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Margo Emont

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Endocrinology
AddressChicago IL 60637
ORCID ORCID Icon0000-0001-9873-2784 Additional info
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    5K01DK134806-02     (Margo Emont)Dec 1, 2022 - Nov 30, 2027
    NIH/NIDDK
    Investigating the regulation of distinct human adipocyte subpopulations
    Role Description: In order to better understand the composition of human white adipose tissue, we performed single nucleus RNA sequencing, which allowed us to collect information about individual cell types within this complex tissue. We found several distinct types of adipocytes, some of which are associated with body weight and risk of type 2 diabetes (T2D). Here we will identify which factors predispose to the development of one adipocyte type over another, with the goal of finding targets for treatments that can ameliorate metabolic diseases like T2D.
    Role: PI
    F32DK124914     (EMONT, MARGO PREMINGER)Jun 30, 2020 - Jun 29, 2022
    NIH
    Investigating the Regulation of IRF4 in Adipocytes
    Role: Principal Investigator
    F31DK112625     (EMONT, MARGO PREMINGER)Sep 30, 2016 - Sep 29, 2019
    NIH
    Regulation of Thermogenesis in Adipocytes Through TRPA1
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Emont MP, Wu J. IL-13 priming in precursors drives beige adipogenesis and enhances metabolic homeostasis. J Clin Invest. 2025 Jun 02; 135(11). PMID: 40454479; PMCID: PMC12126245.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Loft A, Emont MP, Weinstock A, Divoux A, Ghosh A, Wagner A, Hertzel AV, Maniyadath B, Deplancke B, Liu B, Scheele C, Lumeng C, Ding C, Ma C, Wolfrum C, Strieder-Barboza C, Li C, Truong DD, Bernlohr DA, Stener-Victorin E, Kershaw EE, Yeger-Lotem E, Shamsi F, Hui HX, Camara H, Zhong J, Kalucka J, Ludwig JA, Semon JA, Jalkanen J, Whytock KL, Dumont KD, Sparks LM, Muir LA, Fang L, Massier L, Saraiva LR, Beyer MD, Jeschke MG, Mori MA, Boroni M, Walsh MJ, Patti ME, Lynes MD, Blüher M, Rydén M, Hamda N, Solimini NL, Mejhert N, Gao P, Gupta RK, Murphy R, Pirouzpanah S, Corvera S, Tang S, Das SK, Schmidt SF, Zhang T, Nelson TM, O'Sullivan TE, Efthymiou V, Wang W, Tong Y, Tseng YH, Mandrup S, Rosen ED. Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution. Nat Metab. 2025 May; 7(5):875-894. PMID: 40360756.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    3. Emont MP, Essene AL, Gulko A, Bozadjieva-Kramer N, Jacobs C, Nagesh S, Seeley RJ, Tsai LT, Rosen ED. Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue. Mol Metab. 2025 May; 95:102126. PMID: 40139440; PMCID: PMC11999362.
      Citations: 3     Fields:    Translation:Animals
    4. Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED. Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population. bioRxiv. 2025 Feb 19. PMID: 40027673; PMCID: PMC11870541.
      Citations:    
    5. Yu X, Chen S, Funcke JB, Straub LG, Pirro V, Emont MP, Droz BA, Collins KA, Joung C, Pearson MJ, James CM, Babu GJ, Efthymiou V, Vernon A, Patti ME, An YA, Rosen ED, Coghlan MP, Samms RJ, Scherer PE, Kusminski CM. The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice. Cell Metab. 2025 Jan 07; 37(1):187-204.e7. PMID: 39642881; PMCID: PMC11711001.
      Citations: 11     Fields:    Translation:AnimalsCells
    6. Chatterjee E, Betti MJ, Sheng Q, Lin P, Emont MP, Li G, Amancherla K, Limpitikul WB, Whittaker OR, Luong K, Azzam C, Gee D, Hutter M, Flanders K, Sahu P, Garcia-Contreras M, Gokulnath P, Flynn CR, Brown J, Yu D, Rosen ED, Jensen KV, Gamazon ER, Shah R, Das S. The extracellular vesicle transcriptome provides tissue-specific functional genomic annotation relevant to disease susceptibility in obesity. medRxiv. 2024 Nov 18. PMID: 39606385; PMCID: PMC11601731.
      Citations:    
    7. Vargas-Castillo A, Sun Y, Smythers AL, Grauvogel L, Dumesic PA, Emont MP, Tsai LT, Rosen ED, Zammit NW, Shaffer SM, Ordonez M, Chouchani ET, Gygi SP, Wang T, Sharma AK, Balaz M, Wolfrum C, Spiegelman BM. Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle. Cell Metab. 2024 Sep 03; 36(9):2146-2155.e5. PMID: 39084217; PMCID: PMC12005060.
      Citations: 9     Fields:    Translation:AnimalsCells
    8. Gulko A, Essene A, Belmont-Rausch DM, Veregge M, Pant D, Tenen D, Kapel BS, Emont MP, Pers TH, Rosen ED, Tsai LT. Protocol for flow cytometry-assisted single-nucleus RNA sequencing of human and mouse adipose tissue with sample multiplexing. STAR Protoc. 2024 03 15; 5(1):102893. PMID: 38416649; PMCID: PMC10909897.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED. Author Correction: A single-cell atlas of human and mouse white adipose tissue. Nature. 2023 Aug; 620(7973):E14. PMID: 37495702.
      Citations: 5     Fields:    
    10. Emont MP, Rosen ED. Exploring the heterogeneity of white adipose tissue in mouse and man. Curr Opin Genet Dev. 2023 06; 80:102045. PMID: 37094486; PMCID: PMC10330284.
      Citations: 8     Fields:    Translation:HumansCells
    11. Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. 2022 11 23; 185(24):4654-4673.e28. PMID: 36334589; PMCID: PMC10040263.
      Citations: 16     Fields:    Translation:HumansAnimals
    12. Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022 03 23; 14(637):eabh3831. PMID: 35320000; PMCID: PMC9162056.
      Citations: 19     Fields:    Translation:Animals
    13. Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022 03; 603(7903):926-933. PMID: 35296864; PMCID: PMC9504827.
      Citations: 365     Fields:    Translation:HumansAnimals
    14. Westcott GP, Emont MP, Li J, Jacobs C, Tsai L, Rosen ED. Mesothelial cells are not a source of adipocytes in mice. Cell Rep. 2021 07 13; 36(2):109388. PMID: 34260927; PMCID: PMC8317472.
      Citations: 21     Fields:    Translation:AnimalsCells
    15. Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J. Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. Dev Cell. 2020 07 06; 54(1):106-116.e5. PMID: 32533922; PMCID: PMC7343629.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    16. Liao J, Jiang J, Jun H, Qiao X, Emont MP, Kim DI, Wu J. HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16. Endocrinology. 2018 07 01; 159(7):2520-2527. PMID: 29757434; PMCID: PMC6456926.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Emont MP, Kim DI, Wu J. Development, activation, and therapeutic potential of thermogenic adipocytes. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 01; 1864(1):13-19. PMID: 29763732; PMCID: PMC6240366.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    18. Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, Kim DI, Emont MP, Zestos AG, Cho JS, Liu J, Kennedy RT, Maillard I, Xu XZS, Wu J. An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling. Nat Med. 2018 06; 24(6):814-822. PMID: 29785025; PMCID: PMC5992032.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    19. Kim DI, Liao J, Emont MP, Park MJ, Jun H, Ramakrishnan SK, Lin JD, Shah YM, Omary MB, Wu J. An OLTAM system for analysis of brown/beige fat thermogenic activity. Int J Obes (Lond). 2018 04; 42(4):939-945. PMID: 29359735; PMCID: PMC5962373.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Yu H, Emont M, Jun H, Wu J. Isolation and Differentiation of Murine Primary Brown/Beige Preadipocytes. Methods Mol Biol. 2018; 1773:273-282. PMID: 29687396.
      Citations: 9     Fields:    Translation:AnimalsCells
    21. Jiang J, Emont MP, Jun H, Qiao X, Liao J, Kim DI, Wu J. Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. Metabolism. 2017 12; 77:58-64. PMID: 29046261; PMCID: PMC5685898.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Soofi A, Wolf KI, Emont MP, Qi N, Martinez-Santibanez G, Grimley E, Ostwani W, Dressler GR. The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice. J Biol Chem. 2017 06 02; 292(22):9051-9062. PMID: 28424263; PMCID: PMC5454091.
      Citations: 21     Fields:    Translation:AnimalsCells
    23. Liu L, Zheng LD, Donnelly SR, Emont MP, Wu J, Cheng Z. Isolation of Mouse Stromal Vascular Cells for Monolayer Culture. Methods Mol Biol. 2017; 1566:9-16. PMID: 28244036.
      Citations: 12     Fields:    Translation:AnimalsCells
    24. Emont MP, Yu H, Jun H, Hong X, Maganti N, Stegemann JP, Wu J. Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro. Endocrinology. 2015 Dec; 156(12):4761-8. PMID: 26425808; PMCID: PMC4655212.
      Citations: 24     Fields:    Translation:AnimalsCells
    25. Emont MP, Yu H, Wu J. Transcriptional control and hormonal response of thermogenic fat. J Endocrinol. 2015 May; 225(2):R35-47. PMID: 25804606; PMCID: PMC4426224.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Emont MP, Mantis S, Kahn JH, Landeche M, Han X, Sargis RM, Cohen RN. Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015 May 15; 407:52-6. PMID: 25766503; PMCID: PMC4390535.
      Citations: 5     Fields:    Translation:AnimalsCells
    27. Vaicik MK, Thyboll Kortesmaa J, Kortesmaa J, Soininen R, Chong LY, Emont M, Cohen RN, Brey EM, Tryggvason K, Movérare-Skrtic S, Bergström G, Ohlsson C, Rozell B. Laminin a4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One. 2014; 9(10):e109854. PMID: 25310607; PMCID: PMC4195691.
      Citations: 31     Fields:    Translation:AnimalsCells
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