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Frederick Howard

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ly E, Howard FM, Chen N, Hahn O, Fleming GF, Nanda R, Patel S, Thimothy L, Yang H. Evaluation of cyclin-dependent kinase 4/6 inhibitor-induced serum creatinine elevations in patients with hormone receptor positive breast cancer. J Oncol Pharm Pract. 2024 Dec 09; 10781552241305417. PMID: 39648753.
      Citations:    Fields:    
    2. Howard FM, Hieromnimon HM, Ramesh S, Dolezal J, Kochanny S, Zhang Q, Feiger B, Peterson J, Fan C, Perou CM, Vickery J, Sullivan M, Cole K, Khramtsova G, Pearson AT. Generative adversarial networks accurately reconstruct pan-cancer histology from pathologic, genomic, and radiographic latent features. Sci Adv. 2024 Nov 15; 10(46):eadq0856. PMID: 39546597; PMCID: PMC11567005.
      Citations: 1     Fields:    Translation:Humans
    3. Zhao F, Polley E, McClellan J, Howard F, Olopade OI, Huo D. Predicting pathologic complete response to neoadjuvant chemotherapy in breast cancer using a machine learning approach. Breast Cancer Res. 2024 Oct 29; 26(1):148. PMID: 39472970; PMCID: PMC11520773.
      Citations:    Fields:    Translation:Humans
    4. Lin K, Michaels E, Polley E, O'Donnell PH, Howard FM, Hahn O, Fleming GF, Nanda R, Chen N, Yang H. Retrospective evaluation of adjuvant capecitabine dosing patterns in triple negative breast cancer. J Oncol Pharm Pract. 2024 Oct 13; 10781552241289581. PMID: 39397422.
      Citations:    Fields:    
    5. Freeman JQ, Huo D, Howard FM. ASO Author Reflections: Breast-Conserving Surgery After Neoadjuvant Systemic Therapy for Early-Stage Breast Cancer: Quantitative Biomarkers and Disparities in the Precision-Medicine Era. Ann Surg Oncol. 2024 Dec; 31(13):8904-8905. PMID: 39313726.
      Citations: 1     Fields:    Translation:Humans
    6. Shatsky RA, Trivedi MS, Yau C, Nanda R, Rugo HS, Davidian M, Tsiatis B, Wallace AM, Chien AJ, Stringer-Reasor E, Boughey JC, Omene C, Rozenblit M, Kalinsky K, Elias AD, Vaklavas C, Beckwith H, Williams N, Arora M, Nangia C, Roussos Torres ET, Thomas B, Albain KS, Clark AS, Falkson C, Hershman DL, Isaacs C, Thomas A, Tseng J, Sanford A, Yeung K, Boles S, Chen YY, Huppert L, Jahan N, Parker C, Giridhar K, Howard FM, Blackwood MM, Sanft T, Li W, Onishi N, Asare AL, Beineke P, Norwood P, Brown-Swigart L, Hirst GL, Matthews JB, Moore B, Symmans WF, Price E, Heditsian D, LeStage B, Perlmutter J, Pohlmann P, DeMichele A, Yee D, van 't Veer LJ, Hylton NM, Esserman LJ. Datopotamab-deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial. Nat Med. 2024 Dec; 30(12):3737-3747. PMID: 39277672.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    7. Freeman JQ, Shubeck SP, Chen N, Yarlagadda SR, Nanda R, Huo D, Howard FM. Quantitative Biomarkers, Genomic Assays, and Demographics Associated with Breast-Conserving Surgery Following Neoadjuvant Therapy in Early-Stage, Hormone Receptor-Positive, HER-Negative Breast Cancer. Ann Surg Oncol. 2024 Dec; 31(13):8829-8842. PMID: 39251516; PMCID: PMC11549201.
      Citations:    Fields:    Translation:Humans
    8. Choudhury D, Dolezal JM, Dyer E, Kochanny S, Ramesh S, Howard FM, Margalus JR, Schroeder A, Schulte J, Garassino MC, Kather JN, Pearson AT. Developing a low-cost, open-source, locally manufactured workstation and computational pipeline for automated histopathology evaluation using deep learning. EBioMedicine. 2024 Sep; 107:105276. PMID: 39197222; PMCID: PMC11399610.
      Citations:    Fields:    Translation:Humans
    9. Freeman JQ, Zhao F, Howard FM, Nanda R, Olopade OI, Huo D. Assessing the Relationship Between Neighborhood Socioeconomic Disadvantage and Telemedicine Use Among Patients With Breast Cancer and Examining Differential Provisions of Oncology Services Between Telehealth and In-Person Visits: Quantitative Study. JMIR Cancer. 2024 Jul 18; 10:e55438. PMID: 39024570; PMCID: PMC11294759.
      Citations:    
    10. Ríos-Hoyo A, Shan NL, Li A, Pearson AT, Pusztai L, Howard FM. Evaluation of large language models as a diagnostic aid for complex medical cases. Front Med (Lausanne). 2024; 11:1380148. PMID: 38966538; PMCID: PMC11222590.
      Citations: 3     
    11. Dhungana A, Vannier A, Zhao F, Freeman JQ, Saha P, Sullivan M, Yao K, Flores EM, Olopade OI, Pearson AT, Huo D, Howard FM. Development and validation of a clinical breast cancer tool for accurate prediction of recurrence. NPJ Breast Cancer. 2024 Jun 15; 10(1):46. PMID: 38879577; PMCID: PMC11180107.
      Citations: 1     
    12. Howard FM, Li A, Riffon MF, Garrett-Mayer E, Pearson AT. Characterizing the Increase in Artificial Intelligence Content Detection in Oncology Scientific Abstracts From 2021 to 2023. JCO Clin Cancer Inform. 2024 May; 8:e2400077. PMID: 38822755; PMCID: PMC11371107.
      Citations:    Fields:    Translation:Humans
    13. Dolezal JM, Kochanny S, Dyer E, Ramesh S, Srisuwananukorn A, Sacco M, Howard FM, Li A, Mohan P, Pearson AT. Slideflow: deep learning for digital histopathology with real-time whole-slide visualization. BMC Bioinformatics. 2024 Mar 27; 25(1):134. PMID: 38539070; PMCID: PMC10967068.
      Citations: 10     Fields:    
    14. Vannier AGL, Dhungana A, Zhao F, Chen N, Shubeck S, Hahn OM, Nanda R, Jaskowiak NT, Fleming GF, Olopade OI, Pearson AT, Huo D, Howard FM. Validation of the RSClin risk calculator in the National Cancer Data Base. Cancer. 2024 Apr 15; 130(8):1210-1220. PMID: 38146744; PMCID: PMC10948297.
      Citations: 3     Fields:    Translation:Humans
    15. Howard FM, Peiffer DS, Huo D. Classification of Breast Cancer According to ERBB2 Immunohistochemistry Scores-Reply. JAMA Oncol. 2023 09 01; 9(9):1299-1300. PMID: 37498624.
      Citations:    Fields:    Translation:Humans
    16. Ren Z, Pineda FD, Howard FM, Fan X, Nanda R, Abe H, Kulkarni K, Karczmar GS. Bilateral asymmetry of quantitative parenchymal kinetics at ultrafast DCE-MRI predict response to neoadjuvant chemotherapy in patients with HER2+ breast cancer. Magn Reson Imaging. 2023 Dec; 104:9-15. PMID: 37611646; PMCID: PMC10879456.
      Citations: 1     Fields:    Translation:Humans
    17. Omoleye OJ, Woodard AE, Howard FM, Zhao F, Yoshimatsu TF, Zheng Y, Pearson AT, Levental M, Aribisala BS, Kulkarni K, Karczmar GS, Olopade OI, Abe H, Huo D. External Evaluation of a Mammography-based Deep Learning Model for Predicting Breast Cancer in an Ethnically Diverse Population. Radiol Artif Intell. 2023 Nov; 5(6):e220299. PMID: 38074785; PMCID: PMC10698602.
      Citations: 3     Fields:    
    18. Dolezal JM, Wolk R, Hieromnimon HM, Howard FM, Srisuwananukorn A, Karpeyev D, Ramesh S, Kochanny S, Kwon JW, Agni M, Simon RC, Desai C, Kherallah R, Nguyen TD, Schulte JJ, Cole K, Khramtsova G, Garassino MC, Husain AN, Li H, Grossman R, Cipriani NA, Pearson AT. Deep learning generates synthetic cancer histology for explainability and education. NPJ Precis Oncol. 2023 May 29; 7(1):49. PMID: 37248379; PMCID: PMC10227067.
      Citations: 13     
    19. Miyashita M, Bell JSK, Wenric S, Karaesmen E, Rhead B, Kase M, Kaneva K, De La Vega FM, Zheng Y, Yoshimatsu TF, Khramtsova G, Liu F, Zhao F, Howard FM, Nanda R, Beaubier N, White KP, Huo D, Olopade OI. Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations. Breast Cancer Res. 2023 05 25; 25(1):58. PMID: 37231433; PMCID: PMC10210411.
      Citations: 8     Fields:    Translation:Humans
    20. Freeman JQ, Shubeck S, Howard FM, Chen N, Nanda R, Huo D. Evaluation of multigene assays as predictors for response to neoadjuvant chemotherapy in early-stage breast cancer patients. NPJ Breast Cancer. 2023 May 06; 9(1):33. PMID: 37149628; PMCID: PMC10164191.
      Citations: 6     
    21. Terman E, Sheade J, Zhao F, Howard FM, Jaskowiak N, Tseng J, Chen N, Hahn O, Fleming G, Huo D, Nanda R. The impact of race and age on response to neoadjuvant therapy and long-term outcomes in Black and White women with early-stage breast cancer. Breast Cancer Res Treat. 2023 Jul; 200(1):75-83. PMID: 37120458; PMCID: PMC10224832.
      Citations: 5     Fields:    Translation:Humans
    22. Gao CA, Howard FM, Markov NS, Dyer EC, Ramesh S, Luo Y, Pearson AT. Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers. NPJ Digit Med. 2023 Apr 26; 6(1):75. PMID: 37100871; PMCID: PMC10133283.
      Citations: 92     
    23. Howard FM, Dolezal J, Kochanny S, Khramtsova G, Vickery J, Srisuwananukorn A, Woodard A, Chen N, Nanda R, Perou CM, Olopade OI, Huo D, Pearson AT. Integration of clinical features and deep learning on pathology for the prediction of breast cancer recurrence assays and risk of recurrence. NPJ Breast Cancer. 2023 Apr 14; 9(1):25. PMID: 37059742; PMCID: PMC10104799.
      Citations: 15     
    24. Peiffer DS, Zhao F, Chen N, Hahn OM, Nanda R, Olopade OI, Huo D, Howard FM. Clinicopathologic Characteristics and Prognosis of ERBB2-Low Breast Cancer Among Patients in the National Cancer Database. JAMA Oncol. 2023 04 01; 9(4):500-510. PMID: 36821125; PMCID: PMC9951099.
      Citations: 49     Fields:    Translation:Humans
    25. Terman E, Sheade J, Zhao F, Howard FM, Jaskowiak N, Tseng J, Chen N, Hahn O, Fleming G, Huo D, Nanda R. The Impact of Race and Age on Response to Neoadjuvant Therapy and Long-Term Outcomes in Black and White Women with Early-Stage Breast Cancer. Res Sq. 2023 Mar 16. PMID: 36993723; PMCID: PMC10055663.
      Citations:    
    26. Zhao F, Miyashita M, Hattori M, Yoshimatsu T, Howard F, Kaneva K, Jones R, Bell JSK, Fleming GF, Jaskowiak N, Nanda R, Zheng Y, Huo D, Olopade OI. Racial Disparities in Pathological Complete Response Among Patients Receiving Neoadjuvant Chemotherapy for Early-Stage Breast Cancer. JAMA Netw Open. 2023 03 01; 6(3):e233329. PMID: 36995716; PMCID: PMC10064259.
      Citations: 16     Fields:    Translation:Humans
    27. Shubeck S, Zhao F, Howard FM, Olopade OI, Huo D. Response to Treatment, Racial and Ethnic Disparity, and Survival in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy in the US. JAMA Netw Open. 2023 03 01; 6(3):e235834. PMID: 36995711; PMCID: PMC10064248.
      Citations: 15     Fields:    Translation:Humans
    28. Chen N, Michaels E, Nanda R, Howard F. The evolving therapeutic landscape of antibody-drug conjugates in breast cancer. Expert Rev Anticancer Ther. 2022 12; 22(12):1325-1331. PMID: 36408586; PMCID: PMC9833603.
      Citations: 1     Fields:    Translation:Humans
    29. Howard FM, Kather JN, Pearson AT. Multimodal deep learning: An improvement in prognostication or a reflection of batch effect? Cancer Cell. 2023 01 09; 41(1):5-6. PMID: 36368319.
      Citations: 6     Fields:    Translation:Humans
    30. Wu C, Hormuth DA, Lorenzo G, Jarrett AM, Pineda F, Howard FM, Karczmar GS, Yankeelov TE. Towards Patient-Specific Optimization of Neoadjuvant Treatment Protocols for Breast Cancer Based on Image-Guided Fluid Dynamics. IEEE Trans Biomed Eng. 2022 11; 69(11):3334-3344. PMID: 35439121; PMCID: PMC9640301.
      Citations: 8     Fields:    Translation:Humans
    31. Howard FM, He G, Peterson JR, Pfeiffer JR, Earnest T, Pearson AT, Abe H, Cole JA, Nanda R. Highly accurate response prediction in high-risk early breast cancer patients using a biophysical simulation platform. Breast Cancer Res Treat. 2022 Nov; 196(1):57-66. PMID: 36063220; PMCID: PMC9550684.
      Citations: 6     Fields:    Translation:Humans
    32. Howard FM, Pearson AT, Nanda R. Clinical trials of immunotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2022 Aug; 195(1):1-15. PMID: 35834065; PMCID: PMC9338129.
      Citations: 21     Fields:    Translation:Humans
    33. Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT. Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma. JAMA Netw Open. 2022 04 01; 5(4):e227240. PMID: 35416988; PMCID: PMC9008506.
      Citations: 3     Fields:    Translation:HumansCells
    34. Ren Z, Pineda FD, Howard FM, Hill E, Szasz T, Safi R, Medved M, Nanda R, Yankeelov TE, Abe H, Karczmar GS. Differences Between Ipsilateral and Contralateral Early Parenchymal Enhancement Kinetics Predict Response of Breast Cancer to Neoadjuvant Therapy. Acad Radiol. 2022 10; 29(10):1469-1479. PMID: 35351365.
      Citations: 3     Fields:    Translation:Humans
    35. Howard FM, Villamar D, He G, Pearson AT, Nanda R. The emerging role of immune checkpoint inhibitors for the treatment of breast cancer. Expert Opin Investig Drugs. 2022 Jun; 31(6):531-548. PMID: 34569400; PMCID: PMC8995399.
      Citations: 9     Fields:    Translation:Humans
    36. Howard FM, Dolezal J, Kochanny S, Schulte J, Chen H, Heij L, Huo D, Nanda R, Olopade OI, Kather JN, Cipriani N, Grossman RL, Pearson AT. The impact of site-specific digital histology signatures on deep learning model accuracy and bias. Nat Commun. 2021 07 20; 12(1):4423. PMID: 34285218; PMCID: PMC8292530.
      Citations: 89     Fields:    Translation:Humans
    37. Gao CA, Howard FM, Siner JM, Candido TD, Ferrante LE. Lung-Protective Ventilation Over 6 Years at a Large Academic Medical Center: An Evaluation of Trends, Adherence, and Perceptions of Benefit. Crit Care Explor. 2021 Jan; 3(1):e0325. PMID: 33458691; PMCID: PMC7803935.
      Citations: 1     
    38. Howard FM, Olopade OI. Epidemiology of Triple-Negative Breast Cancer: A Review. Cancer J. 2021 Jan-Feb 01; 27(1):8-16. PMID: 33475288.
      Citations: 104     Fields:    Translation:Humans
    39. Howard FM, Kochanny S, Koshy M, Spiotto M, Pearson AT. Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer. JAMA Netw Open. 2020 11 02; 3(11):e2025881. PMID: 33211108; PMCID: PMC7677764.
      Citations: 57     Fields:    Translation:Humans
    40. Howard FM, Gao CA, Sankey C. Implementation of an automated scheduling tool improves schedule quality and resident satisfaction. PLoS One. 2020; 15(8):e0236952. PMID: 32780751; PMCID: PMC7418963.
      Citations: 3     Fields:    Translation:Humans
    41. Howard FM, Pearson AT. Prognosis and Treatment of Non-Small Cell Lung Cancer in the Age of Deep Learning. JAMA Netw Open. 2020 06 01; 3(6):e206368. PMID: 32492160.
      Citations: 2     Fields:    Translation:Humans
    42. Howard F, Sankey C. Pneumococcal Bacteremia Complicated by Hemophagocytic Lymphohistiocytosis. J Gen Intern Med. 2019 08; 34(8):1653-1657. PMID: 31011972; PMCID: PMC6667527.
      Citations: 1     Fields:    Translation:HumansCells
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