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Suzanne D. Conzen

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology/Oncology
AddressChicago IL 60637
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    Collapse Research 
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    R01CA239719     (BRADY, MATTHEW J)Jul 1, 2020 - Jun 30, 2026
    NIH
    Effects of chronic pubertal stressors on mammary gland biology and cancer risk
    Role: Co-Principal Investigator
    R01CA238519     (CONZEN, SUZANNE DANIELA)Mar 1, 2019 - Feb 28, 2025
    NIH
    Estrogen and glucocorticoid receptor crosstalk in ER+ breast
    Role: Principal Investigator
    R21CA239048     (CONZEN, SUZANNE DANIELA)Mar 1, 2019 - Feb 28, 2021
    NIH
    NNMT regulation of m6A RNA modification in TNBC progression
    Role: Principal Investigator
    R21CA223426     (CONZEN, SUZANNE DANIELA)Jan 18, 2019 - Dec 31, 2021
    NIH
    Identification of a prognostic and predictive glucocorticoid receptor signature for ovarian cancer
    Role: Principal Investigator
    R01CA148814     (CONZEN, SUZANNE DANIELA)Jun 20, 2011 - Apr 30, 2018
    NIH
    Identifying mechanisms linking stress biology to human breast cancer
    Role: Principal Investigator
    R21CA149472     (CONZEN, SUZANNE DANIELA)Sep 30, 2010 - Aug 31, 2013
    NIH
    The role of SGK1 in triple-negative breast cancer resistance to treatment
    Role: Principal Investigator
    K08CA090459     (CONZEN, SUZANNE DANIELA)May 11, 2001 - Apr 30, 2006
    NIH
    Survival Signaling in Breast Cancer
    Role: Principal Investigator
    R01CA089208     (CONZEN, SUZANNE DANIELA)Dec 1, 2000 - Mar 31, 2018
    NIH
    Glucocorticoid receptor-mediated survival signaling in breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marin Z, Wang X, Collison DW, McFadden C, Lin J, Borges HM, Chen B, Mehra D, Shen Q, Galecki S, Daetwyler S, Sheppard SJ, Thien P, Porter BA, Conzen SD, Shepherd DP, Fiolka R, Dean KM. Navigate: an open-source platform for smart light-sheet microscopy. Nat Methods. 2024 Nov; 21(11):1967-1969. PMID: 39261640; PMCID: PMC11540721.
      Citations: 3     Fields:    
    2. Taya M, Hou X, Veneris JT, Kazi N, Larson MC, Maurer MJ, Heinzen EP, Chen H, Lastra R, Oberg AL, Weroha SJ, Fleming GF, Conzen SD. Investigation of selective glucocorticoid receptor modulation in high-grade serous ovarian cancer PDX models. J Gynecol Oncol. 2024 Jun 14. PMID: 38909640.
      Citations:    Fields:    
    3. Clark AB, Conzen SD. Glucocorticoid receptor-mediated oncogenic activity is dependent on breast cancer subtype. J Steroid Biochem Mol Biol. 2024 Oct; 243:106518. PMID: 38734115.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Bennett L, Jaiswal PK, Harkless RV, Long TM, Gao N, Vandenburg B, Selman P, Durdana I, Lastra RR, Vander Griend D, Adelaiye-Ogala R, Szmulewitz RZ, Conzen SD. Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2024 Apr 02; 23(4):552-563. PMID: 38030378; PMCID: PMC10985475.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Porter BA, Frerich C, Lainé M, Clark AB, Durdana I, Lee J, Taya M, Sahoo S, Greene GL, Bennett L, Conzen SD. Glucocorticoid Receptor Activation in Lobular Breast Cancer Is Associated with Reduced Cell Proliferation and Promotion of Metastases. Cancers (Basel). 2023 Sep 22; 15(19). PMID: 37835373; PMCID: PMC10571671.
      Citations:    
    6. Kurnit KC, Steiner M, Lastra RR, Weroha SJ, Cursio J, Lengyel E, Fleming GF, Conzen SD. High glucocorticoid receptor expression in the sarcomatous versus carcinomatous elements of Mullerian carcinosarcomas. Gynecol Oncol Rep. 2022 Jun; 41:100987. PMID: 35519002; PMCID: PMC9065886.
      Citations: 2     
    7. Falcinelli M, Thaker PH, Lutgendorf SK, Conzen SD, Flint MS, Flaherty RL. The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms. Cancer Res. 2021 10 15; 81(20):5131-5140. PMID: 34266894; PMCID: PMC8530873.
      Citations: 16     Fields:    Translation:HumansCells
    8. Blatt EB, Kopplin N, Kumar S, Mu P, Conzen SD, Raj GV. Overcoming oncogene addiction in breast and prostate cancers: a comparative mechanistic overview. Endocr Relat Cancer. 2021 02; 28(2):R31-R46. PMID: 33263560; PMCID: PMC8218927.
      Citations: 3     Fields:    Translation:Humans
    9. Bergstrom CP, Keshvani N, Conzen SD. Diagnostic Imaging for Breast Pain: A Teachable Moment. JAMA Intern Med. 2020 10 01; 180(10):1363-1364. PMID: 32804195.
      Citations: 1     Fields:    Translation:Humans
    10. Mustafi D, Valek R, Fitch M, Werner V, Fan X, Markiewicz E, Fernandez S, Zamora M, Mueller J, Olopade OI, Conzen SD, Brady MJ, Karczmar GS. Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed. 2020 10; 33(10):e4363. PMID: 32881124; PMCID: PMC8034829.
      Citations: 1     Fields:    Translation:Animals
    11. Narayan V, Harrison M, Cheng H, Kenfield S, Aggarwal R, Kwon D, McKay R, Hauger R, Hart N, Conzen S, Borno H, Jim H, Dicker A, Dorff T, Moslehi J, Mucci L, Parsons JK, Saad F, Soule H, Morgans A, Ryan CJ. Improving research for prostate cancer survivorship: A statement from the Survivorship Research in Prostate Cancer (SuRECaP) working group. Urol Oncol. 2020 03; 38(3):83-93. PMID: 31734020.
      Citations: 17     Fields:    Translation:Humans
    12. Tonsing-Carter E, Hernandez KM, Kim CR, Harkless RV, Oh A, Bowie KR, West-Szymanski DC, Betancourt-Ponce MA, Green BD, Lastra RR, Fleming GF, Chandarlapaty S, Conzen SD. Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res. 2019 07 24; 21(1):82. PMID: 31340854; PMCID: PMC6651939.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    13. Yeh AC, Li H, Zhu Y, Zhang J, Khramtsova G, Drukker K, Edwards A, McGregor S, Yoshimatsu T, Zheng Y, Niu Q, Abe H, Mueller J, Conzen S, Ji Y, Giger ML, Olopade OI. Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling. Cancer Imaging. 2019 Jul 15; 19(1):48. PMID: 31307537; PMCID: PMC6628478.
      Citations: 33     Fields:    Translation:Humans
    14. Veneris JT, Huang L, Churpek JE, Conzen SD, Fleming GF. Glucocorticoid receptor expression is associated with inferior overall survival independent of BRCA mutation status in ovarian cancer. Int J Gynecol Cancer. 2019 Feb; 29(2):357-364. PMID: 30683758.
      Citations: 9     Fields:    
    15. Mustafi D, Leinroth A, Fan X, Markiewicz E, Zamora M, Mueller J, Conzen SD, Karczmar GS. Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer. Int J Biomed Imaging. 2019; 2019:5987425. PMID: 30792738; PMCID: PMC6354161.
      Citations: 4     
    16. Johnson MB, Hoffmann JN, You HM, Lastra RR, Fernandez S, Strober JW, Allaw AB, Brady MJ, Conzen SD, McClintock MK. Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia. 2018 06; 23(1-2):59-73. PMID: 29687293; PMCID: PMC6207373.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. West DC, Kocherginsky M, Tonsing-Carter EY, Dolcen DN, Hosfield DJ, Lastra RR, Sinnwell JP, Thompson KJ, Bowie KR, Harkless RV, Skor MN, Pierce CF, Styke SC, Kim CR, de Wet L, Greene GL, Boughey JC, Goetz MP, Kalari KR, Wang L, Fleming GF, Conzen SD, Györffy B. Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer. Clin Cancer Res. 2018 07 15; 24(14):3433-3446. PMID: 29636357; PMCID: PMC6530562.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    18. He D, Mustafi D, Fan X, Fernandez S, Markiewicz E, Zamora M, Mueller J, Sachleben JR, Brady MJ, Conzen SD, Karczmar GS. Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets. PLoS One. 2018; 13(1):e0190929. PMID: 29324859; PMCID: PMC5764316.
      Citations: 5     Fields:    Translation:Animals
    19. Press DJ, Ibraheem A, Dolan ME, Goss KH, Conzen S, Huo D. Racial disparities in omission of oncotype DX but no racial disparities in chemotherapy receipt following completed oncotype DX test results. Breast Cancer Res Treat. 2018 Feb; 168(1):207-220. PMID: 29181717.
      Citations: 19     Fields:    Translation:Humans
    20. House L, Seminerio MJ, Mirkov S, Ramirez J, Skor M, Sachleben JR, Isikbay M, Singhal H, Greene GL, Vander Griend D, Conzen SD, Ratain MJ. Metabolism of megestrol acetate in vitro and the role of oxidative metabolites. Xenobiotica. 2018 Oct; 48(10):973-983. PMID: 29050522; PMCID: PMC6129397.
      Citations: 2     Fields:    Translation:HumansCells
    21. Tangen IL, Veneris JT, Halle MK, Werner HM, Trovik J, Akslen LA, Salvesen HB, Conzen SD, Fleming GF, Krakstad C. Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. Gynecol Oncol. 2017 12; 147(3):672-677. PMID: 28927900.
      Citations: 9     Fields:    Translation:HumansCells
    22. Mustafi D, Fernandez S, Markiewicz E, Fan X, Zamora M, Mueller J, Brady MJ, Conzen SD, Karczmar GS. MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed. 2017 Oct; 30(10). PMID: 28661075; PMCID: PMC5764539.
      Citations: 7     Fields:    Translation:Animals
    23. Conzen SD. Recent advances in understanding glucocorticoid receptor function in cancer. Clin Adv Hematol Oncol. 2017 May; 15(5):338-340. PMID: 28591089; PMCID: PMC5996375.
      Citations: 6     Fields:    Translation:HumansAnimals
    24. Veneris JT, Darcy KM, Mhawech-Fauceglia P, Tian C, Lengyel E, Lastra RR, Pejovic T, Conzen SD, Fleming GF. High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer. Gynecol Oncol. 2017 07; 146(1):153-160. PMID: 28456378; PMCID: PMC5955699.
      Citations: 23     Fields:    Translation:Humans
    25. Kach J, Long TM, Selman P, Tonsing-Carter EY, Bacalao MA, Lastra RR, de Wet L, Comiskey S, Gillard M, VanOpstall C, West DC, Chan WC, Griend DV, Conzen SD, Szmulewitz RZ. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 08; 16(8):1680-1692. PMID: 28428441; PMCID: PMC5544558.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    26. Markiewicz E, Fan X, Mustafi D, Zamora M, Conzen SD, Karczmar GS. MRI ductography of contrast agent distribution and leakage in normal mouse mammary ducts and ducts with in situ cancer. Magn Reson Imaging. 2017 07; 40:48-52. PMID: 28366759; PMCID: PMC5531061.
      Citations: 3     Fields:    Translation:HumansAnimals
    27. Nanda R, Stringer-Reasor EM, Saha P, Kocherginsky M, Gibson J, Libao B, Hoffman PC, Obeid E, Merkel DE, Khramtsova G, Skor M, Krausz T, Cohen RN, Ratain MJ, Fleming GF, Conzen SD. A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer. Springerplus. 2016; 5(1):947. PMID: 27386391; PMCID: PMC4929099.
      Citations: 19     
    28. Li H, Zhu Y, Burnside ES, Huang E, Drukker K, Hoadley KA, Fan C, Conzen SD, Zuley M, Net JM, Sutton E, Whitman GJ, Morris E, Perou CM, Ji Y, Giger ML. Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set. NPJ Breast Cancer. 2016; 2. PMID: 27853751; PMCID: PMC5108580.
      Citations: 175     
    29. Li H, Zhu Y, Burnside ES, Drukker K, Hoadley KA, Fan C, Conzen SD, Whitman GJ, Sutton EJ, Net JM, Ganott M, Huang E, Morris EA, Perou CM, Ji Y, Giger ML. MR Imaging Radiomics Signatures for Predicting the Risk of Breast Cancer Recurrence as Given by Research Versions of MammaPrint, Oncotype DX, and PAM50 Gene Assays. Radiology. 2016 Nov; 281(2):382-391. PMID: 27144536; PMCID: PMC5069147.
      Citations: 234     Fields:    Translation:Humans
    30. West DC, Pan D, Tonsing-Carter EY, Hernandez KM, Pierce CF, Styke SC, Bowie KR, Garcia TI, Kocherginsky M, Conzen SD. GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER+ Breast Cancer Outcome. Mol Cancer Res. 2016 08; 14(8):707-19. PMID: 27141101; PMCID: PMC5008962.
      Citations: 53     Fields:    Translation:HumansCells
    31. Volden PA, Skor MN, Johnson MB, Singh P, Patel FN, McClintock MK, Brady MJ, Conzen SD. Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation. Cancer Prev Res (Phila). 2016 05; 9(5):367-78. PMID: 26862086; PMCID: PMC4854771.
      Citations: 29     Fields:    Translation:AnimalsCells
    32. Agyeman AS, Jun WJ, Proia DA, Kim CR, Skor MN, Kocherginsky M, Conzen SD. Hsp90 Inhibition Results in Glucocorticoid Receptor Degradation in Association with Increased Sensitivity to Paclitaxel in Triple-Negative Breast Cancer. Horm Cancer. 2016 Apr; 7(2):114-26. PMID: 26858237; PMCID: PMC4789079.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    33. Burnside ES, Drukker K, Li H, Bonaccio E, Zuley M, Ganott M, Net JM, Sutton EJ, Brandt KR, Whitman GJ, Conzen SD, Lan L, Ji Y, Zhu Y, Jaffe CC, Huang EP, Freymann JB, Kirby JS, Morris EA, Giger ML. Using computer-extracted image phenotypes from tumors on breast magnetic resonance imaging to predict breast cancer pathologic stage. Cancer. 2016 Mar 01; 122(5):748-57. PMID: 26619259; PMCID: PMC4764425.
      Citations: 35     Fields:    Translation:Humans
    34. Singh P, Brock CO, Volden PA, Hernandez K, Skor M, Kocherginsky M, Park JE, Brady MJ, Conzen SD. Glucocorticoid receptor ChIP-sequencing of subcutaneous fat reveals modulation of inflammatory pathways. Obesity (Silver Spring). 2015 Nov; 23(11):2286-93. PMID: 26408078; PMCID: PMC4818951.
      Citations: 5     Fields:    Translation:HumansCells
    35. Kach J, Conzen SD, Szmulewitz RZ. Targeting the glucocorticoid receptor in breast and prostate cancers. Sci Transl Med. 2015 Sep 16; 7(305):305ps19. PMID: 26378243; PMCID: PMC4807967.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    36. Fan X, Macleod K, Mustafi D, Conzen SD, Markiewicz E, Zamora M, Vosicky J, Mueller J, Karczmar GS. Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers. PLoS One. 2015; 10(7):e0129212. PMID: 26208092; PMCID: PMC4514815.
      Citations: 3     Fields:    Translation:Animals
    37. Mustafi D, Zamora M, Fan X, Markiewicz E, Mueller J, Conzen SD, Karczmar GS. MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology. NMR Biomed. 2015 Sep; 28(9):1078-86. PMID: 26152557; PMCID: PMC4696760.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF, Conzen SD. Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015 Sep; 138(3):656-62. PMID: 26115975; PMCID: PMC4556542.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    39. Fan X, Mustafi D, Markiewicz E, Zamora M, Vosicky J, Leinroth A, Mueller J, Macleod K, Conzen SD, Karczmar GS. Mammary cancer initiation and progression studied with magnetic resonance imaging. Breast Cancer Res. 2014 Dec 16; 16(6):495. PMID: 25510596; PMCID: PMC4303211.
      Citations: 7     Fields:    Translation:Animals
    40. Maranville JC, Nanda R, Fleming GF, Skor MN, Di Rienzo A, Conzen SD. Gene expression of peripheral blood cells reveals pathways downstream of glucocorticoid receptor antagonism and nab-paclitaxel treatment. Pharmacogenet Genomics. 2014 Sep; 24(9):451-8. PMID: 25000515; PMCID: PMC4122588.
      Citations:    Fields:    Translation:Humans
    41. Markiewicz E, Fan X, Mustafi D, Zamora M, Roman BB, Jansen SA, Macleod K, Conzen SD, Karczmar GS. High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media. Magn Reson Imaging. 2015 Jan; 33(1):161-5. PMID: 25179139; PMCID: PMC4267960.
      Citations: 5     Fields:    Translation:Animals
    42. Sachleben JR, Yi R, Volden PA, Conzen SD. Aliphatic chain length by isotropic mixing (ALCHIM): determining composition of complex lipid samples by ¹H NMR spectroscopy. J Biomol NMR. 2014 Jul; 59(3):161-73. PMID: 24831341; PMCID: PMC4479961.
      Citations: 1     Fields:    Translation:AnimalsCells
    43. Isikbay M, Otto K, Kregel S, Kach J, Cai Y, Vander Griend DJ, Conzen SD, Szmulewitz RZ. Glucocorticoid receptor activity contributes to resistance to androgen-targeted therapy in prostate cancer. Horm Cancer. 2014 Apr; 5(2):72-89. PMID: 24615402; PMCID: PMC4440041.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    44. Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, Volden PA, Wu W, Roe MW, Conzen SD. Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death. J Biol Chem. 2013 Nov 08; 288(45):32708-32719. PMID: 24043625; PMCID: PMC3820905.
      Citations: 9     Fields:    Translation:HumansCells
    45. Skor MN, Wonder EL, Kocherginsky M, Goyal A, Hall BA, Cai Y, Conzen SD. Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res. 2013 Nov 15; 19(22):6163-72. PMID: 24016618; PMCID: PMC3860283.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    46. Makinen MW, Bamba R, Ikejimba L, Wietholt C, Chen CT, Conzen SD. The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells. Dalton Trans. 2013 Sep 07; 42(33):11862-7. PMID: 23644715; PMCID: PMC3733664.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    47. Volden PA, Wonder EL, Skor MN, Carmean CM, Patel FN, Ye H, Kocherginsky M, McClintock MK, Brady MJ, Conzen SD. Chronic social isolation is associated with metabolic gene expression changes specific to mammary adipose tissue. Cancer Prev Res (Phila). 2013 Jul; 6(7):634-45. PMID: 23780289; PMCID: PMC3881320.
      Citations: 29     Fields:    Translation:AnimalsCells
    48. Obeid EI, Conzen SD. The role of adrenergic signaling in breast cancer biology. Cancer Biomark. 2013; 13(3):161-9. PMID: 23912488.
      Citations: 15     Fields:    Translation:HumansCells
    49. Volden PA, Conzen SD. The influence of glucocorticoid signaling on tumor progression. Brain Behav Immun. 2013 Mar; 30 Suppl:S26-31. PMID: 23164950; PMCID: PMC3987853.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    50. Hall BA, Kim TY, Skor MN, Conzen SD. Serum and glucocorticoid-regulated kinase 1 (SGK1) activation in breast cancer: requirement for mTORC1 activity associates with ER-alpha expression. Breast Cancer Res Treat. 2012 Sep; 135(2):469-79. PMID: 22842983; PMCID: PMC3891577.
      Citations: 21     Fields:    Translation:HumansCells
    51. Hipp E, Fan X, Jansen SA, Markiewicz EJ, Vosicky J, Newstead GM, Conzen SD, Krausz T, Karczmar GS. T(2)* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland. Med Phys. 2012 Mar; 39(3):1309-13. PMID: 22380363; PMCID: PMC3292598.
      Citations: 4     Fields:    Translation:Animals
    52. Fleming GF, Ma CX, Huo D, Sattar H, Tretiakova M, Lin L, Hahn OM, Olopade FO, Nanda R, Hoffman PC, Naughton MJ, Pluard T, Conzen SD, Ellis MJ. Phase II trial of temsirolimus in patients with metastatic breast cancer. Breast Cancer Res Treat. 2012 Nov; 136(2):355-63. PMID: 22245973; PMCID: PMC3658119.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    53. Pan D, Kocherginsky M, Conzen SD. Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011 Oct 15; 71(20):6360-70. PMID: 21868756; PMCID: PMC3514452.
      Citations: 140     Fields:    Translation:HumansCells
    54. Melhem-Bertrandt A, Chavez-Macgregor M, Lei X, Brown EN, Lee RT, Meric-Bernstam F, Sood AK, Conzen SD, Hortobagyi GN, Gonzalez-Angulo AM. Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer. J Clin Oncol. 2011 Jul 01; 29(19):2645-52. PMID: 21632501; PMCID: PMC3139371.
      Citations: 228     Fields:    Translation:Humans
    55. Szmulewitz RZ, Chung E, Al-Ahmadie H, Daniel S, Kocherginsky M, Razmaria A, Zagaja GP, Brendler CB, Stadler WM, Conzen SD. Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers. Prostate. 2012 Feb 01; 72(2):157-64. PMID: 21563193; PMCID: PMC6000822.
      Citations: 35     Fields:    Translation:Humans
    56. Jansen SA, Conzen SD, Fan X, Markiewicz E, Krausz T, Newstead GM, Karczmar GS. In vivo MRI of early stage mammary cancers and the normal mouse mammary gland. NMR Biomed. 2011 Aug; 24(7):880-7. PMID: 21264977; PMCID: PMC4251780.
      Citations: 6     Fields:    Translation:HumansAnimals
    57. Gehlert S, Murray A, Sohmer D, McClintock M, Conzen S, Olopade O. The importance of transdisciplinary collaborations for understanding and resolving health disparities. Soc Work Public Health. 2010 May; 25(3):408-22. PMID: 20446184.
      Citations: 24     Fields:    Translation:Humans
    58. Hermes GL, Delgado B, Tretiakova M, Cavigelli SA, Krausz T, Conzen SD, McClintock MK. Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22393-8. PMID: 20018726; PMCID: PMC2799783.
      Citations: 105     Fields:    Translation:HumansAnimals
    59. Jansen SA, Paunesku T, Fan X, Woloschak GE, Vogt S, Conzen SD, Krausz T, Newstead GM, Karczmar GS. Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model. Radiology. 2009 Nov; 253(2):399-406. PMID: 19864527; PMCID: PMC2770112.
      Citations: 33     Fields:    Translation:Animals
    60. Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock MK, Conzen SD. A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev Res (Phila). 2009 Oct; 2(10):850-861. PMID: 19789294; PMCID: PMC4707045.
      Citations: 60     Fields:    Translation:Animals
    61. Luca F, Kashyap S, Southard C, Zou M, Witonsky D, Di Rienzo A, Conzen SD. Adaptive variation regulates the expression of the human SGK1 gene in response to stress. PLoS Genet. 2009 May; 5(5):e1000489. PMID: 19461886; PMCID: PMC2679193.
      Citations: 22     Fields:    Translation:HumansCells
    62. Melhem A, Yamada SD, Fleming GF, Delgado B, Brickley DR, Wu W, Kocherginsky M, Conzen SD. Administration of glucocorticoids to ovarian cancer patients is associated with expression of the anti-apoptotic genes SGK1 and MKP1/DUSP1 in ovarian tissues. Clin Cancer Res. 2009 May 01; 15(9):3196-204. PMID: 19383827; PMCID: PMC4707040.
      Citations: 43     Fields:    Translation:HumansCells
    63. Jansen SA, Conzen SD, Fan X, Markiewicz EJ, Newstead GM, Karczmar GS. Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study. Breast Cancer Res. 2009; 11(5):R65. PMID: 19732414; PMCID: PMC2790840.
      Citations: 10     Fields:    Translation:Animals
    64. Boutros T, Nantel A, Emadali A, Tzimas G, Conzen S, Chevet E, Metrakos PP. The MAP kinase phosphatase-1 MKP-1/DUSP1 is a regulator of human liver response to transplantation. Am J Transplant. 2008 Dec; 8(12):2558-68. PMID: 19032224.
      Citations: 14     Fields:    Translation:HumansCells
    65. Jansen SA, Conzen SD, Fan X, Krausz T, Zamora M, Foxley S, River J, Newstead GM, Karczmar GS. Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation. Phys Med Biol. 2008 Oct 07; 53(19):5481-93. PMID: 18780960; PMCID: PMC4251813.
      Citations: 17     Fields:    Translation:Animals
    66. Belova L, Delgado B, Kocherginsky M, Melhem A, Olopade OI, Conzen SD. Glucocorticoid receptor expression in breast cancer associates with older patient age. Breast Cancer Res Treat. 2009 Aug; 116(3):441-7. PMID: 18668364; PMCID: PMC4535812.
      Citations: 15     Fields:    Translation:Humans
    67. Belova L, Brickley DR, Ky B, Sharma SK, Conzen SD. Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. J Biol Chem. 2008 Jul 04; 283(27):18821-31. PMID: 18456663; PMCID: PMC2441554.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    68. Conzen SD. Minireview: nuclear receptors and breast cancer. Mol Endocrinol. 2008 Oct; 22(10):2215-28. PMID: 18417735; PMCID: PMC2582530.
      Citations: 68     Fields:    Translation:HumansAnimals
    69. Pew T, Zou M, Brickley DR, Conzen SD. Glucocorticoid (GC)-mediated down-regulation of urokinase plasminogen activator expression via the serum and GC regulated kinase-1/forkhead box O3a pathway. Endocrinology. 2008 May; 149(5):2637-45. PMID: 18239069; PMCID: PMC2329267.
      Citations: 4     Fields:    Translation:HumansCells
    70. Belova L, Sharma S, Brickley DR, Nicolarsen JR, Patterson C, Conzen SD. Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP. Biochem J. 2006 Dec 01; 400(2):235-44. PMID: 16895519; PMCID: PMC1652829.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    71. Petrella A, Ercolino SF, Festa M, Gentilella A, Tosco A, Conzen SD, Parente L. Dexamethasone inhibits TRAIL-induced apoptosis of thyroid cancer cells via Bcl-xL induction. Eur J Cancer. 2006 Dec; 42(18):3287-93. PMID: 17070682.
      Citations: 21     Fields:    Translation:HumansCells
    72. Pang D, Kocherginsky M, Krausz T, Kim SY, Conzen SD. Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther. 2006 Aug; 5(8):933-40. PMID: 16775428.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    73. Bogusz AM, Brickley DR, Pew T, Conzen SD. A novel N-terminal hydrophobic motif mediates constitutive degradation of serum- and glucocorticoid-induced kinase-1 by the ubiquitin-proteasome pathway. FEBS J. 2006 Jul; 273(13):2913-28. PMID: 16817852.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    74. Wu W, Zou M, Brickley DR, Pew T, Conzen SD. Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells. Mol Endocrinol. 2006 Oct; 20(10):2304-14. PMID: 16690749.
      Citations: 33     Fields:    Translation:HumansCells
    75. Kao J, Conzen S, Fleming G, Recant W, Heimann R. In response to Dr. Formenti et al. (Int J Radiat Oncol Biol Phys 2005, 63:1275-1276). Int J Radiat Oncol Biol Phys. 2006 Feb 01; 64(2):658. PMID: 16414377.
      Citations: 1     Fields:    Translation:Humans
    76. Sahoo S, Brickley DR, Kocherginsky M, Conzen SD. Coordinate expression of the PI3-kinase downstream effectors serum and glucocorticoid-induced kinase (SGK-1) and Akt-1 in human breast cancer. Eur J Cancer. 2005 Nov; 41(17):2754-9. PMID: 16246546.
      Citations: 26     Fields:    Translation:Humans
    77. Kao J, Conzen SD, Jaskowiak NT, Song DH, Recant W, Singh R, Masters GA, Fleming GF, Heimann R. Concomitant radiation therapy and paclitaxel for unresectable locally advanced breast cancer: results from two consecutive phase I/II trials. Int J Radiat Oncol Biol Phys. 2005 Mar 15; 61(4):1045-53. PMID: 15752883.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    78. McClintock MK, Conzen SD, Gehlert S, Masi C, Olopade F. Mammary cancer and social interactions: identifying multiple environments that regulate gene expression throughout the life span. J Gerontol B Psychol Sci Soc Sci. 2005 Mar; 60 Spec No 1:32-41. PMID: 15863708.
      Citations: 41     Fields:    Translation:HumansAnimals
    79. Wu W, Pew T, Zou M, Pang D, Conzen SD. Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005 Feb 11; 280(6):4117-24. PMID: 15590693.
      Citations: 77     Fields:    Translation:HumansCells
    80. Zou M, Conzen SD. A new dynamic Bayesian network (DBN) approach for identifying gene regulatory networks from time course microarray data. Bioinformatics. 2005 Jan 01; 21(1):71-9. PMID: 15308537.
      Citations: 148     Fields:    Translation:AnimalsCells
    81. Wu W, Chaudhuri S, Brickley DR, Pang D, Karrison T, Conzen SD. Microarray analysis reveals glucocorticoid-regulated survival genes that are associated with inhibition of apoptosis in breast epithelial cells. Cancer Res. 2004 Mar 01; 64(5):1757-64. PMID: 14996737.
      Citations: 134     Fields:    Translation:HumansCells
    82. Poelman SM, Heimann R, Fleming GF, Recant WM, Conzen SD. Invariant p53 immunostaining in primary and recurrent breast cancer. Eur J Cancer. 2004 Jan; 40(1):28-32. PMID: 14687786.
      Citations: 1     Fields:    Translation:Humans
    83. Ramljak D, Coticchia CM, Nishanian TG, Saji M, Ringel MD, Conzen SD, Dickson RB. Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells. Exp Cell Res. 2003 Jul 15; 287(2):397-410. PMID: 12837294.
      Citations: 14     Fields:    Translation:AnimalsCells
    84. Benz C, Clark G, Conzen S, Dorn R, Fuqua S, Gralow J, Greene G, Heimann R, Hellman S, Lippman M, Rosen N, Weiner L. Consensus statement: Expedition Inspiration fund for breast cancer research meeting 2002. Breast Cancer Res Treat. 2003 Mar; 78(1):127-31. PMID: 12611465.
      Citations:    Fields:    Translation:HumansCells
    85. Conzen SD. Current status of selective estrogen receptor modulators (SERMs). Cancer J. 2003 Jan-Feb; 9(1):4-14. PMID: 12602762.
      Citations: 5     Fields:    Translation:HumansCells
    86. Brickley DR, Mikosz CA, Hagan CR, Conzen SD. Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem. 2002 Nov 08; 277(45):43064-70. PMID: 12218062.
      Citations: 41     Fields:    Translation:HumansCells
    87. Benz CC, Hilakivi-Clarke L, Conzen S, Dorn RV, Fleming GF, Grant K, Greene G, Hellman S, Henderson C, Hoover R, Hryniuk W, Jeffrey S, Lippman M, Lung J, Mitchell M, Pike M. Expedition inspiration consensus 2001. Breast Cancer Res Treat. 2001 Dec; 70(3):213-9. PMID: 11804185.
      Citations:    Fields:    Translation:Humans
    88. Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD. Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem. 2001 May 18; 276(20):16649-54. PMID: 11278764.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    89. Poelman SM, Adeyanju MO, Robertson MA, Recant WM, Karrison T, Fleming GF, Olopade OI, Conzen SD. Human breast cancer susceptibility to paclitaxel therapy is independent of Bcl-2 expression. Clin Cancer Res. 2000 Oct; 6(10):4043-8. PMID: 11051254.
      Citations: 3     Fields:    Translation:Humans
    90. Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol Cell Biol. 2000 Aug; 20(16):6008-18. PMID: 10913183; PMCID: PMC86077.
      Citations: 32     Fields:    Translation:AnimalsCells
    91. Moran TJ, Gray S, Mikosz CA, Conzen SD. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000 Feb 15; 60(4):867-72. PMID: 10706096.
      Citations: 64     Fields:    Translation:HumansCells
    92. Conzen SD, Snay CA, Cole CN. Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen. J Virol. 1997 Jun; 71(6):4536-43. PMID: 9151847; PMCID: PMC191675.
      Citations: 2     Fields:    Translation:AnimalsCells
    93. Kennedy SG, Wagner AJ, Conzen SD, Bellacosa A, Tsichlis PN, Hay N, Jordán J. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 1997 Mar 15; 11(6):701-13. PMID: 9087425.
      Citations: 282     Fields:    Translation:AnimalsCells
    94. Conzen SD, Kaufman PA, Arvizu C, LeMarbre P, Maurer LH, Mott LA, Mills LE. Phase II trial of tamoxifen, etoposide, mitoxantrone, and cisplatin in patients with metastatic breast carcinoma. Cancer. 1996 Nov 01; 78(9):1906-11. PMID: 8909310.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    95. Lu M, Conzen SD, Cole CN, Arrick BA. Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells. Cancer Res. 1996 Oct 15; 56(20):4578-81. PMID: 8840964.
      Citations: 23     Fields:    Translation:HumansCells
    96. Conzen SD, Cole CN. The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. Oncogene. 1995 Dec 07; 11(11):2295-302. PMID: 8570180.
      Citations: 20     Fields:    Translation:AnimalsCells
    97. Conzen SD, Janeway CA. Defective antigen presentation in chronically protein-deprived mice. Immunology. 1988 Apr; 63(4):683-9. PMID: 3130310; PMCID: PMC1454782.
      Citations: 4     Fields:    Translation:AnimalsCells
    98. Janeway CA, Bottomly K, Babich J, Conrad P, Conzen S, Jones B, Kaye J, Katz M, McVay L, Murphy DB, Tite J. Quantitative variation in la antigen expression plays a central role in immune regulation. Immunol Today. 1984 Apr; 5(4):99-105. PMID: 25291703.
      Citations: 26     Fields:    
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