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Francisco Bezanilla

InstitutionUniversity of Chicago
DepartmentBiochemistry and Molecular Biology
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R21EY027101     (BEZANILLA, FRANCISCO J)Apr 1, 2017 - Mar 31, 2020
    Cell-targeted Gold Nanoparticles for Photo-excitation fo Retinal Ganglion Cells
    Role: Principal Investigator

    S10RR026988     (BEZANILLA, FRANCISCO J)Feb 18, 2010 - Feb 17, 2011
    ISS ChronosBH Fluorescence Lifetime Spectrometer
    Role: Principal Investigator

    R03TW008351     (BEZANILLA, FRANCISCO J)Aug 10, 2009 - May 31, 2013
    Charge translocation by the sodium-potassium pump in the giant axon of the Humbol
    Role: Principal Investigator

    R21MH078822     (BEZANILLA, FRANCISCO J)Aug 1, 2006 - Jul 31, 2009
    Surface Plasmon-coupled Fluorescence Microscope to Study Ion Channel Dynamics
    Role: Principal Investigator

    R01GM030376     (BEZANILLA, FRANCISCO J)Aug 1, 1981 - Mar 31, 2026
    The Electrophysiological Studies of Voltage Gated Channels
    Role: Principal Investigator

    R37GM030376     (BEZANILLA, FRANCISCO J)Aug 1, 1981 - Jul 31, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bassetto CAZ, Pfeffermann J, Yadav R, Strassgschwandtner S, Glasnov T, Bezanilla F, Pohl P. Photolipid excitation triggers depolarizing optocapacitive currents and action potentials. Nat Commun. 2024 Feb 07; 15(1):1139. PMID: 38326372; PMCID: PMC10850502.
      Citations:    Fields:    Translation:Cells
    2. Liu Y, Bassetto CAZ, Pinto BI, Bezanilla F. A mechanistic reinterpretation of fast inactivation in voltage-gated Na+ channels. Nat Commun. 2023 08 21; 14(1):5072. PMID: 37604801; PMCID: PMC10442390.
      Citations: 5     Fields:    
    3. Bassetto CAZ, Pfeffermann J, Yadav R, Strassgschwandtner S, Glasnov T, Bezanilla F, Pohl P. Photolipid excitation triggers depolarizing optocapacitive currents and action potentials. bioRxiv. 2023 Aug 14. PMID: 37645959; PMCID: PMC10462005.
    4. Liu Y, Bassetto CAZ, Pinto BI, Bezanilla F. A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na+ Channels. Res Sq. 2023 May 22. PMID: 37292679; PMCID: PMC10246267.
    5. Liu Y, Bassetto CAZ, Pinto BI, Bezanilla F. A Mechanistic Reinterpretation of Fast Inactivation in Voltage-Gated Na + Channels. bioRxiv. 2023 Apr 28. PMID: 37162849; PMCID: PMC10168311.
    6. Bassetto CAZ, Bezanilla F, Costa F, Guardiani C, Giacomello A. Noncanonical electromechanical coupling paths in cardiac hERG potassium channel. Nat Commun. 2023 02 27; 14(1):1110. PMID: 36849440; PMCID: PMC9971164.
      Citations: 3     Fields:    Translation:Cells
    7. Bassetto CAZ, Pinto BI, Latorre R, Bezanilla F. Ion channel thermodynamics studied with temperature jumps measured at the cell membrane. Biophys J. 2023 02 21; 122(4):661-671. PMID: 36654507; PMCID: PMC9989882.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Pinto BI, Bassetto CAZ, Bezanilla F. Optocapacitance: physical basis and its application. Biophys Rev. 2022 Apr; 14(2):569-577. PMID: 35528029; PMCID: PMC9042976.
      Citations: 7     
    9. Priest MF, Lee EE, Bezanilla F. Tracking the movement of discrete gating charges in a voltage-gated potassium channel. Elife. 2021 11 15; 10. PMID: 34779404; PMCID: PMC8635975.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. Catacuzzeno L, Franciolini F, Bezanilla F, Eisenberg RS. Gating current noise produced by Brownian models of a voltage sensor. Biophys J. 2021 09 21; 120(18):3983-4001. PMID: 34411574; PMCID: PMC8510977.
      Citations: 4     Fields:    Translation:Cells
    11. Bassetto CA, Bezanilla F, Carvalho-de-Souza JL. Molecular basis for functional connectivity between the voltage sensor and the selectivity filter gate in Shaker K+ channels. Elife. 2021 02 23; 10. PMID: 33620313; PMCID: PMC7943188.
      Citations: 11     Fields:    Translation:Animals
    12. Moreno C, Yano S, Bezanilla F, Holmgren M, Latorre R. Transient Electrical Currents Mediated by the Na+/K+-ATPase: A Tour from Basic Biophysics to Human Diseases. Biophys J. 2020 07 21; 119(2):236-242. PMID: 32579966; PMCID: PMC7376075.
      Citations: 7     Fields:    Translation:Humans
    13. Rastogi SK, Garg R, Scopelliti MG, Pinto BI, Hartung JE, Kim S, Murphey CGE, Johnson N, San Roman D, Bezanilla F, Cahoon JF, Gold MS, Chamanzar M, Cohen-Karni T. Remote nongenetic optical modulation of neuronal activity using fuzzy graphene. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13339-13349. PMID: 32482882; PMCID: PMC7306804.
      Citations: 20     Fields:    Translation:AnimalsCells
    14. Du X, Carvalho-de-Souza JL, Wei C, Kubota T, Staisch J, Hain T, Petrossian N, Xu M, Bezanilla F, Gomez CM, Carrasquel-Ursulaez W, Lorenzo Y, Gonzalez N, Latorre R. Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6023-6034. PMID: 32132200; PMCID: PMC7084159.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    15. Bassetto CAZ, Carvalho-de-Souza JL, Bezanilla F. Metal Bridge in S4 Segment Supports Helix Transition in Shaker Channel. Biophys J. 2020 02 25; 118(4):922-933. PMID: 31635788; PMCID: PMC7037500.
      Citations: 5     Fields:    Translation:Cells
    16. Bezanilla F, Carvalho-de-Souza JL. Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker. Nat Commun. 2019 08 08; 10(1):3584. PMID: 31395867; PMCID: PMC6687735.
      Citations: 15     Fields:    Translation:AnimalsCells
    17. Li X, Wei W, Bezanilla F, Tian B, Acarón Ledesma H, Carvalho-de-Souza JL. An atlas of nano-enabled neural interfaces. Nat Nanotechnol. 2019 07; 14(7):645-657. PMID: 31270446; PMCID: PMC6800006.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    18. Jiang Y, Parameswaran R, Li X, Gao X, Meng L, Bezanilla F, Shepherd GMG, Tian B, Carvalho-de-Souza JL. Nongenetic optical neuromodulation with silicon-based materials. Nat Protoc. 2019 05; 14(5):1339-1376. PMID: 30980031; PMCID: PMC6557640.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    19. Carvalho-de-Souza JL, Nag OK, Oh E, Huston AL, Vurgaftman I, Pepperberg DR, Bezanilla F, Delehanty JB. Cholesterol Functionalization of Gold Nanoparticles Enhances Photoactivation of Neural Activity. ACS Chem Neurosci. 2019 03 20; 10(3):1478-1487. PMID: 30589551; PMCID: PMC6608567.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Lee EEL, Bezanilla F. Methodological improvements for fluorescence recordings in Xenopus laevis oocytes. J Gen Physiol. 2019 02 04; 151(2):264-272. PMID: 30606741; PMCID: PMC6363413.
      Citations: 7     Fields:    Translation:AnimalsCells
    21. Horng TL, Eisenberg RS, Liu C, Bezanilla F. Continuum Gating Current Models Computed with Consistent Interactions. Biophys J. 2019 01 22; 116(2):270-282. PMID: 30612713; PMCID: PMC6350011.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    22. Bezanilla F. Influences: The Cell Physiology Laboratory in Montemar, Chile. J Gen Physiol. 2018 11 05; 150(11):1464-1468. PMID: 30341084; PMCID: PMC6219681.
      Citations: 1     Fields:    Translation:Animals
    23. Bezanilla F. Gating currents. J Gen Physiol. 2018 07 02; 150(7):911-932. PMID: 29941430; PMCID: PMC6028497.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    24. Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA. Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape. J Gen Physiol. 2018 07 02; 150(7):1017-1024. PMID: 29866793; PMCID: PMC6028492.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Carrasquel-Ursulaez W, Alvarez O, Bezanilla F, Latorre R. Determination of the Stoichiometry between a- and ?1 Subunits of the BK Channel Using LRET. Biophys J. 2018 06 05; 114(11):2493-2497. PMID: 29705199; PMCID: PMC6129150.
      Citations: 5     Fields:    Translation:Cells
    26. Tian B, Xu S, Rogers JA, Cestellos-Blanco S, Yang P, Bezanilla F, Liu J, Bao Z, Hjort M, Cao Y, Melosh N, Lanzani G, Benfenati F, Galli G, Gygi F, Kautz R, Gorodetsky AA, Kim SS, Lu TK, Anikeeva P, Cifra M, Havelka D, Jiang Y, Carvalho-de-Souza JL, Krivosudský O. Roadmap on semiconductor-cell biointerfaces. Phys Biol. 2018 03 09; 15(3):031002. PMID: 29205173; PMCID: PMC6599646.
      Citations: 15     Fields:    
    27. Parameswaran R, Jiang Y, Burke MJ, Zimmerman JF, Koehler K, Phillips AW, Yi J, Adams EJ, Bezanilla F, Tian B, Carvalho-de-Souza JL. Photoelectrochemical modulation of neuronal activity with free-standing coaxial silicon nanowires. Nat Nanotechnol. 2018 03; 13(3):260-266. PMID: 29459654; PMCID: PMC6029690.
      Citations: 65     Fields:    Translation:AnimalsCells
    28. Mathur C, Johnson KR, Tong BA, Miranda P, Srikumar D, Basilio D, Bezanilla F, Holmgren M, Latorre R. Demonstration of ion channel synthesis by isolated squid giant axon provides functional evidence for localized axonal membrane protein translation. Sci Rep. 2018 02 02; 8(1):2207. PMID: 29396520; PMCID: PMC5797086.
      Citations: 11     Fields:    Translation:AnimalsCells
    29. Brugarolas P, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B, Sánchez-Rodríguez JE. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607. PMID: 29330383; PMCID: PMC5766510.
      Citations: 19     Fields:    Translation:HumansAnimals
    30. Carvalho-de-Souza JL, Bezanilla F. Nonsensing residues in S3-S4 linker's C terminus affect the voltage sensor set point in K+ channels. J Gen Physiol. 2018 02 05; 150(2):307-321. PMID: 29321262; PMCID: PMC5806678.
      Citations: 11     Fields:    Translation:AnimalsCells
    31. Nanazashvili M, Fosque B, Bezanilla F, Sackin H, Sánchez-Rodríguez JE. LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b. Biophys J. 2018 01 09; 114(1):88-97. PMID: 29320699; PMCID: PMC5773755.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. Pepperberg DR, Bezanilla F, Carvalho-de-Souza JL, Pinto BI. Optocapacitive Generation of Action Potentials by Microsecond Laser Pulses of Nanojoule Energy. Biophys J. 2018 01 23; 114(2):283-288. PMID: 29273263; PMCID: PMC5984948.
      Citations: 30     Fields:    Translation:Cells
    33. Kubota T, Dang B, Carvalho-de-Souza JL, Correa AM, Bezanilla F. Nav channel binder containing a specific conjugation-site based on a low toxicity ß-scorpion toxin. Sci Rep. 2017 11 27; 7(1):16329. PMID: 29180755; PMCID: PMC5703725.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F. Corrigendum: Infrared light excites cells by changing their electrical capacitance. Nat Commun. 2017 11 10; 8:16148. PMID: 29125141; PMCID: PMC5684604.
      Citations: 4     Fields:    
    35. Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F. Correspondence: Reply to 'Revisiting the theoretical cell membrane thermal capacitance response'. Nat Commun. 2017 11 10; 8(1):1432. PMID: 29127286; PMCID: PMC5681563.
      Citations: 1     Fields:    
    36. Lee EEL, Bezanilla F. Biophysical Characterization of Genetically Encoded Voltage Sensor ASAP1: Dynamic Range Improvement. Biophys J. 2017 Nov 21; 113(10):2178-2181. PMID: 29108650; PMCID: PMC5700382.
      Citations: 5     Fields:    Translation:AnimalsCells
    37. Kubota T, Correa AM, Bezanilla F. Mechanism of functional interaction between potassium channel Kv1.3 and sodium channel NavBeta1 subunit. Sci Rep. 2017 03 28; 7:45310. PMID: 28349975; PMCID: PMC5368567.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    38. Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):E1857-E1865. PMID: 28202723; PMCID: PMC5347571.
      Citations: 19     Fields:    Translation:AnimalsCells
    39. Dang B, Shen R, Kubota T, Mandal K, Bezanilla F, Roux B, Kent SB. Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew Chem Int Ed Engl. 2017 03 13; 56(12):3324-3328. PMID: 28194851; PMCID: PMC5507063.
      Citations: 5     Fields:    Translation:Cells
    40. Barchad-Avitzur O, Priest MF, Dekel N, Bezanilla F, Parnas H, Ben-Chaim Y. A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor. Biophys J. 2016 Oct 04; 111(7):1396-1408. PMID: 27705763; PMCID: PMC5052511.
      Citations: 17     Fields:    Translation:AnimalsCells
    41. Jiang Y, Wong RC, Luo Z, Isheim D, Zuo X, Nicholls AW, Jung IW, Yue J, Liu DJ, Wang Y, De Andrade V, Xiao X, Navrazhnykh L, Weiss DE, Wu X, Seidman DN, Bezanilla F, Tian B, Carvalho-de-Souza JL. Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces. Nat Mater. 2016 09; 15(9):1023-30. PMID: 27348576; PMCID: PMC5388139.
      Citations: 53     Fields:    
    42. Dang B, Kubota T, Mandal K, Correa AM, Bezanilla F, Kent SB. Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8639-42. PMID: 27244051; PMCID: PMC5001624.
      Citations: 5     Fields:    Translation:AnimalsCells
    43. Hyde HC, Luk LY, Kent SB, Castillo JP, Sánchez-Rodríguez JE, Zaelzer CA, Aguayo D, Sepúlveda RV, Gonzalez-Nilo FD, Bezanilla F, Latorre R. ß1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):E3231-9. PMID: 27217576; PMCID: PMC4988589.
      Citations: 8     Fields:    Translation:AnimalsCells
    44. Labro AJ, Priest MF, Snyders DJ, Bezanilla F, Lacroix JJ. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nat Commun. 2015 Dec 17; 6:10173. PMID: 26673941; PMCID: PMC4703866.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    45. Treger JS, Priest MF, Bezanilla F. Single-molecule fluorimetry and gating currents inspire an improved optical voltage indicator. Elife. 2015 Nov 24; 4:e10482. PMID: 26599732; PMCID: PMC4658195.
      Citations: 23     Fields:    Translation:AnimalsCells
    46. Li Q, Shen R, Treger JS, Wanderling SS, Milewski W, Siwowska K, Bezanilla F, Perozo E. Resting state of the human proton channel dimer in a lipid bilayer. Proc Natl Acad Sci U S A. 2015 Nov 03; 112(44):E5926-35. PMID: 26443860; PMCID: PMC4640771.
      Citations: 38     Fields:    Translation:HumansCells
    47. Rui H, Das A, Castillo JP, Basilio D, Roux B, Latorre R, Bezanilla F, Holmgren M. Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase. Nat Commun. 2015 Jul 24; 6:7622. PMID: 26205423; PMCID: PMC4515779.
      Citations: 23     Fields:    Translation:AnimalsCells
    48. Treger JS, Dang B, Kent SB, Pepperberg DR, Bezanilla F, Carvalho-de-Souza JL. Photosensitivity of neurons enabled by cell-targeted gold nanoparticles. Neuron. 2015 Apr 08; 86(1):207-17. PMID: 25772189; PMCID: PMC4393361.
      Citations: 122     Fields:    Translation:AnimalsCells
    49. Khalili-Araghi F, Miranda P, Holmgren M, Bezanilla F, Sánchez-Rodríguez JE, Roux B. A structural rearrangement of the Na+/K+-ATPase traps ouabain within the external ion permeation pathway. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1335-1344. PMID: 25637661; PMCID: PMC4457281.
      Citations: 5     Fields:    Translation:AnimalsCells
    50. Priest M, Bezanilla F. Functional Site-Directed Fluorometry. Adv Exp Med Biol. 2015; 869:55-76. PMID: 26381940.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    51. Treger JS, Priest MF, Iezzi R, Bezanilla F. Real-time imaging of electrical signals with an infrared FDA-approved dye. Biophys J. 2014 Sep 16; 107(6):L09-12. PMID: 25229155; PMCID: PMC4167294.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    52. Kubota T, Bezanilla F, Correa AM, Lacroix JJ. Probing a-3(10) transitions in a voltage-sensing S4 helix. Biophys J. 2014 Sep 02; 107(5):1117-1128. PMID: 25185547; PMCID: PMC4156671.
      Citations: 14     Fields:    Translation:AnimalsCells
    53. Dang B, Kubota T, Correa AM, Bezanilla F, Kent SB. Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8970-4. PMID: 24989851; PMCID: PMC5477175.
      Citations: 10     Fields:    Translation:AnimalsCells
    54. Hyde HC, Campos FV, Bezanilla F, Lacroix JJ. Moving gating charges through the gating pore in a Kv channel voltage sensor. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):E1950-9. PMID: 24782544; PMCID: PMC4024920.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    55. Dalmas O, Sompornpisut P, Bezanilla F, Perozo E. Molecular mechanism of Mg2+-dependent gating in CorA. Nat Commun. 2014 Apr 02; 5:3590. PMID: 24694723; PMCID: PMC4066822.
      Citations: 25     Fields:    Translation:Cells
    56. Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E. A repulsion mechanism explains magnesium permeation and selectivity in CorA. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3002-7. PMID: 24516146; PMCID: PMC3939898.
      Citations: 15     Fields:    Translation:AnimalsCells
    57. Priest MF, Villalba-Galea CA, Bezanilla F, Lacroix JJ. S3-S4 linker length modulates the relaxed state of a voltage-gated potassium channel. Biophys J. 2013 Nov 19; 105(10):2312-22. PMID: 24268143; PMCID: PMC3838747.
      Citations: 24     Fields:    Translation:AnimalsCells
    58. Bezanilla F, Villalba-Galea CA. The gating charge should not be estimated by fitting a two-state model to a Q-V curve. J Gen Physiol. 2013 Dec; 142(6):575-8. PMID: 24218396; PMCID: PMC3840919.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    59. Villalba-Galea CA, Frezza L, Sandtner W, Bezanilla F. Sensing charges of the Ciona intestinalis voltage-sensing phosphatase. J Gen Physiol. 2013 Nov; 142(5):543-55. PMID: 24127524; PMCID: PMC3813379.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    60. Campos FV, Frezza L, Bezanilla F, Lacroix JJ. Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation. Neuron. 2013 Aug 21; 79(4):651-7. PMID: 23972594; PMCID: PMC3907179.
      Citations: 26     Fields:    Translation:AnimalsCells
    61. Dang B, Kubota T, Mandal K, Bezanilla F, Kent SB. Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high-resolution X-ray structure of ShK toxin by racemic protein crystallography. J Am Chem Soc. 2013 Aug 14; 135(32):11911-9. PMID: 23919482; PMCID: PMC3838204.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    62. Capes DL, Goldschen-Ohm MP, Arcisio-Miranda M, Bezanilla F, Chanda B. Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels. J Gen Physiol. 2013 Aug; 142(2):101-12. PMID: 23858005; PMCID: PMC3727307.
      Citations: 108     Fields:    Translation:AnimalsCells
    63. Shapiro MG, Priest MF, Siegel PH, Bezanilla F. Thermal mechanisms of millimeter wave stimulation of excitable cells. Biophys J. 2013 Jun 18; 104(12):2622-8. PMID: 23790370; PMCID: PMC3686354.
      Citations: 14     Fields:    Translation:AnimalsCells
    64. Ruscic KJ, Miceli F, Villalba-Galea CA, Dai H, Mishina Y, Bezanilla F, Goldstein SA. IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):E559-66. PMID: 23359697; PMCID: PMC3574954.
      Citations: 37     Fields:    Translation:HumansCells
    65. Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Bezanilla F, Lacroix JJ, Roux B. Intermediate state trapping of a voltage sensor. J Gen Physiol. 2012 Dec; 140(6):635-52. PMID: 23183699; PMCID: PMC3514728.
      Citations: 37     Fields:    Translation:AnimalsCells
    66. Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B. An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations. J Gen Physiol. 2012 Dec; 140(6):587-94. PMID: 23183694; PMCID: PMC3514734.
      Citations: 114     Fields:    Translation:Cells
    67. Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. J Gen Physiol. 2012 Nov; 140(5):481-93. PMID: 23071266; PMCID: PMC3483114.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    68. Hyde HC, Sandtner W, Vargas E, Dagcan AT, Robertson JL, Roux B, Correa AM, Bezanilla F. Nano-positioning system for structural analysis of functional homomeric proteins in multiple conformations. Structure. 2012 Oct 10; 20(10):1629-40. PMID: 23063010; PMCID: PMC3633233.
      Citations: 8     Fields:    Translation:AnimalsCells
    69. Bezanilla F, Lacroix JJ. Tuning the voltage-sensor motion with a single residue. Biophys J. 2012 Aug 08; 103(3):L23-L25. PMID: 22947880; PMCID: PMC3414891.
      Citations: 17     Fields:    Translation:Cells
    70. Miceli F, Vargas E, Bezanilla F, Taglialatela M. Gating currents from Kv7 channels carrying neuronal hyperexcitability mutations in the voltage-sensing domain. Biophys J. 2012 Mar 21; 102(6):1372-82. PMID: 22455920; PMCID: PMC3309409.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    71. Shapiro MG, Homma K, Villarreal S, Richter CP, Bezanilla F. Infrared light excites cells by changing their electrical capacitance. Nat Commun. 2012 Mar 13; 3:736. PMID: 22415827; PMCID: PMC3316879.
      Citations: 236     Fields:    Translation:HumansAnimalsCells
    72. Gadsby DC, Bezanilla F, Rakowski RF, De Weer P, Holmgren M. The dynamic relationships between the three events that release individual Na? ions from the Na?/K?-ATPase. Nat Commun. 2012 Feb 14; 3:669. PMID: 22334072; PMCID: PMC3293407.
      Citations: 22     Fields:    Translation:AnimalsCells
    73. Dekel N, Priest MF, Parnas H, Parnas I, Bezanilla F. Depolarization induces a conformational change in the binding site region of the M2 muscarinic receptor. Proc Natl Acad Sci U S A. 2012 Jan 03; 109(1):285-90. PMID: 22184214; PMCID: PMC3252955.
      Citations: 20     Fields:    Translation:AnimalsCells
    74. Vargas E, Bezanilla F, Roux B. In search of a consensus model of the resting state of a voltage-sensing domain. Neuron. 2011 Dec 08; 72(5):713-20. PMID: 22153369; PMCID: PMC3268064.
      Citations: 71     Fields:    Translation:AnimalsCells
    75. Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20556-61. PMID: 22143771; PMCID: PMC3251152.
      Citations: 13     Fields:    Translation:AnimalsCells
    76. Sandtner W, Khalili-Araghi F, Roux B, Bezanilla F, Holmgren M, Egwolf B, Sánchez-Rodríguez JE. Ouabain binding site in a functioning Na+/K+ ATPase. J Biol Chem. 2011 Nov 04; 286(44):38177-38183. PMID: 21911500; PMCID: PMC3207469.
      Citations: 26     Fields:    Translation:AnimalsCells
    77. Bezanilla F, Lacroix JJ. Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6444-9. PMID: 21464282; PMCID: PMC3081032.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    78. Halaszovich CR, Schreiber DN, Leitner MG, Bezanilla F, Oliver D, Villalba-Galea CA, Lacroix J. Controlling the activity of a phosphatase and tensin homolog (PTEN) by membrane potential. J Biol Chem. 2011 May 20; 286(20):17945-53. PMID: 21454672; PMCID: PMC3093869.
      Citations: 27     Fields:    Translation:AnimalsCells
    79. Labro AJ, Bezanilla F, Lacroix JJ. Properties of deactivation gating currents in Shaker channels. Biophys J. 2011 Mar 02; 100(5):L28-30. PMID: 21354387; PMCID: PMC3043211.
      Citations: 36     Fields:    Translation:AnimalsCells
    80. Gagnon DG, Bezanilla F. The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers. J Gen Physiol. 2010 Nov; 136(5):555-68. PMID: 20974773; PMCID: PMC2964516.
      Citations: 17     Fields:    Translation:AnimalsCells
    81. Miceli F, Cilio MR, Taglialatela M, Bezanilla F. Gating currents from neuronal K(V)7.4 channels: general features and correlation with the ionic conductance. Channels (Austin). 2009 Jul-Aug; 3(4):274-83. PMID: 19690464.
      Citations: 23     Fields:    Translation:AnimalsCells
    82. Villalba-Galea CA, Miceli F, Taglialatela M, Bezanilla F. Coupling between the voltage-sensing and phosphatase domains of Ci-VSP. J Gen Physiol. 2009 Jul; 134(1):5-14. PMID: 19564425; PMCID: PMC2712979.
      Citations: 48     Fields:    Translation:AnimalsCells
    83. Gagnon DG, Bezanilla F. A single charged voltage sensor is capable of gating the Shaker K+ channel. J Gen Physiol. 2009 May; 133(5):467-83. PMID: 19398775; PMCID: PMC2712970.
      Citations: 39     Fields:    Translation:AnimalsCells
    84. Rosenthal JJ, Seibel BA, Dymowska A, Bezanilla F. Trade-off between aerobic capacity and locomotor capability in an Antarctic pteropod. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6192-6. PMID: 19325127; PMCID: PMC2669364.
      Citations: 4     Fields:    Translation:AnimalsCells
    85. Villalba-Galea CA, Sandtner W, Dimitrov D, Mutoh H, Bezanilla F, Knöpfel T. Charge movement of a voltage-sensitive fluorescent protein. Biophys J. 2009 Jan; 96(2):L19-21. PMID: 19167283; PMCID: PMC2716470.
      Citations: 40     Fields:    Translation:AnimalsCells
    86. McGuire H, Hyde HC, Bezanilla F, Blunck R. Fluorescence detection of the movement of single KcsA subunits reveals cooperativity. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20263-8. PMID: 19074286; PMCID: PMC2629256.
      Citations: 22     Fields:    
    87. Bezanilla F. Ion channels: from conductance to structure. Neuron. 2008 Nov 06; 60(3):456-68. PMID: 18995820.
      Citations: 28     Fields:    Translation:AnimalsCells
    88. Villalba-Galea CA, Sandtner W, Starace DM, Bezanilla F. S4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17600-7. PMID: 18818307; PMCID: PMC2584729.
      Citations: 149     Fields:    Translation:Cells
    89. Campos FV, Chanda B, Bezanilla F, Beirão PS. Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels. J Gen Physiol. 2008 Aug; 132(2):251-63. PMID: 18663133; PMCID: PMC2483334.
      Citations: 45     Fields:    Translation:AnimalsCells
    90. Bezanilla F. How membrane proteins sense voltage. Nat Rev Mol Cell Biol. 2008 Apr; 9(4):323-32. PMID: 18354422.
      Citations: 265     Fields:    Translation:HumansAnimalsCells
    91. Chanda B, Bezanilla F. A common pathway for charge transport through voltage-sensing domains. Neuron. 2008 Feb 07; 57(3):345-51. PMID: 18255028.
      Citations: 39     Fields:    Translation:AnimalsCells
    92. Sandtner W, Bezanilla F, Correa AM. In vivo measurement of intramolecular distances using genetically encoded reporters. Biophys J. 2007 Nov 01; 93(9):L45-7. PMID: 17766346; PMCID: PMC2025654.
      Citations: 33     Fields:    Translation:AnimalsCells
    93. Campos FV, Chanda B, Bezanilla F, Beirão PS. beta-Scorpion toxin modifies gating transitions in all four voltage sensors of the sodium channel. J Gen Physiol. 2007 Sep; 130(3):257-68. PMID: 17698594; PMCID: PMC2151646.
      Citations: 37     Fields:    Translation:AnimalsCells
    94. Campos FV, Chanda B, Bezanilla F, Roux B. Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7904-9. PMID: 17470814; PMCID: PMC1876545.
      Citations: 124     Fields:    Translation:Animals
    95. Bezanilla F. The action potential: from voltage-gated conductances to molecular structures. Biol Res. 2006; 39(3):425-35. PMID: 17106575.
      Citations: 13     Fields:    Translation:AnimalsCells
    96. Ben-Chaim Y, Chanda B, Dascal N, Bezanilla F, Parnas I, Parnas H. Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor. Nature. 2006 Nov 02; 444(7115):106-9. PMID: 17065983.
      Citations: 88     Fields:    Translation:AnimalsCells
    97. Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F, Blunck R. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol. 2006 Nov; 128(5):569-81. PMID: 17043150; PMCID: PMC2151582.
      Citations: 58     Fields:    Translation:Cells
    98. Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15865-70. PMID: 17043236; PMCID: PMC1635094.
      Citations: 24     Fields:    Translation:Cells
    99. Jurisic N, Bezanilla F. Analysis of the optimal channel density of the squid giant axon using a reparameterized Hodgkin-Huxley model. J Neurophysiol. 2006 Aug; 96(2):959; author reply 960. PMID: 16835367.
      Citations:    Fields:    Translation:AnimalsCells
    100. Bannister JP, Chanda B, Bezanilla F, Papazian DM. Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18718-23. PMID: 16339906; PMCID: PMC1317915.
      Citations: 22     Fields:    Translation:AnimalsCells
    101. Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F. A hybrid approach to measuring electrical activity in genetically specified neurons. Nat Neurosci. 2005 Nov; 8(11):1619-26. PMID: 16205716.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    102. Posson DJ, Ge P, Miller C, Bezanilla F, Selvin PR. Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer. Nature. 2005 Aug 11; 436(7052):848-51. PMID: 16094368; PMCID: PMC1409748.
      Citations: 83     Fields:    Translation:AnimalsCells
    103. Chanda B, Asamoah OK, Blunck R, Bezanilla F, Roux B. Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature. 2005 Aug 11; 436(7052):852-6. PMID: 16094369.
      Citations: 148     Fields:    Translation:Cells
    104. Bezanilla F. The origin of subconductance levels in voltage-gated K+ channels. J Gen Physiol. 2005 Aug; 126(2):83-6. PMID: 16043771; PMCID: PMC2266566.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    105. Bezanilla F. The voltage-sensor structure in a voltage-gated channel. Trends Biochem Sci. 2005 Apr; 30(4):166-8. PMID: 15817390.
      Citations: 22     Fields:    Translation:Cells
    106. Bezanilla F. Voltage-gated ion channels. IEEE Trans Nanobioscience. 2005 Mar; 4(1):34-48. PMID: 15816170.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    107. Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM. Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter. J Gen Physiol. 2005 Jan; 125(1):13-36. PMID: 15596535; PMCID: PMC2217483.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    108. Pantoja R, Nagarah JM, Starace DM, Melosh NA, Blunck R, Bezanilla F, Heath JR. Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics. Biosens Bioelectron. 2004 Oct 15; 20(3):509-17. PMID: 15494233.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    109. Bezanilla F. RNA editing of a human potassium channel modifies its inactivation. Nat Struct Mol Biol. 2004 Oct; 11(10):915-6. PMID: 15452561.
      Citations: 3     Fields:    Translation:HumansCells
    110. Kuzmenkin A, Bezanilla F, Correa AM. Gating of the bacterial sodium channel, NaChBac: voltage-dependent charge movement and gating currents. J Gen Physiol. 2004 Oct; 124(4):349-56. PMID: 15365092; PMCID: PMC2233907.
      Citations: 58     Fields:    Translation:AnimalsCells
    111. Dahan DS, Dibas MI, Petersson EJ, Auyeung VC, Chanda B, Bezanilla F, Dougherty DA, Lester HA. A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10195-200. PMID: 15218096; PMCID: PMC454187.
      Citations: 45     Fields:    Translation:AnimalsCells
    112. Blunck R, Starace DM, Correa AM, Bezanilla F. Detecting rearrangements of shaker and NaChBac in real-time with fluorescence spectroscopy in patch-clamped mammalian cells. Biophys J. 2004 Jun; 86(6):3966-80. PMID: 15189893; PMCID: PMC1304298.
      Citations: 31     Fields:    Translation:AnimalsCells
    113. Chanda B, Asamoah OK, Bezanilla F. Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol. 2004 Mar; 123(3):217-30. PMID: 14981134; PMCID: PMC2217449.
      Citations: 58     Fields:    Translation:AnimalsCells
    114. Starace DM, Bezanilla F. A proton pore in a potassium channel voltage sensor reveals a focused electric field. Nature. 2004 Feb 05; 427(6974):548-53. PMID: 14765197.
      Citations: 228     Fields:    Translation:AnimalsCells
    115. Sigg D, Bezanilla F, Stefani E. Fast gating in the Shaker K+ channel and the energy landscape of activation. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7611-5. PMID: 12805566; PMCID: PMC164634.
      Citations: 39     Fields:    Translation:AnimalsCells
    116. Sigg D, Bezanilla F. A physical model of potassium channel activation: from energy landscape to gating kinetics. Biophys J. 2003 Jun; 84(6):3703-16. PMID: 12770877; PMCID: PMC1302953.
      Citations: 21     Fields:    Translation:AnimalsCells
    117. Asamoah OK, Wuskell JP, Loew LM, Bezanilla F. A fluorometric approach to local electric field measurements in a voltage-gated ion channel. Neuron. 2003 Jan 09; 37(1):85-97. PMID: 12526775.
      Citations: 62     Fields:    Translation:AnimalsCells
    118. Bezanilla F, Perozo E. The voltage sensor and the gate in ion channels. Adv Protein Chem. 2003; 63:211-41. PMID: 12629972.
      Citations: 16     Fields:    Translation:Cells
    119. Bezanilla F, Perozo E, Bezanilla F, Perozo E. Structural biology. Force and voltage sensors in one structure. Science. 2002 Nov 22; 298(5598):1562-3. PMID: 12446894.
      Citations: 8     Fields:    Translation:Cells
    120. Chanda B, Bezanilla F, Chanda B, Bezanilla F. Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. J Gen Physiol. 2002 Nov; 120(5):629-45. PMID: 12407076; PMCID: PMC2229551.
      Citations: 169     Fields:    Translation:AnimalsCells
    121. Bezanilla F, Bezanilla F. Voltage sensor movements. J Gen Physiol. 2002 Oct; 120(4):465-73. PMID: 12356849; PMCID: PMC2229527.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    122. Rosenthal JJ, Bezanilla F. A comparison of propagated action potentials from tropical and temperate squid axons: different durations and conduction velocities correlate with ionic conductance levels. J Exp Biol. 2002 Jun; 205(Pt 12):1819-30. PMID: 12042340.
      Citations: 17     Fields:    Translation:AnimalsCells
    123. Rosenthal JJ, Bezanilla F, Rosenthal JJ, Bezanilla F. Extensive editing of mRNAs for the squid delayed rectifier K+ channel regulates subunit tetramerization. Neuron. 2002 May 30; 34(5):743-57. PMID: 12062021.
      Citations: 34     Fields:    Translation:AnimalsCells
    124. Rakowski RF, Bezanilla F, De Weer P, Gadsby DC, Holmgren M, Wagg J. Charge translocation by the Na/K pump. Ann N Y Acad Sci. 1997 Nov 03; 834:231-43. PMID: 9405811.
      Citations: 2     Fields:    Translation:HumansAnimals
    125. Armstrong CM, Bezanilla FM, Horowicz P. Twitches in the presence of ethylene glycol bis( -aminoethyl ether)-N,N'-tetracetic acid. Biochim Biophys Acta. 1972 Jun 23; 267(3):605-8. PMID: 4537984.
      Citations: 184     Fields:    Translation:Animals
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