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Barbara S. Kirschner

TitleEmeritus/Emerita, Professor (CS)
InstitutionUniversity of Chicago
DepartmentPediatrics-Gastroenterology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Prior to retiring from active practice in 2016, my major clinical and research interests involved the care of a large number of children and adolescents with the chronic inflammatory bowel diseases, ulcerative colitis and Crohn's disease. During that time, I was a Co-founder the the PediIBD Consortium which conducted many research studies relating to the pathogenesis, diagnosis, risk of comlications, treatment (including clinical trials of emerging therapies), complications (especially growth failure) and the wide range of variations in the course among children with these conditions. As a Professor Emeritus, I am studying long term outcomes in this population, describing how the prevalence in family history of IBD changes over time and, until recently, continued to collaborate in the multi-center RISK Consortium.


    Collapse Biography 
    Collapse education and training
    Woman's Medical College of Pennsylvania, PhiladelphiaMD06/1967Medicine
    University of Chicago, Chicago06/1970Residency - Pediatrics
    University of Chicago, Chicago06/1971Pediatric Immunology
    University of Chicago, Chicago06/1977Fellowship Pediatric Gastroenterology, Hepatology and Nutrition
    Collapse awards and honors
    1966Alpha Omega Alpha National Medical Honor Society, Woman's Medical College of Pennsylvania
    1975 - 1977Andrew W. Mellon Fellow, University of Chicago
    1989Award for Leadership in Patient Education, National Foundation for Ileitis & Colitis
    1993Murray Davidson Lectureship, For Contributions to the Field of Pediatric Gastroenterology, Academy of Pediatrics, Section of Pediatric Gastroenterology & Nutrition
    1995Outstanding Teacher Award, Dept. of Pediatrics, University of Chicago
    1996 - 2014Best Doctors In America List, Woodward/White Publishers
    2000 - 2016America's Top Doctors, Castle Connolly Publishers
    2014Bucksbaum Institute Senior Faculty Scholar Award, University of Chicago
    2017Festschrift Program in My Honor, Dept. of Pediatrics, University of Chicago
    2017Gold Key Award for Outstanding Service to the Division of Biological Science, Alumni Awards Commitee, University of Chicago
    2018Marguerite Herschel Award for Clinical Excellance, Dept. of Pediatrics, University of Chicago

    Collapse ORNG Applications 
    Collapse Featured Presentations

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ta AD, Ollberding NJ, Karns R, Haberman Y, Alazraki AL, Hercules D, Baldassano R, Markowitz J, Heyman MB, Kim S, Kirschner B, Shapiro JM, Noe J, Oliva-Hemker M, Otley A, Pfefferkorn M, Kellermayer R, Snapper S, Rabizadeh S, Xavier R, Dubinsky M, Hyams J, Kugathasan S, Jegga AG, Dillman JR, Denson LA. Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease. Inflamm Bowel Dis. 2021 10 20; 27(11):1707-1718. PMID: 33452801.
      View in: PubMed
    2. Capone K, Rosenberg HJ, Wroblewski K, Gokhale R, Kirschner BS. Change in Prevalence of Family History During Long-term Follow-up of Patients With Pediatric-onset Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2019 06; 68(6):829-834. PMID: 30628987.
      View in: PubMed
    3. Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Valencia CA, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan S. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflamm Bowel Dis. 2019 02 21; 25(3):547-560. PMID: 30124884.
      View in: PubMed
    4. Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Crandall WV, Mack DR, Griffiths AM, Heyman MB, Baker SS, Kellermayer R, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Kirschner BS, Keljo DJ, Guthery SL, Cohen SA, Snapper S, Evans J, Dubinsky M, Aronow B, Hyams JS, Kugathasan S, Huttenhower C, Xavier RJ, Denson LA. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol. 2019 03; 12(2):491-502. PMID: 30542108.
      View in: PubMed
    5. Lindoso L, Mondal K, Venkateswaran S, Somineni HK, Ballengee C, Walters TD, Griffiths A, Noe JD, Crandall W, Snapper S, Rabizadeh S, Rosh JR, LeLeiko N, Guthery S, Mack D, Kellermayer R, Gulati AS, Pfefferkorn MD, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley A, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Stephens MC, Baldassano R, Dubinsky MC, Markowitz J, Denson LA, Hyams J, Kugathasan S, Ananthakrishnan AN. The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. Am J Gastroenterol. 2018 10; 113(10):1524-1529. PMID: 30267029.
      View in: PubMed
    6. Shaw KA, Cutler DJ, Okou D, Dodd A, Aronow BJ, Haberman Y, Stevens C, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery S, Dubinsky MC, Shapiro JM, Otley AR, Daly M, Denson LA, Kugathasan S, Zwick ME. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes Immun. 2019 02; 20(2):131-142. PMID: 29593342.
      View in: PubMed
    7. Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou DT, Dodd A, Quinn K, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan S. Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease. Gastroenterology. 2018 06; 154(8):2097-2110. PMID: 29454792.
      View in: PubMed
    8. Haberman Y, BenShoshan M, Di Segni A, Dexheimer PJ, Braun T, Weiss B, Walters TD, Baldassano RN, Noe JD, Markowitz J, Rosh J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Kellermayer R, Patel A, Otley A, Steiner SJ, Gulati AS, Guthery SL, LeLeiko N, Moulton D, Kirschner BS, Snapper S, Avivi C, Barshack I, Oliva-Hemker M, Cohen SA, Keljo DJ, Ziring D, Anikster Y, Aronow B, Hyams JS, Kugathasan S, Denson LA. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflamm Bowel Dis. 2018 01 18; 24(2):346-360. PMID: 29361088.
      View in: PubMed
    9. Bertha M, Vasantharoopan A, Kumar A, Bruce BB, Prince J, Hofmekler T, Okou D, Chopra P, Wang G, Sauer C, Landers CJ, Hussain SZ, Cross RK, Baldassano RN, Kappelman MD, Katz J, Alexander JS, Kirschner BS, Moulton DE, Osuntokun BO, Patel A, Saeed S, Klapproth JA, Dhere TA, Dubinsky MC, McGovern D, Kugathasan S. IBD Serology and Disease Outcomes in African Americans With Crohn's Disease. Inflamm Bowel Dis. 2017 12 19; 24(1):209-216. PMID: 29272484.
      View in: PubMed
    10. Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet. 2017 04 29; 389(10080):1710-1718. PMID: 28259484.
      View in: PubMed
    11. Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 01; 152(1):206-217.e2. PMID: 27693347.
      View in: PubMed
    12. Wang F, Kaplan JL, Gold BD, Bhasin MK, Ward NL, Kellermayer R, Kirschner BS, Heyman MB, Dowd SE, Cox SB, Dogan H, Steven B, Ferry GD, Cohen SA, Baldassano RN, Moran CJ, Garnett EA, Drake L, Otu HH, Mirny LA, Libermann TA, Winter HS, Korolev KS. Detecting Microbial Dysbiosis Associated with Pediatric Crohn Disease Despite the High Variability of the Gut Microbiota. Cell Rep. 2016 Feb 02; 14(4):945-955. PMID: 26804920.
      View in: PubMed
    13. Kamdar K, Khakpour S, Chen J, Leone V, Brulc J, Mangatu T, Antonopoulos DA, Chang EB, Kahn SA, Kirschner BS, Young G, DePaolo RW. Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease. Cell Host Microbe. 2016 Jan 13; 19(1):21-31. PMID: 26764594.
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    14. Sasaki MM, Skol AD, Hungate EA, Bao R, Huang L, Kahn SA, Allan JM, Brant SR, McGovern DP, Peter I, Silverberg MS, Cho JH, Kirschner BS, Onel K. Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease. Inflamm Bowel Dis. 2016 Jan; 22(1):20-7. PMID: 26480299.
      View in: PubMed
    15. Greenley RN, Gumidyala AP, Nguyen E, Plevinsky JM, Poulopoulos N, Thomason MM, Walter JG, Wojtowicz AA, Blank E, Gokhale R, Kirschner BS, Miranda A, Noe JD, Stephens MC, Werlin S, Kahn SA. Can You Teach a Teen New Tricks? Problem Solving Skills Training Improves Oral Medication Adherence in Pediatric Patients with Inflammatory Bowel Disease Participating in a Randomized Trial. Inflamm Bowel Dis. 2015 Nov; 21(11):2649-57. PMID: 26218142.
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    16. Cordova J, Gokhale R, Kirschner B. Fever and Upper GI Hemorrhage in a 10-Year-Old Girl With Newly Diagnosed Ulcerative Colitis. Gastroenterology. 2015 Oct; 149(4):867-9. PMID: 26319038.
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    17. Huang C, Haritunians T, Okou DT, Cutler DJ, Zwick ME, Taylor KD, Datta LW, Maranville JC, Liu Z, Ellis S, Chopra P, Alexander JS, Baldassano RN, Cross RK, Dassopoulos T, Dhere TA, Duerr RH, Hanson JS, Hou JK, Hussain SZ, Isaacs KL, Kachelries KE, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kumar A, Kwon JH, Lazarev M, Mannon P, Moulton DE, Osuntokun BO, Patel A, Rioux JD, Rotter JI, Saeed S, Scherl EJ, Silverberg MS, Silverman A, Targan SR, Valentine JF, Wang MH, Simpson CL, Bridges SL, Kimberly RP, Rich SS, Cho JH, Rienzo AD, Kao LWH, McGovern DPB, Brant SR, Kugathasan S. Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans. Gastroenterology. 2015 Nov; 149(6):1575-1586. PMID: 26278503.
      View in: PubMed
    18. Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, LeLeiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS. Increased effectiveness of early therapy with anti-tumor necrosis factor-a vs an immunomodulator in children with Crohn's disease. Gastroenterology. 2014 Feb; 146(2):383-91. PMID: 24162032.
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    19. Kelley-Quon LI, Jen HC, Ziring DA, Gupta N, Kirschner BS, Ferry GD, Cohen SA, Winter HS, Heyman MB, Gold BD, Shew SB. Predictors of proctocolectomy in children with ulcerative colitis. J Pediatr Gastroenterol Nutr. 2012 Nov; 55(5):534-40. PMID: 22684351.
      View in: PubMed
    20. Felipez LM, Gokhale R, Tierney MP, Kirschner BS. Thalidomide use and outcomes in pediatric patients with Crohn disease refractory to infliximab and adalimumab. J Pediatr Gastroenterol Nutr. 2012 Jan; 54(1):28-33. PMID: 21681114.
      View in: PubMed
    21. Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Gold BD, Cohen SA, Winter HS, Baldassano RN, Abramson O, Smith T, Heyman MB. Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients. Inflamm Bowel Dis. 2010 Apr; 16(4):638-44. PMID: 19760783.
      View in: PubMed
    22. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec; 41(12):1335-40. PMID: 19915574.
      View in: PubMed
    23. Jose FA, Garnett EA, Vittinghoff E, Ferry GD, Winter HS, Baldassano RN, Kirschner BS, Cohen SA, Gold BD, Abramson O, Heyman MB. Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 2009 Jan; 15(1):63-8. PMID: 18626963.
      View in: PubMed
    24. Heyman MB, Garnett EA, Shaikh N, Huen K, Jose FA, Harmatz P, Winter HS, Baldassano RN, Cohen SA, Gold BD, Kirschner BS, Ferry GD, Stege E, Holland N. Folate concentrations in pediatric patients with newly diagnosed inflammatory bowel disease. Am J Clin Nutr. 2009 Feb; 89(2):545-50. PMID: 19116333.
      View in: PubMed
    25. White JM, O'Connor S, Winter HS, Heyman MB, Kirschner BS, Ferry GD, Cohen SA, Baldassano RN, Smith T, Clemons T, Gold BD. Inflammatory bowel disease in African American children compared with other racial/ethnic groups in a multicenter registry. Clin Gastroenterol Hepatol. 2008 Dec; 6(12):1361-9. PMID: 18848910.
      View in: PubMed
    26. Gupta N, Bostrom AG, Kirschner BS, Cohen SA, Abramson O, Ferry GD, Gold BD, Winter HS, Baldassano RN, Smith T, Heyman MB. Presentation and disease course in early- compared to later-onset pediatric Crohn's disease. Am J Gastroenterol. 2008 Aug; 103(8):2092-8. PMID: 18796101.
      View in: PubMed
    27. Heyman MB, Garnett EA, Wojcicki J, Gupta N, Davis C, Cohen SA, Gold BD, Kirschner BS, Baldassano RN, Ferry GD, Winter HS, Kaplan S. Growth hormone treatment for growth failure in pediatric patients with Crohn's disease. J Pediatr. 2008 Nov; 153(5):651-8, 658.e1-3. PMID: 18589450.
      View in: PubMed
    28. Holland N, Dong J, Garnett E, Shaikh N, Huen K, Harmatz P, Olive A, Winter HS, Gold BD, Cohen SA, Baldassano RN, Kirschner BS, Heyman MB. Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn's disease and age-related changes in Th1/Th2 cytokine profiles. Pediatr Res. 2008 Mar; 63(3):257-62. PMID: 18287963.
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    29. Perrin JM, Kuhlthau K, Chughtai A, Romm D, Kirschner BS, Ferry GD, Cohen SA, Gold BD, Heyman MB, Baldassano RN, Winter HS. Measuring quality of life in pediatric patients with inflammatory bowel disease: psychometric and clinical characteristics. J Pediatr Gastroenterol Nutr. 2008 Feb; 46(2):164-71. PMID: 18223375.
      View in: PubMed
    30. Gupta N, Bostrom AG, Kirschner BS, Ferry GD, Winter HS, Baldassano RN, Gold BD, Abramson O, Smith T, Cohen SA, Heyman MB. Gender differences in presentation and course of disease in pediatric patients with Crohn disease. Pediatrics. 2007 Dec; 120(6):e1418-25. PMID: 18055660.
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    31. Navarro FA, Hanauer SB, Kirschner BS. Effect of long-term low-dose prednisone on height velocity and disease activity in pediatric and adolescent patients with Crohn disease. J Pediatr Gastroenterol Nutr. 2007 Sep; 45(3):312-8. PMID: 17873743.
      View in: PubMed
    32. Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America. J Pediatr Gastroenterol Nutr. 2007 May; 44(5):653-74. PMID: 17460505.
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    33. Kirschner BS, Huo D. Timing infliximab therapy in pediatric Crohn's disease. Gastroenterology. 2007 Mar; 132(3):1167-70. PMID: 17383435.
      View in: PubMed
    34. Bousvaros A, Sylvester F, Kugathasan S, Szigethy E, Fiocchi C, Colletti R, Otley A, Amre D, Ferry G, Czinn SJ, Splawski JB, Oliva-Hemker M, Hyams JS, Faubion WA, Kirschner BS, Dubinsky MC. Challenges in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2006 Sep; 12(9):885-913. PMID: 16954808.
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    35. Kahn SA, Kirschner BS. Massive intestinal bleeding in a child with superior mesenteric artery aneurysm and gastrointestinal tuberculosis. J Pediatr Gastroenterol Nutr. 2006 Aug; 43(2):256-9. PMID: 16877995.
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    36. Gupta N, Cohen SA, Bostrom AG, Kirschner BS, Baldassano RN, Winter HS, Ferry GD, Smith T, Abramson O, Gold BD, Heyman MB. Risk factors for initial surgery in pediatric patients with Crohn's disease. Gastroenterology. 2006 Apr; 130(4):1069-77. PMID: 16618401.
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    37. Markowitz J, Markowitz JE, Bousvaros A, Crandall W, Faubion W, Kirschner BS, Perrault J, Rosh J, Winter H. Workshop report: prevention of postoperative recurrence in Crohn's disease. J Pediatr Gastroenterol Nutr. 2005 Aug; 41(2):145-51. PMID: 16056092.
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    38. Jacobstein DA, Markowitz JE, Kirschner BS, Ferry G, Cohen SA, Gold BD, Winter HS, Heyman MB, Baldassano RN. Premedication and infusion reactions with infliximab: results from a pediatric inflammatory bowel disease consortium. Inflamm Bowel Dis. 2005 May; 11(5):442-6. PMID: 15867583.
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    39. Heyman MB, Kirschner BS, Gold BD, Ferry G, Baldassano R, Cohen SA, Winter HS, Fain P, King C, Smith T, El-Serag HB. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr. 2005 Jan; 146(1):35-40. PMID: 15644819.
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    40. Mamula P, Cohen SA, Ferry GD, Kirschner BS, Winter HS, Innes A, Patel J, Baldassano RN. CDP571, a humanized anti-tumor necrosis factor-alpha monoclonal antibody in pediatric Crohn's disease. Inflamm Bowel Dis. 2004 Nov; 10(6):723-30. PMID: 15626889.
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    41. Gokhale R, Kirschner BS. Transition of care between paediatric and adult gastroenterology. Assessment of growth and nutrition. Best Pract Res Clin Gastroenterol. 2003 Apr; 17(2):153-62. PMID: 12676112.
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    42. Verhave M, Baldassano RN, Bousvaros A, Grand RJ, Kirschner BS. Research agenda for pediatric gastroenterology, hepatology and nutrition: chronic inflammatory bowel disease. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S286-90. PMID: 12394367.
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    43. Buller H, Chin S, Kirschner B, Kohn J, Markowitz J, Moore D, Murch S, Taminiau J. Inflammatory bowel disease in children and adolescents: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 2:S151-8. PMID: 12192184.
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    44. Gupta P, Gokhale R, Kirschner BS. 6-mercaptopurine metabolite levels in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2001 Oct; 33(4):450-4. PMID: 11698762.
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    45. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nuñez G, Cho JH. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001 May 31; 411(6837):603-6. PMID: 11385577.
      View in: PubMed
    46. Brant SR, Panhuysen CI, Bailey-Wilson JE, Rohal PM, Lee S, Mann J, Ravenhill G, Kirschner BS, Hanauer SB, Cho JH, Bayless TM. Linkage heterogeneity for the IBD1 locus in Crohn's disease pedigrees by disease onset and severity. Gastroenterology. 2000 Dec; 119(6):1483-90. PMID: 11113069.
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    47. Bousvaros A, Kirschner BS, Werlin SL, Parker-Hartigan L, Daum F, Freeman KB, Balint JP, Day AS, Griffiths AM, Zurakowski D, Ferry GD, Leichtner AM. Oral tacrolimus treatment of severe colitis in children. J Pediatr. 2000 Dec; 137(6):794-9. PMID: 11113835.
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    48. Gupta P, Andrew H, Kirschner BS, Guandalini S. Is lactobacillus GG helpful in children with Crohn's disease? Results of a preliminary, open-label study. J Pediatr Gastroenterol Nutr. 2000 Oct; 31(4):453-7. PMID: 11045848.
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    49. Shulman RJ, Boyle JT, Colletti RB, Friedman R, Heyman MB, Kearns G, Kirschner BS, Levy J, Mitchell AA, Van Hare G. An updated medical position statement of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2000 Sep; 31(3):232-3. PMID: 10997363.
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    50. Bousvaros A, Marcon M, Treem W, Waters P, Issenman R, Couper R, Burnell R, Rosenberg A, Rabinovich E, Kirschner BS. Chronic recurrent multifocal osteomyelitis associated with chronic inflammatory bowel disease in children. Dig Dis Sci. 1999 Dec; 44(12):2500-7. PMID: 10630504.
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    51. Shulman RJ, Boyle JT, Colletti RB, Friedman RA, Heyman MB, Kearns G, Kirschner BS, Levy J, Mitchell AA, Van Hare G. The use of cisapride in children. The North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 1999 May; 28(5):529-33. PMID: 10328132.
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    52. Kirschner BS. Differences in the management of inflammatory bowel disease in children and adolescents compared to adults. Neth J Med. 1998 Dec; 53(6):S13-8. PMID: 9883009.
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    53. Brant SR, Fu Y, Fields CT, Baltazar R, Ravenhill G, Pickles MR, Rohal PM, Mann J, Kirschner BS, Jabs EW, Bayless TM, Hanauer SB, Cho JH. American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12. Gastroenterology. 1998 Nov; 115(5):1056-61. PMID: 9797357.
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    54. Kirschner BS. Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease. Gastroenterology. 1998 Oct; 115(4):813-21. PMID: 9753482.
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    55. Kirschner B. Malignancy and aneuploidy: prevention and early detection. Inflamm Bowel Dis. 1998 Aug; 4(3):216-20. PMID: 9741025.
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    56. Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, Pickles MR, Qin L, Fu Y, Mann JS, Kirschner BS, Jabs EW, Weber J, Hanauer SB, Bayless TM, Brant SR. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13):7502-7. PMID: 9636179.
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    57. Gokhale R, Favus MJ, Karrison T, Sutton MM, Rich B, Kirschner BS. Bone mineral density assessment in children with inflammatory bowel disease. Gastroenterology. 1998 May; 114(5):902-11. PMID: 9558278.
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    58. Kirschner BS. Methotrexate therapy for pediatric patients with inflammatory bowel disease. Inflamm Bowel Dis. 1998 May; 4(2):121-3. PMID: 9687222.
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    59. Gokhale R, Huttenlocher PR, Brady L, Kirschner BS. Use of barbiturates in the treatment of cyclic vomiting during childhood. J Pediatr Gastroenterol Nutr. 1997 Jul; 25(1):64-7. PMID: 9226529.
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    60. Cho JH, Fu Y, Kirschner BS, Hanauer SB. Confirmation of a susceptibility locus for Crohn's disease on chromosome 16. Inflamm Bowel Dis. 1997; 3(3):186-90. PMID: 23282803.
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    61. Wasserman D, Hoekstra JH, Tolia V, Taylor CJ, Kirschner BS, Takeda J, Bell GI, Taub R, Rand EB. Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption. J Clin Invest. 1996 Nov 15; 98(10):2398-402. PMID: 8941659.
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    62. Kirschner BS. Report from the NASPGN Therapeutics Subcommittee. Report of the activities of the gastrointestinal advisory committee to the FDA. J Pediatr Gastroenterol Nutr. 1996 Nov; 23(4):397-8. PMID: 8956173.
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    63. Kirschner BS. Ulcerative colitis in children. Pediatr Clin North Am. 1996 Feb; 43(1):235-54. PMID: 8596682.
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    64. Kirschner BS, Ferry GD. Clinical Trials in IBD: A Pediatric Perspective. Inflamm Bowel Dis. 1996; 2(2):118-20. PMID: 23282518.
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    65. Blecker U, McKeithan TW, Hart J, Kirschner BS. Resolution of Helicobacter pylori-associated gastric lymphoproliferative disease in a child. Gastroenterology. 1995 Sep; 109(3):973-7. PMID: 7657127.
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    66. Kirschner BS. Ulcerative colitis and Crohn's disease in children. Diagnosis and management. Gastroenterol Clin North Am. 1995 Mar; 24(1):99-117. PMID: 7729863.
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    67. Mittal NK, Kirschner BS. Chronic inflammatory bowel disease. Indian J Pediatr. 1994 Nov-Dec; 61(6):655-63. PMID: 7721370.
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    68. Ferry GD, Kirschner BS, Grand RJ, Issenman RM, Griffiths AM, Vanderhoof JA, Fiedorek SC, Winter HS, Hassall EG, Watkins JB, et al. Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial. J Pediatr Gastroenterol Nutr. 1993 Jul; 17(1):32-8. PMID: 8102399.
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    69. Kirschner BS. Permanent growth failure in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1993 May; 16(4):368-9. PMID: 8315542.
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    70. Lashner BA, Shaheen NJ, Hanauer SB, Kirschner BS. Passive smoking is associated with an increased risk of developing inflammatory bowel disease in children. Am J Gastroenterol. 1993 Mar; 88(3):356-9. PMID: 8438840.
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    71. Fishbein M, Kirschner BS, Gonzales-Vallina R, Ben-Ami T, Lee PC, Weisenberg E, Schmidt-Sommerfeld E. Menetrier's disease associated with formula protein allergy and small intestinal injury in an infant. Gastroenterology. 1992 Nov; 103(5):1664-8. PMID: 1426887.
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    72. Tripathi RC, Kirschner BS, Kipp M, Tripathi BJ, Slotwiner D, Borisuth NS, Karrison T, Ernest JT. Corticosteroid treatment for inflammatory bowel disease in pediatric patients increases intraocular pressure. Gastroenterology. 1992 Jun; 102(6):1957-61. PMID: 1587414.
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    73. Hyams JS, Mandel F, Ferry GD, Gryboski JD, Kibort PM, Kirschner BS, Griffiths AM, Katz AJ, Boyle JT. Relationship of common laboratory parameters to the activity of Crohn's disease in children. J Pediatr Gastroenterol Nutr. 1992 Feb; 14(2):216-22. PMID: 1593378.
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    74. Tripathi RC, Kipp MA, Tripathi BJ, Kirschner BS, Borisuth NS, Shevell SK, Ernest JT. Ocular toxicity of prednisone in pediatric patients with inflammatory bowel disease. Lens Eye Toxic Res. 1992; 9(3-4):469-82. PMID: 1301798.
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    75. Kirschner BS, Baker AL, Thorp FK. Growth in adulthood after liver transplantation for glycogen storage disease type I. Gastroenterology. 1991 Jul; 101(1):238-41. PMID: 2044912.
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    76. Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, Kirschner BS, Griffiths AM, Katz AJ, Grand RJ, Boyle JT, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr. 1991 May; 12(4):439-47. PMID: 1678008.
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    77. Tonsgard JH, Stephens JK, Rhead WJ, Penn D, Horwitz AL, Kirschner BS, Whitington PF, Berger S, Tripp ME. Defect in fatty acid oxidation: laboratory and pathologic findings in a patient. Pediatr Neurol. 1991 Mar-Apr; 7(2):125-30. PMID: 2059253.
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    78. Schmidt-Sommerfeld E, Kirschner BS, Stephens JK. Endoscopic and histologic findings in the upper gastrointestinal tract of children with Crohn's disease. J Pediatr Gastroenterol Nutr. 1990 Nov; 11(4):448-54. PMID: 2262833.
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    79. Kirschner BS. Growth and development in chronic inflammatory bowel disease. Acta Paediatr Scand Suppl. 1990; 366:98-104; discussion 105. PMID: 2206013.
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    80. Kirschner BS, Schmidt-Sommerfeld E, Stephens JK. Gastroduodenal Crohn's disease in childhood. J Pediatr Gastroenterol Nutr. 1989 Aug; 9(2):138-40. PMID: 2809935.
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    81. Hirsch BZ, Whitington PF, Kirschner BS, Black DD, Bostwick DG, Yousefzadeh DK. Isolated granulomatous gastritis in an adolescent. Dig Dis Sci. 1989 Feb; 34(2):292-6. PMID: 2914549.
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    82. Kleinman RE, Balistreri WF, Heyman MB, Kirschner BS, Lake AM, Motil KJ, Seidman E, Udall JN. Nutritional support for pediatric patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 1989 Jan; 8(1):8-12. PMID: 2499674.
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    83. Kirschner BS. Nutritional consequences of inflammatory bowel disease on growth. J Am Coll Nutr. 1988 Aug; 7(4):301-8. PMID: 3062057.
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    84. Kirschner BS. Inflammatory bowel disease in children. Pediatr Clin North Am. 1988 Feb; 35(1):189-208. PMID: 2893329.
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    85. Kirschner BS, Sutton MM. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Gastroenterology. 1986 Oct; 91(4):830-6. PMID: 3743961.
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    86. Kirschner BS, Samowitz WS. Secondary amyloidosis in Crohn's disease of childhood. J Pediatr Gastroenterol Nutr. 1986 Sep-Oct; 5(5):816-21. PMID: 3761115.
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    87. Kirschner BS. Nutritional supplementation and growth restoration in juvenile Crohn's disease: a new approach. Nutr Rev. 1983 Feb; 41(2):67-8. PMID: 6866339.
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    88. Watkins JB, Klein PD, Schoeller DA, Kirschner BS, Park R, Perman JA. Diagnosis and differentiation of fat malabsorption in children using 13C-labeled lipids: trioctanoin, triolein, and palmitic acid breath tests. Gastroenterology. 1982 May; 82(5 Pt 1):911-7. PMID: 7060913.
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    89. Kirschner BS, DeFavaro MV, Jensen W. Lactose malabsorption in children and adolescents with inflammatory bowel disease. Gastroenterology. 1981 Nov; 81(5):829-32. PMID: 6895202.
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    90. Kirschner BS, Klich JR, Kalman SS, deFavaro MV, Rosenberg IH. Reversal of growth retardation in Crohn's disease with therapy emphasizing oral nutritional restitution. Gastroenterology. 1981 Jan; 80(1):10-5. PMID: 6778756.
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    91. Casper RC, Kirschner B, Sandstead HH, Jacob RA, Davis JM. An evaluation of trace metals, vitamins, and taste function in anorexia nervosa. Am J Clin Nutr. 1980 Aug; 33(8):1801-8. PMID: 7405882.
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    92. Kirschner BS, Voinchet O, Rosenberg IH. Growth retardation in inflammatory bowel disease. Gastroenterology. 1978 Sep; 75(3):504-11. PMID: 680509.
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    93. Esterly NB, Furey NL, Kirschner BS, Kretschmer RR, Septon RM. Chronic bullous dermatosis of childhood. Arch Dermatol. 1977 Jan; 113(1):42-6. PMID: 318816.
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    94. Kirschner BS, Pachman LM. Letter: IgA deficiency and recurrent pneumonia in the Schwartz-jampel syndrome. J Pediatr. 1976 Jun; 88(6):1060-1. PMID: 1271178.
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    95. Kirschner BS, Holinger PH. Laryngeal obstruction in children sarcoidosis. J Pediatr. 1976 Feb; 88(2):263-5. PMID: 1249689.
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    96. Esterly NB, Arak G, Furey N, Ginsberg M, Howell SE, Kirschner BS, Miller M, Zurbrugg J. The obstetrician and breast feeding: some views of women physicians. J Reprod Med. 1975 Mar; 14(3):89-97. PMID: 1127676.
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