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David Grdina

TitleProfessor
InstitutionUniversity of Chicago
DepartmentRadiation & Cellular Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    My research has focused on the development of radio-protective drugs for use in the prevention of radiation-induced genomic instability and subsequent processes leading to cancer development. Specifically, studies are directed at very low dose radiation and select phosphorothioate drug exposures to induce adaptive responses affecting genomic instability development.


    Collapse Biography 
    Collapse education and training
    St. Mary's College, Winona MNBA6/1966Biology
    University of Kansas, Lawrence KSMS6/1969Radiation Biophysics
    University of Kansas, Lawrence KSPhD6/1971Radiation Biophysics
    University of Houston, Houston TXMBA8/1980Finance
    Collapse awards and honors
    1988 - 1988Japanese Government Research Award for Foreign Specialists, Chiba National Laboratory, Chiba Japan
    1993 - 1993John Yuhas Award for Excellence in Research, University of Pennsylvania

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Candas-Green D, Xie B, Huang J, Fan M, Wang A, Menaa C, Zhang Y, Zhang L, Jing D, Azghadi S, Zhou W, Liu L, Jiang N, Li T, Gao T, Sweeney C, Shen R, Lin TY, Pan CX, Ozpiskin OM, Woloschak G, Grdina DJ, Vaughan AT, Wang JM, Xia S, Monjazeb AM, Murphy WJ, Sun LQ, Chen HW, Lam KS, Weichselbaum RR, Li JJ. Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Nat Commun. 2020 09 14; 11(1):4591. PMID: 32929084.
      View in: PubMed
    2. Murley JS, Arbiser JL, Weichselbaum RR, Grdina DJ. ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. Free Radic Biol Med. 2018 08 01; 123:39-52. PMID: 29660403.
      View in: PubMed
    3. Murley JS, Miller RC, Weichselbaum RR, Grdina DJ. TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response. Radiat Res. 2017 11; 188(5):579-590. PMID: 28813624.
      View in: PubMed
    4. Nantajit D, Jetawattana S, Suriyo T, Grdina DJ, Satayavivad J. Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells. Radiat Res. 2017 07; 188(1):66-74. PMID: 28492344.
      View in: PubMed
    5. Murley JS, Miller RC, Senlik RR, Rademaker AW, Grdina DJ. Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions. Int J Radiat Biol. 2017 07; 93(7):665-675. PMID: 28281393.
      View in: PubMed
    6. Miller RC, Murley JS, Rademaker AW, Woloschak GE, Li JJ, Weichselbaum RR, Grdina DJ. Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity. Free Radic Biol Med. 2016 10; 99:110-119. PMID: 27427516.
      View in: PubMed
    7. Haley BM, Paunesku T, Grdina DJ, Woloschak GE. The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose. PLoS One. 2015; 10(12):e0140989. PMID: 26649569.
      View in: PubMed
    8. Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ. CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. Cell Rep. 2015 Dec 15; 13(10):2056-63. PMID: 26670043.
      View in: PubMed
    9. Grdina DJ, Murley JS, Miller RC, Woloschak GE, Li JJ. NF?B and Survivin-Mediated Radio-Adaptive Response. Radiat Res. 2015 Apr; 183(4):391-7. PMID: 25763931.
      View in: PubMed
    10. Jin C, Qin L, Shi Y, Candas D, Fan M, Lu CL, Vaughan AT, Shen R, Wu LS, Liu R, Li RF, Murley JS, Woloschak G, Grdina DJ, Li JJ. CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection. Free Radic Biol Med. 2015 Apr; 81:77-87. PMID: 25578653.
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    11. Miller RC, Murley JS, Grdina DJ. Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70. PMID: 24754562.
      View in: PubMed
    12. Ormsby RJ, Lawrence MD, Blyth BJ, Bexis K, Bezak E, Murley JS, Grdina DJ, Sykes PJ. Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent. Cell Biol Toxicol. 2014 Feb; 30(1):55-66. PMID: 24459009.
      View in: PubMed
    13. Toy W, Shen Y, Won H, Green B, Sakr RA, Will M, Li Z, Gala K, Fanning S, King TA, Hudis C, Chen D, Taran T, Hortobagyi G, Greene G, Berger M, Baselga J, Chandarlapaty S. ESR1 ligand-binding domain mutations in hormone-resistant breast cancer. Nat Genet. 2013 Dec; 45(12):1439-45. PMID: 24185512.
      View in: PubMed
    14. Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Li JJ, Woloschak GE, Weichselbaum RR. A survivin-associated adaptive response in radiation therapy. Cancer Res. 2013 Jul 15; 73(14):4418-28. PMID: 23651635.
      View in: PubMed
    15. Liu W, Haley B, Kwasny MJ, Li JJ, Grdina DJ, Paunesku T, Woloschak GE. Comparing radiation toxicities across species: an examination of radiation effects in Mus musculus and Peromyscus leucopus. Int J Radiat Biol. 2013 Jun; 89(6):391-400. PMID: 23362954.
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    16. Liu W, Haley BM, Kwasny MJ, Li JJ, Grdina DJ, Paunesku T, Woloschak GE. The effects of radiation and dose-fractionation on cancer and non-tumor disease development. Int J Environ Res Public Health. 2012 Dec 18; 9(12):4688-703. PMID: 23249856.
      View in: PubMed
    17. Grdina DJ, Murley JS, Miller RC, Mauceri HJ, Sutton HG, Thirman MJ, Li JJ, Woloschak GE, Weichselbaum RR. A manganese superoxide dismutase (SOD2)-mediated adaptive response. Radiat Res. 2013 Feb; 179(2):115-24. PMID: 23237540.
      View in: PubMed
    18. Candas D, Fan M, Nantajit D, Vaughan AT, Murley JS, Woloschak GE, Grdina DJ, Li JJ. CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress. J Mol Cell Biol. 2013 Jun; 5(3):166-75. PMID: 23243068.
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    19. Eldridge A, Fan M, Woloschak G, Grdina DJ, Chromy BA, Li JJ. Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection. Free Radic Biol Med. 2012 Nov 15; 53(10):1838-47. PMID: 23000060.
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    20. Fu P, Murley JS, Grdina DJ, Birukova AA, Birukov KG. Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit Care Med. 2011 Dec; 39(12):2711-21. PMID: 21765345.
      View in: PubMed
    21. Murley JS, Baker KL, Miller RC, Darga TE, Weichselbaum RR, Grdina DJ. SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radic Biol Med. 2011 Nov 15; 51(10):1918-25. PMID: 21945096.
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    22. Murley JS, Kataoka Y, Miller RC, Li JJ, Woloschak G, Grdina DJ. SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. Radiat Res. 2011 Jan; 175(1):57-65. PMID: 21175348.
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    23. Dziegielewski J, Goetz W, Murley JS, Grdina DJ, Morgan WF, Baulch JE. Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat Res. 2010 Feb; 173(2):175-83. PMID: 20095849.
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    24. Ahmed KM, Nantajit D, Fan M, Murley JS, Grdina DJ, Li JJ. Coactivation of ATM/ERK/NF-kappaB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes. Free Radic Biol Med. 2009 Jun 01; 46(11):1543-50. PMID: 19324081.
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    25. Grdina DJ, Murley JS, Kataoka Y, Baker KL, Kunnavakkam R, Coleman MC, Spitz DR. Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. Int J Radiat Oncol Biol Phys. 2009 Mar 01; 73(3):886-96. PMID: 19215822.
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    26. Fu P, Birukova AA, Xing J, Sammani S, Murley JS, Garcia JG, Grdina DJ, Birukov KG. Amifostine reduces lung vascular permeability via suppression of inflammatory signalling. Eur Respir J. 2009 Mar; 33(3):612-24. PMID: 19010997.
      View in: PubMed
    27. Dziegielewski J, Baulch JE, Goetz W, Coleman MC, Spitz DR, Murley JS, Grdina DJ, Morgan WF. WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radic Biol Med. 2008 Dec 15; 45(12):1674-81. PMID: 18845240.
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    28. Paunesku D, Paunesku T, Wahl A, Kataoka Y, Murley J, Grdina DJ, Woloschak GE. Incidence of tissue toxicities in gamma ray and fission neutron-exposed mice treated with Amifostine. Int J Radiat Biol. 2008 Aug; 84(8):623-34. PMID: 18661379.
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    29. Murley JS, Nantajit D, Baker KL, Kataoka Y, Li JJ, Grdina DJ. Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiat Res. 2008 May; 169(5):495-505. PMID: 18439041.
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    30. Kataoka Y, Murley JS, Baker KL, Grdina DJ. Relationship between phosphorylated histone H2AX formation and cell survival in human microvascular endothelial cells (HMEC) as a function of ionizing radiation exposure in the presence or absence of thiol-containing drugs. Radiat Res. 2007 Jul; 168(1):106-14. PMID: 17723002.
      View in: PubMed
    31. Murley JS, Kataoka Y, Baker KL, Diamond AM, Morgan WF, Grdina DJ. Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha. Radiat Res. 2007 Apr; 167(4):465-74. PMID: 17388698.
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    32. Kataoka Y, Bindokas VP, Duggan RC, Murley JS, Grdina DJ. Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells. J Radiat Res. 2006 Nov; 47(3-4):245-57. PMID: 16960336.
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    33. Murley JS, Kataoka Y, Weydert CJ, Oberley LW, Grdina DJ. Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065. Free Radic Biol Med. 2006 Mar 15; 40(6):1004-16. PMID: 16540396.
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    34. Grdina DJ, Murley JS, Kataoka Y, Zhou D, Seed TM. Radioprotectors: current status and new directions. Radiat Res. 2005 Jun; 163(6):704-5. PMID: 16044505.
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    35. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004 Dec; 162(6):711-28. PMID: 15548121.
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    36. Murley JS, Kataoka Y, Cao D, Li JJ, Oberley LW, Grdina DJ. Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiat Res. 2004 Nov; 162(5):536-46. PMID: 15624308.
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    37. Khodarev NN, Kataoka Y, Murley JS, Weichselbaum RR, Grdina DJ. Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). Int J Radiat Oncol Biol Phys. 2004 Oct 01; 60(2):553-63. PMID: 15380592.
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    38. Elas M, Parasca A, Grdina DJ, Halpern HJ. Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochim Biophys Acta. 2003 Mar 20; 1637(2):151-5. PMID: 12633903.
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    39. Grdina DJ, Kataoka Y, Murley JS, Swedberg K, Lee JY, Hunter N, Weichselbaum RR, Milas L. Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol. 2002 Dec; 29(6 Suppl 19):22-8. PMID: 12577239.
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    40. Murley JS, Kataoka Y, Weydert CJ, Oberley LW, Grdina DJ. Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine. Radiat Res. 2002 Jul; 158(1):101-9. PMID: 12071809.
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    41. Kataoka Y, Murley JS, Khodarev NN, Weichselbaum RR, Grdina DJ. Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. Int J Radiat Oncol Biol Phys. 2002 May 01; 53(1):180-9. PMID: 12007958.
      View in: PubMed
    42. Grdina DJ, Murley JS, Kataoka Y, Epperly W. Relationships between cytoprotection and mutation prevention by WR-1065. Mil Med. 2002 Feb; 167(2 Suppl):51-3. PMID: 11873516.
      View in: PubMed
    43. Khodarev NN, Yu J, Nodzenski E, Murley JS, Kataoka Y, Brown CK, Grdina DJ, Weichselbaum RR. Method of RNA purification from endothelial cells for DNA array experiments. Biotechniques. 2002 Feb; 32(2):316, 318, 320. PMID: 11848408.
      View in: PubMed
    44. Grdina DJ, Kataoka Y, Murley JS, Hunter N, Weichselbaum RR, Milas L. Inhibition of spontaneous metastases formation by amifostine. Int J Cancer. 2002 Jan 10; 97(2):135-41. PMID: 11774255.
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    45. Grdina DJ, Murley JS, Kataoka Y. Radioprotectants: current status and new directions. Oncology. 2002; 63 Suppl 2:2-10. PMID: 12466639.
      View in: PubMed
    46. Grdina DJ, Murley JS, Kataoka Y, Calvin DP. Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells. Semin Radiat Oncol. 2002 Jan; 12(1 Suppl 1):103-11. PMID: 11917294.
      View in: PubMed
    47. Murley JS, Kataoka Y, Hallahan DE, Roberts JC, Grdina DJ. Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic Biol Med. 2001 Jun 15; 30(12):1426-39. PMID: 11390188.
      View in: PubMed
    48. Mansur DB, Kataoka Y, Grdina DJ, Diamond AM. Radiosensitivity of mammalian cell lines engineered to overexpress cytosolic glutathione peroxidase. Radiat Res. 2001 Apr; 155(4):536-42. PMID: 11260655.
      View in: PubMed
    49. Kataoka Y, Murley JS, Patel R, Grdina DJ. Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. Int J Radiat Biol. 2000 May; 76(5):633-9. PMID: 10866285.
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    50. Snyder RD, Grdina DJ. Further evidence that the radioprotective aminothiol, WR-1065, catalytically inactivates mammalian topoisomerase II. Cancer Res. 2000 Mar 01; 60(5):1186-8. PMID: 10728671.
      View in: PubMed
    51. Grdina DJ, Kataoka Y, Murley JS. Amifostine: mechanisms of action underlying cytoprotection and chemoprevention. Drug Metabol Drug Interact. 2000; 16(4):237-79. PMID: 11201306.
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    52. Halpern HJ, Chandramouli GV, Barth ED, Yu C, Peric M, Grdina DJ, Teicher BA. Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance. Cancer Res. 1999 Nov 15; 59(22):5836-41. PMID: 10582707.
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    53. Cai Y, Wu MH, Ludeman SM, Grdina DJ, Dolan ME. Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity. Cancer Res. 1999 Jul 01; 59(13):3059-63. PMID: 10397244.
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    54. Grdina DJ, Hunter N, Kataoka Y, Murley JS, Milas L. Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide. Semin Oncol. 1999 Apr; 26(2 Suppl 7):22-7. PMID: 10348256.
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    55. Grdina DJ, Murley JS, Roberts JC. Effects of thiols on topoisomerase-II alpha activity and cell cycle progression. Cell Prolif. 1998 Oct-Dec; 31(5-6):217-29. PMID: 9925989.
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    56. Liu SC, Murley JS, Woloschak G, Grdina DJ. Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine. Carcinogenesis. 1997 Dec; 18(12):2457-9. PMID: 9450496.
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    57. Murley JS, Constantinou A, Kamath NS, Grdina DJ. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase II alpha leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun-Jul; 30(6-7):283-94. PMID: 9451419.
      View in: PubMed
    58. Woloschak GE, Paunesku T, Libertin CR, Chang-Liu CM, Churchill M, Panozzo J, Grdina D, Gemmell MA, Giometti C. Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice. Carcinogenesis. 1996 Nov; 17(11):2357-65. PMID: 8968049.
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    59. Diamond AM, Dale P, Murray JL, Grdina DJ. The inhibition of radiation-induced mutagenesis by the combined effects of selenium and the aminothiol WR-1065. Mutat Res. 1996 Sep 23; 356(2):147-54. PMID: 8841479.
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    60. Schwartz JL, Cowan J, Grdina DJ, Weichselbaum RR. Attenuation of G2-phase cell cycle checkpoint control is associated with increased frequencies of unrejoined chromosome breaks in human tumor cells. Radiat Res. 1996 Aug; 146(2):139-43. PMID: 8693063.
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    61. Kataoka Y, Perrin J, Hunter N, Milas L, Grdina DJ. Antimutagenic effects of amifostine: clinical implications. Semin Oncol. 1996 Aug; 23(4 Suppl 8):53-7. PMID: 8783668.
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    62. Halpern HJ, Yu C, Peric M, Barth ED, Karczmar GS, River JN, Grdina DJ, Teicher BA. Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry. Radiat Res. 1996 May; 145(5):610-8. PMID: 8619027.
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    63. Sidjanin D, Grdina D, Woloschak GE. UV-induced changes in cell cycle and gene expression within rabbit lens epithelial cells. Photochem Photobiol. 1996 Jan; 63(1):79-85. PMID: 8577869.
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    64. Murley JS, Grdina DJ. The effects of cycloheximide and WR-1065 on radiation-induced repair processes: a mechanism for chemoprevention. Carcinogenesis. 1995 Nov; 16(11):2699-705. PMID: 7586189.
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    65. Woloschak GE, Paunesku T, Chang-Liu CM, Grdina DJ. Expression of thymidine kinase messenger RNA and a related transcript is modulated by radioprotector WR1065. Cancer Res. 1995 Nov 01; 55(21):4788-92. PMID: 7585506.
      View in: PubMed
    66. Grdina DJ, Shigematsu N, Dale P, Newton GL, Aguilera JA, Fahey RC. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action. Carcinogenesis. 1995 Apr; 16(4):767-74. PMID: 7728953.
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    67. Halpern HJ, Yu C, Peric M, Barth E, Grdina DJ, Teicher BA. Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):13047-51. PMID: 7809170.
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    68. Meechan PJ, Haraf DJ, Diamond AM, Grdina DJ. Varying levels of radioprotection from the effects of JANUS neutrons in repair-deficient xrs-5 hamster cells treated with azacytidine. Radiat Res. 1994 Dec; 140(3):437-40. PMID: 7526412.
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    69. Thraves PJ, Varghese S, Jung M, Grdina DJ, Rhim JS, Dritschilo A. Transformation of human epidermal keratinocytes with fission neutrons. Carcinogenesis. 1994 Dec; 15(12):2867-73. PMID: 8001248.
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    70. Matsushita S, Ando K, Koike S, Grdina DJ, Furukawa S. Radioprotection by WR-151327 against the late normal tissue damage in mouse hind legs from gamma ray radiation. Int J Radiat Oncol Biol Phys. 1994 Nov 15; 30(4):867-72. PMID: 7960989.
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    71. Schwartz JL, Sedita BA, Laffely N, Grdina DJ. Chromosome terminal deletion formation in Chinese hamster ovary cells. Mutat Res. 1994 Nov 01; 311(1):125-31. PMID: 7526165.
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    72. Shigematsu N, Schwartz JL, Grdina DJ. Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis. 1994 Jul; 9(4):355-60. PMID: 7968578.
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    73. Hallahan DE, Bleakman D, Virudachalam S, Lee D, Grdina D, Kufe DW, Weichselbaum RR. The role of intracellular calcium in the cellular response to ionizing radiation. Radiat Res. 1994 Jun; 138(3):392-400. PMID: 8184014.
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    74. Grdina DJ, Constantinou A, Shigematsu N, Murley JS. Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065). Radiat Res. 1994 Apr; 138(1):44-52. PMID: 8146299.
      View in: PubMed
    75. Kataoka Y, Perrin J, Grdina DJ. Induction of hprt mutations in mice after exposure to fission-spectrum neutrons or 60Co gamma rays. Radiat Res. 1993 Nov; 136(2):289-92. PMID: 8248487.
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    76. Murley JS, Grdina DJ, Meechan PJ. Effects of growth media on cell cycle progression in CHO cells exposed to the radioprotector WR-1065. Cell Prolif. 1992 Nov; 25(6):643-50. PMID: 1457610.
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    77. Constantinou A, Grdina D, Kiguchi K, Huberman E. The effect of topoisomerase inhibitors on the expression of differentiation markers and cell cycle progression in human K-562 leukemia cells. Exp Cell Res. 1992 Nov; 203(1):100-6. PMID: 1330653.
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    78. Carnes BA, Grdina DJ. In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis. Int J Radiat Biol. 1992 May; 61(5):567-76. PMID: 1349621.
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    79. Grdina DJ, Kataoka Y, Basic I, Perrin J. The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation. Carcinogenesis. 1992 May; 13(5):811-4. PMID: 1316813.
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    80. Kataoka Y, Basic I, Perrin J, Grdina DJ. Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice. Int J Radiat Biol. 1992 Mar; 61(3):387-92. PMID: 1347072.
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    81. Meechan PJ, Haraf DJ, Diamond AM, Grdina DJ. Reversion of radiosensitivity in azacytidine-treated XRS5 cells does not result in full radioprotection by WR-1065. Int J Radiat Oncol Biol Phys. 1992; 23(5):999-1002. PMID: 1379219.
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    82. Grdina DJ, Sigdestad CP. Chemical protection and cell-cycle effects on radiation-induced mutagenesis. Cell Prolif. 1992 Jan; 25(1):23-9. PMID: 1540681.
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    83. Hallahan DE, Virudachalam S, Grdina D, Weichselbaum RR. The isoquinoline sulfonamide H7 attenuates radiation-mediated protein kinase C activation and delays the onset of x-ray-induced G2 arrest. Int J Radiat Oncol Biol Phys. 1992; 24(4):687-92. PMID: 1429092.
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    84. Grdina DJ, Dale P, Weichselbaum R. Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326. Int J Radiat Oncol Biol Phys. 1992; 22(4):813-5. PMID: 1544855.
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    85. Rotmensch J, Atcher RW, Schwartz JL, Grdina DJ. Analysis of ascites from patients with ovarian carcinoma by cell flow cytometry. Gynecol Oncol. 1992 Jan; 44(1):10-2. PMID: 1730415.
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    86. Grdina DJ, Garnes BA, Nagy B. Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons. Adv Space Res. 1992; 12(2-3):257-63. PMID: 11537016.
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    87. Grdina DJ, Wright BJ, Carnes BA. Protection by WR-151327 against late-effect damage from fission-spectrum neutrons. Radiat Res. 1991 Oct; 128(1 Suppl):S124-7. PMID: 1924738.
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    88. Hanson WR, Grdina DJ. Misoprostol, a PGE1 analog, protects mice from fission-neutron injury. Radiat Res. 1991 Oct; 128(1 Suppl):S12-7. PMID: 1656482.
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    89. Grdina DJ, Carnes BA, Grahn D, Sigdestad CP. Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Res. 1991 Aug 15; 51(16):4125-30. PMID: 1651155.
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    90. Schwartz JL, Mustafi R, Beckett MA, Czyzewski EA, Farhangi E, Grdina DJ, Rotmensch J, Weichselbaum RR. Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities. Int J Radiat Biol. 1991 Jun; 59(6):1341-52. PMID: 1677380.
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    91. Sigdestad CP, Bergquist BL, Grdina DJ. The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation. Cell Prolif. 1991 May; 24(3):271-80. PMID: 2039803.
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    92. Murley JS, Grdina DJ, Meechan PJ. Accumulation of CHO cells in G2 phase following exposure to WR-1065. Radiat Res. 1991 May; 126(2):223-8. PMID: 2023993.
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    93. Quiet CA, Weichselbaum RR, Grdina DJ. Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 1991 Apr; 20(4):733-8. PMID: 2004949.
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    94. Meechan PJ, Vaughan AT, Giometti CS, Grdina DJ. Association of WR-1065 with CHO AA8 cells, nuclei, and nucleoids. Radiat Res. 1991 Feb; 125(2):152-7. PMID: 1996372.
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    95. Vaughan AT, Allan IM, Gordon DJ, Grdina DJ, Milner AM. Analysis of free radical damage within single cells using flow cytometry. Mol Aspects Med. 1991; 12(2):129-35. PMID: 1712885.
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    96. Gordon DJ, Milner AE, Beaney RP, Grdina DJ, Vaughan AT. Cellular radiosensitivity in V79 cells is linked to alterations in chromatin structure. Int J Radiat Oncol Biol Phys. 1990 Nov; 19(5):1199-201. PMID: 2254112.
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    97. van Beek ME, Doak RL, Sigdestad CP, Grdina DJ. Pathological effects of the radiation protector WR-151327 in mice. Radiat Res. 1990 Oct; 124(1):79-84. PMID: 2236499.
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    98. Gordon DJ, Milner AE, Beaney RP, Grdina DJ, Vaughan AT. The increase in radioresistance of Chinese hamster cells cultured as spheroids is correlated to changes in nuclear morphology. Radiat Res. 1990 Feb; 121(2):175-9. PMID: 2305035.
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    99. Rotmensch J, Schwartz JL, Atcher RW, Grdina DJ, Toohill M, Weichselbaum RW. The inherent cellular radiosensitivity of epithelial ovarian carcinoma. Gynecol Oncol. 1989 Dec; 35(3):282-5. PMID: 2599460.
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    100. Vaughan AT, Grdina DJ, Meechan PJ, Milner AE, Gordon DJ. Conformational changes in chromatin structure induced by the radioprotective aminothiol, WR 1065. Br J Cancer. 1989 Dec; 60(6):893-6. PMID: 2605099.
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    101. Rotmensch J, Schwartz JL, Beckett MA, Grdina DJ, Toohill P, Weischelbaum RR. Characterization of a human ovarian carcinoma. Anal Quant Cytol Histol. 1989 Oct; 11(5):324-30. PMID: 2478138.
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    102. Rotmensch J, Atcher RW, Hines J, Grdina D, Schwartz JS, Toohill M, Herbst AL. The development of alpha-emitting radionuclide lead 212 for the potential treatment of ovarian carcinoma. Am J Obstet Gynecol. 1989 Apr; 160(4):789-97. PMID: 2712112.
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    103. Grdina DJ, Sigdestad CP, Carnes BA. Protection by WR1065 and WR151326 against fission-neutron-induced mutations at the HGPRT locus in V79 cells. Radiat Res. 1989 Mar; 117(3):500-10. PMID: 2928472.
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    104. Nagy B, Grdina DJ. Plasminogen activator activity in clonogenic cell populations separated from a murine fibrosarcoma. Clin Exp Metastasis. 1989 Mar-Apr; 7(2):243-50. PMID: 2920477.
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    105. Rotmensch J, Atcher RW, Schlenker R, Hines J, Grdina D, Block BS, Press MF, Herbst AL, Weichselbaum RR. The effect of the alpha-emitting radionuclide lead-212 on human ovarian carcinoma: a potential new form of therapy. Gynecol Oncol. 1989 Feb; 32(2):236-9. PMID: 2910786.
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    106. Grdina DJ, Nagy B, Hill CK, Sigdestad CP. Protection against radiation-induced mutagenesis in V79 cells by 2-[(aminopropyl)amino] ethanethiol under conditions of acute hypoxia. Radiat Res. 1989 Feb; 117(2):251-8. PMID: 2922471.
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    107. Atcher RW, Russo A, DeGraff WG, Moore M, Grdina DJ, Mitchell JB. Halogenated pyrimidines as radiosensitizers for high-LET radiation. Radiat Res. 1989 Feb; 117(2):351-5. PMID: 2922478.
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    108. Grdina DJ, Sigdestad CP, Dale PJ, Perrin JM. The effect of 2-[(aminopropyl)amino] ethanethiol on fission-neutron-induced DNA damage and repair. Br J Cancer. 1989 Jan; 59(1):17-21. PMID: 2667608.
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    109. Grdina DJ, Sigdestad CP. Radiation protectors: the unexpected benefits. Drug Metab Rev. 1989; 20(1):13-42. PMID: 2653762.
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    110. Sigdestad CP, Doak KW, Grdina DJ. Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl. Experientia. 1988 Aug 15; 44(8):707-8. PMID: 3410003.
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    111. Sigdestad CP, Guilford W, Perrin J, Grdina DJ. Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors. Cell Tissue Kinet. 1988 May; 21(3):193-200. PMID: 3224366.
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    112. Schwartz JL, Giovanazzi SM, Karrison T, Jones C, Grdina DJ. 2-[(Aminopropyl)amino] ethanethiol-mediated reductions in 60Co gamma-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Radiat Res. 1988 Jan; 113(1):145-54. PMID: 3340717.
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    113. Grdina DJ, Guilford WH, Sigdestad CP, Giometti CS. Effects of radioprotectors on DNA damage and repair, proteins, and cell-cycle progression. Pharmacol Ther. 1988; 39(1-3):133-7. PMID: 3059364.
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    114. Grdina DJ, Nagy B, Sigdestad CP. Radioprotectors in treatment therapy to reduce risk in secondary tumor induction. Pharmacol Ther. 1988; 39(1-3):21-5. PMID: 2849125.
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    115. Zhang JS, Sigdestad CP, Gemmell MA, Grdina DJ. Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res. 1987 Oct; 112(1):156-63. PMID: 3659296.
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    116. Hanson WR, Grdina DJ. Radiation-induced DNA single-strand breaks in the intestinal mucosal cells of mice treated with the radioprotectors WR-2721 or 16-16 dimethyl prostaglandin E2. Int J Radiat Biol Relat Stud Phys Chem Med. 1987 Jul; 52(1):67-76. PMID: 3036726.
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    117. Sigdestad CP, Treacy SH, Knapp LA, Grdina DJ. The effect of 2-[(aminopropyl)amino] ethanethiol (WR-1065) on radiation induced DNA double strand damage and repair in V79 cells. Br J Cancer. 1987 May; 55(5):477-82. PMID: 3606941.
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    118. Peraino C, Grdina DJ, Staffeldt EF, Russell JJ, Prapuolenis A, Carnes BA. Effects of separate and combined treatments with gamma radiation and diethylnitrosamine in neonatal rats on the induction of altered hepatocyte foci and hepatic tumors. Carcinogenesis. 1987 Apr; 8(4):599-600. PMID: 2881633.
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    119. Grdina DJ, Nagy B. The effect of 2-[(aminopropyl)amino] ethanethiol (WR1065) on radiation-induced DNA damage and repair and cell progression in V79 cells. Br J Cancer. 1986 Dec; 54(6):933-41. PMID: 3801289.
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    120. Nagy B, Grdina DJ. Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. Int J Radiat Oncol Biol Phys. 1986 Aug; 12(8):1475-8. PMID: 2428793.
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    121. Sigdestad CP, Grdina DJ, Connor AM, Hanson WR. A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327. Radiat Res. 1986 May; 106(2):224-33. PMID: 3010368.
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    122. Hill CK, Nagy B, Peraino C, Grdina DJ. 2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation. Carcinogenesis. 1986 Apr; 7(4):665-8. PMID: 3698198.
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    123. Nagy B, Dale PJ, Grdina DJ. Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol. Cancer Res. 1986 Mar; 46(3):1132-5. PMID: 3943091.
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    124. Peraino C, Grdina DJ, Carnes BA. Synergistic induction of altered hepatocyte foci by combined gamma radiation and diethylnitrosamine administered to neonatal rats. Carcinogenesis. 1986 Mar; 7(3):445-8. PMID: 2868809.
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    125. Grdina DJ, Peraino C, Carnes BA, Hill CK. Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth. Cancer Res. 1985 Nov; 45(11 Pt 1):5379-81. PMID: 2865003.
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    126. Grdina DJ, Nagy B, Hill CK, Wells RL, Peraino C. The radioprotector WR1065 reduces radiation-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in V79 cells. Carcinogenesis. 1985 Jun; 6(6):929-31. PMID: 4006082.
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    127. Grdina DJ, Jones S, Hunter N. Effectiveness of AMSA alone or in combination with radiation on murine fibrosarcoma pulmonary nodules. Clin Exp Metastasis. 1984 Jul-Sep; 2(3):223-33. PMID: 6549551.
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    128. Grdina DJ, Meistrich ML, Meyn RE, Johnson TS, White RA. Cell synchrony techniques. I. A comparison of methods. Cell Tissue Kinet. 1984 May; 17(3):223-36. PMID: 6538812.
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    129. White RA, Grdina DJ, Meistrich ML, Meyn RE, Johnson TS. Cell synchrony techniques. II. Analysis of cell progression data. Cell Tissue Kinet. 1984 May; 17(3):237-45. PMID: 6538813.
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    130. Grdina DJ, Thames HD, Milas L. Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range. Int J Radiat Oncol Biol Phys. 1984 Mar; 10(3):379-83. PMID: 6706731.
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    131. Grdina DJ, Zin G. Density gradient centrifugation of tumor cells from needle biopsies and their respective source tumors: a comparison of density distributions. Experientia. 1983 Aug 15; 39(8):916-7. PMID: 6873249.
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    132. Grdina DJ, White RA, Stragand JJ. Cytotoxic effects of vincristine on tumour subpopulations separated from pulmonary nodules. Br J Cancer. 1983 Aug; 48(2):279-87. PMID: 6882666.
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    133. Thames HD, Grdina DJ, Milas L. Response of fibrosarcoma cell subpopulations to small doses of radiation delivered in situ. Int J Radiat Oncol Biol Phys. 1983 Feb; 9(2):217-20. PMID: 6833024.
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    134. Mian TA, Theiss JC, Grdina DJ. Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. Cancer Res. 1983 Jan; 43(1):146-9. PMID: 6847763.
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    135. Grdina DJ, White RA. Treatment of artificially-induced pulmonary metastases with fractionated doses of vincristine and/or radiation therapy. Clin Exp Metastasis. 1983 Jan-Mar; 1(1):71-81. PMID: 6543686.
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    136. Brock WA, Swartzendruber DE, Grdina DJ. Kinetic heterogeneity in density-separated murine fibrosarcoma subpopulations. Cancer Res. 1982 Dec; 42(12):4999-5003. PMID: 7139604.
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    137. Grdina DJ, Hunter N. Cyclic-radiation response of murine fibrosarcoma cells grown as pulmonary nodules. Int J Radiat Oncol Biol Phys. 1982 Oct; 8(10):1727-34. PMID: 7153083.
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    138. Grdina DJ. Phase-specific cytotoxicity in vivo of hydroxyurea on murine fibrosarcoma pulmonary nodules. Br J Cancer. 1982 Mar; 45(3):438-46. PMID: 7073937.
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    139. Sigdestad CP, Grdina DJ. Density centrifugation of murine fibrosarcoma cells following in situ labelling with tritiated thymidine. Cell Tissue Kinet. 1981 Nov; 14(6):589-600. PMID: 7296625.
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    140. Sigdestad CP, Grdina DJ. In vivo cell cycle phase-preferential killing of murine fibrosarcoma cells by cisplatin. Cancer Treat Rep. 1981 Sep-Oct; 65(9-10):845-51. PMID: 7196799.
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    141. Sigdestad CP, Grdina DJ. Velocity sedimentation of tumor cells: a comparison of methods. Experientia. 1981 May 15; 37(5):501-2. PMID: 7250324.
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    142. Grdina DJ, Sigdestad CP, Peters LJ. Cytotoxic effect in vivo of selected chemotherapeutic agents on synchronized murine fibrosarcoma cells. Br J Cancer. 1980 Nov; 42(5):677-83. PMID: 6161629.
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    143. Grdina DJ, Meistrich ML. Separation of solid tumor cell populations. Antibiot Chemother (1971). 1980; 28:137-41. PMID: 6998361.
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    144. Grdina DJ, Sigdestad CP, Jovonovich JA. The effect of misonidazole in situ on the radiation response of selected tumor subpopoulations. Cancer Clin Trials. 1980; 3(2):149-54. PMID: 7428138.
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    145. Hunter N, Peters LJ, Grdina DJ, White RA, Bartel A. Radiation sensitivity of murine fibrosarcoma cells separated by centrifugal elutriation. Radiat Res. 1979 Nov; 80(2):389-97. PMID: 504585.
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    146. Grdina DJ, Sigdestad CP, Jovonovich JA. Cytotoxic effect of adriamycin in vivo on synchronized murine fibrosarcoma cells. Int J Radiat Oncol Biol Phys. 1979 Aug; 5(8):1305-8. PMID: 528282.
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    147. Sigdestad CP, Grdina DJ, Ando K. Density gradient centrifugation of cells separated from multicellular tumor spheroids. Experientia. 1979 Jun 15; 35(6):815-7. PMID: 467603.
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    148. Grdina DJ, Sigdestad CP, Peters LJ. Phase-specific cytotoxicity in vivo of hydroxyurea on murine fibrosarcoma cells synchronized by centrifugal elutriation. Br J Cancer. 1979 Feb; 39(2):152-8. PMID: 435364.
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    149. Grdina DJ, Peters LJ, Jones S, Chan E. Separation of cells from a murine fibrosarcoma on the basis of size. I. Relationship between cell size and age as modified by growth in vivo or in vitro. J Natl Cancer Inst. 1978 Jul; 61(1):209-14. PMID: 276627.
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    150. Grdina DJ, Peters LJ, Jones S, Chan E. Separation of cells from a murine fibrosarcoma on the basis of size. II. Differential effects of cell size and age on lung retention and colony formation in normal and preconditioned mice. J Natl Cancer Inst. 1978 Jul; 61(1):215-20. PMID: 276628.
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    151. Grdina DJ, Linde S, Mason K. Response of selected tumour cell populations separated from a fibrosarcoma following irradiation in situ with fast neutrons. Br J Radiol. 1978 Apr; 51(604):291-301. PMID: 647186.
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    152. Meistrich ML, Grdina DJ, Meyn RE, Barlogie B. Separation of cells from mouse solid tumors by centrifugal elutriation. Cancer Res. 1977 Dec; 37(12):4291-6. PMID: 922721.
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    153. Grdina DJ, Hittelman WN, White RA, Meistrich ML. Relevance of density, size and DNA content of tumour cells to the lung colony assay. Br J Cancer. 1977 Dec; 36(6):659-69. PMID: 563726.
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    154. Suzuki N, Frapart M, Grdina DJ, Meistrich ML, Withers HR. Cell cycle dependency of metastatic lung colony formation. Cancer Res. 1977 Oct; 37(10):3690-3. PMID: 908016.
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    155. Grdina DJ, Basic I, Guzzino S, Mason KA. Radiation response of cell populations irradiated in situ and separated from a fibrosarcoma. Radiat Res. 1976 Jun; 66(3):634-43. PMID: 935350.
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    156. Grdina DJ. Separation of clonogenic cells from stationary phase cultures and a murine fibrosarcoma by density-gradient centrifugation. Methods Cell Biol. 1976; 14:213-28. PMID: 1034192.
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    157. Basic I, Milas L, Grdina DJ, Withers HR. In vitro destruction of tumor cells by macrophages from mice treated with Corynebacterium granulosum. J Natl Cancer Inst. 1975 Sep; 55(3):589-96. PMID: 1159835.
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    158. Grdina DJ, Basic I, Mason KA, Withers HR. Radiation response of clonogenic cell populations separated from fibrosarcoma. Radiat Res. 1975 Sep; 63(3):483-93. PMID: 1162034.
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    159. Milas L, Hunter B, Mason K, Grdina D, Withers H. Nonspecific Immunotherapy of Murine Solid Tumors With Corynebacterium granulosum. J Natl Cancer Inst. 1975 Apr; 54(4):895-902. PMID: 1127718.
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    160. Basic I, Milas L, Grdina DJ, Withers HR. Destruction of hamster ovarian cell cultures by peritoneal macrophages from mice treated with Corynebacterium granulosum. J Natl Cancer Inst. 1974 Jun; 52(6):1839-42. PMID: 4857795.
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    161. Grdina DJ, Meistrich ML, Withers HR. Separation of clonogenic cells from stationary phase cultures by density gradient centrifugation. Exp Cell Res. 1974 Mar 30; 85(1):15-22. PMID: 4857085.
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    162. Grdina DJ, Milas L, Mason KA, Withers HR. Separation of cells from a fibrosarcoma in renografin density gradients. J Natl Cancer Inst. 1974 Jan; 52(1):253-7. PMID: 4810965.
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    163. Grdina DJ, Milas L, Hewitt RR, Withers HR. Buoyant density separation of human blood cells in renografin gradients. Exp Cell Res. 1973 Sep; 81(1):250-4. PMID: 4796532.
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    164. Grdina DJ, Lohman PH, Hewitt RR. A fluorometric method for the detection of endodeoxyribonuclease on DNA-polyacrylamide gels. Anal Biochem. 1973 Jan; 51(1):255-64. PMID: 4688017.
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