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Janane Rahbani

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
ORCID ORCID Icon0000-0003-4598-4683 Additional info
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    Collapse Overview 
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    Dr. Rahbani aims at elucidating new basic molecular mechanisms that could provide opportunities for developing novel treatments to limit tumor progression, improve cachexia in cancer patients and combat obesity. The first focus of his laboratory is to understand the multiplex interplay of energy wasting pathways in cancer-associated cachexia. In particular, he is interested in identifying how futile cycles and thermogenesis in adipose tissues contribute to muscle atrophy and how fat and skeletal muscle adapt their metabolism during early stages of cachexia. The second focus of his laboratory is to constrain tumor growth by targeting adipose tissue metabolism and promoting the greatest amount of energy expenditure. Understanding the significant capacity for mitochondria in adipocytes to coordinate various biological outcomes by exerting control over cellular bioenergetics, biosynthesis and signaling will extend insight towards recognizing how to offset metabolic diseases, such as cancer, obesity and diabetes.
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    Collapse Biography 
    Collapse education and training
    Goodman Cancer Institute, CanadaPDF2024Biochemistry
    McGill University, CanadaPh.D2018Chemical Biology
    American University of Beirut, LebanonMSc2012Chemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rahbani JF, Bunk J, Lagarde D, Samborska B, Roesler A, Xiao H, Shaw A, Kaiser Z, Braun JL, Geromella MS, Fajardo VA, Koza RA, Kazak L. Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB. Cell Metab. 2024 03 05; 36(3):526-540.e7. PMID: 38272036.
      Citations:    Fields:    Translation:AnimalsCells
    2. Rahbani JF, Scholtes C, Lagarde DM, Hussain MF, Roesler A, Dykstra CB, Bunk J, Samborska B, O'Brien SL, Tripp E, Pacis A, Angueira AR, Johansen OS, Cinkornpumin J, Hossain I, Lynes MD, Zhang Y, White AP, Pastor WA, Chondronikola M, Sidossis L, Klein S, Kralli A, Cypess AM, Pedersen SB, Jessen N, Tseng YH, Gerhart-Hines Z, Seale P, Calebiro D, Giguère V, Kazak L. ADRA1A-Gaq signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nat Metab. 2022 11; 4(11):1459-1473. PMID: 36344764; PMCID: PMC9684074.
      Citations: 5     Fields:    Translation:Cells
    3. Rahbani JF, Kazak L. A brown fat-selective mechanism of mitochondrial calcium import? Cell Metab. 2022 09 06; 34(9):1231-1233. PMID: 36070679.
      Citations:    Fields:    Translation:Cells
    4. Samborska B, Roy DG, Rahbani JF, Hussain MF, Ma EH, Jones RG, Kazak L. Creatine transport and creatine kinase activity is required for CD8+ T cell immunity. Cell Rep. 2022 03 01; 38(9):110446. PMID: 35235777.
      Citations: 6     Fields:    Translation:Cells
    5. Rahbani JF, Chouchani ET, Spiegelman BM, Kazak L. Measurement of Futile Creatine Cycling Using Respirometry. Methods Mol Biol. 2022; 2448:141-153. PMID: 35167096; PMCID: PMC9165624.
      Citations: 1     Fields:    Translation:Cells
    6. Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. 2021 05; 593(7860):580-585. PMID: 33981039; PMCID: PMC8287965.
      Citations: 32     Fields:    Translation:AnimalsCells
    7. Rahbani JF, Roesler A, Hussain MF, Samborska B, Dykstra CB, Tsai L, Jedrychowski MP, Vergnes L, Reue K, Spiegelman BM, Kazak L. Creatine kinase B controls futile creatine cycling in thermogenic fat. Nature. 2021 02; 590(7846):480-485. PMID: 33597756; PMCID: PMC8647628.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    8. Maguire OA, Ackerman SE, Szwed SK, Maganti AV, Huang X, Kramer DJ, Rosas-Villegas A, Gelfer RG, Turner LE, Ceballos V, Hejazi A, Samborska B, Rahbani JF, Dykstra CB, Annis MG, Luo JD, Carroll TS, Jiang CS, Dannenberg AJ, Siegel PM, Tersey SA, Mirmira RG, Kazak L, Cohen P, Marchildon F. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metab. 2021 03 02; 33(3):499-512.e6. PMID: 33596409; PMCID: PMC7954401.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    9. Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay L, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM. Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity. Nat Metab. 2019; 1(3):360-370. PMID: 31161155; PMCID: PMC6544051.
      Citations: 58     Fields:    Translation:AnimalsCells
    10. Platnich CM, Hariri AA, Rahbani JF, Gordon JB, Sleiman HF, Cosa G. Kinetics of Strand Displacement and Hybridization on Wireframe DNA Nanostructures: Dissecting the Roles of Size, Morphology, and Rigidity. ACS Nano. 2018 12 26; 12(12):12836-12846. PMID: 30485067.
      Citations: 5     Fields:    
    11. Rahbani JF, Hsu JCC, Chidchob P, Sleiman HF. Single-stranded templates as railroad tracks for hierarchical assembly of DNA origami. Nanoscale. 2018 Aug 07; 10(29):13994-13999. PMID: 29995052.
      Citations: 3     Fields:    Translation:Cells
    12. Rahbani JF, Vengut-Climent E, Chidchob P, Gidi Y, Trinh T, Cosa G, Sleiman HF. DNA Nanotubes with Hydrophobic Environments: Toward New Platforms for Guest Encapsulation and Cellular Delivery. Adv Healthc Mater. 2018 03; 7(6):e1701049. PMID: 29356412.
      Citations: 7     Fields:    Translation:HumansCells
    13. Luo X, Chidchob P, Rahbani JF, Sleiman HF. Encapsulation of Gold Nanoparticles into DNA Minimal Cages for 3D-Anisotropic Functionalization and Assembly. Small. 2018 02; 14(5). PMID: 29205958.
      Citations: 3     Fields:    
    14. Rahbani JF, Hariri AA, Cosa G, Sleiman HF. Dynamic DNA Nanotubes: Reversible Switching between Single and Double-Stranded Forms, and Effect of Base Deletions. ACS Nano. 2015 Dec 22; 9(12):11898-908. PMID: 26556531.
      Citations: 3     Fields:    Translation:Cells
    15. Hamblin GD, Rahbani JF, Sleiman HF. Sequential growth of long DNA strands with user-defined patterns for nanostructures and scaffolds. Nat Commun. 2015 May 05; 6:7065. PMID: 25940750.
      Citations: 8     Fields:    Translation:Cells
    16. Rahbani J, Ammar M, Al-Ghoul M. Reaction-diffusion framework: the mechanism of the polymorphic transition of a- to ß-cobalt hydroxide. J Phys Chem A. 2013 Feb 28; 117(8):1685-91. PMID: 23373463.
      Citations: 1     Fields:    
    17. Rahbani J, Behzad AR, Khashab NM, Al-Ghoul M. Characterization of internal structure of hydrated agar and gelatin matrices by cryo-SEM. Electrophoresis. 2013 Feb; 34(3):405-8. PMID: 23161518.
      Citations: 5     Fields:    
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