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John Alverdy

TitleProfessor
InstitutionUniversity of Chicago
DepartmentSurgery-General Surgery
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    John Alverdy, MD, has run a continuously funded NIH-funded laboratory that studies the molecular interactions of bacteria and the intestinal mucosa in order to understand how life-threatening infections arise after trauma and major surgery and during critical illness. He has developed several anti-infective polymer-based compounds that can attenuate the virulence of several multi-drug resistant pathogens that cause life threatening infections in surgical patients and works with the IME to synthesize, refine, and scale the compounds for pre-clinical testing.

    The Alverdy lab seeks to better understand the regulation of virulence expression among potential pathogens through investigating the characteristics of the microbial context, molecular machinery that senses that context, and ultimately the lethal combinations of virulence expression that leads to disease. The majority of our work has focused on the sense and response virulence mechanisms of Pseudomonas aeruginosa, a well characterized and clinically important pathogen. We have shown a remarkable potential for this organisms to respond to host environmental cues related to stress, ischemia, immune activation and nutrient depletion. With this core model of environmental regulation of virulence expression, we are pursuing applications in intestinal transplantation, anastomotic and radiation physiology, necrotizing enterocolitis and ischemia/reperfusion injury. We are also investigating similar sense and response mechanisms in other clinically important organisms, including Staphylococcus aureus and Candida albicans. Finally, we are interested in developing virulence-based therapies to prevent virulence activation through modifications in microenvironment of the stressed host such as phosphate repletion and polymer-mediated mucosal replacement therapies.

    The ultimate goal of understanding microbial virulence is to provide clinical tools to improve the care of patients. However the complexity of the host-pathogen interaction and the vast amounts of mechanistic information available constitutes a formidable barrier to translational research. Computational agent based modeling is a well suited to dynamically represent mechanistic detail in a modifiable context to recapitulate cellular behavior at the tissue, organ and patient levels.

    Collapse Biography 
    Collapse education and training
    Michael Reese Hospital and Medical Center, Chicago, ILResidency in Surgery1985
    University of California, San FranciscoTrauma & Burn Fellowship1983
    Loyola University, Stritch School of Medicine, Chicago, IL(5th Pathway)1980
    Autonomous University , GuadalajaraMD1979
    Marquette University, WisconsinBA1975

    Collapse Research 
    Collapse research activities and funding
    R34GM111550     (ALVERDY, JOHN C.)Sep 20, 2014 - Sep 19, 2015
    NIH
    Serial Endoscopic Surveillance (SES) and Direct Topical Antibiotics (DTA) to prev
    Role: Principal Investigator

    R21AI099713     (ALVERDY, JOHN C.)Apr 15, 2012 - Mar 31, 2014
    NIH
    Interplay of diet and the metabolome in establishment of the juvenile gut microbi
    Role: Principal Investigator

    R01GM062344     (ALVERDY, JOHN C)Feb 1, 2001 - Mar 31, 2026
    NIH
    Gut pathogen virulence and its therapeutic modulation during surgical injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gilbert JA, Alverdy J. Where do the pathogens that cause surgical site infections come from? Sci Transl Med. 2024 Apr 10; 16(742):eado1449. PMID: 38598617.
      Citations:    
    2. Alverdy JC. Neurocognitive Testing, Retirement and Self-Awareness: It's Just Another Judgement Call. J Am Coll Surg. 2024 Apr 09. PMID: 38591785.
      Citations:    
    3. Alverdy JC, Polcari A, Benjamin A. Social determinants of health, the microbiome, and surgical injury. J Trauma Acute Care Surg. 2024 Mar 04. PMID: 38441071.
      Citations:    Fields:    
    4. Alverdy J. Comment on: Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries. Br J Surg. 2024 Mar 02; 111(3). PMID: 38507424.
      Citations: 1     Fields:    Translation:Humans
    5. Vigneswaran Y, Hussain M, Varsanik MA, Corvin C, Gottlieb LJ, Alverdy JC. IDEAL Phase 2a Results: Posterior Rectus Sheath Flap for Hiatal Augmentation in Complex Paraesophageal Hernias. Ann Surg. 2024 Feb 20. PMID: 38375674.
      Citations:    Fields:    
    6. Alverdy JC. Commentary on: Role of Microbiome in the Outcomes Following Surgical Repair of Perianal Fistula: Prospective Cohort Study Design and Preliminary Results. World J Surg. 2023 Dec; 47(12):3380-3381. PMID: 37930384; PMCID: PMC10793211.
      Citations:    Fields:    Translation:Humans
    7. Alverdy JC. Invited Commentary: Scientific Rationale behind Intestinal Alkaline Phosphatase Administration to Enhance Recovery after Pancreaticoduodenectomy. J Am Coll Surg. 2024 Jan 01; 238(1):80-81. PMID: 37870226; PMCID: PMC10795678.
      Citations:    Fields:    Translation:Humans
    8. Alverdy JC. Rationale behind phosphate therapy to modulate the gut microbiome and protect against surgery-related infection. Microbiota Host. 2023 Feb; 1(1). PMID: 37928950; PMCID: PMC10623387.
      Citations:    
    9. Alverdy JC. Expert Commentary on Perioperative Malnutrition. Dis Colon Rectum. 2023 12 01; 66(12):1531. PMID: 37682778.
      Citations:    Fields:    Translation:Humans
    10. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023 08 04; 381(6657):502-508. PMID: 37535745; PMCID: PMC10876062.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Vigneswaran J, Keskey RC, Morgan RB, Alverdy JC, Alpert L, Chang E, Weichselbaum R, Zaborina O, Shogan BD. Western Diet-induced Transcriptional Changes in Anastomotic Tissue Is Associated With Early Local Recurrence in a Mouse Model of Colorectal Surgery. Ann Surg. 2023 12 01; 278(6):954-960. PMID: 37522222; PMCID: PMC10775465.
      Citations:    Fields:    Translation:HumansAnimals
    12. Alverdy JC. Studies Involving Surgical Site Infections (SSIs) Without Culture Results, the Antibiotics Chosen for Prophylaxis and Antibiotic Sensitivity Data: "Are they Actionable?" Ann Surg. 2024 01 01; 279(1):13-14. PMID: 37465974.
      Citations:    Fields:    Translation:Humans
    13. Hyoju S, Machutta K, Krezalek MA, Alverdy JC. What Is the Role of the Gut in Wound Infections? Adv Surg. 2023 09; 57(1):31-46. PMID: 37536860; PMCID: PMC10837732.
      Citations:    Fields:    Translation:Humans
    14. Alverdy JC. The role of dietary prehabilitation on anastomotic healing. Curr Opin Clin Nutr Metab Care. 2023 09 01; 26(5):470-475. PMID: 37389468; PMCID: PMC10527134.
      Citations:    Fields:    Translation:Humans
    15. Pocivavsek L, Alverdy JC, Subramanian T. To Operate or Not? Balancing Advanced Imaging, Machine Learning, and the Doctor-Patient Relationship in Complex Clinical Decision Making. Acad Med. 2023 06 01; 98(6S):S34-S36. PMID: 36811972.
      Citations:    Fields:    Translation:Humans
    16. Long DR, Alverdy JC, Vavilala MS. Updates in Prevention of Surgical Site Infection: Reply. Anesthesiology. 2023 04 01; 138(4):447. PMID: 36661403.
      Citations:    Fields:    Translation:HumansPHPublic Health
    17. Alverdy JC. Rationale for Colonic Pre-Habilitation Prior to Restoration of Gastrointestinal Continuity. Surg Infect (Larchmt). 2023 Apr; 24(3):265-270. PMID: 37010975; PMCID: PMC10061335.
      Citations: 1     Fields:    Translation:Humans
    18. Alverdy JC. Biologically inspired gastrointestinal stapler design: "Getting to Zero" complications. Am J Surg. 2023 07; 226(1):48-52. PMID: 36775790; PMCID: PMC10293041.
      Citations:    Fields:    Translation:Humans
    19. Krezalek MA, Alverdy JC. The Role of the Gut Microbiome on the Development of Surgical Site Infections. Clin Colon Rectal Surg. 2023 Mar; 36(2):133-137. PMID: 36844709; PMCID: PMC9946714.
      Citations: 1     
    20. Alverdy JC. "It Is Not Necessary to Kill Them in Order to Make Them Relatively Harmless": Molecular Diplomacy in the Pathogen-Host Interaction. Surg Infect (Larchmt). 2023 02; 24(1):1-3. PMID: 36521176; PMCID: PMC9894596.
      Citations:    Fields:    Translation:Humans
    21. Zaza S, Alverdy J. Pitfalls and Traps in the Surgical Evaluation of Patients with Irritable Bowel Syndrome (IBS). J Gastrointest Surg. 2023 03; 27(3):568-572. PMID: 36456888; PMCID: PMC10065918.
      Citations:    Fields:    Translation:Humans
    22. Machutta K, Xiao J, Winters CA, Perrott J, Chidambaram S, Kinross JM, Morgan RB, Subramanian T, Cifu AS, Alverdy JC. Defeating Cancel Culture in Surgical Site Infection Research: A Plea to Include Microbial Cultures and Antibiotic Sensitivity Data. Surg Infect (Larchmt). 2022 Dec; 23(10):902-907. PMID: 36399540.
      Citations: 1     Fields:    
    23. Alverdy JC. Association Does Not Equal Causation-Does Thinking You Are Better Make You Better? JAMA Surg. 2022 Oct 05. PMID: 36197693.
      Citations:    Fields:    
    24. Long DR, Alverdy JC, Vavilala MS. Emerging Paradigms in the Prevention of Surgical Site Infection: The Patient Microbiome and Antimicrobial Resistance. Anesthesiology. 2022 08 01; 137(2):252-262. PMID: 35666980; PMCID: PMC9558427.
      Citations: 7     Fields:    Translation:Humans
    25. Hyoju SK, Keskey R, Castillo G, Machutta K, Zaborin A, Zaborina O, Alverdy JC. A Novel Nonantibiotic Gut-directed Strategy to Prevent Surgical Site Infections. Ann Surg. 2022 09 01; 276(3):472-481. PMID: 35749750; PMCID: PMC9869400.
      Citations: 2     Fields:    Translation:Animals
    26. Alverdy JC. Letter to the Editor: Between-Group Comparison Fallacy. Surg Infect (Larchmt). 2022 08; 23(6):609. PMID: 35588202; PMCID: PMC10027335.
      Citations: 3     Fields:    
    27. Chidambaram S, Maheswaran Y, Chan C, Hanna L, Ashrafian H, Markar SR, Sounderajah V, Alverdy JC, Darzi A. Misinformation About the Human Gut Microbiome in YouTube Videos: Cross-sectional Study. JMIR Form Res. 2022 May 16; 6(5):e37546. PMID: 35576578; PMCID: PMC9152718.
      Citations: 1     
    28. Williamson AJ, Jacobson R, van Praagh JB, Gaines S, Koo HY, Lee B, Chan WC, Weichselbaum R, Alverdy JC, Zaborina O, Shogan BD. Enterococcus faecalis promotes a migratory and invasive phenotype in colon cancer cells. Neoplasia. 2022 05; 27:100787. PMID: 35366466; PMCID: PMC8971311.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    29. Jacobson RA, Williamson AJ, Wienholts K, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC. Prevention of Anastomotic Leak Via Local Application of Tranexamic Acid to Target Bacterial-mediated Plasminogen Activation: A Practical Solution to a Complex Problem. Ann Surg. 2021 12 01; 274(6):e1038-e1046. PMID: 31851007; PMCID: PMC7875208.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Williamson AJ, Alverdy JC. Influence of the Microbiome on Anastomotic Leak. Clin Colon Rectal Surg. 2021 Nov; 34(6):439-446. PMID: 34853567; PMCID: PMC8610638.
      Citations: 9     
    31. Mundi MS, Patel JJ, Mechanick JI, Arabi YM, Alverdy J, Puthucheary Z, McClave SA. Case presentation and panel discussion: Critical illness. JPEN J Parenter Enteral Nutr. 2021 11; 45(S2):79-84. PMID: 34383970.
      Citations:    Fields:    Translation:Humans
    32. Toni T, Alverdy J, Gershuni V. Re-examining chemically defined liquid diets through the lens of the microbiome. Nat Rev Gastroenterol Hepatol. 2021 12; 18(12):903-911. PMID: 34594028; PMCID: PMC8815794.
      Citations: 5     Fields:    Translation:Humans
    33. Vigneswaran Y, Bryan AF, Ruhle B, Gottlieb LJ, Alverdy J. Autologous Posterior Rectus Sheath as a Vascularized Onlay Flap: a Novel Approach to Hiatal Hernia Repair. J Gastrointest Surg. 2022 01; 26(1):268-274. PMID: 34506032; PMCID: PMC8760196.
      Citations: 2     Fields:    Translation:Humans
    34. van den Berg FF, Hugenholtz F, Boermeester MA, Zaborina O, Alverdy JC. Spatioregional assessment of the gut microbiota in experimental necrotizing pancreatitis. BJS Open. 2021 09 06; 5(5). PMID: 34518874; PMCID: PMC8438261.
      Citations: 7     Translation:HumansAnimals
    35. Anderson DI, Keskey R, Ackerman MT, Zaborina O, Hyman N, Alverdy JC, Shogan BD. Enterococcus faecalis Is Associated with Anastomotic Leak in Patients Undergoing Colorectal Surgery. Surg Infect (Larchmt). 2021 Dec; 22(10):1047-1051. PMID: 34255574; PMCID: PMC8851212.
      Citations: 8     Fields:    Translation:HumansCells
    36. Miller WD, Keskey R, Alverdy JC. Sepsis and the Microbiome: A Vicious Cycle. J Infect Dis. 2021 06 16; 223(12 Suppl 2):S264-S269. PMID: 33330900; PMCID: PMC8206800.
      Citations: 23     Fields:    Translation:Humans
    37. Alverdy JC, Schardey HM. Anastomotic Leak: Toward an Understanding of Its Root Causes. J Gastrointest Surg. 2021 11; 25(11):2966-2975. PMID: 34100248; PMCID: PMC8815793.
      Citations: 8     Fields:    Translation:Humans
    38. Alverdy JC. Bowel preparation in colorectal surgery: the day of reckoning is here. Br J Surg. 2021 04 30; 108(4):340-341. PMID: 33793758; PMCID: PMC8815791.
      Citations: 1     Fields:    Translation:Humans
    39. Toni T, Alverdy J. Harnessing the Microbiome to Optimize Surgical Outcomes in the COVID-19 Era. Ann Surg Open. 2021 Jun; 2(2):e056. PMID: 36590034; PMCID: PMC9794001.
      Citations:    
    40. Guyton K, Belogortseva N, Levine Z, Kaiser BD, Sangwan N, Hyman N, Shogan BD, Zaborina O, Alverdy JC. Patient Acceptance of Routine Serial Postoperative Endoscopy Following Low Anterior Resection (LAR) and Its Ability to Detect Biomarkers in Anastomotic Lavage Fluid. World J Surg. 2021 07; 45(7):2227-2234. PMID: 33742231; PMCID: PMC8516158.
      Citations: 6     Fields:    Translation:HumansAnimals
    41. Alverdy JC. Peer Review and the Quest for Technical Excellence in Surgery-A Lesson in Self-awareness. JAMA Surg. 2021 02 01; 156(2):e205557. PMID: 33326011.
      Citations:    Fields:    Translation:Humans
    42. Alverdy JC. The Benefits of Robotic Surgery: Are They Technical or Molecular? J Gastrointest Surg. 2021 02; 25(2):578-580. PMID: 33409821; PMCID: PMC7904706.
      Citations:    Fields:    Translation:Humans
    43. Keskey R, Papazian E, Lam A, Toni T, Hyoju S, Thewissen R, Zaborin A, Zaborina O, Alverdy JC. Defining Microbiome Readiness for Surgery: Dietary Prehabilitation and Stool Biomarkers as Predictive Tools to Improve Outcome. Ann Surg. 2022 11 01; 276(5):e361-e369. PMID: 33156068; PMCID: PMC8812511.
      Citations: 11     Fields:    Translation:HumansAnimals
    44. Madariaga MLL, Guthmiller JJ, Schrantz S, Jansen MO, Christensen C, Kumar M, Prochaska M, Wool G, Durkin-Celauro A, Oh WH, Trockman L, Vigneswaran J, Keskey R, Shaw DG, Dugan H, Zheng NY, Cobb M, Utset H, Wang J, Stovicek O, Bethel C, Matushek S, Giurcanu M, Beavis KG, di Sabato D, Meltzer D, Ferguson MK, Kress JP, Shanmugarajah K, Matthews JB, Fung JF, Wilson PC, Alverdy JC, Donington JS. Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial. J Intern Med. 2021 04; 289(4):559-573. PMID: 33034095; PMCID: PMC7675325.
      Citations: 39     Fields:    Translation:HumansCellsCTClinical Trials
    45. van den Berg FF, van Dalen D, Hyoju SK, van Santvoort HC, Besselink MG, Wiersinga WJ, Zaborina O, Boermeester MA, Alverdy J. Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. Gut. 2021 05; 70(5):915-927. PMID: 32873697; PMCID: PMC7917160.
      Citations: 40     Fields:    Translation:HumansAnimals
    46. Alverdy JC, Keskey R, Thewissen R. Can the Cecal Ligation and Puncture Model Be Repurposed To Better Inform Therapy in Human Sepsis? Infect Immun. 2020 08 19; 88(9). PMID: 32571986; PMCID: PMC7440761.
      Citations: 22     Fields:    Translation:HumansAnimals
    47. Alverdy JC. Letter to a Young Surgeon During Coronavirus Disease 2019. Ann Surg Open. 2020 Sep; 1(1):e003. PMID: 37637245; PMCID: PMC10455378.
      Citations:    
    48. Alverdy JC, Gilbert JA, Hyman N. Surgical site infections following elective surgery - Authors' reply. Lancet Infect Dis. 2020 08; 20(8):899. PMID: 32738234.
      Citations:    Fields:    Translation:HumansPHPublic Health
    49. Keskey R, Cone JT, DeFazio JR, Alverdy JC. The use of fecal microbiota transplant in sepsis. Transl Res. 2020 12; 226:12-25. PMID: 32649987; PMCID: PMC7572598.
      Citations: 11     Fields:    Translation:Humans
    50. Lam A, Fleischer B, Alverdy J. The Biology of Anastomotic Healing-the Unknown Overwhelms the Known. J Gastrointest Surg. 2020 09; 24(9):2160-2166. PMID: 32524361; PMCID: PMC7446770.
      Citations: 25     Fields:    Translation:Humans
    51. Zaborin A, Penalver Bernabe B, Keskey R, Sangwan N, Hyoju S, Gottel N, Gilbert JA, Zaborina O, Alverdy JC. Spatial Compartmentalization of the Microbiome between the Lumen and Crypts Is Lost in the Murine Cecum following the Process of Surgery, Including Overnight Fasting and Exposure to Antibiotics. mSystems. 2020 Jun 09; 5(3). PMID: 32518197; PMCID: PMC7289591.
      Citations: 10     Fields:    
    52. Kim SM, DeFazio JR, Hyoju SK, Sangani K, Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris KG, Malik A, Zaborin A, Bouziat R, Ranoa DR, Wiegerinck M, Ernest JD, Shakhsheer BA, Fleming ID, Weichselbaum RR, Antonopoulos DA, Gilbert JA, Barreiro LB, Zaborina O, Jabri B, Alverdy JC. Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nat Commun. 2020 05 11; 11(1):2354. PMID: 32393794; PMCID: PMC7214422.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    53. Christley S, Shogan B, Levine Z, Koo H, Guyton K, Owens S, Gilbert J, Zaborina O, Alverdy JC. Comparative genetics of Enterococcus faecalis intestinal tissue isolates before and after surgery in a rat model of colon anastomosis. PLoS One. 2020; 15(4):e0232165. PMID: 32343730; PMCID: PMC7188289.
      Citations: 4     Fields:    Translation:AnimalsCells
    54. van Praagh JB, Luo JN, Zaborina O, Alverdy JC. Involvement of the Commensal Organism Bacillus subtilis in the Pathogenesis of Anastomotic Leak. Surg Infect (Larchmt). 2020 Dec; 21(10):865-870. PMID: 32310731; PMCID: PMC7703376.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    55. Pimentel MB, Borges FTP, Teymour F, Zaborina OY, Alverdy JC, Fang K, Hong SH, Staneviciute A, He YJ, Papavasiliou G. An in vitro tissue model for screening sustained release of phosphate-based therapeutic attenuation of pathogen-induced proteolytic matrix degradation. J Mater Chem B. 2020 03 25; 8(12):2454-2465. PMID: 32108210; PMCID: PMC7183213.
      Citations:    Fields:    Translation:HumansCells
    56. Beisani M, Alverdy JC, Talavera-Urquijo E, Balibrea JM. Is bariatric surgery resolving NAFLD via microbiota-mediated bile acid ratio reversal? A comprehensive review. Surg Obes Relat Dis. 2020 Sep; 16(9):1361-1369. PMID: 32336663.
      Citations: 12     Fields:    Translation:Humans
    57. Alverdy JC, Hyman N, Gilbert J. Re-examining causes of surgical site infections following elective surgery in the era of asepsis. Lancet Infect Dis. 2020 03; 20(3):e38-e43. PMID: 32006469; PMCID: PMC8019154.
      Citations: 36     Fields:    Translation:HumansPHPublic Health
    58. Gaines S, Hyoju S, Williamson AJ, van Praagh JB, Zaborina O, Rubin DT, Alverdy JC, Shogan BD, Hyman N. Infliximab Does Not Promote the Presence of Collagenolytic Bacteria in a Mouse Model of Colorectal Anastomosis. J Gastrointest Surg. 2020 11; 24(11):2637-2642. PMID: 31898107; PMCID: PMC7931774.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    59. Hyoju SK, Adriaansens C, Wienholts K, Sharma A, Keskey R, Arnold W, van Dalen D, Gottel N, Hyman N, Zaborin A, Gilbert J, van Goor H, Zaborina O, Alverdy JC. Low-fat/high-fibre diet prehabilitation improves anastomotic healing via the microbiome: an experimental model. Br J Surg. 2020 05; 107(6):743-755. PMID: 31879948; PMCID: PMC7875206.
      Citations: 29     Fields:    Translation:Animals
    60. Alverdy JC, Hyman N. Bowel preparation under siege. Br J Surg. 2020 02; 107(3):167-170. PMID: 31872429; PMCID: PMC7938815.
      Citations: 12     Fields:    Translation:Humans
    61. Alverdy JC, Shogan BD. Preparing the bowel for surgery: rethinking the strategy. Nat Rev Gastroenterol Hepatol. 2019 12; 16(12):708-709. PMID: 31548712; PMCID: PMC7987207.
      Citations: 8     Fields:    
    62. Gaines S, van Praagh JB, Williamson AJ, Jacobson RA, Hyoju S, Zaborin A, Mao J, Koo HY, Alpert L, Bissonnette M, Weichselbaum R, Gilbert J, Chang E, Hyman N, Zaborina O, Shogan BD, Alverdy JC. Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery. Gastroenterology. 2020 03; 158(4):958-970.e2. PMID: 31655031; PMCID: PMC7062578.
      Citations: 26     Fields:    Translation:AnimalsCells
    63. Jacobson RA, Wienholts K, Williamson AJ, Gaines S, Hyoju S, van Goor H, Zaborin A, Shogan BD, Zaborina O, Alverdy JC. Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets. Am J Physiol Gastrointest Liver Physiol. 2020 01 01; 318(1):G1-G9. PMID: 31604031; PMCID: PMC6985841.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    64. Guyton KL, Levine ZC, Lowry AC, Lambert L, Gribovskaja-Rupp I, Hyman N, Zaborina O, Alverdy J. Identification of Collagenolytic Bacteria in Human Samples: Screening Methods and Clinical Implications for Resolving and Preventing Anastomotic Leaks and Wound Complications. Dis Colon Rectum. 2019 08; 62(8):972-979. PMID: 31283593; PMCID: PMC6624086.
      Citations: 12     Fields:    Translation:HumansCells
    65. Hyoju SK, Zaborin A, Keskey R, Sharma A, Arnold W, van den Berg F, Kim SM, Gottel N, Bethel C, Charnot-Katsikas A, Jianxin P, Adriaansens C, Papazian E, Gilbert JA, Zaborina O, Alverdy JC. Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts. mBio. 2019 07 30; 10(4). PMID: 31363025; PMCID: PMC6667615.
      Citations: 20     Fields:    Translation:Animals
    66. Nichols D, Pimentel MB, Borges FTP, Hyoju SK, Teymour F, Hong SH, Zaborina OY, Alverdy JC, Papavasiliou G. Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm Formation in vitro. Front Bioeng Biotechnol. 2019; 7:153. PMID: 31297368; PMCID: PMC6607000.
      Citations: 4     
    67. Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O'Keefe SJ, Gaskins HR, Teare J, Yu J, Hughes DJ, Verstraelen H, Burton J, O'Toole PW, Rosenberg DW, Marchesi JR, Kinross JM. International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. Gut. 2019 09; 68(9):1624-1632. PMID: 31092590; PMCID: PMC6709773.
      Citations: 102     Fields:    Translation:HumansAnimals
    68. Alverdy JC. Surgeon as Basic Bench Scientist: A Play in Three Acts. J Surg Res. 2019 09; 241:336-342. PMID: 31071482; PMCID: PMC9382856.
      Citations: 3     Fields:    Translation:Humans
    69. Alverdy JC. The wound environment, microbial virulence and postoperative infection: Practical lessons for the surgeon. Cir Esp (Engl Ed). 2018 Dec; 96(10):612-619. PMID: 30502224.
      Citations: 1     Fields:    Translation:HumansCells
    70. Alverdy JC. Ionic Modulation of Bacterial Virulence and Its Role in Surgical Infection. Surg Infect (Larchmt). 2018 Nov/Dec; 19(8):769-773. PMID: 30359172; PMCID: PMC6302668.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    71. Hyoju SK, Klabbers RE, Aaron M, Krezalek MA, Zaborin A, Wiegerinck M, Hyman NH, Zaborina O, Van Goor H, Alverdy JC. Oral Polyphosphate Suppresses Bacterial Collagenase Production and Prevents Anastomotic Leak Due to Serratia marcescens and Pseudomonas aeruginosa. Ann Surg. 2018 06; 267(6):1112-1118. PMID: 28166091; PMCID: PMC5540820.
      Citations: 32     Fields:    Translation:AnimalsCells
    72. Wiegerinck M, Hyoju SK, Mao J, Zaborin A, Adriaansens C, Salzman E, Hyman NH, Zaborina O, van Goor H, Alverdy JC. Novel de novo synthesized phosphate carrier compound ABA-PEG20k-Pi20 suppresses collagenase production in Enterococcus faecalis and prevents colonic anastomotic leak in an experimental model. Br J Surg. 2018 09; 105(10):1368-1376. PMID: 29658991; PMCID: PMC6827486.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    73. Krezalek MA, Hyoju S, Zaborin A, Okafor E, Chandrasekar L, Bindokas V, Guyton K, Montgomery CP, Daum RS, Zaborina O, Boyle-Vavra S, Alverdy JC. Can Methicillin-resistant Staphylococcus aureus Silently Travel From the Gut to the Wound and Cause Postoperative Infection? Modeling the "Trojan Horse Hypothesis". Ann Surg. 2018 04; 267(4):749-758. PMID: 28187042.
      Citations: 38     Fields:    Translation:AnimalsCells
    74. Alverdy JC. Microbiome Medicine: This Changes Everything. J Am Coll Surg. 2018 05; 226(5):719-729. PMID: 29505823; PMCID: PMC5924601.
      Citations: 9     Fields:    Translation:Humans
    75. Alverdy JC. Hypermetabolism and Nutritional Support in Sepsis. Surg Infect (Larchmt). 2018 Feb/Mar; 19(2):163-167. PMID: 29394142; PMCID: PMC5815446.
      Citations: 5     Fields:    Translation:Humans
    76. Gaines S, Shao C, Hyman N, Alverdy JC. Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. Br J Surg. 2018 01; 105(2):e131-e141. PMID: 29341151; PMCID: PMC5903685.
      Citations: 56     Fields:    Translation:Humans
    77. Belogortseva N, Krezalek M, Guyton K, Labno C, Poroyko V, Zaborina O, Alverdy JC. Media from macrophages co-incubated with Enterococcus faecalis induces epithelial cell monolayer reassembly and altered cell morphology. PLoS One. 2017; 12(8):e0182825. PMID: 28793333; PMCID: PMC5549984.
      Citations: 6     Fields:    Translation:AnimalsCells
    78. Mao J, Zaborin A, Poroyko V, Goldfeld D, Lynd NA, Chen W, Tirrell MV, Zaborina O, Alverdy JC. De Novo Synthesis of Phosphorylated Triblock Copolymers with Pathogen Virulence-Suppressing Properties That Prevent Infection-Related Mortality. ACS Biomater Sci Eng. 2017 Sep 11; 3(9):2076-2085. PMID: 29372179; PMCID: PMC5779099.
      Citations: 5     Fields:    
    79. Gaines S, Alverdy JC. Fecal Micobiota Transplantation to Treat Sepsis of Unclear Etiology. Crit Care Med. 2017 06; 45(6):1106-1107. PMID: 28509739; PMCID: PMC5434704.
      Citations: 4     Fields:    Translation:Humans
    80. Lax S, Sangwan N, Smith D, Larsen P, Handley KM, Richardson M, Guyton K, Krezalek M, Shogan BD, Defazio J, Flemming I, Shakhsheer B, Weber S, Landon E, Garcia-Houchins S, Siegel J, Alverdy J, Knight R, Stephens B, Gilbert JA. Bacterial colonization and succession in a newly opened hospital. Sci Transl Med. 2017 05 24; 9(391). PMID: 28539477; PMCID: PMC5706123.
      Citations: 139     Fields:    Translation:HumansCells
    81. Alverdy JC, Hyman N, Gilbert J, Luo JN, Krezalek M. Preparing the Bowel for Surgery: Learning from the Past and Planning for the Future. J Am Coll Surg. 2017 08; 225(2):324-332. PMID: 28529136; PMCID: PMC5761741.
      Citations: 7     Fields:    Translation:Humans
    82. Alverdy JC, Prachand V. Smoking and Postoperative Surgical Site Infection: Where There's Smoke, There's Fire. JAMA Surg. 2017 05 01; 152(5):484. PMID: 28199452.
      Citations: 3     Fields:    Translation:Humans
    83. Gaines S, Luo JN, Gilbert J, Zaborina O, Alverdy JC. Optimum Operating Room Environment for the Prevention of Surgical Site Infections. Surg Infect (Larchmt). 2017 May/Jun; 18(4):503-507. PMID: 28402706; PMCID: PMC5972753.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    84. Alverdy JC, Luo JN. The Influence of Host Stress on the Mechanism of Infection: Lost Microbiomes, Emergent Pathobiomes, and the Role of Interkingdom Signaling. Front Microbiol. 2017; 8:322. PMID: 28303126; PMCID: PMC5332386.
      Citations: 15     
    85. Krezalek MA, Yeh A, Alverdy JC, Morowitz M. Influence of nutrition therapy on the intestinal microbiome. Curr Opin Clin Nutr Metab Care. 2017 03; 20(2):131-137. PMID: 27997410.
      Citations: 19     Fields:    Translation:Humans
    86. Fleming ID, Krezalek MA, Belogortseva N, Zaborin A, Defazio J, Chandrasekar L, Actis LA, Zaborina O, Alverdy JC. Modeling Acinetobacter baumannii wound infections: The critical role of iron. J Trauma Acute Care Surg. 2017 03; 82(3):557-565. PMID: 28030490; PMCID: PMC5322184.
      Citations: 9     Fields:    Translation:AnimalsCells
    87. Collier ZJ, Gottlieb LJ, Alverdy JC. Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period. Surg Infect (Larchmt). 2017 Apr; 18(3):327-335. PMID: 28394746; PMCID: PMC8881957.
      Citations: 5     Fields:    Translation:HumansCells
    88. Alverdy JC, Krezalek MA. Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis. Crit Care Med. 2017 Feb; 45(2):337-347. PMID: 28098630; PMCID: PMC5245179.
      Citations: 63     Fields:    Translation:HumansAnimals
    89. Alverdy JC, Hyoju SK, Weigerinck M, Gilbert JA. The gut microbiome and the mechanism of surgical infection. Br J Surg. 2017 Jan; 104(2):e14-e23. PMID: 28121030; PMCID: PMC7938814.
      Citations: 33     Fields:    Translation:Humans
    90. Shakhsheer BA, Lec B, Zaborin A, Guyton K, Defnet AM, Bagrodia N, Kandel JJ, Zaborina O, Hernandez SL, Alverdy J. Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats. Int J Colorectal Dis. 2017 Apr; 32(4):539-547. PMID: 27999936.
      Citations: 9     Fields:    Translation:Animals
    91. Zaborin A, Krezalek M, Hyoju S, Defazio JR, Setia N, Belogortseva N, Bindokas VP, Guo Q, Zaborina O, Alverdy JC. Critical role of microbiota within cecal crypts on the regenerative capacity of the intestinal epithelium following surgical stress. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 01; 312(2):G112-G122. PMID: 27979825; PMCID: PMC5338606.
      Citations: 15     Fields:    Translation:Animals
    92. Yin Y, Papavasiliou G, Zaborina OY, Alverdy JC, Teymour F. De Novo Synthesis and Functional Analysis of Polyphosphate-Loaded Poly(Ethylene) Glycol Hydrogel Nanoparticles Targeting Pyocyanin and Pyoverdin Production in Pseudomonas aeruginosa as a Model Intestinal Pathogen. Ann Biomed Eng. 2017 04; 45(4):1058-1068. PMID: 27761766; PMCID: PMC5364061.
      Citations: 6     Fields:    Translation:Cells
    93. Guyton K, Alverdy JC. The gut microbiota and gastrointestinal surgery. Nat Rev Gastroenterol Hepatol. 2017 Jan; 14(1):43-54. PMID: 27729657.
      Citations: 95     Fields:    Translation:HumansPHPublic Health
    94. Krezalek MA, Alverdy JC. The role of the microbiota in surgical recovery. Curr Opin Clin Nutr Metab Care. 2016 Sep; 19(5):347-352. PMID: 27341127; PMCID: PMC5182201.
      Citations: 6     Fields:    
    95. Shakhsheer BA, Versten LA, Luo JN, Defazio JR, Klabbers R, Christley S, Zaborin A, Guyton KL, Krezalek M, Smith DP, Ajami NJ, Petrosino JF, Fleming ID, Belogortseva N, Zaborina O, Alverdy JC. Morphine Promotes Colonization of Anastomotic Tissues with Collagenase - Producing Enterococcus faecalis and Causes Leak. J Gastrointest Surg. 2016 10; 20(10):1744-51. PMID: 27530446; PMCID: PMC10314329.
      Citations: 27     Fields:    Translation:AnimalsCells
    96. Guyton KL, Hyman NH, Alverdy JC. Prevention of Perioperative Anastomotic Healing Complications: Anastomotic Stricture and Anastomotic Leak. Adv Surg. 2016 09; 50(1):129-41. PMID: 27520868; PMCID: PMC5079140.
      Citations: 26     Fields:    Translation:Humans
    97. Miller B, Popejoy MW, Hershberger E, Steenbergen JN, Alverdy J. Characteristics and Outcomes of Complicated Intra-abdominal Infections Involving Pseudomonas aeruginosa from a Randomized, Double-Blind, Phase 3 Ceftolozane-Tazobactam Study. Antimicrob Agents Chemother. 2016 07; 60(7):4387-90. PMID: 27139477; PMCID: PMC4914617.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    98. Alverdy JC. A Video Is Worth a Thousand Words. JAMA Surg. 2016 06 15; 151(6):e160476. PMID: 27074107.
      Citations:    Fields:    
    99. Krezalek MA, Skowron KB, Guyton KL, Shakhsheer B, Hyoju S, Alverdy JC. The intestinal microbiome and surgical disease. Curr Probl Surg. 2016 Jun; 53(6):257-93. PMID: 27497246; PMCID: PMC5079158.
      Citations: 15     Fields:    Translation:HumansAnimals
    100. Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC. The Shift of an Intestinal "Microbiome" to a "Pathobiome" Governs the Course and Outcome of Sepsis Following Surgical Injury. Shock. 2016 May; 45(5):475-82. PMID: 26863118; PMCID: PMC4833524.
      Citations: 63     Fields:    Translation:Humans
    101. Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G973-88. PMID: 27079612; PMCID: PMC4935476.
      Citations: 11     Fields:    Translation:HumansAnimals
    102. Kanteti R, Dhanasingh I, El-Hashani E, Riehm JJ, Stricker T, Nagy S, Zaborin A, Zaborina O, Biron D, Alverdy JC, Im HK, Siddiqui S, Padilla PA, Salgia R. C. elegans and mutants with chronic nicotine exposure as a novel model of cancer phenotype. Cancer Biol Ther. 2016; 17(1):91-103. PMID: 26574927; PMCID: PMC6093410.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    103. Gilbert JA, Alverdy J. Stool consistency as a major confounding factor affecting microbiota composition: an ignored variable? Gut. 2016 Jan; 65(1):1-2. PMID: 26187505.
      Citations: 11     Fields:    Translation:Humans
    104. Shogan BD, Belogortseva N, Luong PM, Zaborin A, Lax S, Bethel C, Ward M, Muldoon JP, Singer M, An G, Umanskiy K, Konda V, Shakhsheer B, Luo J, Klabbers R, Hancock LE, Gilbert J, Zaborina O, Alverdy JC. Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leak. Sci Transl Med. 2015 May 06; 7(286):286ra68. PMID: 25947163; PMCID: PMC5027898.
      Citations: 167     Fields:    Translation:HumansAnimalsCells
    105. Kim M, Christley S, Khodarev NN, Fleming I, Huang Y, Chang E, Zaborina O, Alverdy JC. Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. J Trauma Acute Care Surg. 2015 Apr; 78(4):823-9. PMID: 25807409; PMCID: PMC4376013.
      Citations: 13     Fields:    Translation:AnimalsCells
    106. Defazio J, Fleming ID, Shakhsheer B, Zaborina O, Alverdy JC. The opposing forces of the intestinal microbiome and the emerging pathobiome. Surg Clin North Am. 2014 Dec; 94(6):1151-61. PMID: 25440116; PMCID: PMC4254556.
      Citations: 25     Fields:    Translation:Humans
    107. Zaborin A, Smith D, Garfield K, Quensen J, Shakhsheer B, Kade M, Tirrell M, Tiedje J, Gilbert JA, Zaborina O, Alverdy JC. Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. mBio. 2014 Sep 23; 5(5):e01361-14. PMID: 25249279; PMCID: PMC4173762.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    108. Shogan BD, Smith DP, Christley S, Gilbert JA, Zaborina O, Alverdy JC. Intestinal anastomotic injury alters spatially defined microbiome composition and function. Microbiome. 2014; 2:35. PMID: 25250176; PMCID: PMC4171717.
      Citations: 76     Fields:    
    109. Shogan BD, An GC, Schardey HM, Matthews JB, Umanskiy K, Fleshman JW, Hoeppner J, Fry DE, Garcia-Granereo E, Jeekel H, van Goor H, Dellinger EP, Konda V, Gilbert JA, Auner GW, Alverdy JC. Proceedings of the first international summit on intestinal anastomotic leak, Chicago, Illinois, October 4-5, 2012. Surg Infect (Larchmt). 2014 Oct; 15(5):479-89. PMID: 25215465; PMCID: PMC4382716.
      Citations: 14     Fields:    Translation:Humans
    110. Alverdy JC. Valuable heartburn data that may be difficult to swallow. Surg Obes Relat Dis. 2015 Jan-Feb; 11(1):229. PMID: 25264324.
      Citations:    Fields:    Translation:Humans
    111. Shah M, Zaborin A, Alverdy JC, Scott K, Zaborina O. Localization of DING proteins on PstS-containing outer-surface appendages of Pseudomonas aeruginosa. FEMS Microbiol Lett. 2014 Mar; 352(1):54-61. PMID: 24372739; PMCID: PMC3949141.
      Citations: 4     Fields:    Translation:HumansCells
    112. Zaborina O, Alverdy J, Shah M, Chen Y. Microscopic analysis: morphotypes and cellular appendages. Methods Mol Biol. 2014; 1149:99-107. PMID: 24818901.
      Citations:    Fields:    Translation:Cells
    113. Alverdy J, Gilbert J, DeFazio JR, Sadowsky MJ, Chang EB, Morowitz MJ, Teitelbaum DH. Proceedings of the 2013 A.S.P.E.N. Research workshop: the interface between nutrition and the gut microbiome: implications and applications for human health [corrected]. JPEN J Parenter Enteral Nutr. 2014 Feb; 38(2):167-78. PMID: 24379111; PMCID: PMC3995834.
      Citations: 6     Fields:    Translation:HumansCells
    114. Zaborin A, Defazio JR, Kade M, Kaiser BL, Belogortseva N, Camp DG, Smith RD, Adkins JN, Kim SM, Alverdy A, Goldfeld D, Firestone MA, Collier JH, Jabri B, Tirrell M, Zaborina O, Alverdy JC. Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. Antimicrob Agents Chemother. 2014; 58(2):966-77. PMID: 24277029; PMCID: PMC3910877.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    115. Luong PM, Shogan BD, Zaborin A, Belogortseva N, Shrout JD, Zaborina O, Alverdy JC. Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF. J Bacteriol. 2014 Jan; 196(2):504-13. PMID: 24244000; PMCID: PMC3911258.
      Citations: 24     Fields:    Translation:AnimalsCells
    116. Shogan BD, Smith DP, Packman AI, Kelley ST, Landon EM, Bhangar S, Vora GJ, Jones RM, Keegan K, Stephens B, Ramos T, Kirkup BC, Levin H, Rosenthal M, Foxman B, Chang EB, Siegel J, Cobey S, An G, Alverdy JC, Olsiewski PJ, Martin MO, Marrs R, Hernandez M, Christley S, Morowitz M, Weber S, Gilbert J. The Hospital Microbiome Project: Meeting report for the 2nd Hospital Microbiome Project, Chicago, USA, January 15(th), 2013. Stand Genomic Sci. 2013 Jul 30; 8(3):571-9. PMID: 24501640; PMCID: PMC3910697.
      Citations: 6     
    117. Shogan BD, Carlisle EM, Alverdy JC, Umanskiy K. Do we really know why colorectal anastomoses leak? J Gastrointest Surg. 2013 Sep; 17(9):1698-707. PMID: 23690209.
      Citations: 100     Fields:    Translation:Humans
    118. Smith D, Alverdy J, An G, Coleman M, Garcia-Houchins S, Green J, Keegan K, Kelley ST, Kirkup BC, Kociolek L, Levin H, Landon E, Olsiewski P, Knight R, Siegel J, Weber S, Gilbert J. The Hospital Microbiome Project: Meeting Report for the 1st Hospital Microbiome Project Workshop on sampling design and building science measurements, Chicago, USA, June 7th-8th 2012. Stand Genomic Sci. 2013 Apr 15; 8(1):112-7. PMID: 23961316; PMCID: PMC3739179.
      Citations: 6     
    119. Valuckaite V, Seal J, Zaborina O, Tretiakova M, Testa G, Alverdy JC. High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation. J Surg Res. 2013 Aug; 183(2):869-75. PMID: 23522457; PMCID: PMC3713159.
      Citations: 11     Fields:    Translation:AnimalsCells
    120. Nelson RK, Poroyko V, Morowitz MJ, Liu D, Alverdy JC. Effect of dietary monosaccharides on Pseudomonas aeruginosa virulence. Surg Infect (Larchmt). 2013 Feb; 14(1):35-42. PMID: 23451729; PMCID: PMC3601807.
      Citations: 8     Fields:    Translation:HumansCells
    121. Carlisle EM, Poroyko V, Caplan MS, Alverdy J, Morowitz MJ, Liu D. Murine gut microbiota and transcriptome are diet dependent. Ann Surg. 2013 Feb; 257(2):287-94. PMID: 23001074.
      Citations: 18     Fields:    Translation:AnimalsCells
    122. Stern JR, Olivas AD, Valuckaite V, Zaborina O, Alverdy JC, An G. Agent-based model of epithelial host-pathogen interactions in anastomotic leak. J Surg Res. 2013 Oct; 184(2):730-8. PMID: 23290531; PMCID: PMC4184143.
      Citations: 10     Fields:    Translation:AnimalsCells
    123. Ganai S, Prachand VN, Posner MC, Alverdy JC, Choi E, Hussain M, Waxman I, Patti MG, Roggin KK. Predictors of unsuccessful laparoscopic resection of gastric submucosal neoplasms. J Gastrointest Surg. 2013 Feb; 17(2):244-55; discussion 255-6. PMID: 23225195.
      Citations: 1     Fields:    Translation:Humans
    124. Stern JR, Christley S, Zaborina O, Alverdy JC, An G. Integration of TGF-ß- and EGFR-based signaling pathways using an agent-based model of epithelial restitution. Wound Repair Regen. 2012 Nov-Dec; 20(6):862-71. PMID: 23110640; PMCID: PMC3841986.
      Citations: 13     Fields:    Translation:HumansCells
    125. Alverdy JC. During critical illness the gut does not pass the acid test. Crit Care. 2012 Sep 12; 16(5):150. PMID: 23006320; PMCID: PMC3682247.
      Citations: 1     Fields:    Translation:Humans
    126. Olivas AD, Shogan BD, Valuckaite V, Zaborin A, Belogortseva N, Musch M, Meyer F, Trimble WL, An G, Gilbert J, Zaborina O, Alverdy JC. Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak. PLoS One. 2012; 7(8):e44326. PMID: 22952955; PMCID: PMC3432121.
      Citations: 94     Fields:    Translation:AnimalsCells
    127. Babrowski T, Romanowski K, Fink D, Kim M, Gopalakrishnan V, Zaborina O, Alverdy JC. The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis. Surgery. 2013 Jan; 153(1):36-43. PMID: 22862900; PMCID: PMC3521093.
      Citations: 26     Fields:    Translation:AnimalsCells
    128. Carlisle EM, Liu D, Zaborina O, Alverdy JC. Novel model to study combined effects of microorganisms and oxidants on development of intestinal necrosis. Surg Infect (Larchmt). 2012 Aug; 13(4):238-44. PMID: 22789034.
      Citations:    Fields:    Translation:AnimalsCells
    129. Seal JB, Stern JR, Vanha T, Alverdy JC, Testa G. A catheter-based suture-free approach to bilioenteric anastomosis: a pilot study. Surg Innov. 2013 Apr; 20(2):142-9. PMID: 22696025.
      Citations:    Fields:    Translation:Animals
    130. Zaborin A, Gerdes S, Holbrook C, Liu DC, Zaborina OY, Alverdy JC. Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate. PLoS One. 2012; 7(4):e34883. PMID: 22514685; PMCID: PMC3325935.
      Citations: 38     Fields:    Translation:AnimalsCells
    131. Babrowski T, Holbrook C, Moss J, Gottlieb L, Valuckaite V, Zaborin A, Poroyko V, Liu DC, Zaborina O, Alverdy JC. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration. Ann Surg. 2012 Feb; 255(2):386-93. PMID: 21989372; PMCID: PMC3258463.
      Citations: 60     Fields:    Translation:AnimalsCells
    132. Romanowski K, Zaborin A, Valuckaite V, Rolfes RJ, Babrowski T, Bethel C, Olivas A, Zaborina O, Alverdy JC. Candida albicans isolates from the gut of critically ill patients respond to phosphate limitation by expressing filaments and a lethal phenotype. PLoS One. 2012; 7(1):e30119. PMID: 22253901; PMCID: PMC3258262.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    133. Kim M, Christley S, Alverdy JC, Liu D, An G. Immature oxidative stress management as a unifying principle in the pathogenesis of necrotizing enterocolitis: insights from an agent-based model. Surg Infect (Larchmt). 2012 Feb; 13(1):18-32. PMID: 22217195; PMCID: PMC3292758.
      Citations: 22     Fields:    Translation:HumansCells
    134. Fink D, Romanowski K, Valuckaite V, Babrowski T, Kim M, Matthews JB, Liu D, Zaborina O, Alverdy JC. Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: the role of in vivo virulence activation. J Trauma. 2011 Dec; 71(6):1575-82. PMID: 22002612; PMCID: PMC3245766.
      Citations: 17     Fields:    Translation:AnimalsCells
    135. Edelstein A, Fink D, Musch M, Valuckaite V, Zaborina O, Grubjesic S, Firestone MA, Matthews JB, Alverdy JC. Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption. Shock. 2011 Nov; 36(5):451-7. PMID: 21937955; PMCID: PMC3196772.
      Citations: 5     Fields:    Translation:HumansCells
    136. Poroyko V, Morowitz M, Bell T, Ulanov A, Wang M, Donovan S, Bao N, Gu S, Hong L, Alverdy JC, Bergelson J, Liu DC. Diet creates metabolic niches in the "immature gut" that shape microbial communities. Nutr Hosp. 2011 Nov-Dec; 26(6):1283-95. PMID: 22411374.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    137. Romanowski K, Zaborin A, Fernandez H, Poroyko V, Valuckaite V, Gerdes S, Liu DC, Zaborina OY, Alverdy JC. Prevention of siderophore- mediated gut-derived sepsis due to P. aeruginosa can be achieved without iron provision by maintaining local phosphate abundance: role of pH. BMC Microbiol. 2011 Sep 26; 11:212. PMID: 21943078; PMCID: PMC3195088.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    138. Seal JB, Alverdy JC, Zaborina O, An G. Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis. Theor Biol Med Model. 2011 Sep 19; 8:33. PMID: 21929759; PMCID: PMC3184268.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    139. Neal MD, Alverdy JC, Hall DE, Simmons RL, Zuckerbraun BS. Diverting loop ileostomy and colonic lavage: an alternative to total abdominal colectomy for the treatment of severe, complicated Clostridium difficile associated disease. Ann Surg. 2011 Sep; 254(3):423-7; discussion 427-9. PMID: 21865943.
      Citations: 86     Fields:    Translation:HumansCells
    140. Morowitz MJ, Carlisle EM, Alverdy JC. Contributions of intestinal bacteria to nutrition and metabolism in the critically ill. Surg Clin North Am. 2011 Aug; 91(4):771-85, viii. PMID: 21787967; PMCID: PMC3144392.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    141. Morowitz MJ, Babrowski T, Carlisle EM, Olivas A, Romanowski KS, Seal JB, Liu DC, Alverdy JC. The human microbiome and surgical disease. Ann Surg. 2011 Jun; 253(6):1094-101. PMID: 21422915; PMCID: PMC4854204.
      Citations: 24     Fields:    Translation:Humans
    142. Fink D, Soares R, Matthews JB, Alverdy JC. History, goals, and technique of laparoscopic pancreatic necrosectomy. J Gastrointest Surg. 2011 Jul; 15(7):1092-7. PMID: 21590460.
      Citations: 2     Fields:    Translation:Humans
    143. Malhotra R, Valuckaite V, Staron ML, Theccanat T, D'Souza KM, Alverdy JC, Akhter SA. High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1733-42. PMID: 21335476; PMCID: PMC3094071.
      Citations: 20     Fields:    Translation:AnimalsCells
    144. Zaborina O, Zaborin A, Romanowski K, Babrowski T, Alverdy J. Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans. Curr Pharm Des. 2011; 17(13):1254-60. PMID: 21470113; PMCID: PMC4862579.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    145. Wang Y, Antonopoulos DA, Zhu X, Harrell L, Hanan I, Alverdy JC, Meyer F, Musch MW, Young VB, Chang EB. Laser capture microdissection and metagenomic analysis of intact mucosa-associated microbial communities of human colon. Appl Microbiol Biotechnol. 2010 Dec; 88(6):1333-42. PMID: 20931185; PMCID: PMC3832957.
      Citations: 23     Fields:    Translation:Humans
    146. Poroyko V, White JR, Wang M, Donovan S, Alverdy J, Liu DC, Morowitz MJ. Gut microbial gene expression in mother-fed and formula-fed piglets. PLoS One. 2010 Aug 27; 5(8):e12459. PMID: 20805981; PMCID: PMC2929194.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    147. Prachand VN, Alverdy JC. Gastroesophageal reflux disease and severe obesity: Fundoplication or bariatric surgery? World J Gastroenterol. 2010 Aug 14; 16(30):3757-61. PMID: 20698037; PMCID: PMC2921086.
      Citations: 41     Fields:    Translation:Humans
    148. Patel T, Bickenbach K, Semrad C, Alverdy J. Laparoscopic ileostomy in severe, obscure gastrointestinal hemorrhage: diagnostic laparoscopic ileostomy. Arch Surg. 2010 Aug; 145(8):745-8. PMID: 20713926.
      Citations:    Fields:    Translation:Humans
    149. Munoz D, Chen EY, Fischer S, Sanchez-Johnsen L, Roherig M, Dymek-Valentine M, Alverdy JC, Le Grange D. Changes in desired body shape after bariatric surgery. Eat Disord. 2010 Jul-Aug; 18(4):347-54. PMID: 20603734; PMCID: PMC5670740.
      Citations: 6     Fields:    Translation:Humans
    150. Seal JB, Morowitz M, Zaborina O, An G, Alverdy JC. The molecular Koch's postulates and surgical infection: a view forward. Surgery. 2010 Jun; 147(6):757-65. PMID: 20494210.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    151. Alverdy JC, Prachand V. Stapling and sleeve: science and myths. Surg Laparosc Endosc Percutan Tech. 2010 Jun; 20(3):141-5. PMID: 20551808.
      Citations: 1     Fields:    Translation:Humans
    152. Olivas AD, Umanskiy K, Zuckerbraun B, Alverdy JC. Avoiding colectomy during surgical management of fulminant Clostridium difficile colitis. Surg Infect (Larchmt). 2010 Jun; 11(3):299-305. PMID: 20583866.
      Citations: 11     Fields:    Translation:HumansCells
    153. Morowitz MJ, Poroyko V, Caplan M, Alverdy J, Liu DC. Redefining the role of intestinal microbes in the pathogenesis of necrotizing enterocolitis. Pediatrics. 2010 Apr; 125(4):777-85. PMID: 20308210.
      Citations: 88     Fields:    Translation:Humans
    154. Prachand VN, Ward M, Alverdy JC. Duodenal switch provides superior resolution of metabolic comorbidities independent of weight loss in the super-obese (BMI > or = 50 kg/m2) compared with gastric bypass. J Gastrointest Surg. 2010 Feb; 14(2):211-20. PMID: 19937190.
      Citations: 26     Fields:    Translation:Humans
    155. Alverdy JC. Polymer therapeutics move into the sepsis space. Crit Care Med. 2010 Feb; 38(2):730-1. PMID: 20083951.
      Citations:    Fields:    Translation:HumansAnimals
    156. Mitchell MT, Carabetta JM, Shah RN, O'Riordan MA, Gasparaitis AE, Alverdy JC. Duodenal switch gastric bypass surgery for morbid obesity: imaging of postsurgical anatomy and postoperative gastrointestinal complications. AJR Am J Roentgenol. 2009 Dec; 193(6):1576-80. PMID: 19933650.
      Citations: 5     Fields:    Translation:Humans
    157. Flanagin BA, Mitchell MT, Thistlethwaite WA, Alverdy JC. Diagnosis and treatment of atypical presentations of hiatal hernia following bariatric surgery. Obes Surg. 2010 Mar; 20(3):386-92. PMID: 19856036.
      Citations: 8     Fields:    Translation:Humans
    158. Valuckaite V, Zaborina O, Long J, Hauer-Jensen M, Wang J, Holbrook C, Zaborin A, Drabik K, Katdare M, Mauceri H, Weichselbaum R, Firestone MA, Lee KY, Chang EB, Matthews J, Alverdy JC. Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1041-52. PMID: 19833862; PMCID: PMC2850088.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    159. Prachand VN, Alverdy JC. The role of malabsorption in bariatric surgery. World J Surg. 2009 Oct; 33(10):1989-94. PMID: 19513786.
      Citations: 4     Fields:    Translation:Humans
    160. Chen E, Roehrig M, Herbozo S, McCloskey MS, Roehrig J, Cummings H, Alverdy J, Le Grange D. Compensatory eating disorder behaviors and gastric bypass surgery outcome. Int J Eat Disord. 2009 May; 42(4):363-6. PMID: 19040263.
      Citations: 2     Fields:    Translation:Humans
    161. Zaborin A, Romanowski K, Gerdes S, Holbrook C, Lepine F, Long J, Poroyko V, Diggle SP, Wilke A, Righetti K, Morozova I, Babrowski T, Liu DC, Zaborina O, Alverdy JC. Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6327-32. PMID: 19369215; PMCID: PMC2669342.
      Citations: 109     Fields:    Translation:AnimalsCells
    162. Chiang ET, Camp SM, Dudek SM, Brown ME, Usatyuk PV, Zaborina O, Alverdy JC, Garcia JG. Protective effects of high-molecular weight polyethylene glycol (PEG) in human lung endothelial cell barrier regulation: role of actin cytoskeletal rearrangement. Microvasc Res. 2009 Mar; 77(2):174-86. PMID: 19121327; PMCID: PMC3736723.
      Citations: 26     Fields:    Translation:HumansCells
    163. Alverdy JC, Prachand V, Flanagan B, Thistlethwaite WA, Siegler M, Garfinkel M, Angelos P, Agarwal S, Santry H. Bariatric surgery: a history of empiricism, a future in science. J Gastrointest Surg. 2009 Mar; 13(3):465-77. PMID: 19005732.
      Citations: 8     Fields:    Translation:Humans
    164. Chen EY, McCloskey MS, Doyle P, Roehrig J, Berona J, Alverdy J, le Grange D. Body mass index as a predictor of 1-year outcome in gastric bypass surgery. Obes Surg. 2009 Sep; 19(9):1240-2. PMID: 18839077; PMCID: PMC5670734.
      Citations: 8     Fields:    Translation:Humans
    165. Long J, Zaborina O, Holbrook C, Zaborin A, Alverdy J. Depletion of intestinal phosphate after operative injury activates the virulence of P aeruginosa causing lethal gut-derived sepsis. Surgery. 2008 Aug; 144(2):189-97. PMID: 18656625; PMCID: PMC2601706.
      Citations: 56     Fields:    Translation:AnimalsCells
    166. Gemmel K, Santry HP, Prachand VN, Alverdy JC. Vitamin D deficiency in preoperative bariatric surgery patients. Surg Obes Relat Dis. 2009 Jan-Feb; 5(1):54-9. PMID: 18848507.
      Citations: 29     Fields:    Translation:Humans
    167. Hickson J, Diane Yamada S, Berger J, Alverdy J, O'Keefe J, Bassler B, Rinker-Schaeffer C. Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis. Clin Exp Metastasis. 2009; 26(1):67-76. PMID: 18516689.
      Citations: 31     Fields:    Translation:Humans
    168. Zaborina O, Holbrook C, Chen Y, Long J, Zaborin A, Morozova I, Fernandez H, Wang Y, Turner JR, Alverdy JC. Structure-function aspects of PstS in multi-drug-resistant Pseudomonas aeruginosa. PLoS Pathog. 2008 Feb 08; 4(2):e43. PMID: 18282104; PMCID: PMC2242829.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    169. Mitchell MT, Gasparaitis AE, Alverdy JC. Imaging findings in Roux-en-O and other misconstructions: rare but serious complications of Roux-en-Y gastric bypass surgery. AJR Am J Roentgenol. 2008 Feb; 190(2):367-73. PMID: 18212222.
      Citations: 3     Fields:    Translation:Humans
    170. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. J Leukoc Biol. 2008 Mar; 83(3):461-6. PMID: 18160538.
      Citations: 57     Fields:    Translation:Humans
    171. Munoz DJ, Lal M, Chen EY, Mansour M, Fischer S, Roehrig M, Sanchez-Johnsen L, Dymek-Valenitine M, Alverdy J, le Grange D. Why patients seek bariatric surgery: a qualitative and quantitative analysis of patient motivation. Obes Surg. 2007 Nov; 17(11):1487-91. PMID: 18219776.
      Citations: 45     Fields:    Translation:Humans
    172. Munoz DJ, Chen E, Fischer S, Roehrig M, Sanchez-Johnson L, Alverdy J, Dymek-Valentine M, le Grange D. Considerations for the use of the Beck Depression Inventory in the assessment of weight-loss surgery seeking patients. Obes Surg. 2007 Aug; 17(8):1097-101. PMID: 17953246.
      Citations: 21     Fields:    Translation:Humans
    173. Alverdy JC. NOTES: a surgeon's perspective. Gastrointest Endosc Clin N Am. 2007 Jul; 17(3):605-10, viii. PMID: 17640586.
      Citations:    Fields:    Translation:Humans
    174. Fujiya M, Musch MW, Nakagawa Y, Hu S, Alverdy J, Kohgo Y, Schneewind O, Jabri B, Chang EB. The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter. Cell Host Microbe. 2007 Jun 14; 1(4):299-308. PMID: 18005709.
      Citations: 96     Fields:    Translation:HumansCells
    175. Fischer S, Chen E, Katterman S, Roerhig M, Bochierri-Ricciardi L, Munoz D, Dymek-Valentine M, Alverdy J, le Grange D. Emotional eating in a morbidly obese bariatric surgery-seeking population. Obes Surg. 2007 Jun; 17(6):778-84. PMID: 17879578.
      Citations: 34     Fields:    Translation:Humans
    176. Chen EY, Bocchieri-Ricciardi LE, Munoz D, Fischer S, Katterman S, Roehrig M, Dymek-Valentine M, Alverdy JC, Le Grange D. Depressed mood in class III obesity predicted by weight-related stigma. Obes Surg. 2007 May; 17(5):669-71. PMID: 17658028.
      Citations: 24     Fields:    Translation:Humans
    177. Piano G, Ketteler ER, Prachand V, Devalk E, Van Ha TG, Gewertz BL, Alverdy JC. Safety, feasibility, and outcome of retrievable vena cava filters in high-risk surgical patients. J Vasc Surg. 2007 Apr; 45(4):784-8; discussion 788. PMID: 17398387.
      Citations: 11     Fields:    Translation:Humans
    178. Zaborina O, Lepine F, Xiao G, Valuckaite V, Chen Y, Li T, Ciancio M, Zaborin A, Petrof EO, Petroff E, Turner JR, Rahme LG, Chang E, Alverdy JC. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007 Mar; 3(3):e35. PMID: 17367209; PMCID: PMC1828698.
      Citations: 93     Fields:    Translation:AnimalsCells
    179. Santry HP, Lauderdale DS, Cagney KA, Rathouz PJ, Alverdy JC, Chin MH. Predictors of patient selection in bariatric surgery. Ann Surg. 2007 Jan; 245(1):59-67. PMID: 17197966; PMCID: PMC1867947.
      Citations: 33     Fields:    Translation:Humans
    180. Ross AS, Semrad C, Alverdy J, Waxman I, Dye C. Use of double-balloon enteroscopy to perform PEG in the excluded stomach after Roux-en-Y gastric bypass. Gastrointest Endosc. 2006 Nov; 64(5):797-800. PMID: 17055878.
      Citations: 11     Fields:    Translation:Humans
    181. Prachand VN, Davee RT, Alverdy JC. Duodenal switch provides superior weight loss in the super-obese (BMI > or =50 kg/m2) compared with gastric bypass. Ann Surg. 2006 Oct; 244(4):611-9. PMID: 16998370; PMCID: PMC1856567.
      Citations: 59     Fields:    Translation:Humans
    182. Bocchieri-Ricciardi LE, Chen EY, Munoz D, Fischer S, Dymek-Valentine M, Alverdy JC, le Grange D. Pre-surgery binge eating status: effect on eating behavior and weight outcome after gastric bypass. Obes Surg. 2006 Sep; 16(9):1198-204. PMID: 16989704.
      Citations: 32     Fields:    Translation:Humans
    183. Patel NJ, Zaborina O, Wu L, Wang Y, Wolfgeher DJ, Valuckaite V, Ciancio MJ, Kohler JE, Shevchenko O, Colgan SP, Chang EB, Turner JR, Alverdy JC. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G134-42. PMID: 16901993; PMCID: PMC2694754.
      Citations: 39     Fields:    Translation:HumansCells
    184. Zaborina O, Kohler JE, Wang Y, Bethel C, Shevchenko O, Wu L, Turner JR, Alverdy JC. Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier. Ann Clin Microbiol Antimicrob. 2006 Jun 08; 5:14. PMID: 16762075; PMCID: PMC1513249.
      Citations: 25     Fields:    Translation:HumansCells
    185. Mitchell MT, Gasparaitis AE, Alverdy J. "Identification and management of an errant antiperistaltic roux limb after total gastrectomy". J Gastrointest Surg. 2006 Apr; 10(4):622; author reply 623. PMID: 16627232.
      Citations:    Fields:    Translation:Humans
    186. Wu L, Kohler JE, Zaborina O, Akash G, Musch MW, Chang EB, Alverdy JC. Chronic acid water feeding protects mice against lethal gut-derived sepsis due to Pseudomonas aeruginosa. Curr Issues Intest Microbiol. 2006 Mar; 7(1):19-28. PMID: 16570696.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    187. Santry HP, Alverdy JC, Lauderdale DS. Who are today's bariatric surgeons and which ones join the ASBS? Surg Obes Relat Dis. 2006 Mar-Apr; 2(2):112-6. PMID: 16925333.
      Citations: 4     Fields:    Translation:Humans
    188. Santry HP, Chin MH, Cagney KA, Alverdy JC, Lauderdale DS. The use of multidisciplinary teams to evaluate bariatric surgery patients: results from a national survey in the U.S.A. Obes Surg. 2006 Jan; 16(1):59-66. PMID: 16417760.
      Citations: 15     Fields:    Translation:Humans
    189. Tao Y, Drabik KA, Waypa TS, Musch MW, Alverdy JC, Schneewind O, Chang EB, Petrof EO. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1018-30. PMID: 16306130.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    190. Wu L, Estrada O, Zaborina O, Bains M, Shen L, Kohler JE, Patel N, Musch MW, Chang EB, Fu YX, Jacobs MA, Nishimura MI, Hancock RE, Turner JR, Alverdy JC. Recognition of host immune activation by Pseudomonas aeruginosa. Science. 2005 Jul 29; 309(5735):774-7. PMID: 16051797.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    191. Alverdy J, Zaborina O, Wu L. The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface. Curr Opin Clin Nutr Metab Care. 2005 Mar; 8(2):205-9. PMID: 15716801.
      Citations: 26     Fields:    Translation:Humans
    192. Wu LR, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Turner JR, Alverdy JC. Surgical injury and metabolic stress enhance the virulence of the human opportunistic pathogen Pseudomonas aeruginosa. Surg Infect (Larchmt). 2005; 6(2):185-95. PMID: 16128625.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    193. Kohler JE, Zaborina O, Wu L, Wang Y, Bethel C, Chen Y, Shapiro J, Turner JR, Alverdy JC. Components of intestinal epithelial hypoxia activate the virulence circuitry of Pseudomonas. Am J Physiol Gastrointest Liver Physiol. 2005 May; 288(5):G1048-54. PMID: 15550562.
      Citations: 20     Fields:    Translation:HumansCells
    194. Arvans DL, Vavricka SR, Ren H, Musch MW, Kang L, Rocha FG, Lucioni A, Turner JR, Alverdy J, Chang EB. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol. 2005 Apr; 288(4):G696-704. PMID: 15528251.
      Citations: 38     Fields:    Translation:AnimalsCells
    195. Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability. J Biol Chem. 2004 Dec 31; 279(53):55506-13. PMID: 15507455; PMCID: PMC1237105.
      Citations: 87     Fields:    Translation:HumansCells
    196. Dymek-Valentine M, Rienecke-Hoste R, Alverdy J. Assessment of binge eating disorder in morbidly obese patients evaluated for gastric bypass: SCID versus QEWP-R. Eat Weight Disord. 2004 Sep; 9(3):211-6. PMID: 15656016.
      Citations: 17     Fields:    Translation:Humans
    197. Green AE, Dymek-Valentine M, Pytluk S, Le Grange D, Alverdy J. Psychosocial outcome of gastric bypass surgery for patients with and without binge eating. Obes Surg. 2004 Aug; 14(7):975-85. PMID: 15329189.
      Citations: 29     Fields:    Translation:Humans
    198. Wu L, Zaborina O, Zaborin A, Chang EB, Musch M, Holbrook C, Shapiro J, Turner JR, Wu G, Lee KY, Alverdy JC. High-molecular-weight polyethylene glycol prevents lethal sepsis due to intestinal Pseudomonas aeruginosa. Gastroenterology. 2004 Feb; 126(2):488-98. PMID: 14762786.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    199. Buser A, Dymek-Valentine M, Hilburger J, Alverdy J. Outcome following gastric bypass surgery: impact of past sexual abuse. Obes Surg. 2004 Feb; 14(2):170-4. PMID: 15018744.
      Citations: 11     Fields:    Translation:Humans
    200. Wu L, Holbrook C, Zaborina O, Ploplys E, Rocha F, Pelham D, Chang E, Musch M, Alverdy J. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Ann Surg. 2003 Nov; 238(5):754-64. PMID: 14578740; PMCID: PMC1356156.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    201. Dymek M, Alverdy J, le Grange D, Sánchez-Johnsen LA. Binge eating and eating-related cognitions and behavior in ethnically diverse obese women. Obes Res. 2003 Aug; 11(8):1002-9. PMID: 12917506.
      Citations: 3     Fields:    Translation:Humans
    202. Alverdy JC, Laughlin RS, Wu L. Influence of the critically ill state on host-pathogen interactions within the intestine: gut-derived sepsis redefined. Crit Care Med. 2003 Feb; 31(2):598-607. PMID: 12576972.
      Citations: 54     Fields:    Translation:HumansCells
    203. Dymek MP, Le Grange D, Neven K, Alverdy J, Dymek MP, Le Grange D, Neven K, Alverdy J. Quality of life after gastric bypass surgery: a cross-sectional study. Obes Res. 2002 Nov; 10(11):1135-42. PMID: 12429877.
      Citations: 46     Fields:    Translation:Humans
    204. Boogerd A, Alverdy J, Kumar S, Olson DL, Schwenk WF. Part III. Obesity. Dis Mon. 2002 Nov; 48(11):725-42. PMID: 12474015.
      Citations: 1     Fields:    Translation:Humans
    205. Musch MW, Bookstein C, Rocha F, Lucioni A, Ren H, Daniel J, Xie Y, McSwine RL, Rao MC, Alverdy J, Chang EB. Region-specific adaptation of apical Na/H exchangers after extensive proximal small bowel resection. Am J Physiol Gastrointest Liver Physiol. 2002 Oct; 283(4):G975-85. PMID: 12223358.
      Citations: 12     Fields:    Translation:AnimalsCells
    206. Neven K, Dymek M, leGrange D, Maasdam H, Boogerd AC, Alverdy J, Neven K, Dymek M, leGrange D, Maasdam H, Boogerd AC, Alverdy J. The effects of Roux-en-Y gastric bypass surgery on body image. Obes Surg. 2002 Apr; 12(2):265-9. PMID: 11975226.
      Citations: 11     Fields:    Translation:Humans
    207. Posner MC, Alverdy J. Hand-assisted laparoscopic surgery for cancer. Cancer J. 2002 Mar-Apr; 8(2):144-53. PMID: 11999948.
      Citations: 1     Fields:    Translation:Humans
    208. Rocha F, Laughlin R, Musch MW, Hendrickson BA, Chang EB, Alverdy J. Surgical stress shifts the intestinal Escherichia coli population to that of a more adherent phenotype: role in barrier regulation. Surgery. 2001 Jul; 130(1):65-73. PMID: 11436014.
      Citations: 8     Fields:    Translation:AnimalsCells
    209. Dymek MP, le Grange D, Neven K, Alverdy J. Quality of life and psychosocial adjustment in patients after Roux-en-Y gastric bypass: a brief report. Obes Surg. 2001 Feb; 11(1):32-9. PMID: 11361166.
      Citations: 50     Fields:    Translation:Humans
    210. Buell JF, Alverdy J, Newell KA, Yoshida A, Limsrichamrern S, Woodle ES, Bruce DS, Buell JF, Alverdy J, Newell KA, Yoshida A, Limsrichamrern S, Woodle ES, Bruce DS. Hand-assisted laparoscopic live-donor nephrectomy. J Am Coll Surg. 2001 Jan; 192(1):132-6. PMID: 11192915.
      Citations: 1     Fields:    Translation:Humans
    211. Factor P, Ridge K, Alverdy J, Sznajder JI. Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen. J Appl Physiol (1985). 2000 Nov; 89(5):1759-65. PMID: 11053323.
      Citations: 3     Fields:    Translation:Animals
    212. Alverdy J, Holbrook C, Rocha F, Seiden L, Wu RL, Musch M, Chang E, Ohman D, Suh S. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg. 2000 Oct; 232(4):480-9. PMID: 10998646; PMCID: PMC1421180.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    213. Laughlin RS, Musch MW, Hollbrook CJ, Rocha FM, Chang EB, Alverdy JC. The key role of Pseudomonas aeruginosa PA-I lectin on experimental gut-derived sepsis. Ann Surg. 2000 Jul; 232(1):133-42. PMID: 10862206; PMCID: PMC1421122.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    214. Alverdy J, Vargish T, Desai T, Frawley B, Rosen B. Laparoscopic intracavitary debridement of peripancreatic necrosis: preliminary report and description of the technique. Surgery. 2000 Jan; 127(1):112-4. PMID: 10660768.
      Citations: 15     Fields:    Translation:Humans
    215. Kress JP, Pohlman AS, Alverdy J, Hall JB. The impact of morbid obesity on oxygen cost of breathing (VO(2RESP)) at rest. Am J Respir Crit Care Med. 1999 Sep; 160(3):883-6. PMID: 10471613.
      Citations: 75     Fields:    Translation:Humans
    216. Alverdy JC, Hendrickson B, Guandalini SS, Laughlin RJ, Kent K, Banerjee R. Perturbed bioelectrical properties of the mouse cecum following hepatectomy and starvation: the role of bacterial adherence. Shock. 1999 Sep; 12(3):235-41; discussion 242. PMID: 10485604.
      Citations: 4     Fields:    Translation:Animals
    217. Alverdy JC, Rocha F. Surgical stress, bacteria, and mucosal immune function. Eur J Pediatr Surg. 1999 Aug; 9(4):210-3. PMID: 10532259.
      Citations:    Fields:    Translation:HumansAnimalsCells
    218. Hendrickson BA, Guo J, Laughlin R, Chen Y, Alverdy JC. Increased type 1 fimbrial expression among commensal Escherichia coli isolates in the murine cecum following catabolic stress. Infect Immun. 1999 Feb; 67(2):745-53. PMID: 9916086; PMCID: PMC96382.
      Citations: 14     Fields:    Translation:AnimalsCells
    219. Alverdy J, Stern E. Effect of immunonutrition on virulence strategies in bacteria. Nutrition. 1998 Jul-Aug; 14(7-8):580-4. PMID: 9684260.
      Citations: 1     Fields:    Translation:HumansCells
    220. Alverdy J, Stern E, Poticha S, Baunoch D, Adrian T. Cholecystokinin modulates mucosal immunoglobulin A function. Surgery. 1997 Aug; 122(2):386-92; discussion 392-3. PMID: 9288145.
      Citations: 7     Fields:    Translation:AnimalsCells
    221. Alverdy J, Piano G. Whole gut washout for severe sepsis: review of technique and preliminary results. Surgery. 1997 Jan; 121(1):89-94. PMID: 9001556.
      Citations: 1     Fields:    Translation:Humans
    222. Bergmann BM, Gilliland MA, Feng PF, Russell DR, Shaw P, Wright M, Rechtschaffen A, Alverdy JC. Are physiological effects of sleep deprivation in the rat mediated by bacterial invasion? Sleep. 1996 Sep; 19(7):554-62. PMID: 8899934.
      Citations: 6     Fields:    Translation:Animals
    223. Spitz JC, Ghandi S, Taveras M, Aoys E, Alverdy JC. Characteristics of the intestinal epithelial barrier during dietary manipulation and glucocorticoid stress. Crit Care Med. 1996 Apr; 24(4):635-41. PMID: 8612416.
      Citations: 10     Fields:    Translation:Animals
    224. Spitz J, Yuhan R, Koutsouris A, Blatt C, Alverdy J, Hecht G. Enteropathogenic Escherichia coli adherence to intestinal epithelial monolayers diminishes barrier function. Am J Physiol. 1995 Feb; 268(2 Pt 1):G374-9. PMID: 7864134.
      Citations: 66     Fields:    Translation:Cells
    225. Alverdy J. The effect of nutrition on gastrointestinal barrier function. Semin Respir Infect. 1994 Dec; 9(4):248-55. PMID: 7886322.
      Citations: 8     Fields:    Translation:HumansAnimals
    226. Alverdy JC, Spitz J, Hecht G, Ghandi S. Causes and consequences of bacterial adherence to mucosal epithelia during critical illness. New Horiz. 1994 May; 2(2):264-72. PMID: 7922452.
      Citations: 4     Fields:    Translation:HumansCells
    227. Spitz J, Hecht G, Taveras M, Aoys E, Alverdy J. The effect of dexamethasone administration on rat intestinal permeability: the role of bacterial adherence. Gastroenterology. 1994 Jan; 106(1):35-41. PMID: 8276206.
      Citations: 27     Fields:    Translation:Animals
    228. Alverdy JC, Aoys E. The effect of dexamethasone and endotoxin administration on biliary IgA and bacterial adherence. J Surg Res. 1992 Nov; 53(5):450-4. PMID: 1434594.
      Citations: 2     Fields:    Translation:AnimalsCells
    229. Alverdy JC, Burke D. Total parenteral nutrition: iatrogenic immunosuppression. Nutrition. 1992 Sep-Oct; 8(5):359-65. PMID: 1421782.
      Citations: 4     Fields:    Translation:HumansAnimals
    230. Alverdy J. The importance of the mucosal immune system. Nutr Clin Pract. 1992 Jun; 7(3):99. PMID: 1289689.
      Citations:    Fields:    Translation:Humans
    231. Alverdy J, Aoys E. The effect of glucocorticoid administration on bacterial translocation. Evidence for an acquired mucosal immunodeficient state. Ann Surg. 1991 Dec; 214(6):719-23. PMID: 1741652; PMCID: PMC1358497.
      Citations: 19     Fields:    Translation:Animals
    232. Levine EA, Alverdy JC, Agrawal A. Hepatitis prevalence in trauma patients. Am Surg. 1991 Jun; 57(6):385-7. PMID: 2048852.
      Citations:    Fields:    Translation:Humans
    233. Levine EA, Alverdy JC. Carotid-esophageal fistula following a penetrating neck injury: case report. J Trauma. 1990 Dec; 30(12):1588-90. PMID: 2258978.
      Citations: 2     Fields:    Translation:Humans
    234. Thyssen EP, Hou SH, Alverdy JC, Spiegel DM. Temporary loss of limb function secondary to soft tissue calcification in a patient with rhabdomyolysis-induced acute renal failure. Am J Kidney Dis. 1990 Nov; 16(5):491-4. PMID: 2239944.
      Citations:    Fields:    Translation:Humans
    235. Alverdy JC. Effects of glutamine-supplemented diets on immunology of the gut. JPEN J Parenter Enteral Nutr. 1990 Jul-Aug; 14(4 Suppl):109S-113S. PMID: 2119455.
      Citations: 17     Fields:    Translation:HumansAnimals
    236. Alverdy JC, Aoys E, Moss GS. Effect of commercially available chemically defined liquid diets on the intestinal microflora and bacterial translocation from the gut. JPEN J Parenter Enteral Nutr. 1990 Jan-Feb; 14(1):1-6. PMID: 2325237.
      Citations: 10     Fields:    Translation:AnimalsCells
    237. Burke DJ, Alverdy JC, Aoys E, Moss GS. Glutamine-supplemented total parenteral nutrition improves gut immune function. Arch Surg. 1989 Dec; 124(12):1396-9. PMID: 2511819.
      Citations: 41     Fields:    Translation:AnimalsCells
    238. Alverdy JC, Aoys E, Moss GS. Total parenteral nutrition promotes bacterial translocation from the gut. Surgery. 1988 Aug; 104(2):185-90. PMID: 3135625.
      Citations: 124     Fields:    Translation:Animals
    239. Levine EA, Alverdy JC, Goldberg MC, Moss GS. Does a localized intra-abdominal abscess produce a positive peritoneal lavage? Curr Surg. 1988 Jul-Aug; 45(4):302-3. PMID: 3246157.
      Citations:    Fields:    Translation:Animals
    240. Alverdy JC, Saunders J, Chamberlin WH, Moss GS. Diagnostic peritoneal lavage in intra-abdominal sepsis. Am Surg. 1988 Jul; 54(7):456-9. PMID: 3389596.
      Citations:    Fields:    Translation:Humans
    241. Lim GM, Sheldon GF, Alverdy J. Biliary secretory IgA levels in rats with protein-calorie malnutrition. Ann Surg. 1988 May; 207(5):635-40. PMID: 3132112; PMCID: PMC1493488.
      Citations: 3     Fields:    Translation:Animals
    242. Alverdy J, Chi HS, Sheldon GF. The effect of parenteral nutrition on gastrointestinal immunity. The importance of enteral stimulation. Ann Surg. 1985 Dec; 202(6):681-4. PMID: 3935061; PMCID: PMC1250998.
      Citations: 45     Fields:    Translation:Animals
    243. Alverdy JC, Chi HS, Selivanov V, Morris J, Sheldon GF. The effect of route of nutrient administration on the secretory immune system. Curr Surg. 1985 Jan-Feb; 42(1):10-3. PMID: 3918836.
      Citations: 3     Fields:    Translation:Animals
    244. Selivanov V, Chi HS, Alverdy JC, Morris JA, Sheldon GF. Mortality in retroperitoneal hematoma. J Trauma. 1984 Dec; 24(12):1022-7. PMID: 6512896.
      Citations: 8     Fields:    Translation:Humans
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