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Jill De Jong

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Hematology and Oncology
AddressChicago IL 60637
Phone+1 (773) 702-2646
Email
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    Collapse Overview 
    Collapse overview
    Dr. de Jong treats children with all types of cancer and blood diseases. She is the Director of Pediatric Hematology and has specialized expertise in bone marrow failure, leukemia, autoimmune blood diseases (such as autoimmune hemolytic anemia, autoimmune neutropenia, immune thrombocytopenia purpura and Evans syndrome), hemoglobinopathies (such as thalassemia and sickle cell disease), and bleeding and clotting disorders.

    Her research focuses on hematopoietic stem cells and genetic risks for hematologic malignancy. She is also studying the genetic causes of aplastic anemia. She is co-director of the Pediatric Cancer Genetic Risk clinic and the director of the Pediatric Bone Marrow Failure clinic.

    Collapse Biography 
    Collapse education and training
    Dana Farber Cancer Institute and Boston Children's Hospital, Boston, MAFellowship06/2005Pediatric Hematology-Oncology
    Boston Children's Hospital, Boston, MAResidency06/2002Pediatrics
    University of Wisconsin, Madison, WIMD05/1999Medicine
    University of Wisconsin, Madison, WIPhD05/1997Cancer Biology
    University of Chicago, Chicago, ILAB06/1990Biology
    Collapse awards and honors
    2013 - nowRegional Top Doctor, Pediatric Hematology-Oncology, Castle Connolly
    2010Pritzker Scholar Award, University of Chicago
    1998Alpha Omega Alpha, Medical Honor Society, University of Wisconsin
    1990Phi Beta Kappa, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shimano KA, Sasa G, Broglie L, Gloude NJ, Myers K, Nakano TA, Sharathkumar A, Rothman JA, Pereda MA, Overholt K, Narla A, McGuinn C, Lau BW, Geddis AE, Dror Y, de Jong JLO, Castillo P, Allen SW, Boklan J. Treatment of relapsed/refractory severe aplastic anemia in children: Evidence-based recommendations. Pediatr Blood Cancer. 2024 Aug; 71(8):e31075. PMID: 38764170.
      Citations: 1     Fields:    Translation:Humans
    2. Shimano KA, Rothman JA, Allen SW, Castillo P, de Jong JLO, Dror Y, Geddis AE, Lau BW, McGuinn C, Narla A, Overholt K, Pereda MA, Sharathkumar A, Sasa G, Nakano TA, Myers K, Gloude NJ, Broglie L, Boklan J. Treatment of newly diagnosed severe aplastic anemia in children: Evidence-based recommendations. Pediatr Blood Cancer. 2024 Aug; 71(8):e31070. PMID: 38757488.
      Citations: 3     Fields:    Translation:Humans
    3. Kraft IL, Basdag H, Koppayi A, Rodgers CV, Saygin C, Haribabu Y, Wanjari P, Niu N, Das S, de Jong JLO, Segal J, Godley LA. Sequential tumor molecular profiling identifies likely germline variants. Genet Med. 2024 03; 26(3):101037. PMID: 38054407; PMCID: PMC11401608.
      Citations: 1     Fields:    Translation:HumansCells
    4. McConnell SC, Hernandez KM, Andrade J, de Jong JLO. Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. Sci Rep. 2023 05 13; 13(1):7777. PMID: 37179373; PMCID: PMC10183018.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Wcisel DJ, Dornburg A, McConnell SC, Hernandez KM, Andrade J, de Jong JLO, Litman GW, Yoder JA. A highly diverse set of novel immunoglobulin-like transcript (NILT) genes in zebrafish indicates a wide range of functions with complex relationships to mammalian receptors. Immunogenetics. 2023 02; 75(1):53-69. PMID: 35869336; PMCID: PMC9845131.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Cohen EL, Millikan SE, Morocco PC, de Jong JLO. Hemorrhagic Shock after Neonatal Circumcision: Severe Congenital Factor XIII Deficiency. Case Rep Pediatr. 2021; 2021:5550199. PMID: 34007504; PMCID: PMC8110377.
      Citations: 1     
    7. DiNapoli SE, Martinez-McFaline R, Gribbin CK, Wrighton PJ, Balgobin CA, Nelson I, Leonard A, Maskin CR, Shwartz A, Quenzer ED, Mailhiot D, Kao C, McConnell SC, de Jong JLO, Goessling W, Houvras Y. Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic Acids Res. 2020 04 17; 48(7):e38. PMID: 32064511; PMCID: PMC7144937.
      Citations: 24     Fields:    Translation:AnimalsCells
    8. de Jong JLO. Splicing up hematopoietic development. Blood. 2019 02 21; 133(8):770-771. PMID: 30792220.
      Citations:    Fields:    Translation:AnimalsCells
    9. Baeten JT, Waarts MR, Pruitt MM, Chan WC, Andrade J, de Jong JLO. The side population enriches for leukemia-propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia. Haematologica. 2019 07; 104(7):1388-1395. PMID: 30630989; PMCID: PMC6601080.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    10. Baeten JT, de Jong JLO. Genetic Models of Leukemia in Zebrafish. Front Cell Dev Biol. 2018; 6:115. PMID: 30294597; PMCID: PMC6158309.
      Citations: 17     
    11. Esteban YM, de Jong JLO, Tesher MS. An Overview of Hemophagocytic Lymphohistiocytosis. Pediatr Ann. 2017 Aug 01; 46(8):e309-e313. PMID: 28806468.
      Citations: 49     Fields:    Translation:Humans
    12. Pruitt MM, Marin W, Waarts MR, de Jong JLO. Isolation of the Side Population in Myc-induced T-cell Acute Lymphoblastic Leukemia in Zebrafish. J Vis Exp. 2017 05 04; (123). PMID: 28518092; PMCID: PMC5607890.
      Citations: 2     Fields:    Translation:AnimalsCells
    13. Villanueva G, de Jong JL, McNeer JL. Intravenous Immunoglobulin in the Treatment of Hematologic Disorders in Pediatrics. Pediatr Ann. 2017 Jan 01; 46(1):e13-e18. PMID: 28079913.
      Citations: 1     Fields:    Translation:Humans
    14. McConnell SC, Hernandez KM, Wcisel DJ, Kettleborough RN, Stemple DL, Yoder JA, Andrade J, de Jong JL. Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E5014-23. PMID: 27493218; PMCID: PMC5003237.
      Citations: 30     Fields:    Translation:AnimalsCells
    15. Nassin ML, Lapping-Carr G, de Jong JL. Anemia in the Neonate: The Differential Diagnosis and Treatment. Pediatr Ann. 2015 Jul; 44(7):e159-63. PMID: 26171704; PMCID: PMC6104389.
      Citations: 1     Fields:    Translation:Humans
    16. Yang XH, Li M, Wang B, Zhu W, Desgardin A, Onel K, de Jong J, Chen J, Chen L, Cunningham JM. Systematic computation with functional gene-sets among leukemic and hematopoietic stem cells reveals a favorable prognostic signature for acute myeloid leukemia. BMC Bioinformatics. 2015 Mar 24; 16:97. PMID: 25887548; PMCID: PMC4376348.
      Citations: 4     Fields:    Translation:HumansCells
    17. Ansari DO, Lapping-Carr G, Alikhan M, Tsoukas ML, Stein SL, de Jong JL. A neonate with a vesiculopustular rash. Pediatr Ann. 2015 Jan; 44(1):e1-5. PMID: 25621627.
      Citations: 1     Fields:    Translation:Humans
    18. Dirscherl H, McConnell SC, Yoder JA, de Jong JL. The MHC class I genes of zebrafish. Dev Comp Immunol. 2014 Sep; 46(1):11-23. PMID: 24631581; PMCID: PMC4031684.
      Citations: 18     Fields:    Translation:Animals
    19. McConnell SC, Restaino AC, de Jong JL. Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish. Immunogenetics. 2014 Mar; 66(3):199-213. PMID: 24291825; PMCID: PMC3965299.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. de Jong JL, Zon LI. Histocompatibility and hematopoietic transplantation in the zebrafish. Adv Hematol. 2012; 2012:282318. PMID: 22778744; PMCID: PMC3388487.
      Citations: 5     
    21. Ganis JJ, Hsia N, Trompouki E, de Jong JL, DiBiase A, Lambert JS, Jia Z, Sabo PJ, Weaver M, Sandstrom R, Stamatoyannopoulos JA, Zhou Y, Zon LI. Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR. Dev Biol. 2012 Jun 15; 366(2):185-94. PMID: 22537494; PMCID: PMC3378398.
      Citations: 81     Fields:    Translation:AnimalsCells
    22. de Jong JL, Burns CE, Chen AT, Pugach E, Mayhall EA, Smith AC, Feldman HA, Zhou Y, Zon LI. Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 2011 Apr 21; 117(16):4234-42. PMID: 21346254; PMCID: PMC3087475.
      Citations: 26     Fields:    Translation:Animals
    23. de Jong JL, Davidson AJ, Wang Y, Palis J, Opara P, Pugach E, Daley GQ, Zon LI. Interaction of retinoic acid and scl controls primitive blood development. Blood. 2010 Jul 15; 116(2):201-9. PMID: 20410509; PMCID: PMC2910607.
      Citations: 13     Fields:    Translation:AnimalsCells
    24. Paik EJ, de Jong JL, Pugach E, Opara P, Zon LI. A chemical genetic screen in zebrafish for pathways interacting with cdx4 in primitive hematopoiesis. Zebrafish. 2010 Mar; 7(1):61-8. PMID: 20415644; PMCID: PMC2897134.
      Citations: 17     Fields:    
    25. Smith AC, Raimondi AR, Salthouse CD, Ignatius MS, Blackburn JS, Mizgirev IV, Storer NY, de Jong JL, Chen AT, Zhou Y, Revskoy S, Zon LI, Langenau DM. High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia. Blood. 2010 Apr 22; 115(16):3296-303. PMID: 20056790; PMCID: PMC2858492.
      Citations: 71     Fields:    Translation:AnimalsCells
    26. Gordon DJ, Sloan SR, de Jong JL. A pediatric case series of acute hemolysis after administration of intravenous immunoglobulin. Am J Hematol. 2009 Nov; 84(11):771-2. PMID: 19806664.
      Citations: 5     Fields:    Translation:Humans
    27. Bennett CM, de Jong JL, Neufeld EJ. Targeted ITP strategies: do they elucidate the biology of ITP and related disorders? Pediatr Blood Cancer. 2006 Oct 15; 47(5 Suppl):706-9. PMID: 16933263.
      Citations: 3     Fields:    Translation:Humans
    28. de Jong JL, Zon LI. Use of the zebrafish system to study primitive and definitive hematopoiesis. Annu Rev Genet. 2005; 39:481-501. PMID: 16285869.
      Citations: 101     Fields:    Translation:HumansAnimals
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