07 15; 122(14):2242-50. PMID: 27206146.
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Drazer MW, Salama JK, Hahn OM, Weichselbaum RR, Chmura SJ. Stereotactic body radiotherapy for oligometastatic breast cancer: a new standard of care, or a medical reversal in waiting? Expert Rev Anticancer Ther. 2016 Jun; 16(6):625-32. PMID: 27078719.
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Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, Huang L, Andrade J, Staley JP, Satoh T, Akira S, Weichselbaum RR, Khodarev NN. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs. Oncotarget. 2016 May 03; 7(18):26496-515. PMID: 27034163.
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Koshy M, Malik R, Mahmood U, Husain Z, Weichselbaum RR, Sher DJ. Response. J Natl Cancer Inst. 2016 Mar; 108(3). PMID: 26744479.
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Leisegang M, Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Uckert W, Nakamura Y, Schreiber H. Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation. Clin Cancer Res. 2016 06 01; 22(11):2734-43. PMID: 26667491.
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Reddy AV, Pariser JJ, Pearce SM, Weichselbaum RR, Smith ND, Steinberg GD, Liauw SL. Patterns of Failure After Radical Cystectomy for pT3-4 Bladder Cancer: Implications for Adjuvant Radiation Therapy. Int J Radiat Oncol Biol Phys. 2016 Apr 01; 94(5):1031-9. PMID: 27026309.
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Efimova EV, Takahashi S, Shamsi NA, Wu D, Labay E, Ulanovskaya OA, Weichselbaum RR, Kozmin SA, Kron SJ. Linking Cancer Metabolism to DNA Repair and Accelerated Senescence. Mol Cancer Res. 2016 Feb; 14(2):173-84. PMID: 26538285.
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Mathew B, Takekoshi D, Sammani S, Epshtein Y, Sharma R, Smith BD, Mitra S, Desai AA, Weichselbaum RR, Garcia JG, Jacobson JR. Role of GADD45a in murine models of radiation- and bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1420-9. PMID: 26498248.
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Bronova I, Smith B, Aydogan B, Weichselbaum RR, Vemuri K, Erdelyi K, Makriyannis A, Pacher P, Berdyshev EV. Protection from Radiation-Induced Pulmonary Fibrosis by Peripheral Targeting of Cannabinoid Receptor-1. Am J Respir Cell Mol Biol. 2015 Oct; 53(4):555-62. PMID: 26426981.
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Koshy M, Malik R, Mahmood U, Husain Z, Weichselbaum RR, Sher DJ. Prevalence and Predictors of Inappropriate Delivery of Palliative Thoracic Radiotherapy for Metastatic Lung Cancer. J Natl Cancer Inst. 2015 Dec; 107(12):djv278. PMID: 26424779.
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Deng L, Liang H, Fu S, Weichselbaum RR, Fu YX. From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy. Clin Cancer Res. 2016 Jan 01; 22(1):20-5. PMID: 26362999.
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McCormick S, He Q, Stern J, Khodarev N, Weichselbaum R, Skelly CL. Evidence for the Use of Multiple Mechanisms by Herpes Simplex Virus-1 R7020 to Inhibit Intimal Hyperplasia. PLoS One. 2015; 10(7):e0130264. PMID: 26132411.
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Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Imaging of tumor clones with differential liver colonization. Sci Rep. 2015 Jun 22; 5:10946. PMID: 26094901.
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Binder DC, Fu YX, Weichselbaum RR. Radiotherapy and immune checkpoint blockade: potential interactions and future directions. Trends Mol Med. 2015 Aug; 21(8):463-5. PMID: 26091823.
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Wightman SC, Uppal A, Pitroda SP, Ganai S, Burnette B, Stack M, Oshima G, Khan S, Huang X, Posner MC, Weichselbaum RR, Khodarev NN. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. Br J Cancer. 2015 Jul 14; 113(2):327-35. PMID: 26042934.
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He C, Chan C, Weichselbaum RR, Fleming GF, Yamada SD, Lin W. Nanomedicine for Combination Therapy of Cancer. EBioMedicine. 2015 May; 2(5):366-7. PMID: 26137577.
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Mansour NM, Bernal GM, Wu L, Crawley CD, Cahill KE, Voce DJ, Balyasnikova IV, Zhang W, Spretz R, Nunez L, Larsen GF, Weichselbaum RR, Yamini B. Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. Cancer Res. 2015 May 15; 75(10):2039-48. PMID: 25808868.
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Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK. RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Res. 2015 Mar 31; 43(6):3180-96. PMID: 25765654.
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Khodarev NN, Pitroda SP, Weichselbaum RR. microRNAs and oligometastasis. Aging (Albany NY). 2015 Mar; 7(3):146-7. PMID: 25868522.
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Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. 14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncotarget. 2015 Feb 28; 6(6):3540-52. PMID: 25686838.
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Takahashi H, Jin C, Rajabi H, Pitroda S, Alam M, Ahmad R, Raina D, Hasegawa M, Suzuki Y, Tagde A, Bronson RT, Weichselbaum R, Kufe D. MUC1-C activates the TAK1 inflammatory pathway in colon cancer. Oncogene. 2015 Oct 01; 34(40):5187-97. PMID: 25659581.
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Koshy M, Malik R, Weichselbaum RR, Sher DJ. Increasing radiation therapy dose is associated with improved survival in patients undergoing stereotactic body radiation therapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2015 Feb 01; 91(2):344-50. PMID: 25636759.
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Koshy M, Malik R, Spiotto M, Mahmood U, Weichselbaum R, Sher D. Disparities in treatment of patients with inoperable stage I non-small cell lung cancer: a population-based analysis. J Thorac Oncol. 2015 Feb; 10(2):264-71. PMID: 25371079.
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Crawley CD, Kang S, Bernal GM, Wahlstrom JS, Voce DJ, Cahill KE, Garofalo A, Raleigh DR, Weichselbaum RR, Yamini B. S-phase-dependent p50/NF-?B1 phosphorylation in response to ATR and replication stress acts to maintain genomic stability. Cell Cycle. 2015; 14(4):566-76. PMID: 25590437.
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Burnette B, Weichselbaum RR. The immunology of ablative radiation. Semin Radiat Oncol. 2015 Jan; 25(1):40-5. PMID: 25481265.
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Keck MK, Zuo Z, Khattri A, Stricker TP, Brown CD, Imanguli M, Rieke D, Endhardt K, Fang P, Brägelmann J, DeBoer R, El-Dinali M, Aktolga S, Lei Z, Tan P, Rozen SG, Salgia R, Weichselbaum RR, Lingen MW, Story MD, Ang KK, Cohen EE, White KP, Vokes EE, Seiwert TY. Integrative analysis of head and neck cancer identifies two biologically distinct HPV and three non-HPV subtypes. Clin Cancer Res. 2015 Feb 15; 21(4):870-81. PMID: 25492084.
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Sur MD, In H, Sharpe SM, Baker MS, Weichselbaum RR, Talamonti MS, Posner MC. Defining the Benefit of Adjuvant Therapy Following Resection for Intrahepatic Cholangiocarcinoma. Ann Surg Oncol. 2015 Jul; 22(7):2209-17. PMID: 25476031.
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Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, Huang X, Gajewski TF, Chen ZJ, Fu YX, Weichselbaum RR. STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. Immunity. 2014 Nov 20; 41(5):843-52. PMID: 25517616.
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Bernal GM, Wahlstrom JS, Crawley CD, Cahill KE, Pytel P, Liang H, Kang S, Weichselbaum RR, Yamini B. Loss of Nfkb1 leads to early onset aging. Aging (Albany NY). 2014 Nov; 6(11):931-43. PMID: 25553648.
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Patel P, Aydogan B, Koshy M, Mahmud D, Oh A, Saraf SL, Quigley JG, Khan I, Sweiss K, Mahmud N, Peace DJ, DeMasi V, Awan AM, Weichselbaum RR, Rondelli D. Combination of linear accelerator-based intensity-modulated total marrow irradiation and myeloablative fludarabine/busulfan: a phase I study. Biol Blood Marrow Transplant. 2014 Dec; 20(12):2034-41. PMID: 25234438.
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Seiwert TY, Zuo Z, Keck MK, Khattri A, Pedamallu CS, Stricker T, Brown C, Pugh TJ, Stojanov P, Cho J, Lawrence MS, Getz G, Brägelmann J, DeBoer R, Weichselbaum RR, Langerman A, Portugal L, Blair E, Stenson K, Lingen MW, Cohen EE, Vokes EE, White KP, Hammerman PS. Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas. Clin Cancer Res. 2015 Feb 01; 21(3):632-41. PMID: 25056374.
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Voce DJ, Schmitt AM, Uppal A, McNerney ME, Bernal GM, Cahill KE, Wahlstrom JS, Nassiri A, Yu X, Crawley CD, White KP, Onel K, Weichselbaum RR, Yamini B. Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor. Oncogene. 2015 May 21; 34(21):2807-13. PMID: 25043302.
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Seiwert TY, Wang X, Heitmann J, Villegas-Bergazzi V, Sprott K, Finn S, O'Regan E, Farrow AD, Weichselbaum RR, Lingen MW, Cohen EE, Stenson K, Weaver DT, Vokes EE. DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. PLoS One. 2014; 9(7):e102112. PMID: 25019640.
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Heitmann J, Geeleher P, Zuo Z, Weichselbaum RR, Vokes EE, Fetscher S, Seiwert TY. Poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer. Oral Oncol. 2014 Sep; 50(9):825-31. PMID: 25017803.
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Uppal A, Ferguson MK, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs. Clin Exp Metastasis. 2014 Aug; 31(6):735-48. PMID: 24968866.
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Palma DA, Salama JK, Lo SS, Senan S, Treasure T, Govindan R, Weichselbaum R. The oligometastatic state - separating truth from wishful thinking. Nat Rev Clin Oncol. 2014 09; 11(9):549-57. PMID: 24958182.
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Koshy M, Malik R, Sher DJ, Spiotto M, Mahmood U, Aydogan B, Weichselbaum RR. The effect of radiotherapy dose on survival in stage III non-small-cell lung cancer patients undergoing definitive chemoradiotherapy. Clin Lung Cancer. 2014 Sep; 15(5):365-71. PMID: 24984565.
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Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul 01; 74(13):3546-55. PMID: 24753542.
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Uppal A, Wightman SC, Ganai S, Weichselbaum RR, An G. Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model. Theor Biol Med Model. 2014 Apr 12; 11:17. PMID: 24725600.
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Spiotto MT, Weichselbaum RR. Comparison of 3D confromal radiotherapy and intensity modulated radiotherapy with or without simultaneous integrated boost during concurrent chemoradiation for locally advanced head and neck cancers. PLoS One. 2014; 9(4):e94456. PMID: 24714187.
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Pitroda SP, Pashtan IM, Logan HL, Budke B, Darga TE, Weichselbaum RR, Connell PP. DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy. Sci Transl Med. 2014 Mar 26; 6(229):229ra42. PMID: 24670686.
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Uppal A, Weichselbaum RR, Posner MC. Optimizing management of colorectal hepatic metastases: now and in the future. Eur J Surg Oncol. 2014 Sep; 40(9):1033-5. PMID: 24703655.
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Markert JM, Razdan SN, Kuo HC, Cantor A, Knoll A, Karrasch M, Nabors LB, Markiewicz M, Agee BS, Coleman JM, Lakeman AD, Palmer CA, Parker JN, Whitley RJ, Weichselbaum RR, Fiveash JB, Gillespie GY. A phase 1 trial of oncolytic HSV-1, G207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses. Mol Ther. 2014 May; 22(5):1048-55. PMID: 24572293.
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Tye K, Engelhard HH, Slavin KV, Nicholas MK, Chmura SJ, Kwok Y, Ho DS, Weichselbaum RR, Koshy M. An analysis of radiation necrosis of the central nervous system treated with bevacizumab. J Neurooncol. 2014 Apr; 117(2):321-7. PMID: 24504500.
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Chmura SJ, Salama JK, Weichselbaum RR. Stereotactic radiotherapy for pulmonary metastases. Semin Thorac Cardiovasc Surg. 2013; 25(4):292-9. PMID: 24673958.
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Widau RC, Parekh AD, Ranck MC, Golden DW, Kumar KA, Sood RF, Pitroda SP, Liao Z, Huang X, Darga TE, Xu D, Huang L, Andrade J, Roizman B, Weichselbaum RR, Khodarev NN. RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):E484-91. PMID: 24434553.
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Yang X, Zhang X, Fu ML, Weichselbaum RR, Gajewski TF, Guo Y, Fu YX. Targeting the tumor microenvironment with interferon-ß bridges innate and adaptive immune responses. Cancer Cell. 2014 Jan 13; 25(1):37-48. PMID: 24434209.
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Deng L, Liang H, Burnette B, Beckett M, Darga T, Weichselbaum RR, Fu YX. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest. 2014 Feb; 124(2):687-95. PMID: 24382348.
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Ranck MC, Abundo R, Jefferson G, Kolokythas A, Wenig BL, Weichselbaum RR, Spiotto MT. Effect of postradiotherapy neck dissection on nonregional disease sites. JAMA Otolaryngol Head Neck Surg. 2014 Jan; 140(1):12-21. PMID: 24263403.
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Ranck MC, Golden DW, Corbin KS, Hasselle MD, Liauw SL, Stadler WM, Hahn OM, Weichselbaum RR, Salama JK. Stereotactic body radiotherapy for the treatment of oligometastatic renal cell carcinoma. Am J Clin Oncol. 2013 Dec; 36(6):589-95. PMID: 22868242.
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Connell PP, Weichselbaum RR. Small molecule derived from a natural product that mitigates radiation injury. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18355-6. PMID: 24187150.
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Zakeri K, MacEwan I, Vazirnia A, Cohen EE, Spiotto MT, Haraf DJ, Vokes EE, Weichselbaum RR, Mell LK. Race and competing mortality in advanced head and neck cancer. Oral Oncol. 2014 Jan; 50(1):40-4. PMID: 24134948.
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Liu GF, Ranck MC, Solanki AA, Cao H, Kolokythas A, Wenig BL, Chen L, Ard S, Weichselbaum RR, Halpern H, Spiotto MT. Racial parities in outcomes after radiotherapy for head and neck cancer. Cancer. 2014 Jan 15; 120(2):244-52. PMID: 24122486.
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Burnette B, Weichselbaum RR. Radiation as an immune modulator. Semin Radiat Oncol. 2013 Oct; 23(4):273-80. PMID: 24012341.
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Herman LC, Chen L, Garnett A, Feldman LE, Smith B, Weichselbaum RR, Spiotto MT. Comparison of carboplatin-paclitaxel to docetaxel-cisplatin-5-flurouracil induction chemotherapy followed by concurrent chemoradiation for locally advanced head and neck cancer. Oral Oncol. 2014 Jan; 50(1):52-8. PMID: 24055193.
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Stancevic B, Varda-Bloom N, Cheng J, Fuller JD, Rotolo JA, García-Barros M, Feldman R, Rao S, Weichselbaum RR, Harats D, Haimovitz-Friedman A, Fuks Z, Sadelain M, Kolesnick R. Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure. PLoS One. 2013; 8(8):e69025. PMID: 23936314.
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Mathew B, Jacobson JR, Siegler JH, Moitra J, Blasco M, Xie L, Unzueta C, Zhou T, Evenoski C, Al-Sakka M, Sharma R, Huey B, Bulent A, Smith B, Jayaraman S, Reddy NM, Reddy SP, Fingerle-Rowson G, Bucala R, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JG. Role of migratory inhibition factor in age-related susceptibility to radiation lung injury via NF-E2-related factor-2 and antioxidant regulation. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):269-78. PMID: 23526214.
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Bernal GM, LaRiviere MJ, Mansour N, Pytel P, Cahill KE, Voce DJ, Kang S, Spretz R, Welp U, Noriega SE, Nunez L, Larsen GF, Weichselbaum RR, Yamini B. Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma. Nanomedicine. 2014 Jan; 10(1):149-57. PMID: 23891990.
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Elas M, Magwood JM, Butler B, Li C, Wardak R, DeVries R, Barth ED, Epel B, Rubinstein S, Pelizzari CA, Weichselbaum RR, Halpern HJ. EPR oxygen images predict tumor control by a 50% tumor control radiation dose. Cancer Res. 2013 Sep 01; 73(17):5328-35. PMID: 23861469.
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Liang H, Deng L, Burnette B, Weichselbaum RR, Fu YX. Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells. Oncoimmunology. 2013 Sep 01; 2(9):e25668. PMID: 24319637.
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Natarajan V, Dudek SM, Jacobson JR, Moreno-Vinasco L, Huang LS, Abassi T, Mathew B, Zhao Y, Wang L, Bittman R, Weichselbaum R, Berdyshev E, Garcia JG. Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):6-17. PMID: 23449739.
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Koshy M, Fedewa SA, Malik R, Ferguson MK, Vigneswaran WT, Feldman L, Howard A, Abdelhady K, Weichselbaum RR, Virgo KS. Improved survival associated with neoadjuvant chemoradiation in patients with clinical stage IIIA(N2) non-small-cell lung cancer. J Thorac Oncol. 2013 Jul; 8(7):915-22. PMID: 23608815.
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Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Li JJ, Woloschak GE, Weichselbaum RR. A survivin-associated adaptive response in radiation therapy. Cancer Res. 2013 Jul 15; 73(14):4418-28. PMID: 23651635.
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Liang H, Deng L, Chmura S, Burnette B, Liadis N, Darga T, Beckett MA, Lingen MW, Witt M, Weichselbaum RR, Fu YX. Radiation-induced equilibrium is a balance between tumor cell proliferation and T cell-mediated killing. J Immunol. 2013 Jun 01; 190(11):5874-81. PMID: 23630355.
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Corbin KS, Hellman S, Weichselbaum RR. Extracranial oligometastases: a subset of metastases curable with stereotactic radiotherapy. J Clin Oncol. 2013 Apr 10; 31(11):1384-90. PMID: 23460715.
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Liauw SL, Connell PP, Weichselbaum RR. New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci Transl Med. 2013 Feb 20; 5(173):173sr2. PMID: 23427246.
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Rudra S, Malik R, Ranck MC, Farrey K, Golden DW, Hasselle MD, Weichselbaum RR, Salama JK. Stereotactic body radiation therapy for curative treatment of adrenal metastases. Technol Cancer Res Treat. 2013 Jun; 12(3):217-24. PMID: 23369155.
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Solanki AA, Weichselbaum RR, Appelbaum D, Farrey K, Yenice KM, Chmura SJ, Salama JK. The utility of FDG-PET for assessing outcomes in oligometastatic cancer patients treated with stereotactic body radiotherapy: a cohort study. Radiat Oncol. 2012 Dec 18; 7:216. PMID: 23244066.
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Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Thirman MJ, Li JJ, Woloschak GE, Weichselbaum RR. A manganese superoxide dismutase (SOD2)-mediated adaptive response. Radiat Res. 2013 Feb; 179(2):115-24. PMID: 23237540.
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Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PLoS One. 2012; 7(12):e50141. PMID: 23251360.
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Crawley CD, Raleigh DR, Kang S, Voce DJ, Schmitt AM, Weichselbaum RR, Yamini B. DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-?B p50 and a single nucleotide in the ?B-site. Nucleic Acids Res. 2013 Jan; 41(2):764-74. PMID: 23180782.
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Seiwert TY, Darga T, Haraf D, Blair EA, Stenson K, Cohen EE, Salama JK, Villaflor V, Witt ME, Lingen MW, Weichselbaum RR, Vokes EE. A phase I dose escalation study of Ad GV.EGR.TNF.11D (TNFerade™ Biologic) with concurrent chemoradiotherapy in patients with recurrent head and neck cancer undergoing reirradiation. Ann Oncol. 2013 Mar; 24(3):769-76. PMID: 23104721.
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Burnette B, Fu YX, Weichselbaum RR. The confluence of radiotherapy and immunotherapy. Front Oncol. 2012; 2:143. PMID: 23087904.
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Poirot M, Silvente-Poirot S, Weichselbaum RR. Cholesterol metabolism and resistance to tamoxifen. Curr Opin Pharmacol. 2012 Dec; 12(6):683-9. PMID: 23063783.
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Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor endothelial inflammation predicts clinical outcome in diverse human cancers. PLoS One. 2012; 7(10):e46104. PMID: 23056240.
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Corbin KS, Ranck MC, Hasselle MD, Golden DW, Partouche J, Wu T, Chmura SJ, Weichselbaum RR, Salama JK. Feasibility and toxicity of hypofractionated image guided radiation therapy for large volume limited metastatic disease. Pract Radiat Oncol. 2013 Oct-Dec; 3(4):316-22. PMID: 24674404.
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Jin C, Rajabi H, Pitroda S, Li A, Kharbanda A, Weichselbaum R, Kufe D. Cooperative interaction between the MUC1-C oncoprotein and the Rab31 GTPase in estrogen receptor-positive breast cancer cells. PLoS One. 2012; 7(7):e39432. PMID: 22792175.
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Khodarev NN, Roizman B, Weichselbaum RR. Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth. Clin Cancer Res. 2012 Jun 01; 18(11):3015-21. PMID: 22615451.
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Gorshkova I, Zhou T, Mathew B, Jacobson JR, Takekoshi D, Bhattacharya P, Smith B, Aydogan B, Weichselbaum RR, Natarajan V, Garcia JG, Berdyshev EV. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. J Lipid Res. 2012 Aug; 53(8):1553-68. PMID: 22615416.
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Skelly CL, He Q, Spiguel L, McCormick S, Weichselbaum R. Modulating vascular intimal hyperplasia using HSV-1 mutant requires activated MEK. Gene Ther. 2013 Feb; 20(2):215-24. PMID: 22418062.
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Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Spleen cells from young but not old immunized mice eradicate large established cancers. Clin Cancer Res. 2012 May 01; 18(9):2526-33. PMID: 22415314.
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Meng Y, Efimova EV, Hamzeh KW, Darga TE, Mauceri HJ, Fu YX, Kron SJ, Weichselbaum RR. Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine. Mol Ther. 2012 May; 20(5):1046-55. PMID: 22334019.
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Hasselle MD, Haraf DJ, Rusthoven KE, Golden DW, Salgia R, Villaflor VM, Shah N, Hoffman PC, Chmura SJ, Connell PP, Vokes EE, Weichselbaum RR, Salama JK. Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer. J Thorac Oncol. 2012 Feb; 7(2):376-81. PMID: 22198429.
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Mauceri HJ, Sutton HG, Darga TE, Kocherginsky M, Kochanski J, Weichselbaum RR, Vokes EE. Everolimus exhibits efficacy as a radiosensitizer in a model of non-small cell lung cancer. Oncol Rep. 2012 May; 27(5):1625-9. PMID: 22294050.
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Duarte CW, Willey CD, Zhi D, Cui X, Harris JJ, Vaughan LK, Mehta T, McCubrey RO, Khodarev NN, Weichselbaum RR, Gillespie GY. Expression signature of IFN/STAT1 signaling genes predicts poor survival outcome in glioblastoma multiforme in a subtype-specific manner. PLoS One. 2012; 7(1):e29653. PMID: 22242177.
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Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PLoS One. 2011; 6(12):e28650. PMID: 22174856.
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Schmitt AM, Crawley CD, Kang S, Raleigh DR, Yu X, Wahlstrom JS, Voce DJ, Darga TE, Weichselbaum RR, Yamini B. p50 (NF-?B1) is an effector protein in the cytotoxic response to DNA methylation damage. Mol Cell. 2011 Dec 09; 44(5):785-96. PMID: 22152481.
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Soneru AP, Beckett MA, Weichselbaum RR, Lee RC. Mg ATP and antioxidants augment the radioprotective effect of surfactant copolymers. Health Phys. 2011 Dec; 101(6):731-8. PMID: 22048491.
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Elas M, Hleihel D, Barth ED, Haney CR, Ahn KH, Pelizzari CA, Epel B, Weichselbaum RR, Halpern HJ. Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice. Mol Imaging Biol. 2011 Dec; 13(6):1107-13. PMID: 20960236.
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Salama JK, Hasselle MD, Chmura SJ, Malik R, Mehta N, Yenice KM, Villaflor VM, Stadler WM, Hoffman PC, Cohen EE, Connell PP, Haraf DJ, Vokes EE, Hellman S, Weichselbaum RR. Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease. Cancer. 2012 Jun 01; 118(11):2962-70. PMID: 22020702.
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Koshy M, Villano JL, Dolecek TA, Howard A, Mahmood U, Chmura SJ, Weichselbaum RR, McCarthy BJ. Improved survival time trends for glioblastoma using the SEER 17 population-based registries. J Neurooncol. 2012 Mar; 107(1):207-12. PMID: 21984115.
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Murley JS, Baker KL, Miller RC, Darga TE, Weichselbaum RR, Grdina DJ. SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Nov 15; 51(10):1918-25. PMID: 21945096.
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Connell PP, Weichselbaum RR. A downside to apoptosis in cancer therapy? Nat Med. 2011 Jul 07; 17(7):780-2. PMID: 21738153.
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Wu TH, Schreiber K, Arina A, Khodarev NN, Efimova EV, Rowley DA, Weichselbaum RR, Schreiber H. Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes. Cancer Immun. 2011 Jun 30; 11:2. PMID: 21714479.
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Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, LaRiviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JG. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 2011 Oct; 25(10):3388-400. PMID: 21712494.
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Barreto-Andrade JC, Efimova EV, Mauceri HJ, Beckett MA, Sutton HG, Darga TE, Vokes EE, Posner MC, Kron SJ, Weichselbaum RR. Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation. Mol Cancer Ther. 2011 Jul; 10(7):1185-93. PMID: 21571912.
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Advani SJ, Markert JM, Sood RF, Samuel S, Gillespie GY, Shao MY, Roizman B, Weichselbaum RR. Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1. Gene Ther. 2011 Nov; 18(11):1098-102. PMID: 21544094.
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Weichselbaum RR, Hellman S. Oligometastases revisited. Nat Rev Clin Oncol. 2011 06; 8(6):378-82. PMID: 21423255.
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Labay E, Efimova EV, Quarshie BK, Golden DW, Weichselbaum RR, Kron SJ. Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence. Int J High Throughput Screen. 2011 Mar; 2:1-13. PMID: 26097382.
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Burnette BC, Liang H, Lee Y, Chlewicki L, Khodarev NN, Weichselbaum RR, Fu YX, Auh SL. The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity. Cancer Res. 2011 Apr 01; 71(7):2488-96. PMID: 21300764.
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Kuo WL, Liu J, Mauceri H, Vokes EE, Weichselbaum R, Rosner MR, Cohen EE. Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context. Mol Cancer Ther. 2010 Oct; 9(10):2814-24. PMID: 20876745.
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Mell LK, Jeong JH, Nichols MA, Polite BN, Weichselbaum RR, Chmura SJ. Predictors of competing mortality in early breast cancer. Cancer. 2010 Dec 01; 116(23):5365-73. PMID: 20737562.
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Gutt R, Liauw SL, Weichselbaum RR. The role of radiotherapy in locally advanced pancreatic carcinoma. Nat Rev Gastroenterol Hepatol. 2010 Aug; 7(8):437-47. PMID: 20628346.
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Efimova EV, Mauceri HJ, Golden DW, Labay E, Bindokas VP, Darga TE, Chakraborty C, Barreto-Andrade JC, Crawley C, Sutton HG, Kron SJ, Weichselbaum RR. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res. 2010 Aug 01; 70(15):6277-82. PMID: 20610628.
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Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen CT, LaRiviere PJ, Mauceri H, Sammani S, Husain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JG. Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):415-22. PMID: 20508068.
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MacDermed DM, Khodarev NN, Pitroda SP, Edwards DC, Pelizzari CA, Huang L, Kufe DW, Weichselbaum RR. MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients. BMC Med Genomics. 2010 May 06; 3:16. PMID: 20459602.
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Maitland ML, Lou XJ, Ramirez J, Desai AA, Berlin DS, McLeod HL, Weichselbaum RR, Ratain MJ, Altman RB, Klein TE. Vascular endothelial growth factor pathway. Pharmacogenet Genomics. 2010 May; 20(5):346-9. PMID: 20124951.
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Nichols MA, Mell LK, Hasselle MD, Karrison TG, MacDermed D, Meriwether A, Witt ME, Weichselbaum RR, Chmura SJ. Outcomes in black patients with early breast cancer treated with breast conservation therapy. Int J Radiat Oncol Biol Phys. 2011 Feb 01; 79(2):392-9. PMID: 20434849.
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Gutt R, Tonlaar N, Kunnavakkam R, Karrison T, Weichselbaum RR, Liauw SL. Statin use and risk of prostate cancer recurrence in men treated with radiation therapy. J Clin Oncol. 2010 Jun 01; 28(16):2653-9. PMID: 20421534.
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Lee Y, Yang X, Huang Y, Fan H, Zhang Q, Wu Y, Li J, Hasina R, Cheng C, Lingen MW, Gerstein MB, Weichselbaum RR, Xing HR, Lussier YA. Network modeling identifies molecular functions targeted by miR-204 to suppress head and neck tumor metastasis. PLoS Comput Biol. 2010 Apr 01; 6(4):e1000730. PMID: 20369013.
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Meng Y, Mauceri HJ, Khodarev NN, Darga TE, Pitroda SP, Beckett MA, Kufe DW, Weichselbaum RR. Ad.Egr-TNF and local ionizing radiation suppress metastases by interferon-beta-dependent activation of antigen-specific CD8+ T cells. Mol Ther. 2010 May; 18(5):912-20. PMID: 20197756.
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Huang L, Liao X, Beckett M, Li Y, Khanna KK, Wang Z, Kharbanda S, Weichselbaum R, Kufe D. MUC1-C Oncoprotein Interacts Directly with ATM and Promotes the DNA Damage Response to Ionizing Radiation. Genes Cancer. 2010 Mar; 1(3):239-250. PMID: 20865059.
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Meng Y, Beckett MA, Liang H, Mauceri HJ, van Rooijen N, Cohen KS, Weichselbaum RR. Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy. Cancer Res. 2010 Feb 15; 70(4):1534-43. PMID: 20145121.
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Mell LK, Dignam JJ, Salama JK, Cohen EE, Polite BN, Dandekar V, Bhate AD, Witt ME, Haraf DJ, Mittal BB, Vokes EE, Weichselbaum RR. Predictors of competing mortality in advanced head and neck cancer. J Clin Oncol. 2010 Jan 01; 28(1):15-20. PMID: 19933920.
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Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C, Joshi MD, MacDermed D, Weichselbaum R, Kufe D. Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene. 2010 Feb 11; 29(6):920-9. PMID: 19915608.
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Pitroda SP, Wakim BT, Sood RF, Beveridge MG, Beckett MA, MacDermed DM, Weichselbaum RR, Khodarev NN. STAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect. BMC Med. 2009 Nov 05; 7:68. PMID: 19891767.
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Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1041-52. PMID: 19833862.
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Uriel S, Labay E, Francis-Sedlak M, Moya ML, Weichselbaum RR, Ervin N, Cankova Z, Brey EM. Extraction and assembly of tissue-derived gels for cell culture and tissue engineering. Tissue Eng Part C Methods. 2009 Sep; 15(3):309-21. PMID: 19115821.
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Liauw SL, Stadler WM, Correa D, Weichselbaum RR, Jani AB. Dose-escalated radiotherapy for high-risk prostate cancer: outcomes in modern era with short-term androgen deprivation therapy. Int J Radiat Oncol Biol Phys. 2010 May 01; 77(1):125-30. PMID: 19695789.
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Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, Pelizzari CA. Characterization of response to radiation mediated gene therapy by means of multimodality imaging. Magn Reson Med. 2009 Aug; 62(2):348-56. PMID: 19449382.
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Cohen EE, Baru J, Huo D, Haraf DJ, Crowley M, Witt ME, Blair EA, Weichselbaum RR, Rosen F, Vokes EE, Stenson K. Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy. Head Neck. 2009 Aug; 31(8):1013-21. PMID: 19340870.
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Khodarev NN, Roach P, Pitroda SP, Golden DW, Bhayani M, Shao MY, Darga TE, Beveridge MG, Sood RF, Sutton HG, Beckett MA, Mauceri HJ, Posner MC, Weichselbaum RR. STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. PLoS One. 2009 Jun 08; 4(6):e5821. PMID: 19503789.
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Liauw SL, Weichselbaum RR, Rash C, Correa D, Al-Hallaq HA, Pelizzari CA, Jani AB. Biochemical control and toxicity after intensity-modulated radiation therapy for prostate cancer. Technol Cancer Res Treat. 2009 Jun; 8(3):201-6. PMID: 19445537.
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Weichselbaum RR, Kufe D. Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers. Cancer Gene Ther. 2009 Aug; 16(8):609-19. PMID: 19444302.
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Efimova EV, Liang H, Pitroda SP, Labay E, Darga TE, Levina V, Lokshin A, Roizman B, Weichselbaum RR, Khodarev NN. Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling. Int J Radiat Biol. 2009 May; 85(5):421-31. PMID: 19437244.
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Liauw SL, Fricano J, Correa D, Weichselbaum RR, Jani AB. Dose-escalated radiation therapy for intermediate-risk prostate cancer: patient selection for androgen deprivation therapy using percentage of positive cores. Cancer. 2009 Apr 15; 115(8):1784-90. PMID: 19208426.
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Lee Y, Auh SL, Wang Y, Burnette B, Wang Y, Meng Y, Beckett M, Sharma R, Chin R, Tu T, Weichselbaum RR, Fu YX. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood. 2009 Jul 16; 114(3):589-95. PMID: 19349616.
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Khodarev NN, Pitroda SP, Beckett MA, MacDermed DM, Huang L, Kufe DW, Weichselbaum RR. MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res. 2009 Apr 01; 69(7):2833-7. PMID: 19318547.
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Pitroda SP, Khodarev NN, Beckett MA, Kufe DW, Weichselbaum RR. MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5837-41. PMID: 19289846.
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Weichselbaum RR. MUCing around with tumor suppression. Cancer Biol Ther. 2008 Dec; 7(12):1968-9. PMID: 18981734.
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Spiguel LR, Chandiwal A, Vosicky JE, Weichselbaum RR, Skelly CL. Concomitant proliferation and caspase-3 mediated apoptosis in response to low shear stress and balloon injury. J Surg Res. 2010 Jun 01; 161(1):146-55. PMID: 19482308.
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Gutt R, Liauw SL, Weichselbaum RR. Adjuvant radiotherapy for resected pancreatic cancer: a lack of benefit or a lack of adequate trials? Nat Clin Pract Gastroenterol Hepatol. 2009 Jan; 6(1):38-46. PMID: 19029997.
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Weichselbaum RR, Ishwaran H, Yoon T, Nuyten DS, Baker SW, Khodarev N, Su AW, Shaikh AY, Roach P, Kreike B, Roizman B, Bergh J, Pawitan Y, van de Vijver MJ, Minn AJ. An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18490-5. PMID: 19001271.
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Al-Hallaq HA, Mell LK, Bradley JA, Chen LF, Ali AN, Weichselbaum RR, Newstead GM, Chmura SJ. Magnetic resonance imaging identifies multifocal and multicentric disease in breast cancer patients who are eligible for partial breast irradiation. Cancer. 2008 Nov 01; 113(9):2408-14. PMID: 18823018.
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Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy. Cancer Gene Ther. 2009 Apr; 16(4):373-81. PMID: 18974777.
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Jayathilaka K, Sheridan SD, Bold TD, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15848-53. PMID: 18840682.
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Macdermed DM, Weichselbaum RR, Salama JK. A rationale for the targeted treatment of oligometastases with radiotherapy. J Surg Oncol. 2008 Sep 01; 98(3):202-6. PMID: 18618604.
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Salama JK, Chmura SJ, Mehta N, Yenice KM, Stadler WM, Vokes EE, Haraf DJ, Hellman S, Weichselbaum RR. An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. Clin Cancer Res. 2008 Aug 15; 14(16):5255-9. PMID: 18698045.
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Seiwert TY, Haraf DJ, Cohen EE, Stenson K, Witt ME, Dekker A, Kocherginsky M, Weichselbaum RR, Chen HX, Vokes EE. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol. 2008 Apr 01; 26(10):1732-41. PMID: 18375903.
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Liauw SL, Weichselbaum RR, Zagaja GP, Jani AB. Salvage radiotherapy after postprostatectomy biochemical failure: does pretreatment radioimmunoscintigraphy help select patients with locally confined disease? Int J Radiat Oncol Biol Phys. 2008 Aug 01; 71(5):1316-21. PMID: 18234446.
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Bickenbach KA, Veerapong J, Shao MY, Mauceri HJ, Posner MC, Kron SJ, Weichselbaum RR. Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy. Cancer Gene Ther. 2008 Mar; 15(3):133-9. PMID: 18157146.
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Katdare M, Efimova EV, Labay E, Khodarev NN, Darga TE, Garofalo M, Nakamura S, Kufe DW, Posner MC, Weichselbaum RR. Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB. Int J Oncol. 2007 Dec; 31(6):1519-28. PMID: 17982679.
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Mell LK, Weichselbaum RR. More on cetuximab in head and neck cancer. N Engl J Med. 2007 Nov 22; 357(21):2201-2; author reply 2202-3. PMID: 18032774.
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Yamini B, Yu X, Pytel P, Galanopoulos N, Rawlani V, Veerapong J, Bickenbach K, Weichselbaum RR. Adenovirally delivered tumor necrosis factor-alpha improves the antiglioma efficacy of concomitant radiation and temozolomide therapy. Clin Cancer Res. 2007 Oct 15; 13(20):6217-23. PMID: 17947489.
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Roeske JC, Nunez L, Hoggarth M, Labay E, Weichselbaum RR. Characterization of the theorectical radiation dose enhancement from nanoparticles. Technol Cancer Res Treat. 2007 Oct; 6(5):395-401. PMID: 17877427.
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Khodarev NN, Minn AJ, Efimova EV, Darga TE, Labay E, Beckett M, Mauceri HJ, Roizman B, Weichselbaum RR. Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells. Cancer Res. 2007 Oct 01; 67(19):9214-20. PMID: 17909027.
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Smith KD, Shao MY, Posner MC, Weichselbaum RR. Tumor genotype determines susceptibility to oncolytic herpes simplex virus mutants: strategies for clinical application. Future Oncol. 2007 Oct; 3(5):545-56. PMID: 17927520.
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Advani SJ, Weichselbaum RR, Chmura SJ. Enhancing radiotherapy with genetically engineered viruses. J Clin Oncol. 2007 Sep 10; 25(26):4090-5. PMID: 17827458.
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Veerapong J, Bickenbach KA, Shao MY, Smith KD, Posner MC, Roizman B, Weichselbaum RR. Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity. Cancer Res. 2007 Sep 01; 67(17):8301-6. PMID: 17804745.
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MacGill RS, Davis TA, Macko J, Mauceri HJ, Weichselbaum RR, King CR. Local gene delivery of tumor necrosis factor alpha can impact primary tumor growth and metastases through a host-mediated response. Clin Exp Metastasis. 2007; 24(7):521-31. PMID: 17653822.
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Yamini B, Yu X, Dolan ME, Wu MH, Darga TE, Kufe DW, Weichselbaum RR. Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding. Cancer Res. 2007 Jul 15; 67(14):6889-98. PMID: 17638900.
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Skelly CL, Chandiwal A, Vosicky JE, Weichselbaum RR, Roizman B. Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12474-8. PMID: 17626787.
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Sharma RR, Weichselbaum RR. Angiogenesis inhibition: the next frontier in multimodal therapy for glioblastoma multiforme. Nat Clin Pract Oncol. 2007 Aug; 4(8):454-5. PMID: 17609654.
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Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, Yu P, Fu YX, Weichselbaum RR, Rowley DA, Kranz DM, Schreiber H. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med. 2007 Jan 22; 204(1):49-55. PMID: 17210731.
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Advani SJ, Mezhir JJ, Roizman B, Weichselbaum RR. ReVOLT: radiation-enhanced viral oncolytic therapy. Int J Radiat Oncol Biol Phys. 2006 Nov 01; 66(3):637-46. PMID: 17011442.
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Mezhir JJ, Smith KD, Kimchi ET, Park JO, Lopez CA, Mauceri HJ, Beckett MA, Hellman S, Weichselbaum RR, Posner MC. Establishment of a syngeneic model of hepatic colorectal oligometastases. J Surg Res. 2006 Dec; 136(2):288-93. PMID: 16930623.
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Kao J, Milano MT, Javaheri A, Garofalo MC, Chmura SJ, Weichselbaum RR, Kron SJ. gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy. Curr Cancer Drug Targets. 2006 May; 6(3):197-205. PMID: 16712457.
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Connell PP, Jayathilaka K, Haraf DJ, Weichselbaum RR, Vokes EE, Lingen MW. Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers. Int J Oncol. 2006 May; 28(5):1113-9. PMID: 16596227.
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Milano MT, Vokes EE, Kao J, Jackson W, List MA, Stenson KM, Witt ME, Dekker A, MacCracken E, Garofalo MC, Chmura SJ, Weichselbaum RR, Haraf DJ. Intensity-modulated radiation therapy in advanced head and neck patients treated with intensive chemoradiotherapy: preliminary experience and future directions. Int J Oncol. 2006 May; 28(5):1141-51. PMID: 16596230.
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Jani AB, Feinstein JM, Pasciak R, Krengel S, Weichselbaum RR. Role of external beam radiotherapy with low-dose-rate brachytherapy in treatment of prostate cancer. Urology. 2006 May; 67(5):1007-11. PMID: 16635512.
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Shafaee Z, Schmidt H, Du W, Posner M, Weichselbaum R. Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother Pharmacol. 2006 Dec; 58(6):765-70. PMID: 16552573.
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Smith KD, Mezhir JJ, Bickenbach K, Veerapong J, Charron J, Posner MC, Roizman B, Weichselbaum RR. Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1. J Virol. 2006 Feb; 80(3):1110-20. PMID: 16414988.
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Mezhir JJ, Smith KD, Posner MC, Senzer N, Yamini B, Kufe DW, Weichselbaum RR. Ionizing radiation: a genetic switch for cancer therapy. Cancer Gene Ther. 2006 Jan 01; 13(1):1-6. PMID: 16082378.
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Mezhir JJ, Schmidt H, Yamini B, Senzer NN, Posner MC, Kufe DW, Weichselbaum RR. Chemo-inducible gene therapy. Anticancer Drugs. 2005 Nov; 16(10):1053-8. PMID: 16222146.
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Mezhir JJ, Advani SJ, Smith KD, Darga TE, Poon AP, Schmidt H, Posner MC, Roizman B, Weichselbaum RR. Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses. Cancer Res. 2005 Oct 15; 65(20):9479-84. PMID: 16230412.
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Weichselbaum RR. Bugging the intestinal response to radiation. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13363-4. PMID: 16159964.
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Murphy KT, Wardak A, Beckett MA, Lopez CA, Mehta N, Kimchi E, Salloum RM, Jaskowiak NT, Posner MC, Ohno T, Kufe DW, Weichselbaum RR, Mauceri HJ. Forphenicinol enhances the antitumor effects of cyclophosphamide in a model of squamous cell carcinoma. Cancer Chemother Pharmacol. 2005 Sep; 56(3):317-21. PMID: 15887016.
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Weichselbaum RR. How does antiangiogenic therapy affect brain tumor response to radiation? Nat Clin Pract Oncol. 2005 May; 2(5):232-3. PMID: 16264953.
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Weichselbaum R. Radiation's outer limits. Nat Med. 2005 May; 11(5):477-8. PMID: 15875051.
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Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR, Khodarev NN. Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation. Cancer Res. 2005 Apr 15; 65(8):3146-54. PMID: 15833844.
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Milano MT, Vokes EE, Salama JK, Stenson KM, Kao J, Witt ME, Mittal BB, Argiris A, Weichselbaum RR, Haraf DJ. Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy. Int J Radiat Oncol Biol Phys. 2005 Mar 15; 61(4):1096-106. PMID: 15752889.
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Hellman S, Weichselbaum RR. Importance of local control in an era of systemic therapy. Nat Clin Pract Oncol. 2005 Feb; 2(2):60-1. PMID: 16264859.
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Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25; 280(12):11147-51. PMID: 15657060.
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Baldwin ZK, Chandiwal A, Balasubramanian V, Pearce BJ, Curi MA, Skelly CL, Huang WW, Vosicky JE, Roizman B, Weichselbaum RR, Schwartz LB. Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1. J Vasc Surg. 2005 Jan; 41(1):115-21. PMID: 15696053.
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Mehta N, Mauer AM, Hellman S, Haraf DJ, Cohen EE, Vokes EE, Weichselbaum RR. Analysis of further disease progression in metastatic non-small cell lung cancer: implications for locoregional treatment. Int J Oncol. 2004 Dec; 25(6):1677-83. PMID: 15547705.
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Khodarev NN, Kataoka Y, Murley JS, Weichselbaum RR, Grdina DJ. Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Int J Radiat Oncol Biol Phys. 2004 Oct 01; 60(2):553-63. PMID: 15380592.
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Yamini B, Yu X, Gillespie GY, Kufe DW, Weichselbaum RR. Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma. Cancer Res. 2004 Sep 15; 64(18):6381-4. PMID: 15374943.
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Greenebaum B, Blossfield K, Hannig J, Carrillo CS, Beckett MA, Weichselbaum RR, Lee RC. Poloxamer 188 prevents acute necrosis of adult skeletal muscle cells following high-dose irradiation. Burns. 2004 Sep; 30(6):539-47. PMID: 15302418.
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Mundt AJ, Vijayakumar S, Nemunaitis J, Sandler A, Schwartz H, Hanna N, Peabody T, Senzer N, Chu K, Rasmussen CS, Kessler PD, Rasmussen HS, Warso M, Kufe DW, Gupta TD, Weichselbaum RR. A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities. Clin Cancer Res. 2004 Sep 01; 10(17):5747-53. PMID: 15355902.
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Lopez CA, Kimchi ET, Mauceri HJ, Park JO, Mehta N, Murphy KT, Beckett MA, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Chemoinducible gene therapy: a strategy to enhance doxorubicin antitumor activity. Mol Cancer Ther. 2004 Sep; 3(9):1167-75. PMID: 15367711.
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Connell PP, Kron SJ, Weichselbaum RR. Relevance and irrelevance of DNA damage response to radiotherapy. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):1245-51. PMID: 15279813.
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Jani AB, Blend MJ, Hamilton R, Brendler C, Pelizzari C, Krauz L, Sapra B, Vijayakumar S, Awan A, Weichselbaum RR. Radioimmunoscintigraphy for postprostatectomy radiotherapy: analysis of toxicity and biochemical control. J Nucl Med. 2004 Aug; 45(8):1315-22. PMID: 15299055.
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Brown CK, Khodarev NN, Yu J, Moo-Young T, Labay E, Darga TE, Posner MC, Weichselbaum RR, Mauceri HJ. Glioblastoma cells block radiation-induced programmed cell death of endothelial cells. FEBS Lett. 2004 May 07; 565(1-3):167-70. PMID: 15135073.
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Connell PP, Siddiqui N, Hoffman S, Kuang A, Khatipov EA, Weichselbaum RR, Bishop DK. A hot spot for RAD51C interactions revealed by a peptide that sensitizes cells to cisplatin. Cancer Res. 2004 May 01; 64(9):3002-5. PMID: 15126333.
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Jani AB, Blend MJ, Hamilton R, Brendler C, Pelizzari C, Krauz L, Vijayakumar S, Sapra B, Awan A, Weichselbaum RR. Influence of radioimmunoscintigraphy on postprostatectomy radiotherapy treatment decision making. J Nucl Med. 2004 Apr; 45(4):571-8. PMID: 15073252.
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Khodarev NN, Labay E, Darga T, Yu J, Mauceri H, Gupta N, Kataoka Y, Weichselbaum RR. Endothelial cells co-cultured with wild-type and dominant/negative p53-transfected glioblastoma cells exhibit differential sensitivity to radiation-induced apoptosis. Int J Cancer. 2004 Mar 20; 109(2):214-9. PMID: 14750172.
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Lopez CA, Park JO, Mauceri HJ, Beckett MA, Weichselbaum RR, Posner MC. Control of gene therapy by MDR1 and EGR1 promoter sequences in transcriptional targeting by chemotherapy (Review). Int J Oncol. 2004 Mar; 24(3):731-6. PMID: 14767560.
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Jani AB, Spelbring D, Hamilton R, Blend MJ, Pelizzari C, Brendler C, Krauz L, Vijayakumar S, Sapra B, Weichselbaum RR. Impact of radioimmunoscintigraphy on definition of clinical target volume for radiotherapy after prostatectomy. J Nucl Med. 2004 Feb; 45(2):238-46. PMID: 14960642.
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Khodarev NN, Beckett M, Labay E, Darga T, Roizman B, Weichselbaum RR. STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells. Proc Natl Acad Sci U S A. 2004 Feb 10; 101(6):1714-9. PMID: 14755057.
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Senzer N, Mani S, Rosemurgy A, Nemunaitis J, Cunningham C, Guha C, Bayol N, Gillen M, Chu K, Rasmussen C, Rasmussen H, Kufe D, Weichselbaum R, Hanna N. TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. J Clin Oncol. 2004 Feb 15; 22(4):592-601. PMID: 14726502.
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Haraf DJ, Rosen FR, Stenson K, Argiris A, Mittal BB, Witt ME, Brockstein BE, List MA, Portugal L, Pelzer H, Weichselbaum RR, Vokes EE. Induction chemotherapy followed by concomitant TFHX chemoradiotherapy with reduced dose radiation in advanced head and neck cancer. Clin Cancer Res. 2003 Dec 01; 9(16 Pt 1):5936-43. PMID: 14676118.
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Advani SJ, Durand LO, Weichselbaum RR, Roizman B. Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1. J Virol. 2003 Nov; 77(22):11927-32. PMID: 14581529.
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Taneja N, Davis M, Choy JS, Beckett MA, Singh R, Kron SJ, Weichselbaum RR. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem. 2004 Jan 16; 279(3):2273-80. PMID: 14561744.
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Bartelink H, Benz C, Cleveland D, Dorn R, Gralow J, Gradishar WJ, Grant K, Heimann R, Hellman S, Hudis C, Kerbel R, Lippman M, Lung J, Posner MC, Steeg P, Vestal R, Weichselbaum RR, Zetter B. Expedition Inspiration Fund for Breast Cancer Research Meeting 2003. Breast Cancer Res Treat. 2003 Jul; 80(2):139-44. PMID: 12908816.
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Kufe D, Weichselbaum R. Radiation therapy: activation for gene transcription and the development of genetic radiotherapy-therapeutic strategies in oncology. Cancer Biol Ther. 2003 Jul-Aug; 2(4):326-9. PMID: 14508100.
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Connell PP, Weichselbaum RR. Gene therapy: the challenges of translating laboratory research into clinical practice. J Clin Oncol. 2003 Jun 15; 21(12):2230-1. PMID: 12805319.
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Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J Vasc Surg. 2003 Jun; 37(6):1294-300. PMID: 12764278.
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Rosen FR, Haraf DJ, Kies MS, Stenson K, Portugal L, List MA, Brockstein BE, Mittal BB, Rademaker AW, Witt ME, Pelzer H, Weichselbaum RR, Vokes EE. Multicenter randomized Phase II study of paclitaxel (1-hour infusion), fluorouracil, hydroxyurea, and concomitant twice daily radiation with or without erythropoietin for advanced head and neck cancer. Clin Cancer Res. 2003 May; 9(5):1689-97. PMID: 12738722.
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Oh JL, Vokes EE, Kies MS, Mittal BB, Witt ME, Weichselbaum RR, Haraf DJ. Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal cancer. Ann Oncol. 2003 Apr; 14(4):564-9. PMID: 12649102.
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Advani SJ, Weichselbaum RR, Roizman B. Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4825-30. PMID: 12665617.
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Khodarev NN, Yu J, Labay E, Darga T, Brown CK, Mauceri HJ, Yassari R, Gupta N, Weichselbaum RR. Tumour-endothelium interactions in co-culture: coordinated changes of gene expression profiles and phenotypic properties of endothelial cells. J Cell Sci. 2003 Mar 15; 116(Pt 6):1013-22. PMID: 12584245.
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Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B, Weichselbaum RR, Pelizzari CA. Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. Genomics. 2003 Feb; 81(2):202-9. PMID: 12620398.
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Gupta VK, Park JO, Kurihara T, Koons A, Mauceri HJ, Jaskowiak NT, Kufe DW, Weichselbaum RR, Posner MC. Selective gene expression using a DF3/MUC1 promoter in a human esophageal adenocarcinoma model. Gene Ther. 2003 Feb; 10(3):206-12. PMID: 12571627.
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Vokes EE, Stenson K, Rosen FR, Kies MS, Rademaker AW, Witt ME, Brockstein BE, List MA, Fung BB, Portugal L, Mittal BB, Pelzer H, Weichselbaum RR, Haraf DJ. Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer. J Clin Oncol. 2003 Jan 15; 21(2):320-6. PMID: 12525525.
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Gorski DH, Mauceri HJ, Salloum RM, Halpern A, Seetharam S, Weichselbaum RR. Prolonged treatment with angiostatin reduces metastatic burden during radiation therapy. Cancer Res. 2003 Jan 15; 63(2):308-11. PMID: 12543780.
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Salloum RM, Saunders MP, Mauceri HJ, Hanna NN, Gorski DH, Posner MC, Stratford IJ, Weichselbaum RR. Dual induction of the Epo-Egr-TNF-alpha- plasmid in hypoxic human colon adenocarcinoma produces tumor growth delay. Am Surg. 2003 Jan; 69(1):24-7. PMID: 12575775.
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Grdina DJ, Kataoka Y, Murley JS, Swedberg K, Lee JY, Hunter N, Weichselbaum RR, Milas L. Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol. 2002 Dec; 29(6 Suppl 19):22-8. PMID: 12577239.
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Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH, Mauceri HJ. Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol. 2002 Nov; 3(11):665-71. PMID: 12424068.
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Ren X, Cao C, Zhu L, Yoshida K, Kharbanda S, Weichselbaum R, Kufe D. Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor. Cancer Biol Ther. 2002 Nov-Dec; 1(6):703-8. PMID: 12642697.
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Rasmussen H, Rasmussen C, Lempicki M, Durham R, Brough D, King CR, Weichselbaum R. TNFerade Biologic: preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene. Cancer Gene Ther. 2002 Nov; 9(11):951-7. PMID: 12386834.
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Mauceri HJ, Seetharam S, Beckett MA, Schumm LP, Koons A, Gupta VK, Park JO, Manan A, Lee JY, Montag AG, Kufe DW, Weichselbaum RR. Angiostatin potentiates cyclophosphamide treatment of metastatic disease. Cancer Chemother Pharmacol. 2002 Nov; 50(5):412-8. PMID: 12439600.
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Advani SJ, Weichselbaum RR, Whitley RJ, Roizman B. Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications. Clin Microbiol Infect. 2002 Sep; 8(9):551-63. PMID: 12427216.
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Hogg RP, Honorio S, Martinez A, Agathanggelou A, Dallol A, Fullwood P, Weichselbaum R, Kuo MJ, Maher ER, Latif F. Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma. Eur J Cancer. 2002 Aug; 38(12):1585-92. PMID: 12142046.
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Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Transcriptional control of viral gene therapy by cisplatin. J Clin Invest. 2002 Aug; 110(3):403-10. PMID: 12163460.
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Gupta VK, Park JO, Jaskowiak NT, Mauceri HJ, Seetharam S, Weichselbaum RR, Posner MC. Combined gene therapy and ionizing radiation is a novel approach to treat human esophageal adenocarcinoma. Ann Surg Oncol. 2002 Jun; 9(5):500-4. PMID: 12052763.
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Kataoka Y, Murley JS, Khodarev NN, Weichselbaum RR, Grdina DJ. Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Int J Radiat Oncol Biol Phys. 2002 May 01; 53(1):180-9. PMID: 12007958.
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Mauceri HJ, Seetharam S, Beckett MA, Lee JY, Gupta VK, Gately S, Stack MS, Brown CK, Swedberg K, Kufe DW, Weichselbaum RR. Tumor production of angiostatin is enhanced after exposure to TNF-alpha. Int J Cancer. 2002 Feb 01; 97(4):410-5. PMID: 11802200.
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Khodarev NN, Yu J, Nodzenski E, Murley JS, Kataoka Y, Brown CK, Grdina DJ, Weichselbaum RR. Method of RNA purification from endothelial cells for DNA array experiments. Biotechniques. 2002 Feb; 32(2):316, 318, 320. PMID: 11848408.
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Grdina DJ, Kataoka Y, Murley JS, Hunter N, Weichselbaum RR, Milas L. Inhibition of spontaneous metastases formation by amifostine. Int J Cancer. 2002 Jan 10; 97(2):135-41. PMID: 11774255.
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Chung SM, Advani SJ, Bradley JD, Kataoka Y, Vashistha K, Yan SY, Markert JM, Gillespie GY, Whitley RJ, Roizman B, Weichselbaum RR. The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma. Gene Ther. 2002 Jan; 9(1):75-80. PMID: 11850725.
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Gupta VK, Jaskowiak NT, Beckett MA, Mauceri HJ, Grunstein J, Johnson RS, Calvin DA, Nodzenski E, Pejovic M, Kufe DW, Posner MC, Weichselbaum RR. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J. 2002 Jan-Feb; 8(1):47-54. PMID: 11895203.
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Abdalla I, Ignacio L, Vaida F. Evolution of toxicity after conformal radiotherapy for prostate cancer. Prostate Cancer Prostatic Dis. 2002; 5(4):296-303. PMID: 12627215.
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Jani AB, Vaida F, Hanks G, Asbell S, Sartor O, Moul JW, Roach M, Brachman D, Kalokhe U, Muller-Runkel R, Ray P, Ignacio L, Awan A, Weichselbaum RR, Vijayakumar S. Changing face and different countenances of prostate cancer: racial and geographic differences in prostate-specific antigen (PSA), stage, and grade trends in the PSA era. Int J Cancer. 2001 Dec 20; 96(6):363-71. PMID: 11745507.
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Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo. Gene Ther. 2001 Dec; 8(24):1840-6. PMID: 11821937.
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Yin L, Ohno T, Weichselbaum R, Kharbanda S, Kufe D. The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther. 2001 Nov; 1(1):43-8. PMID: 12467237.
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Advani SJ, Weichselbaum RR, Roizman B. cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor. J Virol. 2001 Nov; 75(21):10326-33. PMID: 11581401.
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Khodarev NN, Park JO, Yu J, Gupta N, Nodzenski E, Roizman B, Weichselbaum RR. Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12665-70. PMID: 11675498.
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Mauceri HJ, Seetharam S, Salloum RM, Vokes EE, Weichselbaum RR. Treatment of head and neck and esophageal xenografts employing Alimta and concurrent ionizing radiation. Int J Oncol. 2001 Oct; 19(4):833-5. PMID: 11562763.
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Gupta N, Wang H, McLeod TL, Naus CC, Kyurkchiev S, Advani S, Yu J, Perbal B, Weichselbaum RR. Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Mol Pathol. 2001 Oct; 54(5):293-9. PMID: 11577170.
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Chmura SJ, Gupta N, Advani SJ, Kufe DW, Weichselbaum RR. Prospects for viral-based strategies enhancing the anti-tumor effects of ionizing radiation. Semin Radiat Oncol. 2001 Oct; 11(4):338-45. PMID: 11677658.
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Advani SJ, Hagglund R, Weichselbaum RR, Roizman B. Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize. J Virol. 2001 Sep; 75(17):7904-12. PMID: 11483735.
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Gasior SL, Olivares H, Ear U, Hari DM, Weichselbaum R, Bishop DK. Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8411-8. PMID: 11459983.
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Sharma A, Mani S, Hanna N, Guha C, Vikram B, Weichselbaum RR, Sparano J, Sood B, Lee D, Regine W, Muhodin M, Valentino J, Herman J, Desimone P, Arnold S, Carrico J, Rockich AK, Warner-Carpenter J, Barton-Baxter M. Clinical protocol. An open-label, phase I, dose-escalation study of tumor necrosis factor-alpha (TNFerade Biologic) gene transfer with radiation therapy for locally advanced, recurrent, or metastatic solid tumors. Hum Gene Ther. 2001 Jun 10; 12(9):1109-31. PMID: 11399232.
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Gupta N, Nodzenski E, Khodarev NN, Yu J, Khorasani L, Beckett MA, Kufe DW, Weichselbaum RR. Angiostatin effects on endothelial cells mediated by ceramide and RhoA. EMBO Rep. 2001 Jun; 2(6):536-40. PMID: 11415988.
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Kies MS, Haraf DJ, Rosen F, Stenson K, List M, Brockstein B, Chung T, Mittal BB, Pelzer H, Portugal L, Rademaker A, Weichselbaum R, Vokes EE. Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J Clin Oncol. 2001 Apr 01; 19(7):1961-9. PMID: 11283128.
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Mantz CA, Vokes EE, Kies MS, Mittal B, Witt ME, List MA, Weichselbaum RR, Haraf DJ. Sequential induction chemotherapy and concomitant chemoradiotherapy in the management of locoregionally advanced laryngeal cancer. Ann Oncol. 2001 Mar; 12(3):343-7. PMID: 11332146.
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Mantz CA, Vokes EE, Stenson K, Kies MS, Mittal B, Witt ME, List MA, Weichselbaum RR, Haraf DJ. Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced oropharyngeal cancer. Cancer J. 2001 Mar-Apr; 7(2):140-8. PMID: 11324767.
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Ito Y, Pandey P, Sathyanarayana P, Ling P, Rana A, Weichselbaum R, Tan TH, Kufe D, Kharbanda S. Interaction of hematopoietic progenitor kinase 1 and c-Abl tyrosine kinase in response to genotoxic stress. J Biol Chem. 2001 May 25; 276(21):18130-8. PMID: 11278340.
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Weichselbaum RR, Kufe DW, Advani SJ, Roizman B. Molecular targeting of gene therapy and radiotherapy. Acta Oncol. 2001; 40(6):735-8. PMID: 11765068.
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Connell PP, Ignacio L, Haraf D, Awan AM, Halpern H, Abdalla I, Nautiyal J, Jani AB, Weichselbaum RR, Vijayakumar S. Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience. J Clin Oncol. 2001 Jan 01; 19(1):54-61. PMID: 11134195.
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Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15; 60(24):6958-63. PMID: 11156396.
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Pelizzari CA, Khodarev NN, Gupta N, Calvin DP, Weichselbaum RR. Quantitative analysis of DNA array autoradiographs. Nucleic Acids Res. 2000 Nov 15; 28(22):4577-81. PMID: 11071949.
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Advani SJ, Weichselbaum RR, Roizman B. The role of cdc2 in the expression of herpes simplex virus genes. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10996-1001. PMID: 10995483.
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Hanna NN, Seetharam S, Mauceri HJ, Beckett MA, Jaskowiak NT, Salloum RM, Hari D, Dhanabal M, Ramchandran R, Kalluri R, Sukhatme VP, Kufe DW, Weichselbaum RR. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J. 2000 Sep-Oct; 6(5):287-93. PMID: 11079167.
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Advani SJ, Weichselbaum RR, Roizman B. E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1. J Virol. 2000 Sep; 74(17):7842-50. PMID: 10933691.
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Pandey P, Saleh A, Nakazawa A, Kumar S, Srinivasula SM, Kumar V, Weichselbaum R, Nalin C, Alnemri ES, Kufe D, Kharbanda S. Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90. EMBO J. 2000 Aug 15; 19(16):4310-22. PMID: 10944114.
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Bhattacharyya A, Ear US, Koller BH, Weichselbaum RR, Bishop DK. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. J Biol Chem. 2000 Aug 04; 275(31):23899-903. PMID: 10843985.
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Schwartz JL, Jordan R, Kaufmann WK, Rasey J, Russell KJ, Weichselbaum RR. Evidence for the expression of radiation-induced potentially lethal damage being a p53-dependent process. Int J Radiat Biol. 2000 Aug; 76(8):1037-43. PMID: 10947116.
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Yoshida K, Weichselbaum R, Kharbanda S, Kufe D. Role for Lyn tyrosine kinase as a regulator of stress-activated protein kinase activity in response to DNA damage. Mol Cell Biol. 2000 Aug; 20(15):5370-80. PMID: 10891478.
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Stenson KM, Haraf DJ, Pelzer H, Recant W, Kies MS, Weichselbaum RR, Vokes EE. The role of cervical lymphadenectomy after aggressive concomitant chemoradiotherapy: the feasibility of selective neck dissection. Arch Otolaryngol Head Neck Surg. 2000 Aug; 126(8):950-6. PMID: 10922226.
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Hannig J, Zhang D, Canaday DJ, Beckett MA, Astumian RD, Weichselbaum RR, Lee RC. Surfactant sealing of membranes permeabilized by ionizing radiation. Radiat Res. 2000 Aug; 154(2):171-7. PMID: 10931689.
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Kharbanda S, Pandey P, Yamauchi T, Kumar S, Kaneki M, Kumar V, Bharti A, Yuan ZM, Ghanem L, Rana A, Weichselbaum R, Johnson G, Kufe D. Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol Cell Biol. 2000 Jul; 20(14):4979-89. PMID: 10866655.
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Sun X, Majumder P, Shioya H, Wu F, Kumar S, Weichselbaum R, Kharbanda S, Kufe D. Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem. 2000 Jun 09; 275(23):17237-40. PMID: 10770918.
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Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R. Anti-angiogenic cues from vascular basement membrane collagen. Cancer Res. 2000 May 01; 60(9):2520-6. PMID: 10811134.
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Hari D, Beckett MA, Sukhatme VP, Dhanabal M, Nodzenski E, Lu H, Mauceri HJ, Kufe DW, Weichselbaum RR. Angiostatin induces mitotic cell death of proliferating endothelial cells. Mol Cell Biol Res Commun. 2000 May; 3(5):277-82. PMID: 10964751.
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Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J Biol Chem. 2000 Apr 14; 275(15):10779-87. PMID: 10753870.
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Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum R, Kufe D, Kharbanda S. Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3. Oncogene. 2000 Apr 13; 19(16):1975-81. PMID: 10803458.
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Chmura SJ, Nodzenski E, Kharbanda S, Pandey P, Quintans J, Kufe DW, Weichselbaum RR. Down-regulation of ceramide production abrogates ionizing radiation-induced cytochrome c release and apoptosis. Mol Pharmacol. 2000 Apr; 57(4):792-6. PMID: 10727527.
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Fortunato JE, Mauceri HJ, Kocharyan H, Song RH, Salloum R, Vosicky J, Swedberg K, Malik S, Abusharif F, Glagov S, Weichselbaum RR, Bassiouny HS. Gene therapy enhances the antiproliferative effect of radiation in intimal hyperplasia. J Surg Res. 2000 Apr; 89(2):155-62. PMID: 10729244.
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Vokes EE, Kies MS, Haraf DJ, Stenson K, List M, Humerickhouse R, Dolan ME, Pelzer H, Sulzen L, Witt ME, Hsieh YC, Mittal BB, Weichselbaum RR. Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J Clin Oncol. 2000 Apr; 18(8):1652-61. PMID: 10764425.
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Stenson KM, MacCracken E, List M, Haraf DJ, Brockstein B, Weichselbaum R, Vokes EE. Swallowing function in patients with head and neck cancer prior to treatment. Arch Otolaryngol Head Neck Surg. 2000 Mar; 126(3):371-7. PMID: 10722011.
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Chmura SJ, Dolan ME, Cha A, Mauceri HJ, Kufe DW, Weichselbaum RR. In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo. Clin Cancer Res. 2000 Feb; 6(2):737-42. PMID: 10690561.
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Kharbanda S, Saxena S, Yoshida K, Pandey P, Kaneki M, Wang Q, Cheng K, Chen YN, Campbell A, Sudha T, Yuan ZM, Narula J, Weichselbaum R, Nalin C, Kufe D. Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage. J Biol Chem. 2000 Jan 07; 275(1):322-7. PMID: 10617621.
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Markert JM, Gillespie GY, Weichselbaum RR, Roizman B, Whitley RJ. Genetically engineered HSV in the treatment of glioma: a review. Rev Med Virol. 2000 Jan-Feb; 10(1):17-30. PMID: 10654002.
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Advani SJ, Brandimarti R, Weichselbaum RR, Roizman B. The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes. J Virol. 2000 Jan; 74(1):8-15. PMID: 10590085.
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Connell PP, Ignacio L, McBride RB, Weichselbaum RR, Vijayakumar S. Caution in interpreting biochemical control rates after treatment of prostate cancer: length of follow-up influences results. Urology. 1999 Nov; 54(5):875-9. PMID: 10565750.
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Terry MA, Hannig J, Carrillo CS, Beckett MA, Weichselbaum RR, Lee RC. Oxidative cell membrane alteration. Evidence for surfactant-mediated sealing. Ann N Y Acad Sci. 1999 Oct 30; 888:274-84. PMID: 10842639.
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Khodarev NN, Advani SJ, Gupta N, Roizman B, Weichselbaum RR. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):12062-7. PMID: 10518576.
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Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Shi Y, Weichselbaum R, Kufe D. Function for p300 and not CBP in the apoptotic response to DNA damage. Oncogene. 1999 Oct 07; 18(41):5714-7. PMID: 10523850.
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Morrison C, Shinohara A, Sonoda E, Yamaguchi-Iwai Y, Takata M, Weichselbaum RR, Takeda S. The essential functions of human Rad51 are independent of ATP hydrolysis. Mol Cell Biol. 1999 Oct; 19(10):6891-7. PMID: 10490626.
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Seetharam S, Staba MJ, Schumm LP, Schreiber K, Schreiber H, Kufe DW, Weichselbaum RR. Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation. Int J Oncol. 1999 Oct; 15(4):769-73. PMID: 10493960.
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Jani AB, Chen MH, Vaida F, Ignacio L, Awan A, Weichselbaum RR, Vijayakumar S. PSA-based outcome analysis after radiation therapy for prostate cancer: a new definition of biochemical failure after intervention. Urology. 1999 Oct; 54(4):700-5. PMID: 10510931.
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Gorski DH, Beckett MA, Jaskowiak NT, Calvin DP, Mauceri HJ, Salloum RM, Seetharam S, Koons A, Hari DM, Kufe DW, Weichselbaum RR. Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res. 1999 Jul 15; 59(14):3374-8. PMID: 10416597.
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Lee MM, Vokes EE, Rosen A, Witt ME, Weichselbaum RR, Haraf DJ. Multimodality therapy in advanced paranasal sinus carcinoma: superior long-term results. Cancer J Sci Am. 1999 Jul-Aug; 5(4):219-23. PMID: 10439167.
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Mantz CA, Nautiyal J, Awan A, Kopnick M, Ray P, Kandel G, Niederberger C, Ignacio L, Dawson E, Fields R, Weichselbaum R, Vijayakumar S. Potency preservation following conformal radiotherapy for localized prostate cancer: impact of neoadjuvant androgen blockade, treatment technique, and patient-related factors. Cancer J Sci Am. 1999 Jul-Aug; 5(4):230-6. PMID: 10439169.
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Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 1999 Jun 24; 399(6738):814-7. PMID: 10391251.
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Lee JS, Jani AB, Pelizzari CA, Haraf DJ, Vokes EE, Weichselbaum RR, Chen GT. Volumetric visualization of head and neck CT data for treatment planning. Int J Radiat Oncol Biol Phys. 1999 Jun 01; 44(3):693-703. PMID: 10348301.
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Bradley JD, Kataoka Y, Advani S, Chung SM, Arani RB, Gillespie GY, Whitley RJ, Markert JM, Roizman B, Weichselbaum RR. Ionizing radiation improves survival in mice bearing intracranial high-grade gliomas injected with genetically modified herpes simplex virus. Clin Cancer Res. 1999 Jun; 5(6):1517-22. PMID: 10389941.
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Advani SJ, Chung SM, Yan SY, Gillespie GY, Markert JM, Whitley RJ, Roizman B, Weichselbaum RR. Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors. Cancer Res. 1999 May 01; 59(9):2055-8. PMID: 10232586.
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Vokes EE, Haraf DJ, Brockstein BE, Weichselbaum RR. Paclitaxel, 5-fluorouracil, hydroxyurea, and concomitant radiation therapy for poor-prognosis head and neck cancer. Semin Radiat Oncol. 1999 Apr; 9(2 Suppl 1):70-6. PMID: 10210543.
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Huang Y, Nakada S, Ishiko T, Utsugisawa T, Datta R, Kharbanda S, Yoshida K, Talanian RV, Weichselbaum R, Kufe D, Yuan ZM. Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol Cell Biol. 1999 Apr; 19(4):2986-97. PMID: 10082566.
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Hannig J, Yu J, Beckett M, Weichselbaum R, Lee RC. Poloxamine 1107 sealing of radiopermeabilized erythrocyte membranes. Int J Radiat Biol. 1999 Mar; 75(3):379-85. PMID: 10203188.
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Mauceri HJ, Hanna NN, Staba MJ, Beckett MA, Kufe DW, Weichselbaum RR. Radiation-inducible gene therapy. C R Acad Sci III. 1999 Feb-Mar; 322(2-3):225-8. PMID: 10196676.
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Schwartz JL, Murnane J, Weichselbaum RR. The contribution of DNA ploidy to radiation sensitivity in human tumour cell lines. Br J Cancer. 1999 Feb; 79(5-6):744-7. PMID: 10070863.
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Haraf DJ, Kies M, Rademaker AW, Stenson K, Mittal B, Pelzer H, Wenig B, Witt ME, Sulzen L, Weichselbaum RR, Vokes EE. Radiation therapy with concomitant hydroxyurea and fluorouracil in stage II and III head and neck cancer. J Clin Oncol. 1999 Feb; 17(2):638-44. PMID: 10080609.
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Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Shioya H, Utsugisawa Y, Yokoyama K, Weichselbaum R, Shi Y, Kufe D. Role for p300 in stabilization of p53 in the response to DNA damage. J Biol Chem. 1999 Jan 22; 274(4):1883-6. PMID: 9890940.
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Chmura SJ, Advani SJ, Kufe DW, Weichselbaum RR. Strategies for enhancing viral-based gene therapy using ionizing radiation. Radiat Oncol Investig. 1999; 7(5):261-9. PMID: 10580895.
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Lee MM, Heimann R, Powers C, Weichselbaum RR, Chen LM. Efficacy of Breast Conservation Therapy in Early Stage Bilateral Breast Cancer. Breast J. 1999 Jan; 5(1):36-41. PMID: 11348254.
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Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene. 1998 Dec 24; 17(25):3309-18. PMID: 9916993.
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Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res. 1998 Dec 15; 58(24):5686-9. PMID: 9865723.
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Chung TD, Mauceri HJ, Hallahan DE, Yu JJ, Chung S, Grdina WL, Yajnik S, Kufe DW, Weichselbaum RR. Tumor necrosis factor-alpha-based gene therapy enhances radiation cytotoxicity in human prostate cancer. Cancer Gene Ther. 1998 Nov-Dec; 5(6):344-9. PMID: 9917088.
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Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D, Kharbanda S. Inactivation of DNA-dependent protein kinase by protein kinase Cdelta: implications for apoptosis. Mol Cell Biol. 1998 Nov; 18(11):6719-28. PMID: 9774685.
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Kumar S, Pandey P, Bharti A, Jin S, Weichselbaum R, Weaver D, Kufe D, Kharbanda S. Regulation of DNA-dependent protein kinase by the Lyn tyrosine kinase. J Biol Chem. 1998 Oct 02; 273(40):25654-8. PMID: 9748231.
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Bishop DK, Ear U, Bhattacharyya A, Calderone C, Beckett M, Weichselbaum RR, Shinohara A. Xrcc3 is required for assembly of Rad51 complexes in vivo. J Biol Chem. 1998 Aug 21; 273(34):21482-8. PMID: 9705276.
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Seetharam S, Nodzenski E, Beckett MA, Heimann R, Cha A, Margulies I, Pastan I, Kufe DW, Weichselbaum RR. Modulation of apoptotic response of a radiation-resistant human carcinoma by Pseudomonas exotoxin-chimeric protein. Cancer Res. 1998 Aug 01; 58(15):3215-20. PMID: 9699644.
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Kies MS, Haraf DJ, Athanasiadis I, Kozloff M, Mittal B, Pelzer H, Rademaker AW, Wenig B, Weichselbaum RR, Vokes EE. Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. J Clin Oncol. 1998 Aug; 16(8):2715-21. PMID: 9704722.
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Mauceri HJ, Hanna NN, Beckett MA, Gorski DH, Staba MJ, Stellato KA, Bigelow K, Heimann R, Gately S, Dhanabal M, Soff GA, Sukhatme VP, Kufe DW, Weichselbaum RR. Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature. 1998 Jul 16; 394(6690):287-91. PMID: 9685160.
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Kharbanda S, Pandey P, Morris PL, Whang Y, Xu Y, Sawant S, Zhu LJ, Kumar N, Yuan ZM, Weichselbaum R, Sawyers CL, Pandita TK, Kufe D. Functional role for the c-Abl tyrosine kinase in meiosis I. Oncogene. 1998 Apr 09; 16(14):1773-7. PMID: 9583675.
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Yuan ZM, Utsugisawa T, Ishiko T, Nakada S, Huang Y, Kharbanda S, Weichselbaum R, Kufe D. Activation of protein kinase C delta by the c-Abl tyrosine kinase in response to ionizing radiation. Oncogene. 1998 Apr 02; 16(13):1643-8. PMID: 9582011.
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Staba MJ, Mauceri HJ, Kufe DW, Hallahan DE, Weichselbaum RR. Adenoviral TNF-alpha gene therapy and radiation damage tumor vasculature in a human malignant glioma xenograft. Gene Ther. 1998 Mar; 5(3):293-300. PMID: 9614548.
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Yuan ZM, Huang Y, Ishiko T, Nakada S, Utsugisawa T, Kharbanda S, Wang R, Sung P, Shinohara A, Weichselbaum R, Kufe D. Regulation of Rad51 function by c-Abl in response to DNA damage. J Biol Chem. 1998 Feb 13; 273(7):3799-802. PMID: 9461559.
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Advani SJ, Sibley GS, Song PY, Hallahan DE, Kataoka Y, Roizman B, Weichselbaum RR. Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors. Gene Ther. 1998 Feb; 5(2):160-5. PMID: 9578834.
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Brockstein B, Haraf DJ, Stenson K, Fasanmade A, Stupp R, Glisson B, Lippman SM, Ratain MJ, Sulzen L, Klepsch A, Weichselbaum RR, Vokes EE. Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. J Clin Oncol. 1998 Feb; 16(2):735-44. PMID: 9469365.
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Vijayakumar S, Vaida F, Weichselbaum R, Hellman S. Race and the Will Rogers phenomenon in prostate cancer. Cancer J Sci Am. 1998 Jan-Feb; 4(1):27-34. PMID: 9467043.
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Hallahan DE, Weichselbaum R. Role of gene therapy in radiation oncology. Cancer Treat Res. 1998; 93:153-67. PMID: 9513780.
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Advani SJ, Chmura SJ, Weichselbaum RR. Radiogenetic therapy: on the interaction of viral therapy and ionizing radiation for improving local control of tumors. Semin Oncol. 1997 Dec; 24(6):633-8. PMID: 9422260.
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Portugal LG, Goldenberg JD, Wenig BL, Ferrer KT, Nodzenski E, Sabnani JB, Javier C, Weichselbaum RR, Vokes EE. Human papillomavirus expression and p53 gene mutations in squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 1997 Nov; 123(11):1230-4. PMID: 9366703.
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Kharbanda S, Yuan ZM, Weichselbaum R, Kufe D. Functional role for the c-Abl protein tyrosine kinase in the cellular response to genotoxic stress. Biochim Biophys Acta. 1997 Oct 24; 1333(2):O1-7. PMID: 9395286.
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Vokes EE, Liebowitz DN, Weichselbaum RR. Nasopharyngeal carcinoma. Lancet. 1997 Oct 11; 350(9084):1087-91. PMID: 10213566.
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Hanna NN, Mauceri HJ, Wayne JD, Hallahan DE, Kufe DW, Weichselbaum RR. Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts. Cancer Res. 1997 Oct 01; 57(19):4205-9. PMID: 9331076.
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Chmura SJ, Mauceri HJ, Advani S, Heimann R, Beckett MA, Nodzenski E, Quintans J, Kufe DW, Weichselbaum RR. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphingomyelinase activation increases tumor killing by ionizing radiation. Cancer Res. 1997 Oct 01; 57(19):4340-7. PMID: 9331096.
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Yuan ZM, Utsugisawa T, Huang Y, Ishiko T, Nakada S, Kharbanda S, Weichselbaum R, Kufe D. Inhibition of phosphatidylinositol 3-kinase by c-Abl in the genotoxic stress response. J Biol Chem. 1997 Sep 19; 272(38):23485-8. PMID: 9295282.
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Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C, Kufe D. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6939-42. PMID: 9192670.
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Heimann R, Ferguson D, Powers C, Suri D, Weichselbaum RR, Hellman S. Race and clinical outcome in breast cancer in a series with long-term follow-up evaluation. J Clin Oncol. 1997 Jun; 15(6):2329-37. PMID: 9196147.
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Weichselbaum RR, Kufe D. Gene therapy of cancer. Lancet. 1997 May; 349 Suppl 2:SII10-2. PMID: 9164440.
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Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D, Kufe D. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature. 1997 Apr 17; 386(6626):732-5. PMID: 9109492.
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Chmura SJ, Nodzenski E, Beckett MA, Kufe DW, Quintans J, Weichselbaum RR. Loss of ceramide production confers resistance to radiation-induced apoptosis. Cancer Res. 1997 Apr 01; 57(7):1270-5. PMID: 9102212.
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Johnston PG, Mick R, Recant W, Behan KA, Dolan ME, Ratain MJ, Beckmann E, Weichselbaum RR, Allegra CJ, Vokes EE. Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. J Natl Cancer Inst. 1997 Feb 19; 89(4):308-13. PMID: 9048835.
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Yuan ZM, Huang Y, Ishiko T, Kharbanda S, Weichselbaum R, Kufe D. Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1437-40. PMID: 9037071.
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Jordán J, Galindo MF, Prehn JH, Weichselbaum RR, Beckett M, Ghadge GD, Roos RP, Leiden JM, Miller RJ. p53 expression induces apoptosis in hippocampal pyramidal neuron cultures. J Neurosci. 1997 Feb 15; 17(4):1397-405. PMID: 9006981.
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Haraf DJ, Stenson K, List M, Witt ME, Weichselbaum RR, Vokes EE. Continuous infusion paclitaxel, 5-fluorouracil, and hydroxyurea with concomitant radiotherapy in patients with advanced or recurrent head and neck cancer. Semin Oncol. 1997 Feb; 24(1 Suppl 2):S2-68-S2-71. PMID: 9045341.
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Mantz CA, Song P, Farhangi E, Nautiyal J, Awan A, Ignacio L, Weichselbaum R, Vijayakumar S. Potency probability following conformal megavoltage radiotherapy using conventional doses for localized prostate cancer. Int J Radiat Oncol Biol Phys. 1997 Feb 01; 37(3):551-7. PMID: 9112452.
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Datta R, Kojima H, Banach D, Bump NJ, Talanian RV, Alnemri ES, Weichselbaum RR, Wong WW, Kufe DW. Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis. J Biol Chem. 1997 Jan 17; 272(3):1965-9. PMID: 8999887.
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Roeske JC, Mundt AJ, Halpern H, Sweeney P, Sutton H, Powers C, Rotmensch J, Waggoner S, Weichselbaum RR. Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. Int J Radiat Oncol Biol Phys. 1997 Jan 15; 37(2):351-8. PMID: 9069307.
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Mauceri HJ, Seung LP, Grdina WL, Swedberg KA, Weichselbaum RR. Increased injection number enhances adenoviral genetic radiotherapy. Radiat Oncol Investig. 1997; 5(5):220-6. PMID: 9372544.
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Hamilton RJ, Sweeney PJ, Pelizzari CA, Yetkin FZ, Holman BL, Garada B, Weichselbaum RR, Chen GT. Functional imaging in treatment planning of brain lesions. Int J Radiat Oncol Biol Phys. 1997 Jan 01; 37(1):181-8. PMID: 9054894.
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Heimann R, Ferguson D, Powers C, Recant WM, Weichselbaum RR, Hellman S. Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer. J Natl Cancer Inst. 1996 Dec 04; 88(23):1764-9. PMID: 8944007.
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Quiet CA, Ferguson DJ, Weichselbaum RR, Hellman S. Natural history of node-positive breast cancer: the curability of small cancers with a limited number of positive nodes. J Clin Oncol. 1996 Dec; 14(12):3105-11. PMID: 8955655.
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Seung LP, Weichselbaum RR, Toledano A, Schreiber K, Schreiber H. Radiation can inhibit tumor growth indirectly while depleting circulating leukocytes. Radiat Res. 1996 Dec; 146(6):612-8. PMID: 8955710.
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Haraf DJ, Weichselbaum RR, Vokes EE. Re-irradiation with concomitant chemotherapy of unresectable recurrent head and neck cancer: a potentially curable disease. Ann Oncol. 1996 Nov; 7(9):913-8. PMID: 9006741.
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Heimann R, Powers C, Halpem HJ, Michel AG, Ewing CA, Wyman B, Recant W, Weichselbaum RR. Breast preservation in stage I and II carcinoma of the breast. The University of Chicago experience. Cancer. 1996 Oct 15; 78(8):1722-30. PMID: 8859185.
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Mauceri HJ, Hanna NN, Wayne JD, Hallahan DE, Hellman S, Weichselbaum RR. Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. Cancer Res. 1996 Oct 01; 56(19):4311-4. PMID: 8813113.
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Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. J Biol Chem. 1996 Sep 27; 271(39):23775-9. PMID: 8798604.
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Hallahan DE, Dunphy E, Kuchibhotla J, Kraft A, Unlap T, Weichselbaum RR. Prolonged c-jun expression in irradiated ataxia telangiectasia fibroblasts. Int J Radiat Oncol Biol Phys. 1996 Sep 01; 36(2):355-60. PMID: 8892460.
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Kharbanda S, Saleem A, Yuan ZM, Kraeft S, Weichselbaum R, Chen LB, Kufe D. Nuclear signaling induced by ionizing radiation involves colocalization of the activated p56/p53lyn tyrosine kinase with p34cdc2. Cancer Res. 1996 Aug 15; 56(16):3617-21. PMID: 8705993.
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Schwartz JL, Cowan J, Grdina DJ, Weichselbaum RR. Attenuation of G2-phase cell cycle checkpoint control is associated with increased frequencies of unrejoined chromosome breaks in human tumor cells. Radiat Res. 1996 Aug; 146(2):139-43. PMID: 8693063.
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Xu J, Kim S, Chen M, Rockow S, Yi SE, Wagner AJ, Hay N, Weichselbaum RR, Li W. Retraction. Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1. Blood. 1996 Aug 01; 88(3):1133. PMID: 8704228.
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Yuan ZM, Huang Y, Whang Y, Sawyers C, Weichselbaum R, Kharbanda S, Kufe D. Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature. 1996 Jul 18; 382(6588):272-4. PMID: 8717045.
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Kharbanda S, Bharti A, Pei D, Wang J, Pandey P, Ren R, Weichselbaum R, Walsh CT, Kufe D. The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1. Proc Natl Acad Sci U S A. 1996 Jul 09; 93(14):6898-901. PMID: 8692915.
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Schwartz JL, Mustafi R, Beckett MA, Weichselbaum RR. DNA double-strand break rejoining rates, inherent radiation sensitivity and human tumour response to radiotherapy. Br J Cancer. 1996 Jul; 74(1):37-42. PMID: 8679455.
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Vijayakumar S, Weichselbaum R, Vaida F, Dale W, Hellman S. Prostate-specific antigen levels in African-Americans correlate with insurance status as an indicator of socioeconomic status. Cancer J Sci Am. 1996 Jul-Aug; 2(4):225-33. PMID: 9166537.
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Hellman S, Weichselbaum RR. Radiation oncology. JAMA. 1996 Jun 19; 275(23):1852-3. PMID: 8642748.
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Chmura SJ, Nodzenski E, Weichselbaum RR, Quintans J. Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase. Cancer Res. 1996 Jun 15; 56(12):2711-4. PMID: 8665499.
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Vokes EE, Mick R, Kies MS, Dolan ME, Malone D, Athanasiadis I, Haraf DJ, Kozloff M, Weichselbaum RR, Ratain MJ. Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer. J Clin Oncol. 1996 May; 14(5):1663-71. PMID: 8622086.
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Dong Y, Wen P, Manome Y, Parr M, Hirshowitz A, Chen L, Hirschowitz EA, Crystal R, Weichselbaum R, Kufe DW, Fine HA. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine. Hum Gene Ther. 1996 Apr 10; 7(6):713-20. PMID: 8919593.
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Haraf DJ, Nodzenski E, Brachman D, Mick R, Montag A, Graves D, Vokes EE, Weichselbaum RR. Human papilloma virus and p53 in head and neck cancer: clinical correlates and survival. Clin Cancer Res. 1996 Apr; 2(4):755-62. PMID: 9816227.
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Johnston GR, Feeney DA, Rivers WJ, Weichselbaum R. Diagnostic imaging of the feline lower urinary tract. Vet Clin North Am Small Anim Pract. 1996 Mar; 26(2):401-15. PMID: 8711874.
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Chmura SJ, Nodzenski E, Crane MA, Virudachalam S, Hallahan DE, Weichselbaum RR, Quintans J. Cross-talk between ceramide and PKC activity in the control of apoptosis in WEHI-231. Adv Exp Med Biol. 1996; 406:39-55. PMID: 8910670.
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Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. C-jun and Egr-1 participate in DNA synthesis and cell survival in response to ionizing radiation exposure. J Biol Chem. 1995 Dec 22; 270(51):30303-9. PMID: 8530452.
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Emoto Y, Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R, Weichselbaum R, et al. Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells. EMBO J. 1995 Dec 15; 14(24):6148-56. PMID: 8557034.
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Sibley GS, Mundt AJ, Shapiro C, Jacobs R, Chen G, Weichselbaum R, Vijayakumar S. The treatment of stage III nonsmall cell lung cancer using high dose conformal radiotherapy. Int J Radiat Oncol Biol Phys. 1995 Dec 01; 33(5):1001-7. PMID: 7493826.
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Seung LP, Mauceri HJ, Beckett MA, Hallahan DE, Hellman S, Weichselbaum RR. Genetic radiotherapy overcomes tumor resistance to cytotoxic agents. Cancer Res. 1995 Dec 01; 55(23):5561-5. PMID: 7585635.
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Xu J, Kim S, Chen M, Rockow S, Yi SE, Wagner AJ, Hay N, Weichselbaum RR, Li W. Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating factor-1. Blood. 1995 Oct 01; 86(7):2774-88. PMID: 7545471.
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Vokes EE, Haraf DJ, Stenson K, Stupp R, Malone D, Levin J, Weichselbaum RR. The role of paclitaxel in the treatment of head and neck cancer. Semin Oncol. 1995 Oct; 22(5 Suppl 12):8-12. PMID: 7481866.
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Mundt AJ, Sibley G, Williams S, Hallahan D, Nautiyal J, Weichselbaum RR. Patterns of failure following high-dose chemotherapy and autologous bone marrow transplantation with involved field radiotherapy for relapsed/refractory Hodgkin's disease. Int J Radiat Oncol Biol Phys. 1995 Sep 30; 33(2):261-70. PMID: 7673013.
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Hallahan DE, Vokes EE, Rubin SJ, O'Brien S, Samuels B, Vijaykumar S, Kufe DW, Phillips R, Weichselbaum RR. Phase I dose-escalation study of tumor necrosis factor-alpha and concomitant radiation therapy. Cancer J Sci Am. 1995 Sep-Oct; 1(3):204-9. PMID: 9166477.
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Hellman S, Weichselbaum RR. Radiation oncology and the new biology. Cancer J Sci Am. 1995 Sep-Oct; 1(3):174-9. PMID: 9166470.
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Kharbanda S, Ren R, Pandey P, Shafman TD, Feller SM, Weichselbaum RR, Kufe DW. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature. 1995 Aug 31; 376(6543):785-8. PMID: 7651539.
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Haraf DJ, Rubin SJ, Sweeney P, Kuchnir FT, Sutton HG, Chodak GW, Weichselbaum RR. Photon neutron mixed-beam radiotherapy of locally advanced prostate cancer. Int J Radiat Oncol Biol Phys. 1995 Aug 30; 33(1):3-14. PMID: 7642429.
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Kharbanda S, Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum R, Woodgett J, Avruch J, Kyriakis J, et al. Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11; 270(32):18871-4. PMID: 7642542.
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Hallahan DE, Mauceri HJ, Seung LP, Dunphy EJ, Wayne JD, Hanna NN, Toledano A, Hellman S, Kufe DW, Weichselbaum RR. Spatial and temporal control of gene therapy using ionizing radiation. Nat Med. 1995 Aug; 1(8):786-91. PMID: 7585181.
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Shafman TD, Saleem A, Kyriakis J, Weichselbaum R, Kharbanda S, Kufe DW. Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation. Cancer Res. 1995 Aug 01; 55(15):3242-5. PMID: 7614455.
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Sibley GS, Mundt AJ, Goldman S, Nachman J, Reft C, Weichselbaum RR, Hallahan DE, Johnson L. Patterns of failure following total body irradiation and bone marrow transplantation with or without a radiotherapy boost for advanced neuroblastoma. Int J Radiat Oncol Biol Phys. 1995 Jul 15; 32(4):1127-35. PMID: 7607934.
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Mundt AJ, Awan A, Sibley GS, Simon M, Rubin SJ, Samuels B, Wong W, Beckett M, Vijayakumar S, Weichselbaum RR. Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: clinical and radiobiological results. Int J Radiat Oncol Biol Phys. 1995 Jul 15; 32(4):977-85. PMID: 7607972.
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Vokes EE, Stupp R, Haraf D, Moran W, Malone D, Wenig B, Sweeney P, Weichselbaum RR. Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancer. Semin Oncol. 1995 Jun; 22(3 Suppl 6):47-52. PMID: 7597433.
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Quiet CA, Ferguson DJ, Weichselbaum RR, Hellman S. Natural history of node-negative breast cancer: a study of 826 patients with long-term follow-up. J Clin Oncol. 1995 May; 13(5):1144-51. PMID: 7738620.
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Weichselbaum RR. Growth factors alter the therapeutic ratio in radiotherapy. Cancer J Sci Am. 1995 May-Jun; 1(1):28-9. PMID: 9166450.
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Vijayakumar S, Quadri SF, Sen S, Vaida F, Ignacio L, Weichselbaum RR. Measurement of weekly prostate specific antigen levels in patients receiving pelvic radiotherapy for nonprostatic malignancies. Int J Radiat Oncol Biol Phys. 1995 Apr 30; 32(1):189-95. PMID: 7536721.
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Datta R, Manome Y, Taneja N, Boise LH, Weichselbaum R, Thompson CB, Slapak CA, Kufe D. Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation. Cell Growth Differ. 1995 Apr; 6(4):363-70. PMID: 7794804.
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Chen M, Quintans J, Fuks Z, Thompson C, Kufe DW, Weichselbaum RR. Suppression of Bcl-2 messenger RNA production may mediate apoptosis after ionizing radiation, tumor necrosis factor alpha, and ceramide. Cancer Res. 1995 Mar 01; 55(5):991-4. PMID: 7867010.
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Spellman JE, Kulesz-Martin MF, Blumenson LE, Beckett MA, Weichselbaum RR. Clonal interactions in a human squamous cell carcinoma. J Surg Res. 1995 Feb; 58(2):165-74. PMID: 7861768.
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Hellman S, Weichselbaum RR. Oligometastases. J Clin Oncol. 1995 Jan; 13(1):8-10. PMID: 7799047.
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Panje WR, Namon AJ, Vokes E, Haraf DJ, Weichselbaum RR. Surgical management of the head and neck cancer patient following concomitant multimodality therapy. Laryngoscope. 1995 Jan; 105(1):97-101. PMID: 7837923.
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Weichselbaum RR, Beckett MA, Vokes EE, Brachman DG, Haraf D, Hallahan D, Kufe D. Cellular and molecular mechanisms of radioresistance. Cancer Treat Res. 1995; 74:131-40. PMID: 7779612.
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Haraf DJ, Weichselbaum RR, Vokes EE. Timing and sequencing of chemoradiotherapy. Cancer Treat Res. 1995; 74:173-98. PMID: 7779616.
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Krishnasamy S, Vokes EE, Dohrmann GJ, Mick R, Garcia JC, Kolker JD, Wollmann RL, Hekmatpanah J, Weichselbaum RR. Concomitant chemoradiotherapy, neutron boost, and adjuvant chemotherapy for anaplastic astrocytoma and glioblastoma multiforme. Cancer Invest. 1995; 13(5):453-9. PMID: 7552809.
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Vokes EE, Haraf DJ, Mick R, McEvilly JM, Weichselbaum RR. Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognosis head and neck cancer. J Clin Oncol. 1994 Nov; 12(11):2351-9. PMID: 7525886.
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Kharbanda S, Yuan ZM, Taneja N, Weichselbaum R, Kufe D. p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C. Oncogene. 1994 Oct; 9(10):3005-11. PMID: 8084605.
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Weichselbaum RR, Hallahan D, Fuks Z, Kufe D. Radiation induction of immediate early genes: effectors of the radiation-stress response. Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):229-34. PMID: 8083118.
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Mundt AJ, Sibley GS, Williams S, Rubin SJ, Heimann R, Halpern H, Weichselbaum RR. Patterns of failure of complete responders following high-dose chemotherapy and autologous bone marrow transplantation for metastatic breast cancer: implications for the use of adjuvant radiation therapy. Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):151-60. PMID: 8083108.
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Weichselbaum RR, Hallahan DE, Beckett MA, Mauceri HJ, Lee H, Sukhatme VP, Kufe DW. Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. 1994 Aug 15; 54(16):4266-9. PMID: 8044769.
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Kharbanda S, Yuan ZM, Rubin E, Weichselbaum R, Kufe D. Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. J Biol Chem. 1994 Aug 12; 269(32):20739-43. PMID: 8051175.
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Hallahan DE, Virudachalam S, Kufe DW, Weichselbaum RR. Ketoconazole attenuates radiation-induction of tumor necrosis factor. Int J Radiat Oncol Biol Phys. 1994 Jul 01; 29(4):777-80. PMID: 8040024.
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Kharbanda S, Saleem A, Shafman T, Emoto Y, Weichselbaum R, Kufe D. Activation of the pp90rsk and mitogen-activated serine/threonine protein kinases by ionizing radiation. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5416-20. PMID: 8202500.
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Hallahan DE, Bleakman D, Virudachalam S, Lee D, Grdina D, Kufe DW, Weichselbaum RR. The role of intracellular calcium in the cellular response to ionizing radiation. Radiat Res. 1994 Jun; 138(3):392-400. PMID: 8184014.
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Sweeney PJ, Haraf DJ, Vokes EE, Dougherty M, Weichselbaum RR. Radiation therapy in head and neck cancer: indications and limitations. Semin Oncol. 1994 Jun; 21(3):296-303. PMID: 8209262.
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Stupp R, Weichselbaum RR, Vokes EE. Combined modality therapy of head and neck cancer. Semin Oncol. 1994 Jun; 21(3):349-58. PMID: 8209266.
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Hellman S, Weichselbaum RR. Radiation oncology. JAMA. 1994 Jun 01; 271(21):1712-4. PMID: 8182867.
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Canaday D, Li P, Weichselbaum R, Astumian RD, Lee RC. Membrane permeability changes in gamma-irradiated muscle cells. Ann N Y Acad Sci. 1994 May 31; 720:153-9. PMID: 8010634.
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Hallahan DE, Virudachalam S, Kuchibhotla J, Kufe DW, Weichselbaum RR. Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):4897-901. PMID: 8197153.
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Canaday D, Li P, Weichselbaum R, Astumian RD, Lee RC. Membrane Permeability Changes in Gamma-irradiated Muscle Cellsa. Ann N Y Acad Sci. 1994 May; 720(1):153-159. PMID: 28621859.
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Wong WW, Mick R, Haraf DJ, Weichselbaum RR, Vokes EE. Time-dose relationship for local tumor control following alternate week concomitant radiation and chemotherapy of advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 1994 Apr 30; 29(1):153-62. PMID: 8175423.
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Kharbanda S, Saleem A, Datta R, Yuan ZM, Weichselbaum R, Kufe D. Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res. 1994 Mar 15; 54(6):1412-4. PMID: 8137239.
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Cowan JM, Beckett MA, Weichselbaum RR. Chromosome changes characterizing in vitro response to radiation in human squamous cell carcinoma lines. Cancer Res. 1993 Nov 15; 53(22):5542-7. PMID: 8221696.
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Manome Y, Datta R, Taneja N, Shafman T, Bump E, Hass R, Weichselbaum R, Kufe D. Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation. Biochemistry. 1993 Oct 12; 32(40):10607-13. PMID: 8399205.
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Vokes EE, Weichselbaum RR. Measurable impact: multimodality therapy of head and neck cancer. Int J Radiat Oncol Biol Phys. 1993 Sep 30; 27(2):481-2. PMID: 7691785.
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Czerski L, Majors A, Ng TC, Vijayakumar S, Weichselbaum R. Growth and magnetic resonance characteristics of human squamous cell carcinoma xenografts implanted with cells suspended in Matrigel. NMR Biomed. 1993 Sep-Oct; 6(5):297-301. PMID: 8268061.
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Brachman DG, Beckett M, Graves D, Haraf D, Vokes E, Weichselbaum RR. p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines. Cancer Res. 1993 Aug 15; 53(16):3667-9. PMID: 8339273.
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Rosen A, Vokes EE, Scher N, Haraf D, Weichselbaum RR, Panje WR. Locoregionally advanced paranasal sinus carcinoma. Favorable survival with multimodality therapy. Arch Otolaryngol Head Neck Surg. 1993 Jul; 119(7):743-6. PMID: 8318204.
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Pekarek LA, Weichselbaum RR, Beckett MA, Nachman J, Schreiber H. Footprinting of individual tumors and their variants by constitutive cytokine expression patterns. Cancer Res. 1993 May 01; 53(9):1978-81. PMID: 8481898.
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Vogelzang NJ, Moormeier JA, Awan AM, Weichselbaum RR, Farah R, Straus FH, Schoenberg HW, Chodak GW. Methotrexate, vinblastine, doxorubicin and cisplatin followed by radiotherapy or surgery for muscle invasive bladder cancer: the University of Chicago experience. J Urol. 1993 Apr; 149(4):753-7. PMID: 8455237.
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Datta R, Taneja N, Sukhatme VP, Qureshi SA, Weichselbaum R, Kufe DW. Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2419-22. PMID: 8384722.
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Hallahan DE, Gius D, Kuchibhotla J, Sukhatme V, Kufe DW, Weichselbaum RR. Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. J Biol Chem. 1993 Mar 05; 268(7):4903-7. PMID: 8444868.
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Hass R, Gunji H, Hirano M, Weichselbaum R, Kufe D. Phorbol ester-induced monocytic differentiation is associated with G2 delay and down-regulation of cdc25 expression. Cell Growth Differ. 1993 Mar; 4(3):159-66. PMID: 8466854.
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Datta R, Weichselbaum R, Kufe DW. Ionizing radiation down-regulates histone H1 gene expression by transcriptional and post-transcriptional mechanisms. Radiat Res. 1993 Feb; 133(2):176-81. PMID: 8438058.
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Vokes EE, Ratain MJ, Mick R, McEvilly JM, Haraf D, Kozloff M, Hamasaki V, Weichselbaum RR, Panje WR, Wenig B, et al. Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis. J Clin Oncol. 1993 Feb; 11(2):360-8. PMID: 8426214.
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Vokes EE, Weichselbaum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med. 1993 Jan 21; 328(3):184-94. PMID: 8417385.
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Manome Y, Weichselbaum RR, Kufe DW, Fine HA. Effect of Bcl-2 on ionizing radiation and 1-beta-D-arabinofuranosylcytosine-induced internucleosomal DNA fragmentation and cell survival in human myeloid leukemia cells. Oncol Res. 1993; 5(3):139-44. PMID: 8260751.
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Hallahan DE, Haimovitz-Friedman A, Kufe DW, Fuks Z, Weichselbaum RR. The role of cytokines in radiation oncology. Important Adv Oncol. 1993; 71-80. PMID: 8505057.
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Datta R, Rubin E, Sukhatme V, Qureshi S, Hallahan D, Weichselbaum RR, Kufe DW. Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10149-53. PMID: 1332031.
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Vijayakumar S, Karrison T, Weichselbaum RR, Chan S, Quadri SF, Awan AM. Racial differences in prostate-specific antigen levels in patients with local-regional prostate cancer. Cancer Epidemiol Biomarkers Prev. 1992 Nov-Dec; 1(7):541-5. PMID: 1284591.
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Vijayakumar S, Czerski L, Majors A, Valenzuela R, Beckett M, Weichselbaum R, Ng T. Phosphorous metabolite and cell cycle kinetic response of two human squamous cell carcinomas to radiation. Cancer Res. 1992 Oct 01; 52(19):5299-306. PMID: 1394134.
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Datta R, Hallahan DE, Kharbanda SM, Rubin E, Sherman ML, Huberman E, Weichselbaum RR, Kufe DW. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry. 1992 Sep 08; 31(35):8300-6. PMID: 1525167.
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Datta R, Hass R, Gunji H, Weichselbaum R, Kufe D. Down-regulation of cell cycle control genes by ionizing radiation. Cell Growth Differ. 1992 Sep; 3(9):637-44. PMID: 1419913.
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Brachman DG, Graves D, Vokes E, Beckett M, Haraf D, Montag A, Dunphy E, Mick R, Yandell D, Weichselbaum RR. Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res. 1992 Sep 01; 52(17):4832-6. PMID: 1324797.
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Weichselbaum RR, Beckett MA, Hallahan DE, Kufe DW, Vokes EE. Molecular targets to overcome radioresistance. Semin Oncol. 1992 Aug; 19(4 Suppl 11):14-20. PMID: 1509276.
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Vokes EE, Haraf DJ, Weichselbaum RR, McEvilly JM, Sutton HG, Panje WR. Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. Semin Oncol. 1992 Aug; 19(4 Suppl 11):47-56. PMID: 1509281.
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Vokes EE, Weichselbaum RR, Mick R, McEvilly JM, Haraf DJ, Panje WR. Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. J Natl Cancer Inst. 1992 Jun 03; 84(11):877-82. PMID: 1375657.
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Vokes EE, Haraf DJ, Panje WR, Schilsky RL, Weichselbaum RR. Hydroxyurea with concomitant radiotherapy for locally advanced head and neck cancer. Semin Oncol. 1992 Jun; 19(3 Suppl 9):53-8. PMID: 1641658.
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Haraf DJ, Vokes EE, Weichselbaum RR, Panje WR. Concomitant chemoradiotherapy with cisplatin, 5-fluorouracil and hydroxyurea in poor-prognosis head and neck cancer. Laryngoscope. 1992 Jun; 102(6):630-6. PMID: 1602911.
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Cowan JM, Beckett MA, Ahmed-Swan S, Weichselbaum RR. Cytogenetic evidence of the multistep origin of head and neck squamous cell carcinomas. J Natl Cancer Inst. 1992 May 20; 84(10):793-7. PMID: 1573667.
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Wong WW, Vijayakumar S, Weichselbaum RR. Prognostic indicators in node-negative early stage breast cancer. Am J Med. 1992 May; 92(5):539-48. PMID: 1580300.
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Dunphy EJ, Beckett MA, Thompson LH, Weichselbaum RR. Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines. Radiat Res. 1992 May; 130(2):166-70. PMID: 1574572.
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Hass R, Gunji H, Datta R, Kharbanda S, Hartmann A, Weichselbaum R, Kufe D. Differentiation and retrodifferentiation of human myeloid leukemia cells is associated with reversible induction of cell cycle-regulatory genes. Cancer Res. 1992 Mar 15; 52(6):1445-50. PMID: 1531783.
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Hallahan DE, Virudachalam S, Schwartz JL, Panje N, Mustafi R, Weichselbaum RR. Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation. Radiat Res. 1992 Mar; 129(3):345-50. PMID: 1542722.
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Rubin E, Kharbanda S, Gunji H, Weichselbaum R, Kufe D. cis-Diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res. 1992 Feb 15; 52(4):878-82. PMID: 1737349.
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Platanias LC, Putterman AM, Vijayakumar S, Recant W, Weichselbaum RR, Bitran JD. Treatment and prognosis of orbital non-Hodgkin's lymphomas. Am J Clin Oncol. 1992 Feb; 15(1):79-83. PMID: 1372464.
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Vokes EE, Beckett M, Karrison T, Weichselbaum RR. The interaction of 5-fluorouracil, hydroxyurea, and radiation in two human head and neck cancer cell lines. Oncology. 1992; 49(6):454-60. PMID: 1465284.
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Fuks Z, Weichselbaum RR. Radiation tolerance and the new biology: growth factor involvement in radiation injury to the lung. Int J Radiat Oncol Biol Phys. 1992; 24(1):183-4. PMID: 1512157.
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Vokes EE, Moormeier JA, Ratain MJ, Egorin MJ, Haraf DJ, Mick R, Weichselbaum RR. 5-Fluorouracil, leucovorin, hydroxyurea, and escalating doses of continuous-infusion cisplatin with concomitant radiotherapy: a clinical and pharmacologic study. Cancer Chemother Pharmacol. 1992; 29(3):178-84. PMID: 1733549.
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Grdina DJ, Dale P, Weichselbaum R. Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326. Int J Radiat Oncol Biol Phys. 1992; 22(4):813-5. PMID: 1544855.
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Vokes EE, Haraf DJ, McEvilly JM, Mick R, Kozloff MF, Goldman MD, Moran WJ, Clendeninn NJ, Collier MA, Weichselbaum RR, et al. Neoadjuvant PFL augmented by methotrexate and piritrexim followed by concomitant chemoradiotherapy for advanced head and neck cancer: a feasible and active approach. Ann Oncol. 1992 Jan; 3(1):79-81. PMID: 1606074.
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Jaffe DR, Montero-Puerner Y, Beckett MA, Cowan JM, Weichselbaum RR, Diamond AM. Differential retention of tumor- and differentiation-suppressor functions in cells derived from a human squamous cell carcinoma. Mol Carcinog. 1992; 5(4):278-85. PMID: 1497804.
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Hallahan DE, Virudachalam S, Grdina D, Weichselbaum RR. The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest. Int J Radiat Oncol Biol Phys. 1992; 24(4):687-92. PMID: 1429092.
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Weichselbaum RR. Epigenetic effects on radiosensitivity: the extracellular matrix and growth factors. Eur J Cancer. 1992; 28A(4-5):723-4. PMID: 1524891.
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Weichselbaum RR, Hallahan DE, Sukhatme VP, Kufe DW. Gene therapy targeted by ionizing radiation. Int J Radiat Oncol Biol Phys. 1992; 24(3):565-7. PMID: 1399745.
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Devine SM, Vokes EE, Weichselbaum RR. Chemotherapeutic and biologic radiation enhancement. Curr Opin Oncol. 1991 Dec; 3(6):1087-95. PMID: 1843111.
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Brachman DG, Hallahan DE, Beckett MA, Yandell DW, Weichselbaum RR. p53 gene mutations and abnormal retinoblastoma protein in radiation-induced human sarcomas. Cancer Res. 1991 Dec 01; 51(23 Pt 1):6393-6. PMID: 1933904.
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Hallahan DE, Virudachalam S, Beckett M, Sherman ML, Kufe D, Weichselbaum RR. Mechanisms of X-ray-mediated protooncogene c-jun expression in radiation-induced human sarcoma cell lines. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1677-81. PMID: 1801783.
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Haraf DJ, Vokes EE, Panje WR, Weichselbaum RR. Survival and analysis of failure following hydroxyurea, 5-fluorouracil and concomitant radiation therapy in poor prognosis head and neck cancer. Am J Clin Oncol. 1991 Oct; 14(5):419-26. PMID: 1719793.
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Hallahan DE, Virudachalam S, Sherman ML, Huberman E, Kufe DW, Weichselbaum RR. Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation. Cancer Res. 1991 Sep 01; 51(17):4565-9. PMID: 1873801.
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Awan AM, Vokes EE, Weichselbaum RR. Recent advances in radiation therapy for head and neck cancer. Hematol Oncol Clin North Am. 1991 Aug; 5(4):635-55. PMID: 1890057.
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Vokes EE, Awan AM, Weichselbaum RR. Radiotherapy with concomitant chemotherapy for head and neck cancer. Hematol Oncol Clin North Am. 1991 Aug; 5(4):753-67. PMID: 1890065.
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Haraf DJ, Drucker DR, Weichselbaum RR, Diamond AM. Radioresistant derivatives of radiosensitive CHO cells obtained following treatment with 5-azacytidine retain their sensitivity to cisplatin. Radiat Res. 1991 Aug; 127(2):226-9. PMID: 1719578.
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Vokes EE, Mick R, Lester EP, Panje WR, Weichselbaum RR. Cisplatin and fluorouracil chemotherapy does not yield long-term benefit in locally advanced head and neck cancer: results from a single institution. J Clin Oncol. 1991 Aug; 9(8):1376-84. PMID: 2072141.
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Brach MA, Hass R, Sherman ML, Gunji H, Weichselbaum R, Kufe D. Ionizing radiation induces expression and binding activity of the nuclear factor kappa B. J Clin Invest. 1991 Aug; 88(2):691-5. PMID: 1864978.
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Halpern HJ, Jaffe DR, Nguyen TD, Haraf DJ, Spencer DP, Bowman MK, Weichselbaum RR, Diamond AM. Measurement of bioreduction rates of cells with distinct responses to ionizing radiation and cisplatin. Biochim Biophys Acta. 1991 Jul 10; 1093(2-3):121-4. PMID: 1650577.
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Mick R, Vokes EE, Weichselbaum RR, Panje WR. Prognostic factors in advanced head and neck cancer patients undergoing multimodality therapy. Otolaryngol Head Neck Surg. 1991 Jul; 105(1):62-73. PMID: 1909010.
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Schwartz JL, Mustafi R, Beckett MA, Czyzewski EA, Farhangi E, Grdina DJ, Rotmensch J, Weichselbaum RR. Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities. Int J Radiat Biol. 1991 Jun; 59(6):1341-52. PMID: 1677380.
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Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW. Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. J Clin Invest. 1991 May; 87(5):1794-7. PMID: 2022746.
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Weichselbaum RR, Hallahan DE, Sukhatme V, Dritschilo A, Sherman ML, Kufe DW. Biological consequences of gene regulation after ionizing radiation exposure. J Natl Cancer Inst. 1991 Apr 03; 83(7):480-4. PMID: 2005631.
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Quiet CA, Weichselbaum RR, Grdina DJ. Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 1991 Apr; 20(4):733-8. PMID: 2004949.
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Springate SC, Haraf D, Weichselbaum RR. Temporal bone chemodectomas--comparing surgery and radiation therapy. Oncology (Williston Park). 1991 Apr; 5(4):131-7; discussion 140, 143. PMID: 1651096.
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Hallahan DE, Sukhatme VP, Sherman ML, Virudachalam S, Kufe D, Weichselbaum RR. Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2156-60. PMID: 1900938.
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Farah R, Chodak GW, Vogelzang NJ, Awan AM, Quiet CA, Moormeier J, Schoenberg H, Weichselbaum RR. Curative radiotherapy following chemotherapy for invasive bladder carcinoma (a preliminary report). Int J Radiat Oncol Biol Phys. 1991 Mar; 20(3):413-7. PMID: 1995525.
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Singer PA, Tasch ES, Stocking C, Rubin S, Siegler M, Weichselbaum R. Sex or survival: trade-offs between quality and quantity of life. J Clin Oncol. 1991 Feb; 9(2):328-34. PMID: 1988579.
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Samuels BL, Murray JL, Cohen MB, Safa AR, Sinha BK, Townsend AJ, Beckett MA, Weichselbaum RR. Increased glutathione peroxidase activity in a human sarcoma cell line with inherent doxorubicin resistance. Cancer Res. 1991 Jan 15; 51(2):521-7. PMID: 1845955.
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Weichselbaum RR. Cellular and molecular aspects of human tumor radioresistance. Important Adv Oncol. 1991; 73-83. PMID: 1869283.
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Rubin SJ, Hallahan DE, Ashman CR, Brachman DG, Beckett MA, Virudachalam S, Yandell DW, Weichselbaum RR. Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genes. J Surg Oncol. 1991 Jan; 46(1):31-6. PMID: 1986144.
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Gradishar W, Vokes E, Schilsky R, Weichselbaum R, Panje W. Vascular events in patients receiving high-dose infusional 5-fluorouracil-based chemotherapy: the University of Chicago experience. Med Pediatr Oncol. 1991; 19(1):8-15. PMID: 1990260.
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Weichselbaum RR. Possible applications of biotechnology to radiotherapy. Eur J Cancer. 1991; 27(4):405-7. PMID: 1828165.
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Moormeier JA, Williams SF, Kaminer LS, Ellis ED, Garner M, Farah R, Weichselbaum RR, Bitran JD. Autologous Bone Marrow Transplantation Followed by Involved Field Radiotherapy in Patients with Relapsed or Refractory Hodgkin's Disease. Leuk Lymphoma. 1991; 5(4):243-8. PMID: 27467846.
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Roeske JC, Chen GT, Atcher RW, Pelizzari CA, Rotmensch J, Haraf D, Montag A, Weichselbaum RR. Modeling of dose to tumor and normal tissue from intraperitoneal radioimmunotherapy with alpha and beta emitters. Int J Radiat Oncol Biol Phys. 1990 Dec; 19(6):1539-48. PMID: 2262379.
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Awan AM, Weichselbaum RR. Palliative radiotherapy. Hematol Oncol Clin North Am. 1990 Dec; 4(6):1169-81. PMID: 1704880.
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Cowan JM, Beckett MA, Tarbell N, Weichselbaum RR. Symmetrical chromosome rearrangements in cell lines established from human radiation-induced sarcomas. Cancer Genet Cytogenet. 1990 Nov 01; 50(1):125-37. PMID: 2253180.
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Hartsell WF, Farah R, Murthy A, Golomb H, Weichselbaum R. Is pelvic irradiation necessary in stage III1A Hodgkin's disease? Int J Radiat Oncol Biol Phys. 1990 Sep; 19(3):715-9. PMID: 2211220.
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Rotmensch J, Roeske J, Chen G, Pelizzari C, Montag A, Weichselbaum R, Herbst AL. Estimates of dose to intraperitoneal micrometastases from alpha and beta emitters in radioimmunotherapy. Gynecol Oncol. 1990 Sep; 38(3):478-85. PMID: 2227565.
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Cowan JM, Beckett MA, Tarbell NJ, Weichselbaum RR. Monosomy 12p in a radiation-induced germ cell tumor. Genes Chromosomes Cancer. 1990 Sep; 2(3):186-90. PMID: 2078509.
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Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW. Ionizing radiation regulates expression of the c-jun protooncogene. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5663-6. PMID: 2116003.
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Weichselbaum RR, Beckett MA, Vijayakumar S, Simon MA, Awan AM, Nachman J, Panje WR, Goldman ME, Tybor AG, Moran WJ, et al. Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy. Int J Radiat Oncol Biol Phys. 1990 Aug; 19(2):313-9. PMID: 2394610.
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Jaffe DR, Haraf D, Schwartz JL, Weichselbaum RR, Diamond AM. Radioresistant derivatives of an X-ray-sensitive CHO cell line exhibit distinct patterns of sensitivity to DNA-damaging agents. Carcinogenesis. 1990 Aug; 11(8):1265-9. PMID: 1696853.
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Vokes EE, Panje WR, Mick R, Kozloff MF, Moran WJ, Sutton HG, Goldman MD, Tybor AG, Weichselbaum RR. A randomized study comparing two regimens of neoadjuvant and adjuvant chemotherapy in multimodal therapy for locally advanced head and neck cancer. Cancer. 1990 Jul 15; 66(2):206-13. PMID: 2196107.
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Springate SC, Weichselbaum RR. Radiation or surgery for chemodectoma of the temporal bone: a review of local control and complications. Head Neck. 1990 Jul-Aug; 12(4):303-7. PMID: 2163370.
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Rader JS, Haraf DJ, Halpern HJ, Rotmensch J, Spelbring DR, Sutton H, Javaheri G, Weichselbaum RR. Radiation therapy in the treatment of cervical cancer: the University of Chicago/Michael Reese Hospital experience. J Surg Oncol. 1990 Jul; 44(3):157-65. PMID: 2370799.
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Schwartz JL, Mustafi R, Beckett MA, Weichselbaum RR. Prediction of the radiation sensitivity of human squamous cell carcinoma cells using DNA filter elution. Radiat Res. 1990 Jul; 123(1):1-6. PMID: 2371374.
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Hallahan DE, Beckett MA, Kufe D, Weichselbaum RR. The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines. Int J Radiat Oncol Biol Phys. 1990 Jul; 19(1):69-74. PMID: 2380097.
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Vokes EE, Weichselbaum RR. Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Oncol. 1990 May; 8(5):911-34. PMID: 2185342.
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Rotmensch J, Rubin SJ, Sutton HG, Javaheri G, Halpern HJ, Schwartz JL, Stewart M, Weichselbaum RR, Herbst AL. Preoperative radiotherapy followed by radical vulvectomy with inguinal lymphadenectomy for advanced vulvar carcinomas. Gynecol Oncol. 1990 Feb; 36(2):181-4. PMID: 2298406.
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Vokes EE, Schilsky RL, Weichselbaum RR, Kozloff MF, Panje WR. Induction chemotherapy with cisplatin, fluorouracil, and high-dose leucovorin for locally advanced head and neck cancer: a clinical and pharmacologic analysis. J Clin Oncol. 1990 Feb; 8(2):241-7. PMID: 1688926.
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Hallahan DE, Michel AG, Halpern HJ, Awan AM, Desser R, Bitran J, Recant W, Wyman B, Spelbring DR, Weichselbaum RR. Breast conserving surgery and definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1989 Dec; 17(6):1211-6. PMID: 2557305.
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Hallahan DE, Spriggs DR, Beckett MA, Kufe DW, Weichselbaum RR. Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):10104-7. PMID: 2602359.
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Weichselbaum RR, Rotmensch J, Ahmed-Swan S, Beckett MA. Radiobiological characterization of 53 human tumor cell lines. Int J Radiat Biol. 1989 Nov; 56(5):553-60. PMID: 2573646.
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Hallahan DE, Farah R, Vokes EE, Bitran JD, Ultmann JE, Golomb HM, Weichselbaum RR. The patterns of failure in patients with pathological stage I and II diffuse histiocytic lymphoma treated with radiation therapy alone. Int J Radiat Oncol Biol Phys. 1989 Oct; 17(4):767-71. PMID: 2674082.
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Farah R, Golomb HM, Hallahan DE, Desser RK, Griem ML, Blough R, Ultmann JE, Weichselbaum RR. Radiation therapy for pathologic stage III Hodgkin's disease with and without chemotherapy. Int J Radiat Oncol Biol Phys. 1989 Oct; 17(4):761-6. PMID: 2777665.
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Weichselbaum RR, Dunphy EJ, Beckett MA, Tybor AG, Moran WJ, Goldman ME, Vokes EE, Panje WR. Epidermal growth factor receptor gene amplification and expression in head and neck cancer cell lines. Head Neck. 1989 Sep-Oct; 11(5):437-42. PMID: 2807884.
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Vokes EE, Moran WJ, Mick R, Weichselbaum RR, Panje WR. Neoadjuvant and adjuvant methotrexate, cisplatin, and fluorouracil in multimodal therapy of head and neck cancer. J Clin Oncol. 1989 Jul; 7(7):838-45. PMID: 2661732.
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Vokes EE, Bitran JD, Hoffman PC, Ferguson MK, Weichselbaum RR, Golomb HM. Neoadjuvant vindesine, etoposide, and cisplatin for locally advanced non-small cell lung cancer. Final report of a phase 2 study. Chest. 1989 Jul; 96(1):110-3. PMID: 2544349.
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Weichselbaum RR, Beckett MA, Vijayakumar S, Ahmed-Swan S, Dritschilo A, Schwartz JL, Moran WJ, Goldman ME, Tybor AG, Vokes EE, et al. Radioresistant tumor cell lines derived from head and neck radiation failures. Head Neck. 1989 Jul-Aug; 11(4):343-8. PMID: 2753702.
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Kasid UN, Weichselbaum RR, Brennan T, Mark GE, Dritschilo A. Sensitivities of NIH/3T3-derived clonal cell lines to ionizing radiation: significance for gene transfer studies. Cancer Res. 1989 Jun 15; 49(12):3396-400. PMID: 2720693.
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Vokes EE, Panje WR, Schilsky RL, Mick R, Awan AM, Moran WJ, Goldman MD, Tybor AG, Weichselbaum RR. Hydroxyurea, fluorouracil, and concomitant radiotherapy in poor-prognosis head and neck cancer: a phase I-II study. J Clin Oncol. 1989 Jun; 7(6):761-8. PMID: 2715806.
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Farah R, Weichselbaum RR. Management of stage I and II Hodgkin's disease. Hematol Oncol Clin North Am. 1989 Jun; 3(2):253-63. PMID: 2663826.
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Farah R, Weichselbaum RR. Substaging of stage III Hodgkin's disease. Hematol Oncol Clin North Am. 1989 Jun; 3(2):277-86. PMID: 2663828.
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Schwartz JL, Karrison T, Le Beau MM, Larson RA, Sagher D, Strauss B, Rowley JD, Weichselbaum RR. Chromosomal sensitivity of lymphocytes from individuals with therapy-related acute nonlymphocytic leukemia. Mutat Res. 1989 Apr; 216(2):119-26. PMID: 2494444.
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Vokes EE, Schilsky RL, Weichselbaum RR, Guaspari A, Guarnieri CM, Whaling SM, Panje WR. Cisplatin, 5-fluorouracil, and high-dose oral leucovorin for advanced head and neck cancer. Cancer. 1989 Mar 15; 63(6 Suppl):1048-53. PMID: 2783881.
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Kasid U, Pfeifer A, Brennan T, Beckett M, Weichselbaum RR, Dritschilo A, Mark GE. Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma. Science. 1989 Mar 10; 243(4896):1354-6. PMID: 2466340.
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Panje WR, Dohrmann GJ, Pitcock JK, Scher N, Weichselbaum RR, Sutton HG, Vokes E, Moss J. The transfacial approach for combined anterior craniofacial tumor ablation. Arch Otolaryngol Head Neck Surg. 1989 Mar; 115(3):301-7. PMID: 2917065.
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Rotmensch J, Atcher RW, Schlenker R, Hines J, Grdina D, Block BS, Press MF, Herbst AL, Weichselbaum RR. The effect of the alpha-emitting radionuclide lead-212 on human ovarian carcinoma: a potential new form of therapy. Gynecol Oncol. 1989 Feb; 32(2):236-9. PMID: 2910786.
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Vokes EE, Schilsky RL, Choi KE, Magid DM, Guarnieri CM, Whaling SM, Ratain MJ, Weichselbaum RR, Panje WR. A randomized study of inpatient versus outpatient continuous infusion chemotherapy for patients with locally advanced head and neck cancer. Cancer. 1989 Jan 01; 63(1):30-6. PMID: 2910422.
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Pelizzari CA, Chen GT, Spelbring DR, Weichselbaum RR, Chen CT. Accurate three-dimensional registration of CT, PET, and/or MR images of the brain. J Comput Assist Tomogr. 1989 Jan-Feb; 13(1):20-6. PMID: 2492038.
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Weichselbaum RR, Beckett MA, Diamond AA. An important step in radiation carcinogenesis may be inactivation of cellular genes. Int J Radiat Oncol Biol Phys. 1989 Jan; 16(1):277-82. PMID: 2643596.
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Rotmensch J, Beckett MA, Toohill P, Weichselbaum RR, Schwartz JL. Comparative analysis of the inherent radiosensitivity of ovarian carcinoma. Gynecol Obstet Invest. 1989; 28(4):215-8. PMID: 2620865.
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Magid DM, Vokes EE, Schilsky RL, Guarnieri CM, Whaling SM, Weichselbaum RR, Panje WR. A randomized study of inpatient versus outpatient continuous intravenous infusion chemotherapy: psychosocial aspects. Sel Cancer Ther. 1989; 5(3):137-45. PMID: 2682877.
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Rotmensch J, Turkula TE, Weichselbaum RR, Schwartz JL. Cytogenetic observations of a human ovarian carcinoma clinically resistant to therapy. Am J Obstet Gynecol. 1988 Nov; 159(5):1099-103. PMID: 3189443.
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Haraf DJ, Weichselbaum RR. Treatment selection in T1 and T2 vocal cord carcinoma. Oncology (Williston Park). 1988 Oct; 2(10):41-50. PMID: 3275034.
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Schwartz JL, Rotmensch J, Giovanazzi S, Cohen MB, Weichselbaum RR. Faster repair of DNA double-strand breaks in radioresistant human tumor cells. Int J Radiat Oncol Biol Phys. 1988 Oct; 15(4):907-12. PMID: 3182330.
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Weichselbaum RR, Beckett MA, Simon MA, McCauley C, Haraf D, Awan A, Samuels B, Nachman J, Dritschilo A. In vitro radiobiological parameters of human sarcoma cell lines. Int J Radiat Oncol Biol Phys. 1988 Oct; 15(4):937-42. PMID: 3182333.
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Schwartz JL, Rotmensch J, Beckett MA, Jaffe DR, Toohill M, Giovanazzi SM, McIntosh J, Weichselbaum RR. X-ray and cis-diamminedichloroplatinum(II) cross-resistance in human tumor cell lines. Cancer Res. 1988 Sep 15; 48(18):5133-5. PMID: 3409240.
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Weichselbaum RR, Beckett MA, Schwartz JL, Dritschilo A. Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy. Int J Radiat Oncol Biol Phys. 1988 Sep; 15(3):575-9. PMID: 3417487.
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Beckett MA, Weichselbaum RR. Southern analysis of human head and neck cancer cells for homologous sequences using yeast gamma repair genes. J Surg Oncol. 1988 Aug; 38(4):257-60. PMID: 3045425.
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Ackland SP, Schilsky RL, Beckett MA, Weichselbaum RR. Synergistic cytotoxicity and DNA strand break formation by bromodeoxyuridine and bleomycin in human tumor cells. Cancer Res. 1988 Aug 01; 48(15):4244-9. PMID: 2455593.
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Farah R, Ultmann J, Griem M, Golomb H, Kalokhe U, Desser R, Blough R, Weichselbaum R. Extended mantle radiation therapy for pathologic stage I and II Hodgkin's disease. J Clin Oncol. 1988 Jun; 6(6):1047-52. PMID: 3373259.
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Scher N, Poe D, Kuchnir F, Reft C, Weichselbaum R, Panje WR. Radiotherapy of the resected mandible following stainless steel plate fixation. Laryngoscope. 1988 May; 98(5):561-3. PMID: 3129630.
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Weichselbaum RR, Beckett MA, Dahlberg W, Dritschilo A. Heterogeneity of radiation response of a parent human epidermoid carcinoma cell line and four clones. Int J Radiat Oncol Biol Phys. 1988 May; 14(5):907-12. PMID: 3360658.
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Vokes EE, Panje WR, Weichselbaum RR, Schilsky RL, Moran WJ, Awan AM, Guarnieri CM. Concomitant hydroxyurea, 5-fluorouracil, and radiation therapy for recurrent head and neck cancer: early results. Otolaryngol Head Neck Surg. 1988 Apr; 98(4):295-8. PMID: 3132681.
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Weichselbaum RR, Beckett M, Diamond A. Some retinoblastomas, osteosarcomas, and soft tissue sarcomas may share a common etiology. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2106-9. PMID: 3162593.
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Vokes EE, Choi KE, Schilsky RL, Moran WJ, Guarnieri CM, Weichselbaum RR, Panje WR. Cisplatin, fluorouracil, and high-dose leucovorin for recurrent or metastatic head and neck cancer. J Clin Oncol. 1988 Apr; 6(4):618-26. PMID: 3258629.
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Vokes EE, Moran WJ, Awan AM, Schilsky RL, Goldman M, Sutton HG, Weichselbaum RR, Panje WR. Sequential administration of methotrexate, cisplatin, and 5-fluorouracil in multimodal therapy for locally advanced head and neck cancer. NCI Monogr. 1988; (6):353-6. PMID: 3352782.
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Key LL, Weichselbaum RR, Carnes DL. A link between calcitriol and bone resorption. Bone Miner. 1988 Jan; 3(3):201-9. PMID: 3207945.
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Kasid U, Pfeifer A, Weichselbaum RR, Dritschilo A, Mark GE. The raf oncogene is associated with a radiation-resistant human laryngeal cancer. Science. 1987 Aug 28; 237(4818):1039-41. PMID: 3616625.
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Schwartz JL, Giovanazzi S, Weichselbaum RR. Recovery from sublethal and potentially lethal damage in an X-ray-sensitive CHO cell. Radiat Res. 1987 Jul; 111(1):58-67. PMID: 3602355.
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Jacobs RH, Awan A, Bitran JD, Hoffman PC, Little AG, Ferguson MK, Weichselbaum R, Golomb HM. Prophylactic cranial irradiation in adenocarcinoma of the lung. A possible role. Cancer. 1987 Jun 15; 59(12):2016-9. PMID: 3567864.
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Weichselbaum RR, Beckett M. The maximum recovery potential of human tumor cells may predict clinical outcome in radiotherapy. Int J Radiat Oncol Biol Phys. 1987 May; 13(5):709-13. PMID: 3570893.
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Billings PC, Weichselbaum RR, Kennedy AR. Expression and methylation of the Blym gene in human tumor cell lines. Eur J Cancer Clin Oncol. 1987 Mar; 23(3):331-7. PMID: 3036538.
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Holden SA, Teicher BA, Boeheim K, Weichselbaum RR, Ervin TJ. Platinum complexes inhibit repair of potentially lethal damage following bleomycin treatment. Br J Cancer. 1987 Mar; 55(3):245-8. PMID: 2436643.
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Ervin TJ, Clark JR, Weichselbaum RR, Fallon BG, Miller D, Fabian RL, Posner MR, Norris CM, Tuttle SA, Schoenfeld DA, et al. An analysis of induction and adjuvant chemotherapy in the multidisciplinary treatment of squamous-cell carcinoma of the head and neck. J Clin Oncol. 1987 Jan; 5(1):10-20. PMID: 2433406.
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Hayes DF, Lechan RM, Posner MR, Weichselbaum RR, Miller D, Ervin TJ. The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck. J Surg Oncol. 1986 Jul; 32(3):150-2. PMID: 3525992.
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Albert DM, Walton DS, Weichselbaum RR, Cassady JR, Little JB, Leombruno D, Trantravahi R, Puliafito CA. Fibroblast radiosensitivity and intraocular fibrovascular proliferation following radiotherapy for bilateral retinoblastoma. Br J Ophthalmol. 1986 May; 70(5):336-42. PMID: 2421761.
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Weichselbaum RR. Radioresistant and repair proficient cells may determine radiocurability in human tumors. Int J Radiat Oncol Biol Phys. 1986 Apr; 12(4):637-9. PMID: 3700168.
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Weichselbaum RR, Dahlberg W, Beckett M, Karrison T, Miller D, Clark J, Ervin TJ. Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2684-8. PMID: 3458227.
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Dryja TP, Rapaport JM, Epstein J, Goorin AM, Weichselbaum R, Koufos A, Cavenee WK. Chromosome 13 homozygosity in osteosarcoma without retinoblastoma. Am J Hum Genet. 1986 Jan; 38(1):59-66. PMID: 3004203.
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Greenberger JS, FitzGerald TJ, Rothstein L, Pierce J, Sakakeeny MA, Weichselbaum RR, Naparstek E, Newburger P, Griffin J, Bast R, et al. Long-term culture of human granulocytes and granulocyte progenitor cells. Prog Clin Biol Res. 1986; 211:159-85. PMID: 3008194.
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Little JB, Nagasawa H, Weichselbaum RR, Lovett DR, Schmit A, Kochenburger RJ, Blumberg PM. Differing patterns of cytotoxicity of the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in various human cell strains. Carcinogenesis. 1985 Dec; 6(12):1703-8. PMID: 3864565.
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Ervin TJ, Clark JR, Weichselbaum RR. Multidisciplinary treatment of advanced squamous carcinoma of the head and neck. Semin Oncol. 1985 Dec; 12(4 Suppl 6):71-8. PMID: 3909421.
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Posner MR, Weichselbaum RR, Fitzgerald TJ, Clark JR, Rose C, Fabian RL, Norris CM, Miller D, Tuttle SA, Ervin TJ. Treatment complications after sequential combination chemotherapy and radiotherapy with or without surgery in previously untreated squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1985 Nov; 11(11):1887-93. PMID: 2414254.
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Loeffler JS, Larson DA, Clark JR, Weichselbaum RR, Norris CM, Ervin TJ. Treatment of perineural metastasis from squamous carcinoma of the skin with aggressive combination chemotherapy and irradiation. J Surg Oncol. 1985 Jul; 29(3):181-3. PMID: 4079398.
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Weichselbaum RR, Dahlberg W, Little JB. Inherently radioresistant cells exist in some human tumors. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4732-5. PMID: 3860821.
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Weichselbaum RR, Clark JR, Miller D, Posner MR, Ervin TJ. Combined modality treatment of head and neck cancer with cisplatin, bleomycin, methotrexate-leucovorin chemotherapy. Cancer. 1985 May 01; 55(9 Suppl):2149-55. PMID: 2579724.
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Schwartz JL, Morgan WF, Weichselbaum RR. Different efficiencies of interaction between 3-aminobenzamide and various monofunctional alkylating agents in the induction of sister chromatid exchanges. Carcinogenesis. 1985 May; 6(5):699-704. PMID: 4006055.
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Schwartz JL, Morgan WF, Brown-Lindquist P, Afzal V, Weichselbaum RR, Wolff S. Comutagenic effects of 3-aminobenzamide in Chinese hamster ovary cells. Cancer Res. 1985 Apr; 45(4):1556-9. PMID: 3978624.
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Weichselbaum RR, Tomkinson K, Little JB. Repair of potentially lethal X-ray damage in fibroblasts derived from patients with hereditary and D-deletion retinoblastoma. Int J Radiat Biol Relat Stud Phys Chem Med. 1985 Apr; 47(4):445-56. PMID: 3872857.
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Schwartz JL, Weichselbaum RR. Similar sensitivity of human lymphoblast cells proficient or deficient in nucleotide biosynthesis to the cytotoxic and cell cycle effects of 3-aminobenzamide. Exp Cell Res. 1985 Mar; 157(1):271-5. PMID: 2982628.
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Schwenn MR, Weichselbaum RR, Little JB. Investigation of the cytotoxic effects of DNA damaging agents on neurofibromatosis cells. Mutat Res. 1985 Jan-Feb; 142(1-2):55-8. PMID: 3919286.
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Schwartz JL, Weichselbaum RR. Antipain-mediated suppression of sister chromatid exchanges induced by an inhibitor of poly (ADP-ribose) polymerase. Environ Mutagen. 1985; 7(5):703-9. PMID: 3930238.
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Yuhas JM, Blake S, Weichselbaum RR. Quantitation of the response of human tumor spheroids to daily radiation exposures. Int J Radiat Oncol Biol Phys. 1984 Dec; 10(12):2323-7. PMID: 6511528.
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Brock WA, Williams M, McNaney D, Milas L, Peters LJ, Weichselbaum RR. Modification by dexamethasone of radiation response of in vitro cultured cells. Int J Radiat Oncol Biol Phys. 1984 Nov; 10(11):2113-7. PMID: 6490436.
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Imperato JP, Weichselbaum RR, Ervin TJ. The role of post-operative radiation therapy in the treatment of malignant tumors of the parotid gland. J Surg Oncol. 1984 Nov; 27(3):163-7. PMID: 6492811.
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Dritschilo A, Brennan T, Weichselbaum RR, Mossman KL. Response of human fibroblasts to low dose rate gamma irradiation. Radiat Res. 1984 Nov; 100(2):387-95. PMID: 6494446.
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Umans RS, Weichselbaum RR, Johnson CM, Kennedy AR. Protease inhibitor antipain reduces nuclear binding of estrogen-receptor complex in MCF-7 breast tumor cells. Carcinogenesis. 1984 Oct; 5(10):1355-7. PMID: 6488457.
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Weichselbaum RR. The role of DNA repair processes in the response of human tumors to fractionated radiotherapy. Int J Radiat Oncol Biol Phys. 1984 Jul; 10(7):1127-34. PMID: 6378848.
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Weichselbaum RR, Little JB, Tomkinson K, Evans S, Yuhas J. Repair of fractionated radiation in plateau phase cultures of human tumor cells and human multicellular tumor spheroids. Radiother Oncol. 1984 Jun; 2(1):41-7. PMID: 6505275.
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Weichselbaum R, Dahlberg W, Little JB, Ervin TJ, Miller D, Hellman S, Rheinwald JG. Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy. Br J Cancer. 1984 May; 49(5):595-601. PMID: 6722007.
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Posner MR, Ervin TJ, Miller D, Fabian RL, Norris CM, Weichselbaum RR, Rose C. Incidence of hypothyroidism following multimodality treatment for advanced squamous cell cancer of the head and neck. Laryngoscope. 1984 Apr; 94(4):451-54. PMID: 6708688.
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Ervin TJ, Weichselbaum RR, Fabian RL, Miller D, Norris CM, Posner MR, Rose C, Lockhart P, Tuttle SA, MacIntyre JM, et al. Advanced squamous carcinoma of the head and neck. A preliminary report of neoadjuvant chemotherapy with cisplatin, bleomycin, and methotrexate. Arch Otolaryngol. 1984 Apr; 110(4):241-5. PMID: 6200097.
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Kufe DW, Weichselbaum R, Egan EM, Dahlberg W, Fram RJ. Lethal effects of 1-beta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repair. Mol Pharmacol. 1984 Mar; 25(2):322-6. PMID: 6700578.
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Umans RS, Weichselbaum RR, Johnson CM, Little JB. Effects of estradiol concentration on levels of nuclear estrogen receptors in MCF-7 breast tumor cells. J Steroid Biochem. 1984 Feb; 20(2):605-9. PMID: 6708541.
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Albert DM, McGhee CN, Seddon JM, Weichselbaum RR. Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy. Am J Ophthalmol. 1984 Feb; 97(2):189-96. PMID: 6696029.
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Ervin TJ, Weichselbaum RR, Miller D, Posner MR, Fabian RL, Rose C, Norris CM. The role of chemotherapy for advanced carcinoma of the supraglottic and glottic larynx. Otolaryngol Clin North Am. 1984 Feb; 17(1):209-14. PMID: 6201796.
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Dryja TP, Rapaport JM, Weichselbaum R, Bruns GA. Chromosome 13 restriction fragment length polymorphisms. Hum Genet. 1984; 65(4):320-4. PMID: 6319270.
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Schwartz JL, Weichselbaum RR. The mechanism of 3-aminobenzamide-mediated increases in spontaneous and induced SCEs. Basic Life Sci. 1984; 29 Pt A:293-304. PMID: 6442569.
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Guichard M, Weichselbaum RR, Little JB, Malaise EP. Potentially lethal damage repair as a possible determinant of human tumour radiosensitivity. Radiother Oncol. 1984 Jan; 1(3):263-9. PMID: 6505262.
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Odukoya O, Schwartz J, Weichselbaum R, Shklar G. An epidermoid carcinoma cell line derived from hamster 7,12-dimethylbenz[a]anthracene-induced buccal pouch tumors. J Natl Cancer Inst. 1983 Dec; 71(6):1253-64. PMID: 6418942.
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Weichselbaum RR, Rose CM, Ervin TJ, Miller D. Radiobiologic research for head and neck cancer therapy. Therapeutic implications. Arch Otolaryngol. 1983 Dec; 109(12):792-6. PMID: 6357165.
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Posner MR, Weichselbaum RR, Carrol E, Fabian RL, Miller D, Ervin TJ. Small cell carcinomas of the larynx: results of combined modality treatments. Laryngoscope. 1983 Jul; 93(7):946-8. PMID: 6306368.
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Mauch P, Greenberg H, Lewin A, Cassady JR, Weichselbaum R, Hellman S. Prognostic factors in patients with subdiaphragmatic Hodgkin's disease. Hematol Oncol. 1983 Jul-Sep; 1(3):205-14. PMID: 6677563.
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Weichselbaum R, Albert DM, Cassady JR, Little JB. An in vitro investigation of x-ray sensitivity in fibroblasts from patients with retinoblastoma. Invest Ophthalmol Vis Sci. 1983 Jul; 24(7):958-61. PMID: 6862797.
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Griem K, Weichselbaum RR, Umans RS, Gifford L, Little JB. Work in progress: radioprotection of human breast cancer cells by elevation of intracellular cyclic AMP. Radiology. 1983 Jul; 148(1):289-90. PMID: 6190195.
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Weichselbaum RR, Withers HR, Tomkinson K, Little J. Potentially lethal damage repair (PLDR) in X-irradiated cultures of a normal human diploid fibroblast cell strain. Int J Radiat Biol Relat Stud Phys Chem Med. 1983 Mar; 43(3):313-9. PMID: 6601080.
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Key LL, Carnes DL, Weichselbaum R, Anast CS. Platelet-derived growth factor stimulates bone resorption by monocyte monolayers. Endocrinology. 1983 Feb; 112(2):761-2. PMID: 6848370.
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Bloomer WD, McLaughlin WH, Milius RA, Weichselbaum RR, Adelstein SJ. Estrogen receptor-mediated cytotoxicity using iodine-125. J Cell Biochem. 1983; 21(1):39-45. PMID: 6874726.
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Weichselbaum RR, Nichols WW, Albert DM, Little JB. In vitro radiosensitivity of fibroblasts derived from patients with retinoblastoma and abnormalities of chromosome 13. Retina. 1983; 3(2):126-30. PMID: 6878899.
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Weichselbaum RR, Little JB. Repair of potentially lethal X ray damage and possible applications to clinical radiotherapy. Int J Radiat Oncol Biol Phys. 1983 Jan; 9(1):91-6. PMID: 6841181.
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Schwartz JL, Weichselbaum R, Frim SR. The effect of aging on the density and distribution of oral mucosal Langerhans cells. Exp Gerontol. 1983; 18(1):65-71. PMID: 6192008.
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Posner MR, Ervin TJ, Weichselbaum RR, Fabian RL, Miller D. Chemotherapy of advanced salivary gland neoplasms. Cancer. 1982 Dec 01; 50(11):2261-4. PMID: 6754060.
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Weichselbaum RR, Little JB. Radioresistance in some human tumor cells conferred in vitro by repair of potentially lethal X-ray damage. Radiology. 1982 Nov; 145(2):511-3. PMID: 7134460.
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Weichselbaum RR, Little JB. The differential response of human tumours to fractionated radiation may be due to a post-irradiation repair process. Br J Cancer. 1982 Oct; 46(4):532-7. PMID: 7138762.
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Umans RS, Weichselbaum RR, Johnson CM, Little JB. Effects of serum-free defined medium on MCF-7 cell nuclear estrogen-receptor levels. Mol Cell Endocrinol. 1982 Sep; 28(1):91-98. PMID: 7128922.
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Richie JP, Weichselbaum RR, Little JB. Importance of repair of potentially lethal damage in assays of cytotoxic agents. Surgery. 1982 Aug; 92(2):380-4. PMID: 7101131.
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Weichselbaum RR, Ervin TJ, Miller D. Chemical modulation of the hypoxic fraction in the treatment of head and neck cancer. Ann Otol Rhinol Laryngol. 1982 Jul-Aug; 91(4 Pt 1):461-4. PMID: 7114734.
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Kinsella TJ, Little JB, Nove J, Weichselbaum RR, Li FP, Meyer RJ, Marchetto DJ, Patterson WB. Heterogeneous response to X-ray and ultraviolet light irradiations of cultured skin fibroblasts in two families with Gardner's Syndrome. J Natl Cancer Inst. 1982 May; 68(5):697-701. PMID: 6951083.
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Weichselbaum RR, Posner MR, Ervin TJ, Fabian RL, Miller D. Toxicity of aggressive multimodality therapy including cisplatinum, bleomycin and methotrexate with radiation and/or surgery for advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 1982 May; 8(5):909-13. PMID: 6179911.
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Gordon W, Antman KH, Greenberger JS, Weichselbaum RR, Chaffey JT. Radiation therapy in the management of patients with mesothelioma. Int J Radiat Oncol Biol Phys. 1982 Jan; 8(1):19-25. PMID: 6174494.
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Weichselbaum RR, Malcolm AW, Little JB. Fraction size and the repair of potentially lethal radiation damage in a human melanoma cell line. Possible implications for radiotherapy. Radiology. 1982 Jan; 142(1):225-7. PMID: 7053535.
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Weichselbaum RR, Schmit A, Little JB. Cellular repair factors influencing radiocurability of human malignant tumours. Br J Cancer. 1982 Jan; 45(1):10-6. PMID: 7059452.
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Chess J, Ni C, Yin RQ, Wang WJ, Cassady JR, Weichselbaum RR, Albert DM. Rhabdomyosarcoma. Int Ophthalmol Clin. 1982; 22(1):163-82. PMID: 7061196.
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Schwartz J, Solt DB, Pappo J, Weichselbaum R. Distribution of Langerhans cells in normal and carcinogen-treated mucosa of buccal pouches of hamsters. J Dermatol Surg Oncol. 1981 Dec; 7(12):1005-10. PMID: 6802890.
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Kennedy AR, Weichselbaum RR. Effects of dexamethasone and cortisone with x-ray irradiation on transformation of C3H 10T 1/2 cells. Nature. 1981 Nov 05; 294(5836):97-8. PMID: 7290215.
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Nove J, Nichols WW, Weichselbaum RR, Little JB. Abnormalities of human chromosome 13 and in vitro radiosensitivity; a study of 19 fibroblast strains. Mutat Res. 1981 Nov; 84(1):157-67. PMID: 7329430.
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McNeil BJ, Weichselbaum R, Pauker SG. Speech and survival: tradeoffs between quality and quantity of life in laryngeal cancer. N Engl J Med. 1981 Oct 22; 305(17):982-7. PMID: 7278922.
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Ervin TJ, Karp DD, Weichselbaum RR, Posner MR, Fabian RL, Miller D. Role of chemotherapy in the multidisciplinary approach to advanced head and neck cancer: potentials and problems. Ann Otol Rhinol Laryngol. 1981 Sep-Oct; 90(5 Pt 1):506-11. PMID: 7030176.
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Ervin TJ, Weichselbaum R, Miller D, Meshad M, Posner M, Fabian R. Treatment of advanced squamous cell carcinoma of the head and neck with cisplatin, bleomycin, and methotrexate (PBM). Cancer Treat Rep. 1981 Sep-Oct; 65(9-10):787-91. PMID: 6168371.
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Ervin TJ, Kirkwood J, Weichselbaum RR, Miller D, Pitman SW, Frei E. Improved survival for patients with advanced carcinoma of the head and neck treated with methotrexate-leucovorin prior to definitive radiotherapy or surgery. Laryngoscope. 1981 Jul; 91(7):1181-90. PMID: 7017315.
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Sherman DM, Weichselbaum R, Hellman S. The characteristics of long-term survivors of lung cancer treated with radiation. Cancer. 1981 Jun 01; 47(11):2575-80. PMID: 6266635.
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Kirkwood JM, Canellos GP, Ervin TJ, Pitman SW, Weichselbaum R, Miller D. Increased therapeutic index using moderate dose methotrexate and leucovorin twice weekly vs. weekly high dose methotrexate-leucovorin in patients with advanced squamous carcinoma of the head and neck: a safe new effective regimen. Cancer. 1981 May 15; 47(10):2414-21. PMID: 6974039.
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Weichselbaum RR, Greenberger JS, Schmidt A, Karpas A, Moloney WC, Little JB. In vitro radiosensitivity of human leukemia cell lines. Radiology. 1981 May; 139(2):485-7. PMID: 6939019.
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Ervin TJ, Miller D, Weichselbaum R, Fabian RL, Meshad M. Chemotherapy for advanced carcinoma of the head and neck. A clinical update. Arch Otolaryngol. 1981 Apr; 107(4):237-41. PMID: 6971090.
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Cox R, Masson WK, Weichselbaum RR, Nove J, Little JB. The repair of potentially lethal damage in x-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Apr; 39(4):357-65. PMID: 6971846.
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Greenberg HM, Goebel R, Weichselbaum RR, Greenberger JS, Chaffey JT, Cassady JR. Radiation therapy in the treatment of aggressive fibromatoses. Int J Radiat Oncol Biol Phys. 1981 Mar; 7(3):305-10. PMID: 6792167.
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Richie JP, Weichselbaum R, Greenberger J, Marck A. Twice-a-day fractionation preoperative radiotherapy in patients with carcinoma of the bladder: preliminary report. J Urol. 1981 Feb; 125(2):179-81. PMID: 7206049.
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Kennedy AR, Weichselbaum RR. Effects of 17 beta-estradiol on radiation transformation in vitro; inhibition of effects by protease inhibitors. Carcinogenesis. 1981; 2(1):67-9. PMID: 7273291.
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Miller D, Ervin T, Weichselbaum R, Fabian RL. The differential diagnosis of the mass in the neck. A fresh look. Laryngoscope. 1981 Jan; 91(1):140-5. PMID: 7005581.
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Mauch P, Ryback M, Rosenthal D, Weichselbaum R, Hellman S. The influence of initial pathologic stage on the survival of patients who relapse from Hodgkin's disease. Blood. 1980 Nov; 56(5):892-7. PMID: 7426753.
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West GW, Weichselbaum R, Little JB. Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy. Cancer Res. 1980 Oct; 40(10):3665-8. PMID: 7438049.
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Greenberger JS, Eckner RJ, Ostertag W, Colletta G, Boschetti S, Nagasawa H, Karpas A, Weichselbaum RR, Moloney WC. Release of spleen focus-forming virus (SFFV) from differentiation inducible promyelocytic leukemia cell lines transformed in vitro by Friend leukemia virus. Virology. 1980 Sep; 105(2):425-35. PMID: 6932782.
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Bloomer WD, McLaughlin WH, Weichselbaum RR, Tonnesen GL, Hellman S, Seitz DE, Hanson RN, Adelstein SJ, Rosner AL, Burstein NA, Nove JJ, Little JB. Iodine-125-labelled tamoxifen is differentially cytoxic to cells containing oestrogen receptors. Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Aug; 38(2):197-202. PMID: 6968738.
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Weichselbaum RR, Little JB, Nove J, Hellman S, Piro AJ. Lack of selective killing by steroids in normal and malignant cells. J Cell Physiol. 1980 Jun; 103(3):429-33. PMID: 7400225.
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Little JB, Nove J, Weichselbaum RR. Abnormal sensitivity of diploid skin fibroblasts from a family with gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C. Mutat Res. 1980 Apr; 70(2):241-50. PMID: 7374661.
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Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of human tumor cells in vitro. Int J Radiat Oncol Biol Phys. 1980 Apr; 6(4):437-40. PMID: 6930370.
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Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. Cancer Res. 1980 Mar; 40(3):920-5. PMID: 7471105.
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Weichselbaum RR, Little JB. Familial retinoblastoma and ataxia telangiectasia: human models for the study of DNA damage and repair. Cancer. 1980 Feb 15; 45(4):775-9. PMID: 7357494.
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Nove J, Weichselbaum RR, Nichols WW, Albert DM, Little JB. In vitro studies of fibroblasts from patients with retinoblastoma. Int Ophthalmol Clin. 1980; 20(2):211-22. PMID: 6995388.
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Weichselbaum RR, Nove J, Albert D, Little JB. An in vitro investigation of genetic susceptibility to cancer in diploid fibroblasts from retinoblastoma patients. Teratog Carcinog Mutagen. 1980; 1(2):171-9. PMID: 6119809.
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Zakov ZN, Cook SA, Albert DM, Weichselbaum RR. False-positive phosphorus 32 uptake tests in the diagnosis of ocular melanoma. Int Ophthalmol Clin. 1980; 20(2):117-21. PMID: 6995382.
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Weichselbaum RR, Cassady JR, Albert DM, Gonder JR. Multimodality management of orbital rhabdomyosarcoma. Int Ophthalmol Clin. 1980; 20(2):247-59. PMID: 6995390.
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Lubin JR, Gragoudas ES, Albert DM, Weichselbaum RR. Bilateral malignant choroidal melanomas. Int Ophthalmol Clin. 1980; 20(2):103-15. PMID: 6249769.
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Nichols WW, Miller RC, Hoffman E, Albert D, Weichselbaum RR, Nove J, Little JB. Interstitial deletion of chromosome 13 and associated congenital anomalies. Hum Genet. 1979 Nov; 52(2):169-73. PMID: 511172.
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Greenberger JS, Come SE, Weichselbaum RR. Issues of controversy in radiation therapy and combined modality approaches to Hodgkin's disease. Clin Haematol. 1979 Oct; 8(3):611-24. PMID: 387319.
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Ervin TJ, Weichselbaum RR, Greenberger JS. Radiation therapy for non-Hodgkin's lymphoma. Clin Haematol. 1979 Oct; 8(3):657-66. PMID: 387321.
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Walker JP, Weiter JJ, Albert DM, Osborn EL, Weichselbaum RR. Uveal malignant melanoma in three generations of the same family. Am J Ophthalmol. 1979 Oct; 88(4):723-6. PMID: 507144.
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Weichselbaum RR, Nove J, Hellman S, Piro AJ, Little JB. Combination hormonal, chemotherapy and radiotherapy in vitro: implications for therapy in vivo. Int J Radiat Oncol Biol Phys. 1979 Sep; 5(9):1657-61. PMID: 536273.
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Selsky CA, Henson P, Weichselbaum RR, Little JB. Defective reactivation of ultraviolet light-irradiated herpesvirus by a Bloom's syndrome fibroblast strain. Cancer Res. 1979 Sep; 39(9):3392-6. PMID: 225021.
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Mauch P, Weichselbaum R, Botnick L. The significance of positive chorionic gonadotropins in apparently pure seminoma of the testis. Int J Radiat Oncol Biol Phys. 1979 Jun; 5(6):887-9. PMID: 115815.
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Weichselbaum RR, Zakov ZN, Albert DM, Friedman AH, Nove J, Little JB. New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma. Ophthalmology. 1979 Jun; 86(6):1191-201. PMID: 118416.
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McNeil BJ, Weichselbaum R, Pauker SG. Preferences of patients and the fallacy of the five-year survival. N Engl J Med. 1979 Apr 19; 300(16):928. PMID: 423951.
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Kirkwood JM, Miller D, Weichselbaum R, Pitman SW. Predefinitive and postdefinitive chemotherapy for locally advanced squamous carcinoma of the head and neck. Laryngoscope. 1979 Apr; 89(4):573-81. PMID: 311882.
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Fornace AJ, Little JB, Weichselbaum RR. DNA repair in a Fanconi's anemia fibroblast cell strain. Biochim Biophys Acta. 1979 Jan 26; 561(1):99-109. PMID: 420857.
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Nove J, Little JB, Weichselbaum RR, Nichols WW, Hoffman E. Retinoblastoma, chromosome 13, and in vitro cellular radiosensitivity. Cytogenet Cell Genet. 1979; 24(3):176-84. PMID: 477414.
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Greenberger JS, Weichselbaum RR, Botnick LE, Sakakeeny M, Moloney WC. Cell biological effects of total body irradiation on growth and differentiation of acute myelogenous leukemia cells compared to normal bone marrow. Exp Hematol. 1979; 7 Suppl 5:279-89. PMID: 400690.
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McNeil BJ, Weichselbaum R, Pauker SG. Fallacy of the five-year survival in lung cancer. N Engl J Med. 1978 Dec 21; 299(25):1397-401. PMID: 714117.
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Dritschilo A, Weichselbaum R, Cassady JR, Jaffe N, Paed D, Green D, Filler RM. The role of radiation therapy in the treatment of soft tissue sarcomas of childhood. Cancer. 1978 Sep; 42(3):1192-203. PMID: 100208.
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Weichselbaum RR, Hellman S, Piro AJ, Nove JJ, Little JB. Proliferation kinetics of a human breast cancer line in vitro following treatment with 17beta-estradiol and 1-beta-D-arabinofuranosylcytosine. Cancer Res. 1978 Aug; 38(8):2339-42. PMID: 667830.
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Weichselbaum RR, Nove J, Little JB. X-ray sensitivity of diploid fibroblasts from patients with hereditary or sporadic retinoblastoma. Proc Natl Acad Sci U S A. 1978 Aug; 75(8):3962-4. PMID: 279012.
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Weichselbaum RR, Miller D, Pitman SW, Kirkwood J. Initial adjuvant weekly high dose methotrexate with leucovorin rescue in advanced squamous carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 1978 Jul-Aug; 4(7-8):671-4. PMID: 309465.
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Sherman DM, Weichselbaum R, Order SE, Cloud L, Trey C, Piro AJ. Palliation of hepatic metastasis. Cancer. 1978 May; 41(5):2013-7. PMID: 77184.
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Sherman DM, Neptune W, Weichselbaum R, Order SE, Piro AJ. An aggressive approach to marginally resectable lung cancer. Cancer. 1978 May; 41(5):2040-5. PMID: 417800.
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Pitman SW, Miller D, Weichselbaum R. Initial adjuvant therapy in advanced squamous cell carcinoma of the head and neck employing weekly high dose methotrexate with leucovorin rescue. Laryngoscope. 1978 Apr; 88(4):632-8. PMID: 306011.
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Weichselbaum RR, Nove J, Little JB. Deficient recovery from potentially lethal radiation damage in ataxia telengiectasia and xeroderma pigmentosum. Nature. 1978 Jan 19; 271(5642):261-2. PMID: 622166.
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Weichselbaum RR, Liszczak TM, Phillips JP, Little JB, Epstein J, Kornblith PL. Characterization and radiobiologic parameters of medulloblastoma in vitro. Cancer. 1977 Sep; 40(3):1087-96. PMID: 561648.
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Weichselbaum R, Marck A, Hellman S. Pathogenesis of pleural effusion in carcinoma of the breast. Int J Radiat Oncol Biol Phys. 1977 Sep-Oct; 2(9-10):963-5. PMID: 591413.
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Weichselbaum RR, Cassady JR, Jaffe N, Filler RM. Preliminary results of aggressive multimodality therapy for metastatic osteosarcoma. Cancer. 1977 Jul; 40(1):78-83. PMID: 406980.
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Svensson GK, Bjärngard BE, Chen GT, Weichselbaum RR. Superficial doses in treatment of breast with tangential fields using 4MV x-rays. Int J Radiat Oncol Biol Phys. 1977 Jul-Aug; 2(7-8):705-10. PMID: 408311.
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Weichselbaum RR, Nove J, Little JB. Skin fibroblasts from a D-deletion type retinoblastoma patient are abnormally X-ray sensitive. Nature. 1977 Apr 21; 266(5604):726-7. PMID: 876352.
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Jaffe N, Murray J, Traggis D, Cassady RJ, Filler RM, Watts H, Weichselbaum R, Weinstein H. Multidisciplinary treatment for childhood sarcoma. Am J Surg. 1977 Apr; 133(4):405-13. PMID: 300570.
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Weichselbaum R, Little JB, Nove J. Response of human osteosarcoma in vitro to irradiation: evidence for unusual cellular repair activity. Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Mar; 31(3):295-9. PMID: 300732.
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Weichselbaum RR, Cassady JR, Jaffe N, Filler R. The evolution of combination therapy of genitourinary rhabdomyosarcoma in children: a preliminary report. Int J Radiat Oncol Biol Phys. 1977 Mar-Apr; 2(3-4):267-72. PMID: 863760.
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Weichselbaum RR, Epstein J, Little JB, Kornblith P. Inherent cellular radiosensitivity of human tumors of varying clinical curability. AJR Am J Roentgenol. 1976 Dec; 127(6):1027-32. PMID: 1069484.
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Weichselbaum R, Epstein J, Little JB. A technique for developing established cell lines from human osteosarcomas. In Vitro. 1976 Dec; 12(12):833-6. PMID: 1071745.
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Weichselbaum RR, Epstein J, Little JB. In vitro radiosensitivity of human dipliod fibroblasts derived from patients with unusual clinical responses to radiation. Radiology. 1976 Nov; 121(2):479-82. PMID: 981631.
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Weichselbaum RR, Marck A, Hellman S. The role of postoperative irradiation in carcinoma of the breast. Cancer. 1976 Jun; 37(6):2682-90. PMID: 949686.
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Weichselbaum RR, Epstein J, Little JB, Kornblith PL. In vitro cellular radiosensitivity of human malignant tumors. Eur J Cancer. 1976 Jan; 12(1):47-51. PMID: 178509.
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Lampidis TJ, Weichselbaum RR, Little JB. Letter: Gamma-irradiation of mammalian beating heart cells in vitro. Effects on cellular function. Int J Radiat Biol Relat Stud Phys Chem Med. 1975 Jul; 28(1):99-102. PMID: 1081094.
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Weichselbaum R, Patel M, Das Gupta TK. Influence of the pineal on wound healing. Nature. 1975 Mar 27; 254(5498):349. PMID: 1118018.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
|---|
| 1980 | 14 | | 1981 | 16 | | 1982 | 12 | | 1983 | 12 | | 1984 | 17 | | 1985 | 12 | | 1986 | 6 | | 1987 | 7 | | 1988 | 16 | | 1989 | 23 | | 1990 | 17 | | 1991 | 26 | | 1992 | 27 | | 1993 | 16 | | 1994 | 17 | | 1995 | 28 | | 1996 | 22 | | 1997 | 21 | | 1998 | 17 | | 1999 | 23 | | 2000 | 25 | | 2001 | 18 | | 2002 | 16 | | 2003 | 16 | | 2004 | 16 | | 2005 | 11 | | 2006 | 9 | | 2007 | 14 | | 2008 | 11 | | 2009 | 16 | | 2010 | 13 | | 2011 | 15 | | 2012 | 18 | | 2013 | 18 | | 2014 | 24 | | 2015 | 21 | | 2016 | 20 | | 2017 | 19 | | 2018 | 20 | | 2019 | 12 |
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