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Aaron Turkewitz

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
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    A network of membrane-bound organelles, interconnected by dynamic vesicular traffic, is a defining hallmark of eukaryotes. Our laboratory studies membrane traffic in the ciliate Tetrahymena thermophila. Our interest in these cells stems from the fact that Tetrahymena is unicellular and offers a host of experimental advantages; the individual cells are remarkably complex and include features that are usually associated with animal cells but absent in fungi. For example, ciliates have a prominent pathway for regulated secretion of polypeptides from specialized vesicles resembling dense core granules. This is in spite of the fact that ciliates are far more distantly related to animals than are most organisms, including yeast, that are commonly studied by cell biologists. We use genetic, cell biological, informatics and biochemical approaches to dissect this and other pathways of membrane trafficking in these remarkable cells.
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    Collapse Biography 
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    Harvard University, Cambridge, MAPh.D06/1988Biochemistry and Molecular Biology
    UCSF, San Francisco, CA06/1992Cell Biology

    Collapse Research 
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    R01GM105783     (TURKEWITZ, AARON P)May 1, 2014 - Mar 31, 2023
    NIH
    Mechanisms of tether function in endolysosomal trafficking - Renewal - Resubmission 01
    Role: Principal Investigator
    R13HD076526     (COLE, ERIC S.)Mar 1, 2013 - Feb 28, 2014
    NIH
    FASEB SRC on Ciliate Molecular Biology
    Role: Co-Principal Investigator
    R03MH094953     (TURKEWITZ, AARON P)Apr 1, 2012 - Mar 31, 2014
    NIH
    Dissecting neuropeptide secretion via genome sequencing of Tetrahymena mutants
    Role: Principal Investigator
    R01GM077607     (TURKEWITZ, AARON P)Sep 1, 2006 - Aug 31, 2011
    NIH
    Biogenesis of Dense Core Secretory Granules in Tetrahymena
    Role: Principal Investigator
    R01GM059268     (TURKEWITZ, AARON P)Feb 1, 2000 - Jan 31, 2005
    NIH
    FUNCTIONAL ANALYSIS OF CALCIUM STORES IN TETRAHYMENA
    Role: Principal Investigator
    R01GM050946     (TURKEWITZ, AARON P)May 1, 1994 - Apr 30, 2003
    NIH
    MECHANISMS OF REGULATED EXOCYTOSIS IN TETRAHYMENA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sparvoli D, Delabre J, Penarete-Vargas DM, Kumar Mageswaran S, Tsypin LM, Heckendorn J, Theveny L, Maynadier M, Mendon?a Cova M, Berry-Sterkers L, Gu?rin A, Dubremetz JF, Urbach S, Striepen B, Turkewitz AP, Chang YW, Lebrun M, Sparvoli D, Delabre J, Penarete-Vargas DM, Kumar Mageswaran S, Tsypin LM, Heckendorn J, Theveny L, Maynadier M, Mendon?a Cova M, Berry-Sterkers L, Gu?rin A, Dubremetz JF, Urbach S, Striepen B, Turkewitz AP, Chang YW, Lebrun M. An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma. EMBO J. 2022 11 17; 41(22):e111158. PMID: 36245278; PMCID: PMC9670195.
      Citations: 3     Fields:    Translation:AnimalsCells
    2. Kuppannan A, Jiang YY, Maier W, Liu C, Lang CF, Cheng CY, Field MC, Zhao M, Zoltner M, Turkewitz AP, Kuppannan A, Jiang YY, Maier W, Liu C, Lang CF, Cheng CY, Field MC, Zhao M, Zoltner M, Turkewitz AP. A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila. PLoS Genet. 2022 05; 18(5):e1010194. PMID: 35587496; PMCID: PMC9159632.
      Citations:    Fields:    Translation:AnimalsCells
    3. Aquilini E, Cova MM, Mageswaran SK, Dos Santos Pacheco N, Sparvoli D, Penarete-Vargas DM, Najm R, Graindorge A, Suarez C, Maynadier M, Berry-Sterkers L, Urbach S, Fahy PR, Gu?rin AN, Striepen B, Dubremetz JF, Chang YW, Turkewitz AP, Lebrun M, Aquilini E, Cova MM, Mageswaran SK, Dos Santos Pacheco N, Sparvoli D, Penarete-Vargas DM, Najm R, Graindorge A, Suarez C, Maynadier M, Berry-Sterkers L, Urbach S, Fahy PR, Gu?rin AN, Striepen B, Dubremetz JF, Chang YW, Turkewitz AP, Lebrun M. An Alveolata secretory machinery adapted to parasite host cell invasion. Nat Microbiol. 2021 04; 6(4):425-434. PMID: 33495622; PMCID: PMC8886610.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    4. Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS, Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Mol Biol Cell. 2020 12 15; 31(26):2892-2903. PMID: 33112725; PMCID: PMC7927198.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Cheng CY, Orias E, Leu JY, Turkewitz AP, Cheng CY, Orias E, Leu JY, Turkewitz AP. The evolution of germ-soma nuclear differentiation in eukaryotic unicells. Curr Biol. 2020 05 18; 30(10):R502-R510. PMID: 32428490.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    6. Faktorov? D, Nisbet RER, Fern?ndez Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Arest? C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, Garc?a PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Iba?ez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Nov?k Vanclov? AMG, Nowacki M, Nu?ez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turn?ek J, Valach M, Verg? V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Luke? J, Faktorov? D, Nisbet RER, Fern?ndez Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Arest? C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, Garc?a PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Iba?ez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Nov?k Vanclov? AMG, Nowacki M, Nu?ez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turn?ek J, Valach M, Verg? V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Luke? J. Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):551. PMID: 32296171; PMCID: PMC7200595.
      Citations:    Fields:    
    7. Faktorov? D, Nisbet RER, Fern?ndez Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Arest? C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, Garc?a PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Iba?ez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Nov?k Vanclov? AMG, Nowacki M, Nu?ez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turn?ek J, Valach M, Verg? V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Luke? J, Faktorov? D, Nisbet RER, Fern?ndez Robledo JA, Casacuberta E, Sudek L, Allen AE, Ares M, Arest? C, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Bouget FY, Bowler C, Breglia SA, Brownlee C, Burger G, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Elustondo PA, Federici F, Freire-Beneitez V, Freyria NJ, Fukuda K, Garc?a PA, Girguis PR, Gomaa F, Gornik SG, Guo J, Hampl V, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Iba?ez J, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Kachale A, Fujimura-Kamada K, Kaur B, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Lozano JC, Luan F, Maruyama S, Matute T, Miceli C, Minagawa J, Moosburner M, Najle SR, Nanjappa D, Nimmo IC, Noble L, Nov?k Vanclov? AMG, Nowacki M, Nu?ez I, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Ruaud A, Ruiz-Trillo I, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, Turn?ek J, Valach M, Verg? V, von Dassow P, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Luke? J. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):481-494. PMID: 32251396; PMCID: PMC7200600.
      Citations: 24     Fields:    Translation:Animals
    8. Sparvoli D, Zoltner M, Cheng CY, Field MC, Turkewitz AP, Sparvoli D, Zoltner M, Cheng CY, Field MC, Turkewitz AP. Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila. J Cell Sci. 2020 02 12; 133(3). PMID: 31964712; PMCID: PMC7033735.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Sparvoli D, Zoltner M, Cheng CY, Field MC, Turkewitz A. Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila. J Cell Sci. 2020 Jan 01. PMID: 34005156.
      Citations:    
    10. Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, He C, Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, He C. N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA. Genome Biol. 2018 11 19; 19(1):200. PMID: 30454035; PMCID: PMC6245762.
      Citations: 24     Fields:    Translation:AnimalsCells
    11. Sparvoli D, Richardson E, Osakada H, Lan X, Iwamoto M, Bowman GR, Kontur C, Bourland WA, Lynn DH, Pritchard JK, Haraguchi T, Dacks JB, Turkewitz AP, Sparvoli D, Richardson E, Osakada H, Lan X, Iwamoto M, Bowman GR, Kontur C, Bourland WA, Lynn DH, Pritchard JK, Haraguchi T, Dacks JB, Turkewitz AP. Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila. Curr Biol. 2018 03 05; 28(5):697-710.e13. PMID: 29478853; PMCID: PMC5840023.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. de Francisco P, Mart?n-Gonz?lez A, Turkewitz AP, Guti?rrez JC, de Francisco P, Mart?n-Gonz?lez A, Turkewitz AP, Guti?rrez JC. Extreme metal adapted, knockout and knockdown strains reveal a coordinated gene expression among different Tetrahymena thermophila metallothionein isoforms. PLoS One. 2017; 12(12):e0189076. PMID: 29206858; PMCID: PMC5716537.
      Citations: 10     Fields:    Translation:Animals
    13. Tsypin LM, Turkewitz AP, Tsypin LM, Turkewitz AP. The Co-regulation Data Harvester: automating gene annotation starting from a transcriptome database. SoftwareX. 2017; 6:165-171. PMID: 29104906; PMCID: PMC5663188.
      Citations: 2     
    14. Kaur H, Sparvoli D, Osakada H, Iwamoto M, Haraguchi T, Turkewitz AP, Kaur H, Sparvoli D, Osakada H, Iwamoto M, Haraguchi T, Turkewitz AP. An endosomal syntaxin and the AP-3 complex are required for formation and maturation of candidate lysosome-related secretory organelles (mucocysts) in Tetrahymena thermophila. Mol Biol Cell. 2017 Jun 01; 28(11):1551-1564. PMID: 28381425; PMCID: PMC5449153.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Guerrier S, Plattner H, Richardson E, Dacks JB, Turkewitz AP, Guerrier S, Plattner H, Richardson E, Dacks JB, Turkewitz AP. An evolutionary balance: conservation vs innovation in ciliate membrane trafficking. Traffic. 2017 01; 18(1):18-28. PMID: 27696651; PMCID: PMC5182178.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Kontur C, Kumar S, Lan X, Pritchard JK, Turkewitz AP, Kontur C, Kumar S, Lan X, Pritchard JK, Turkewitz AP. Whole Genome Sequencing Identifies a Novel Factor Required for Secretory Granule Maturation in Tetrahymena thermophila. G3 (Bethesda). 2016 08 09; 6(8):2505-16. PMID: 27317773; PMCID: PMC4978903.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Klinger CM, Ramirez-Macias I, Herman EK, Turkewitz AP, Field MC, Dacks JB, Klinger CM, Ramirez-Macias I, Herman EK, Turkewitz AP, Field MC, Dacks JB. Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology. Mol Biochem Parasitol. 2016 Sep - Oct; 209(1-2):88-103. PMID: 27444378; PMCID: PMC5140719.
      Citations: 10     Fields:    Translation:AnimalsCells
    18. Kumar S, Briguglio JS, Turkewitz AP, Kumar S, Briguglio JS, Turkewitz AP. Secretion of Polypeptide Crystals from Tetrahymena thermophila Secretory Organelles (Mucocysts) Depends on Processing by a Cysteine Cathepsin, Cth4p. Eukaryot Cell. 2015 Aug; 14(8):817-33. PMID: 26092918; PMCID: PMC4519746.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Lynch M, Field MC, Goodson HV, Malik HS, Pereira-Leal JB, Roos DS, Turkewitz AP, Sazer S, Lynch M, Field MC, Goodson HV, Malik HS, Pereira-Leal JB, Roos DS, Turkewitz AP, Sazer S. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):16990-4. PMID: 25404324; PMCID: PMC4260604.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    20. Kumar S, Briguglio JS, Turkewitz AP, Kumar S, Briguglio JS, Turkewitz AP. An aspartyl cathepsin, CTH3, is essential for proprotein processing during secretory granule maturation in Tetrahymena thermophila. Mol Biol Cell. 2014 Aug 15; 25(16):2444-60. PMID: 24943840; PMCID: PMC4142616.
      Citations: 9     Fields:    Translation:AnimalsCells
    21. Briguglio JS, Turkewitz AP, Briguglio JS, Turkewitz AP. Tetrahymena thermophila: a divergent perspective on membrane traffic. J Exp Zool B Mol Dev Evol. 2014 Nov; 322(7):500-16. PMID: 24634411; PMCID: PMC4719778.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Amaro F, Turkewitz AP, Mart?n-Gonz?lez A, Guti?rrez JC, Amaro F, Turkewitz AP, Mart?n-Gonz?lez A, Guti?rrez JC. Functional GFP-metallothionein fusion protein from Tetrahymena thermophila: a potential whole-cell biosensor for monitoring heavy metal pollution and a cell model to study metallothionein overproduction effects. Biometals. 2014 Feb; 27(1):195-205. PMID: 24430977; PMCID: PMC4707044.
      Citations: 11     Fields:    Translation:AnimalsCells
    23. Briguglio JS, Kumar S, Turkewitz AP, Briguglio JS, Kumar S, Turkewitz AP. Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena. J Cell Biol. 2013 Nov 11; 203(3):537-50. PMID: 24189272; PMCID: PMC3824020.
      Citations: 23     Fields:    Translation:AnimalsCells
    24. Katz LA, Turkewitz AP, Katz LA, Turkewitz AP. Stalking the wild Tetrahymena. Mol Ecol. 2013 Feb; 22(4):912-4. PMID: 23476937.
      Citations:    Fields:    Translation:Animals
    25. Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD, Poklepovich TJ, Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD. The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids. 2012 Nov; 77(13):1313-20. PMID: 22982564; PMCID: PMC3501532.
      Citations: 7     Fields:    Translation:AnimalsCells
    26. Nusblat AD, Bright LJ, Turkewitz AP, Nusblat AD, Bright LJ, Turkewitz AP. Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments. Methods Cell Biol. 2012; 109:141-75. PMID: 22444145; PMCID: PMC4711351.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Turkewitz AP, Bright LJ, Turkewitz AP, Bright LJ. A Rab-based view of membrane traffic in the ciliate Tetrahymena thermophila. Small GTPases. 2011 Jul; 2(4):222-226. PMID: 22145095; PMCID: PMC3225912.
      Citations: 6     Fields:    
    28. Amaro F, Turkewitz AP, Mart?n-Gonz?lez A, Guti?rrez JC, Amaro F, Turkewitz AP, Mart?n-Gonz?lez A, Guti?rrez JC. Whole-cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila. Microb Biotechnol. 2011 Jul; 4(4):513-22. PMID: 21366892; PMCID: PMC3815263.
      Citations: 18     Fields:    Translation:AnimalsCells
    29. Bright LJ, Kambesis N, Nelson SB, Jeong B, Turkewitz AP, Bright LJ, Kambesis N, Nelson SB, Jeong B, Turkewitz AP. Comprehensive analysis reveals dynamic and evolutionary plasticity of Rab GTPases and membrane traffic in Tetrahymena thermophila. PLoS Genet. 2010 Oct 14; 6(10):e1001155. PMID: 20976245; PMCID: PMC2954822.
      Citations: 29     Fields:    Translation:AnimalsCells
    30. Rahaman A, Miao W, Turkewitz AP, Rahaman A, Miao W, Turkewitz AP. Independent transport and sorting of functionally distinct protein families in Tetrahymena thermophila dense core secretory granules. Eukaryot Cell. 2009 Oct; 8(10):1575-83. PMID: 19684282; PMCID: PMC2756869.
      Citations: 10     Fields:    Translation:AnimalsCells
    31. Rahaman A, Elde NC, Turkewitz AP, Rahaman A, Elde NC, Turkewitz AP. A dynamin-related protein required for nuclear remodeling in Tetrahymena. Curr Biol. 2008 Aug 26; 18(16):1227-33. PMID: 18701286; PMCID: PMC2562171.
      Citations: 16     Fields:    Translation:Animals
    32. Elde NC, Long M, Turkewitz AP, Elde NC, Long M, Turkewitz AP. A role for convergent evolution in the secretory life of cells. Trends Cell Biol. 2007 Apr; 17(4):157-64. PMID: 17329106.
      Citations: 12     Fields:    Translation:AnimalsCells
    33. Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E, Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E. Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol. 2006 Sep; 4(9):e286. PMID: 16933976; PMCID: PMC1557398.
      Citations: 320     Fields:    Translation:AnimalsCells
    34. Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP, Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP. Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS Genet. 2005 Nov; 1(5):e52. PMID: 16276403; PMCID: PMC1277907.
      Citations: 51     Fields:    Translation:Animals
    35. Bowman GR, Smith DG, Michael Siu KW, Pearlman RE, Turkewitz AP, Bowman GR, Smith DG, Michael Siu KW, Pearlman RE, Turkewitz AP. Genomic and proteomic evidence for a second family of dense core granule cargo proteins in Tetrahymena thermophila. J Eukaryot Microbiol. 2005 Jul-Aug; 52(4):291-7. PMID: 16014006.
      Citations: 16     Fields:    Translation:AnimalsCells
    36. Cowan AT, Bowman GR, Edwards KF, Emerson JJ, Turkewitz AP, Cowan AT, Bowman GR, Edwards KF, Emerson JJ, Turkewitz AP. Genetic, genomic, and functional analysis of the granule lattice proteins in Tetrahymena secretory granules. Mol Biol Cell. 2005 Sep; 16(9):4046-60. PMID: 15958493; PMCID: PMC1196318.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Bowman GR, Elde NC, Morgan G, Winey M, Turkewitz AP, Bowman GR, Elde NC, Morgan G, Winey M, Turkewitz AP. Core formation and the acquisition of fusion competence are linked during secretory granule maturation in Tetrahymena. Traffic. 2005 Apr; 6(4):303-23. PMID: 15752136; PMCID: PMC4708285.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Turkewitz AP, Turkewitz AP. Out with a bang! Tetrahymena as a model system to study secretory granule biogenesis. Traffic. 2004 Feb; 5(2):63-8. PMID: 14690495.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    39. Bradshaw NR, Chilcoat ND, Verbsky JW, Turkewitz AP, Bradshaw NR, Chilcoat ND, Verbsky JW, Turkewitz AP. Proprotein processing within secretory dense core granules of Tetrahymena thermophila. J Biol Chem. 2003 Feb 07; 278(6):4087-95. PMID: 12435750.
      Citations: 7     Fields:    Translation:AnimalsCells
    40. Haddad A, Bowman GR, Turkewitz AP, Haddad A, Bowman GR, Turkewitz AP. New class of cargo protein in Tetrahymena thermophila dense core secretory granules. Eukaryot Cell. 2002 Aug; 1(4):583-93. PMID: 12456006; PMCID: PMC117993.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Fillingham JS, Chilcoat ND, Turkewitz AP, Orias E, Reith M, Pearlman RE, Fillingham JS, Chilcoat ND, Turkewitz AP, Orias E, Reith M, Pearlman RE. Analysis of expressed sequence tags (ESTs) in the ciliated protozoan Tetrahymena thermophila. J Eukaryot Microbiol. 2002 Mar-Apr; 49(2):99-107. PMID: 12043965.
      Citations: 13     Fields:    Translation:HumansAnimals
    42. Turkewitz AP, Orias E, Kapler G, Turkewitz AP, Orias E, Kapler G. Functional genomics: the coming of age for Tetrahymena thermophila. Trends Genet. 2002 Jan; 18(1):35-40. PMID: 11750699.
      Citations: 40     Fields:    Translation:Animals
    43. Bowman GR, Turkewitz AP, Bowman GR, Turkewitz AP. Analysis of a mutant exhibiting conditional sorting to dense core secretory granules in Tetrahymena thermophila. Genetics. 2001 Dec; 159(4):1605-16. PMID: 11779800; PMCID: PMC1461923.
      Citations: 18     Fields:    Translation:AnimalsCells
    44. Chilcoat ND, Elde NC, Turkewitz AP, Chilcoat ND, Elde NC, Turkewitz AP. An antisense approach to phenotype-based gene cloning in Tetrahymena. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8709-13. PMID: 11438705; PMCID: PMC37500.
      Citations: 12     Fields:    Translation:AnimalsCells
    45. Turkewitz AP, Chilcoat ND, Haddad A, Verbsky JW, Turkewitz AP, Chilcoat ND, Haddad A, Verbsky JW. Regulated protein secretion in Tetrahymena thermophila. Methods Cell Biol. 2000; 62:347-62. PMID: 10503203.
      Citations: 5     Fields:    Translation:Animals
    46. Verbsky JW, Turkewitz AP, Verbsky JW, Turkewitz AP. Proteolytic processing and Ca2+-binding activity of dense-core vesicle polypeptides in Tetrahymena. Mol Biol Cell. 1998 Feb; 9(2):497-511. PMID: 9450970; PMCID: PMC25279.
      Citations: 17     Fields:    Translation:AnimalsCells
    47. Melia SM, Cole ES, Turkewitz AP, Melia SM, Cole ES, Turkewitz AP. Mutational analysis of regulated exocytosis in Tetrahymena. J Cell Sci. 1998 Jan; 111 ( Pt 1):131-40. PMID: 9394019.
      Citations: 17     Fields:    Translation:AnimalsCells
    48. Chilcoat ND, Turkewitz AP, Chilcoat ND, Turkewitz AP. In vivo analysis of the major exocytosis-sensitive phosphoprotein in Tetrahymena. J Cell Biol. 1997 Dec 01; 139(5):1197-207. PMID: 9382866; PMCID: PMC2140215.
      Citations: 8     Fields:    Translation:AnimalsCells
    49. Haddad A, Turkewitz AP, Haddad A, Turkewitz AP. Analysis of exocytosis mutants indicates close coupling between regulated secretion and transcription activation in Tetrahymena. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10675-80. PMID: 9380694; PMCID: PMC23444.
      Citations: 15     Fields:    Translation:AnimalsCells
    50. Chilcoat ND, Melia SM, Haddad A, Turkewitz AP, Chilcoat ND, Melia SM, Haddad A, Turkewitz AP. Granule lattice protein 1 (Grl1p), an acidic, calcium-binding protein in Tetrahymena thermophila dense-core secretory granules, influences granule size, shape, content organization, and release but not protein sorting or condensation. J Cell Biol. 1996 Dec; 135(6 Pt 2):1775-87. PMID: 8991090; PMCID: PMC2133959.
      Citations: 26     Fields:    Translation:AnimalsCells
    51. Turkewitz AP, Kelly RB, Turkewitz AP, Kelly RB. Immunocytochemical analysis of secretion mutants of Tetrahymena using a mucocyst-specific monoclonal antibody. Dev Genet. 1992; 13(2):151-9. PMID: 1499156.
      Citations: 10     Fields:    Translation:AnimalsCells
    52. Turkewitz AP, Madeddu L, Kelly RB, Turkewitz AP, Madeddu L, Kelly RB. Maturation of dense core granules in wild type and mutant Tetrahymena thermophila. EMBO J. 1991 Aug; 10(8):1979-87. PMID: 2065648; PMCID: PMC452877.
      Citations: 29     Fields:    Translation:AnimalsCells
    53. Turkewitz AP, Harrison SC, Turkewitz AP, Harrison SC. Concentration of transferrin receptor in human placental coated vesicles. J Cell Biol. 1989 Jun; 108(6):2127-35. PMID: 2567737; PMCID: PMC2115582.
      Citations: 4     Fields:    Translation:HumansCells
    54. Turkewitz AP, Schwartz AL, Harrison SC, Turkewitz AP, Schwartz AL, Harrison SC. A pH-dependent reversible conformational transition of the human transferrin receptor leads to self-association. J Biol Chem. 1988 Nov 05; 263(31):16309-15. PMID: 3182794.
      Citations: 13     Fields:    Translation:HumansCells
    55. Turkewitz AP, Amatruda JF, Borhani D, Harrison SC, Schwartz AL, Turkewitz AP, Amatruda JF, Borhani D, Harrison SC, Schwartz AL. A high yield purification of the human transferrin receptor and properties of its major extracellular fragment. J Biol Chem. 1988 Jun 15; 263(17):8318-25. PMID: 3372526.
      Citations: 18     Fields:    Translation:HumansCells
    56. Schwartz AL, Ciechanover A, Merritt S, Turkewitz A, Schwartz AL, Ciechanover A, Merritt S, Turkewitz A. Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. J Biol Chem. 1986 Nov 15; 261(32):15225-32. PMID: 3021767.
      Citations: 12     Fields:    Translation:HumansCells
    57. Turkewitz AP, Sullivan CP, Mescher MF, Turkewitz AP, Sullivan CP, Mescher MF. Large-scale purification of murine I-Ak and I-Ek antigens and characterization of the purified proteins. Mol Immunol. 1983 Nov; 20(11):1139-47. PMID: 6581382.
      Citations: 8     Fields:    Translation:AnimalsCells
    58. Mescher MF, Stallcup KC, Sullivan CP, Turkewitz AP, Herrmann SH, Mescher MF, Stallcup KC, Sullivan CP, Turkewitz AP, Herrmann SH. Purification of murine MHC antigens by monoclonal antibody affinity chromatography. Methods Enzymol. 1983; 92:86-109. PMID: 6574303.
      Citations: 6     Fields:    Translation:HumansAnimals
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