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Siri Greeley

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPediatrics-Endocrinology
AddressChicago IL 60637
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    Collapse Overview 
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    Siri Atma W. Greeley, MD, PhD is an internationally recognized expert on monogenic diabetes. Since 2006, he has pursued patient-oriented and outcomes based clinical research, with a focus on neonatal diabetes. Anyone diagnosed with diabetes before 6 months of age is very likely to have an underlying monogenic cause. Almost 50% of these babies will have a mutation in one of the genes encoding the KATP channel that allows for switching from intensive insulin injections to incredibly good glycemic control on exclusive oral sulfonylurea treatment. Along with a variety of local and international collaborators, Dr. Greeley has made several key contributions to the overall understanding of monogenic forms of diabetes. Among his ongoing efforts are his role as the Chair appointed by the Pediatric Endocrine Society to led an international effort to develop consensus guidelines for diagnosis and management of congenital forms of diabetes

    With the support of Drs. Louis Philipson and Graeme Bell, Dr. Greeley conceived of and developed the web-based University of Chicago Monogenic Diabetes Registry (http://monogenicdiabetes.uchicago.edu) for those with known or suspected monogenic forms of diabetes. The Registry remains the only one of its kind in the Western Hemisphere and now includes well over 2500 participants (over 1400 probands with diabetes as well as family members), of whom over 700 are now known to have an underlying genetic cause. Of these, over 400 were diagnosed with diabetes under a year of age, of whom over 200 have a known monogenic cause (largely due to inclusion in studies at the University of Chicago). The Registry receives frequent inquiries from self-referring patients as well as from an expanding network of clinicians asking advice about interesting or difficult patients. Dr. Greeley is frequently invited to speak about his research, including national meetings of the American Diabetes Association, the Endocrine Society, the Pediatric Endocrine Society, and the American Association of Clinical Endocrinologists (AACE).

    Through the Registry, Dr. Greeley’s overall goal is to clarify phenotype/genotype correlations, response to treatment, and long-term outcome among the rare group of patients with various forms of monogenic neonatal diabetes. Dr. Greeley has over 50 publications, including several studies that have gained international attention and have helped to guide treatment considerations in these patients. With Elbert Huang, Dr. Greeley published the first and only formal cost-effectiveness analysis of genetic testing in neonatal diabetes, demonstrating that testing not only improves quality of life but also represents one of few examples of a medical advancement that is actually cost-saving. His ongoing studies include NIH- and American Diabetes Association funded efforts to understand sleep disturbances, brain functioning and mechanisms of insulin secretion in patients with KATP mutations, as well as the long-term neurodevelopmental consequences of diabetes that begins at a very young age.


    Collapse Biography 
    Collapse education and training
    The University of Chicago Comer Children's Hospital, Chicago, ILFellowship06/2009Pediatric Endocrinology
    The University of Chicago Comer Children's Hospital, Chicago, ILResidency06/2006 Pediatrics
    University of Pennsylvania, Philadelphia, PAMD05/2003Medicine
    University of Pennsylvania, Philadelphia, PAPhD05/2002Immunology
    Columbia University, New York, NYBA and BS05/1995Chemistry and Bioengineering
    Collapse awards and honors
    20173rd DMDEA Gold Medal Oration Award, Dr. Mohan’s Diabetes Education Academy (DMDEA), Chennai, India
    2016Early Career Development Award, Central Society for Clinical and Translational Research (CSCTR)
    2014Ira Rosenthal Memorial Lecture, University of Illinois at Chicago (UIC)
    2009 - 2012Lewis-Sebring Family Foundation Fellow in Diabetes Genetics, Kovler Diabetes Center, University of Chicago
    2009The George M. Eisenberg Foundation for Charities Excellence Award for Pediatrics, University of Chicago Department of Pediatrics
    2008 - 2009Research Fellowship Award, Lawson Wilkins Pediatric Endocrine Society (PES)
    2003Endocrine Society Medical Student Achievement Award, University of Pennsylvania School of Medicine
    1995Magna cum Laude, Columbia University

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    Collapse Research 
    Collapse research activities and funding
    T32DK064582     (PHILIPSON, LOUIS H.)Jul 1, 2003 - Jun 30, 2019
    NIH
    Pediatric Endocrinology Research Training Grant
    Role: Co-Investigator

    K23DK094866     (GREELEY, SIRI ATMA W.)May 1, 2012 - Mar 31, 2015
    NIH
    Incretin Regulation of Insulin Secretion in Human Neonatal Diabetes
    Role: Principal Investigator

    R03DK103096     (GREELEY, SIRI ATMA W.)Jul 22, 2014 - Jun 30, 2016
    NIH
    KCNJ11 Diabetes: Exploring the Role of KATP Channels in the Brain
    Role: Principal Investigator

    U01DK103153     (PHILIPSON, LOUIS H.)Aug 5, 2014 - Apr 30, 2019
    NIH
    Chicagoland Diabetes TrialNet Clinical Center
    Role: Co-Investigator

    R01DK104942     (PHILIPSON, LOUIS H.)Jan 8, 2016 - Dec 31, 2020
    NIH
    Monogenic Diabetes: Next Generation Diagnosis, Treatment and Complications
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Letourneau LR, Greeley SAW. Precision Medicine: Long-Term Treatment with Sulfonylureas in Patients with Neonatal Diabetes Due to KCNJ11 Mutations. Curr Diab Rep. 2019 Jun 27; 19(8):52. PMID: 31250216.
      View in: PubMed
    2. Gregory JM, Smith TJ, Slaughter JC, Mason HR, Hughey CC, Smith MS, Kandasamy B, Greeley SAW, Philipson LH, Naylor RN, Letourneau LR, Abumrad NN, Cherrington AD, Moore DJ. Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2). Diabetes. 2019 Aug; 68(8):1565-1576. PMID: 31092478.
      View in: PubMed
    3. Sanyoura M, Letourneau L, Knight Johnson AE, Del Gaudio D, Greeley SAW, Philipson LH, Naylor RN. GCK-MODY in the US Monogenic Diabetes Registry: Description of 27 unpublished variants. Diabetes Res Clin Pract. 2019 May; 151:231-236. PMID: 31063852.
      View in: PubMed
    4. Johnson MB, De Franco E, Greeley SAW, Letourneau LR, Gillespie KM. Trisomy 21 Is a Cause of Permanent Neonatal Diabetes That Is Autoimmune but Not HLA Associated. Diabetes. 2019 Jul; 68(7):1528-1535. PMID: 30962220.
      View in: PubMed
    5. Yap KL, Johnson AEK, Fischer D, Kandikatla P, Deml J, Nelakuditi V, Halbach S, Jeha GS, Burrage LC, Bodamer O, Benavides VC, Lewis AM, Ellard S, Shah P, Cody D, Diaz A, Devarajan A, Truong L, Greeley SAW, De Leon DD, Edmondson AC, Das S, Thornton P, Waggoner D, Del Gaudio D. Correction: "Congenital hyperinsulinism as the presenting feature of Kabuki syndrome: clinical and molecular characterization of 10 affected individuals". Genet Med. 2019 01; 21(1):262-265. PMID: 30097611.
      View in: PubMed
    6. Dickens LT, Letourneau LR, Sanyoura M, Greeley SAW, Philipson LH, Naylor RN. Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry. Acta Diabetol. 2019 Apr; 56(4):405-411. PMID: 30535721.
      View in: PubMed
    7. Hattersley AT, Greeley SAW, Polak M, Rubio-Cabezas O, Njølstad PR, Mlynarski W, Castano L, Carlsson A, Raile K, Chi DV, Ellard S, Craig ME. ISPAD Clinical Practice Consensus Guidelines 2018: The diagnosis and management of monogenic diabetes in children and adolescents. Pediatr Diabetes. 2018 10; 19 Suppl 27:47-63. PMID: 30225972.
      View in: PubMed
    8. Harris AG, Letourneau LR, Greeley SAW. Monogenic diabetes: the impact of making the right diagnosis. Curr Opin Pediatr. 2018 08; 30(4):558-567. PMID: 29846255.
      View in: PubMed
    9. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409. PMID: 29995861.
      View in: PubMed
    10. Yap KL, Johnson AEK, Fischer D, Kandikatla P, Deml J, Nelakuditi V, Halbach S, Jeha GS, Burrage LC, Bodamer O, Benavides VC, Lewis AM, Ellard S, Shah P, Cody D, Diaz A, Devarajan A, Truong L, Greeley SAW, De Leó-Crutchlow DD, Edmondson AC, Das S, Thornton P, Waggoner D, Del Gaudio D. Congenital hyperinsulinism as the presenting feature of Kabuki syndrome: clinical and molecular characterization of 9 affected individuals. Genet Med. 2019 01; 21(1):233-242. PMID: 29907798.
      View in: PubMed
    11. Letourneau LR, Greeley SAW. Congenital Diabetes: Comprehensive Genetic Testing Allows for Improved Diagnosis and Treatment of Diabetes and Other Associated Features. Curr Diab Rep. 2018 06 13; 18(7):46. PMID: 29896650.
      View in: PubMed
    12. Greeley SAW, Letourneau LR, Philipson LH. Precision medicine in KCNJ11 permanent neonatal diabetes. Lancet Diabetes Endocrinol. 2018 08; 6(8):594-595. PMID: 29880307.
      View in: PubMed
    13. Letourneau LR, Greeley SAW. Congenital forms of diabetes: the beta-cell and beyond. Curr Opin Genet Dev. 2018 06; 50:25-34. PMID: 29454299.
      View in: PubMed
    14. Sanyoura M, Jacobsen L, Carmody D, Del Gaudio D, Alkorta-Aranburu G, Arndt K, Hu Y, Kobiernicki F, Kusmartseva I, Atkinson MA, Philipson LH, Schatz D, Campbell-Thompson M, Greeley SAW. Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA. J Clin Endocrinol Metab. 2018 01 01; 103(1):35-45. PMID: 28938416.
      View in: PubMed
    15. Lemelman MB, Letourneau L, Greeley SAW. Neonatal Diabetes Mellitus: An Update on Diagnosis and Management. Clin Perinatol. 2018 03; 45(1):41-59. PMID: 29406006.
      View in: PubMed
    16. Lanning MS, Carmody D, Szczerbinski L, Letourneau LR, Naylor RN, Greeley SAW. Hypoglycemia in sulfonylurea-treated KCNJ11-neonatal diabetes: Mild-moderate symptomatic episodes occur infrequently but none involving unconsciousness or seizures. Pediatr Diabetes. 2018 05; 19(3):393-397. PMID: 29205704.
      View in: PubMed
    17. Hwang JL, Park SY, Ye H, Sanyoura M, Pastore AN, Carmody D, Del Gaudio D, Wilson JF, Hanis CL, Liu X, Atzmon G, Glaser B, Philipson LH, Greeley SAW. FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Diabetes. 2018 05; 19(3):388-392. PMID: 29193502.
      View in: PubMed
    18. Letourneau LR, Carmody D, Philipson LH, Greeley SAW. Early Intensive Insulin Use May Preserve ß-Cell Function in Neonatal Diabetes Due to Mutations in the Proinsulin Gene. J Endocr Soc. 2018 Jan 01; 2(1):1-8. PMID: 29308449.
      View in: PubMed
    19. Letourneau LR, Carmody D, Wroblewski K, Denson AM, Sanyoura M, Naylor RN, Philipson LH, Greeley SAW. Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis. Diabetes Care. 2017 10; 40(10):e147-e148. PMID: 28779000.
      View in: PubMed
    20. Greeley SA, Littlejohn E, Husain AN, Waggoner D, Gundeti M, Rosenfield RL. The Effect of the Testis on the Ovary: Structure-Function Relationships in a Neonate with a Unilateral Ovotestis (Ovotesticular Disorder of Sex Development)?. Horm Res Paediatr. 2017; 87(3):205-212. PMID: 28253506.
      View in: PubMed
    21. Greeley SA, Zielinski MC, Poudel A, Ye H, Berry S, Taxy JB, Carmody D, Steiner DF, Philipson LH, Wood JR, Hara M. Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab. 2017 01 01; 102(1):1-5. PMID: 27802092.
      View in: PubMed
    22. Smith E, Greeley SA, Ye H, Torgerson TR, Dimmitt R, Atkinson P, Philips J, Goldman F. Extremely Early Onset IPEX Syndrome Caused by a Novel Small Exonic Deletion in FOXP3. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e119-e120. PMID: 25187107.
      View in: PubMed
    23. Landmeier KA, Lanning M, Carmody D, Greeley SAW, Msall ME. ADHD, learning difficulties and sleep disturbances associated with KCNJ11-related neonatal diabetes. Pediatr Diabetes. 2017 Nov; 18(7):518-523. PMID: 27555491.
      View in: PubMed
    24. Carmody D, Pastore AN, Landmeier KA, Letourneau LR, Martin R, Hwang JL, Naylor RN, Hunter SJ, Msall ME, Philipson LH, Scott MN, Greeley SA. Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls. Diabet Med. 2016 10; 33(10):1380-6. PMID: 27223594.
      View in: PubMed
    25. Carmody D, Naylor RN, Bell CD, Berry S, Montgomery JT, Tadie EC, Hwang JL, Greeley SA, Philipson LH. GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated. Acta Diabetol. 2016 Oct; 53(5):703-8. PMID: 27106716.
      View in: PubMed
    26. Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SA. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016 Mar; 33(3):e8-e12. PMID: 26262567.
      View in: PubMed
    27. Perrone ME, Carmody D, Philipson LH, Greeley SA. An online monogenic diabetes discussion group: supporting families and fueling new research. Transl Res. 2015 Nov; 166(5):425-31. PMID: 26184072.
      View in: PubMed
    28. Carmody D, Park SY, Ye H, Perrone ME, Alkorta-Aranburu G, Highland HM, Hanis CL, Philipson LH, Bell GI, Greeley SA. Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism. J Med Genet. 2015 Sep; 52(9):612-6. PMID: 26101329.
      View in: PubMed
    29. Carmody D, Beca FA, Bell CD, Hwang JL, Dickens JT, Devine NA, Mackay DJ, Temple IK, Hays LR, Naylor RN, Philipson LH, Greeley SA. Role of noninsulin therapies alone or in combination in chromosome 6q24-related transient neonatal diabetes: sulfonylurea improves but does not always normalize insulin secretion. Diabetes Care. 2015 Jun; 38(6):e86-7. PMID: 25998302.
      View in: PubMed
    30. Thurber BW, Carmody D, Tadie EC, Pastore AN, Dickens JT, Wroblewski KE, Naylor RN, Philipson LH, Greeley SA. Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia. 2015 Jul; 58(7):1430-5. PMID: 25877689.
      View in: PubMed
    31. Rosenfield RL, DiMeglio LA, Mauras N, Ross J, Shaw ND, Greeley SA, Haymond M, Rubin K, Rhodes ET. Commentary: Launch of a quality improvement network for evidence-based management of uncommon pediatric endocrine disorders: Turner syndrome as a prototype. J Clin Endocrinol Metab. 2015 Apr; 100(4):1234-6. PMID: 25844763.
      View in: PubMed
    32. Greeley SA. Response letter to the editor. J Clin Endocrinol Metab. 2015 Jan; 100(1):L14. PMID: 25559539.
      View in: PubMed
    33. Carmody D, Bell CD, Hwang JL, Dickens JT, Sima DI, Felipe DL, Zimmer CA, Davis AO, Kotlyarevska K, Naylor RN, Philipson LH, Greeley SA. Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons. J Clin Endocrinol Metab. 2014 Dec; 99(12):E2709-14. PMID: 25238204.
      View in: PubMed
    34. Alkorta-Aranburu G, Carmody D, Cheng YW, Nelakuditi V, Ma L, Dickens JT, Das S, Greeley SAW, Del Gaudio D. Phenotypic heterogeneity in monogenic diabetes: the clinical and diagnostic utility of a gene panel-based next-generation sequencing approach. Mol Genet Metab. 2014 Dec; 113(4):315-320. PMID: 25306193.
      View in: PubMed
    35. Blanco M, Khan O, Stanley K, Hageman JR, Greeley SA. Hyperinsulinism in a neonate. Pediatr Ann. 2014 Mar; 43(3):e56-60. PMID: 24605860.
      View in: PubMed
    36. Philla KQ, Bauer AJ, Vogt KS, Greeley SA. Successful transition from insulin to sulfonylurea therapy in a patient with monogenic neonatal diabetes owing to a KCNJ11 F333L [corrected] mutation. Diabetes Care. 2013 Dec; 36(12):e201. PMID: 24265373.
      View in: PubMed
    37. Shalev SA, Tenenbaum-Rakover Y, Horovitz Y, Paz VP, Ye H, Carmody D, Highland HM, Boerwinkle E, Hanis CL, Muzny DM, Gibbs RA, Bell GI, Philipson LH, Greeley SA. Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder. Pediatr Diabetes. 2014 May; 15(3):252-6. PMID: 24138066.
      View in: PubMed
    38. Naylor RN, John PM, Winn AN, Carmody D, Greeley SA, Philipson LH, Bell GI, Huang ES. Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. Diabetes Care. 2014; 37(1):202-9. PMID: 24026547.
      View in: PubMed
    39. Concepcion JP, Reh CS, Daniels M, Liu X, Paz VP, Ye H, Highland HM, Hanis CL, Greeley SA. Neonatal diabetes, gallbladder agenesis, duodenal atresia, and intestinal malrotation caused by a novel homozygous mutation in RFX6. Pediatr Diabetes. 2014 Feb; 15(1):67-72. PMID: 23914949.
      View in: PubMed
    40. McTaggart JS, Jenkinson N, Brittain JS, Greeley SA, Hattersley AT, Ashcroft FM. Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking. PLoS One. 2013; 8(4):e62646. PMID: 23626843.
      View in: PubMed
    41. Flanagan SE, Mackay DJ, Greeley SA, McDonald TJ, Mericq V, Hassing J, Richmond EJ, Martin WR, Acerini C, Kaulfers AM, Flynn DP, Popovic J, Sperling MA, Hussain K, Ellard S, Hattersley AT. Hypoglycaemia following diabetes remission in patients with 6q24 methylation defects: expanding the clinical phenotype. Diabetologia. 2013 Jan; 56(1):218-21. PMID: 23111732.
      View in: PubMed
    42. Shah RP, Spruyt K, Kragie BC, Greeley SA, Msall ME. Visuomotor performance in KCNJ11-related neonatal diabetes is impaired in children with DEND-associated mutations and may be improved by early treatment with sulfonylureas. Diabetes Care. 2012 Oct; 35(10):2086-8. PMID: 22855734.
      View in: PubMed
    43. Greeley SA, Msall ME, Acharya K. Genomic sequencing in newborn screening programs. JAMA. 2012 May 23; 307(20):2146-7; author reply 2147. PMID: 22618896.
      View in: PubMed
    44. Greeley SA, Naylor RN, Philipson LH, Bell GI. Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Curr Diab Rep. 2011 Dec; 11(6):519-32. PMID: 21993633.
      View in: PubMed
    45. Greeley SA, Naylor RN, Cook LS, Tucker SE, Lipton RB, Philipson LH. Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetes. J Diabetes Sci Technol. 2011 Jul 01; 5(4):879-86. PMID: 21880229.
      View in: PubMed
    46. Naylor RN, Greeley SA, Bell GI, Philipson LH. Genetics and pathophysiology of neonatal diabetes mellitus. J Diabetes Investig. 2011 Jun 05; 2(3):158-69. PMID: 24843477.
      View in: PubMed
    47. Lipton RB, Drum ML, Danielson KK, Greeley SA, Bell GI, Hagopian WA. Onset features and subsequent clinical evolution of childhood diabetes over several years. Pediatr Diabetes. 2011 Jun; 12(4 Pt 1):326-34. PMID: 21426455.
      View in: PubMed
    48. Lipton RB, Drum M, Greeley SA, Danielson KK, Bell GI, Hagopian WA. HLA-DQ haplotypes differ by ethnicity in patients with childhood-onset diabetes. Pediatr Diabetes. 2011 Jun; 12(4 Pt 2):388-95. PMID: 21418452.
      View in: PubMed
    49. Greeley SA, John PM, Winn AN, Ornelas J, Lipton RB, Philipson LH, Bell GI, Huang ES. The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes. Diabetes Care. 2011 Mar; 34(3):622-7. PMID: 21273495.
      View in: PubMed
    50. Greeley SA, Tucker SE, Naylor RN, Bell GI, Philipson LH. Neonatal diabetes mellitus: a model for personalized medicine. Trends Endocrinol Metab. 2010 Aug; 21(8):464-72. PMID: 20434356.
      View in: PubMed
    51. Greeley SA, Tucker SE, Worrell HI, Skowron KB, Bell GI, Philipson LH. Update in neonatal diabetes. Curr Opin Endocrinol Diabetes Obes. 2010 Feb; 17(1):13-9. PMID: 19952737.
      View in: PubMed
    52. Kumaraguru J, Flanagan SE, Greeley SA, Nuboer R, Støy J, Philipson LH, Hattersley AT, Rubio-Cabezas O. Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect. Diabetes Care. 2009 Aug; 32(8):1428-30. PMID: 19435956.
      View in: PubMed
    53. Støy J, Greeley SA, Paz VP, Ye H, Pastore AN, Skowron KB, Lipton RB, Cogen FR, Bell GI, Philipson LH. Diagnosis and treatment of neonatal diabetes: a United States experience. Pediatr Diabetes. 2008 Oct; 9(5):450-9. PMID: 18662362.
      View in: PubMed
    54. Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI. Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15040-4. PMID: 17855560.
      View in: PubMed
    55. Ahn J, Watt CD, Man LX, Greeley SA, Shea JA. Educating future leaders of medical research: analysis of student opinions and goals from the MD-PhD SAGE (Students' Attitudes, Goals, and Education) survey. Acad Med. 2007 Jul; 82(7):633-45. PMID: 17595558.
      View in: PubMed
    56. Moore DJ, Noorchashm H, Lin TH, Greeley SA, Naji A. NOD B-cells are insufficient to incite T-cell-mediated anti-islet autoimmunity. Diabetes. 2005 Jul; 54(7):2019-25. PMID: 15983202.
      View in: PubMed
    57. Watt CD, Greeley SA, Shea JA, Ahn J. Educational views and attitudes, and career goals of MD-PhD students at the University of Pennsylvania School of Medicine. Acad Med. 2005 Feb; 80(2):193-8. PMID: 15671328.
      View in: PubMed
    58. Ahn J, Watt CD, Greeley SA, Bernstein J. MD-PhD students in a major training program show strong interest in becoming surgeon-scientists. Clin Orthop Relat Res. 2004 Aug; (425):258-63. PMID: 15292817.
      View in: PubMed
    59. Song HK, Noorchashm H, Lin TH, Moore DJ, Greeley SA, Caton AJ, Naji A. Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis. J Autoimmun. 2003 Dec; 21(4):295-303. PMID: 14624753.
      View in: PubMed
    60. Noorchashm H, Greeley SA, Naji A. The role of t/b lymphocyte collaboration in the regulation of autoimmune and alloimmune responses. Immunol Res. 2003; 27(2-3):443-50. PMID: 12857987.
      View in: PubMed
    61. Greeley SA, Katsumata M, Yu L, Eisenbarth GS, Moore DJ, Goodarzi H, Barker CF, Naji A, Noorchashm H. Elimination of maternally transmitted autoantibodies prevents diabetes in nonobese diabetic mice. Nat Med. 2002 Apr; 8(4):399-402. PMID: 11927947.
      View in: PubMed
    62. Noorchashm H, Greeley SA, Naji A. B-cell deficiency and type 1 diabetes. N Engl J Med. 2002 Feb 14; 346(7):538-9. PMID: 11844863.
      View in: PubMed
    63. Greeley SA, Moore DJ, Noorchashm H, Noto LE, Rostami SY, Schlachterman A, Song HK, Koeberlein B, Barker CF, Naji A. Impaired activation of islet-reactive CD4 T cells in pancreatic lymph nodes of B cell-deficient nonobese diabetic mice. J Immunol. 2001 Oct 15; 167(8):4351-7. PMID: 11591759.
      View in: PubMed
    64. Song HK, Noorchashm H, Lieu YK, Rostami S, Greeley SA, Barker CF, Naji A. Tracking alloreactive cell division in vivo. Transplantation. 1999 Jul 27; 68(2):297-9. PMID: 10440405.
      View in: PubMed
    65. Noorchashm H, Lieu YK, Noorchashm N, Rostami SY, Greeley SA, Schlachterman A, Song HK, Noto LE, Jevnikar AM, Barker CF, Naji A. I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic mice. J Immunol. 1999 Jul 15; 163(2):743-50. PMID: 10395666.
      View in: PubMed
    66. Noorchashm H, Lieu YK, Rostami SY, Song HK, Greeley SA, Bazel S, Barker CF, Naji A. A direct method for the calculation of alloreactive CD4+ T cell precursor frequency. Transplantation. 1999 May 15; 67(9):1281-4. PMID: 10342323.
      View in: PubMed
    67. Song HK, Noorchashm H, Lieu YK, Rostami S, Greeley SA, Barker CF, Naji A. Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation. J Immunol. 1999 Mar 01; 162(5):2467-71. PMID: 10072484.
      View in: PubMed
    68. Song HK, Noorchashm H, Lieu YK, Rostami S, Greeley SA, Barker CF, Naji A. Characterization of the alloimmune response to minor histocompatibility antigens by in vivo MLR. Transplant Proc. 1999 Feb-Mar; 31(1-2):836-7. PMID: 10083363.
      View in: PubMed
    69. Noorchashm H, Lieu YK, Song HK, Rostami SY, Greeley SA, Noorchashm N, Barker CF, Naji A. B lymphocytes influence the shape of the mature preimmune CD4+ TCR repertoire. Transplant Proc. 1999 Feb-Mar; 31(1-2):832-3. PMID: 10083361.
      View in: PubMed
    70. Song HK, Noorchashm H, Lieu YK, Rostami S, Greeley SA, Barker CF, Naji A. In vivo MLR: a novel method for the study of alloimmune responses. Transplant Proc. 1999 Feb-Mar; 31(1-2):834-5. PMID: 10083362.
      View in: PubMed
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