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Amy Weinmann

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Rheumatology
AddressChicago IL 60637
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    R13AI179152     (WEINMANN, AMY SUSAN)Aug 11, 2023 - Jul 31, 2024
    NIH
    The Molecular Mechanisms of Immune Cell Development and Function
    Role: Principal Investigator
    R01DK135090     (KLUG, CHRISTOPHER)Aug 1, 2023 - May 31, 2026
    NIH
    Defining the role of Wnt11 and Wnt5a in regulating hematopoietic and skeletal stem cell self-renewal potential during homeostasis and stress
    Role: Co-Principal Investigator
    R01AI172067     (WEINMANN, AMY SUSAN)Jan 26, 2023 - Dec 31, 2027
    NIH
    Genome organization, evolutionary structural variation, and gene regulation in immunity
    Role: Principal Investigator
    R21AI113026     (WEINMANN, AMY SUSAN)Aug 1, 2014 - Jul 31, 2017
    NIH
    Tet1 activity and function in helper T cells
    Role: Principal Investigator
    R01AI061061     (WEINMANN, AMY SUSAN)Jun 1, 2004 - Jul 31, 2027
    NIH
    Molecular characterization of the role for metabolites in immune cell differentiation
    Role: Principal Investigator
    R56AI061061     (WEINMANN, AMY SUSAN)Jun 1, 2004 - Jul 31, 2022
    NIH
    Molecular characterization of the role for metabolites in immune cell differentiation
    Role: Principal Investigator
    R01AI071272     (WEINMANN, AMY SUSAN)May 1, 2000 - Jun 30, 2012
    NIH
    TRANSCRIPTIONAL CONTROL OF INTERFERON-GAMMA IN T AND NK CELLS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gilbertson SE, Weinmann AS. Discovering effector domains in human transcription factors. Trends Immunol. 2023 07; 44(7):493-495. PMID: 37270301.
      Citations:    Fields:    Translation:Humans
    2. Weinmann AS. Tipping the balance in CD4+ T cells. Nat Immunol. 2023 01; 24(1):8-9. PMID: 36596891.
      Citations:    Fields:    Translation:Cells
    3. Weinmann AS. One degree of separation: urgent questions surrounding new USA laws in women's healthcare. Trends Immunol. 2022 11; 43(11):851-854. PMID: 36182546.
      Citations: 1     Fields:    Translation:Humans
    4. Gilbertson SE, Walter HC, Gardner K, Wren SN, Vahedi G, Weinmann AS. Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans. Cell Rep. 2022 05 03; 39(5):110769. PMID: 35508135; PMCID: PMC9142060.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    5. Gilbertson SE, Weinmann AS. Conservation and divergence in gene regulation between mouse and human immune cells deserves equal emphasis. Trends Immunol. 2021 12; 42(12):1077-1087. PMID: 34740529; PMCID: PMC8616835.
      Citations: 3     Fields:    Translation:HumansAnimals
    6. Weinmann AS. Genome regulation in innate and adaptive immune cells. Immunol Rev. 2021 03; 300(1):5-8. PMID: 33638253.
      Citations:    Fields:    
    7. Moldoveanu Z, Suzuki H, Reily C, Satake K, Novak L, Xu N, Huang ZQ, Knoppova B, Khan A, Hall S, Yanagawa H, Brown R, Winstead CJ, O'Quinn DB, Weinmann A, Gharavi AG, Kiryluk K, Julian BA, Weaver CT, Suzuki Y, Novak J. Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy. J Autoimmun. 2021 03; 118:102593. PMID: 33508637; PMCID: PMC7997636.
      Citations: 20     Fields:    Translation:HumansAnimals
    8. Weinmann AS, Youngblood BA, Smale ST, Brink R, Schatz DG, McHeyzer-Williams M. A Future Outlook on Molecular Mechanisms of Immunity. Trends Immunol. 2020 07; 41(7):549-555. PMID: 32507312.
      Citations:    Fields:    Translation:Humans
    9. Walter HC, Weinmann AS. Are You There? Genetic Variation Impacts Long-Distance Connections in Diabetes. Trends Immunol. 2020 04; 41(4):269-271. PMID: 32169284.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Papillion A, Powell MD, Chisolm DA, Bachus H, Fuller MJ, Weinmann AS, Villarino A, O'Shea JJ, León B, Oestreich KJ, Ballesteros-Tato A. Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells. Sci Immunol. 2019 09 13; 4(39). PMID: 31519812; PMCID: PMC6820141.
      Citations: 56     Fields:    Translation:AnimalsCells
    11. Chisolm DA, Cheng W, Colburn SA, Silva-Sanchez A, Meza-Perez S, Randall TD, Weinmann AS. Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses. Immunity. 2019 07 16; 51(1):155-168.e5. PMID: 31248780; PMCID: PMC6883924.
      Citations: 15     Fields:    Translation:AnimalsCells
    12. Stone SL, Peel JN, Scharer CD, Risley CA, Chisolm DA, Schultz MD, Yu B, Ballesteros-Tato A, Wojciechowski W, Mousseau B, Misra RS, Hanidu A, Jiang H, Qi Z, Boss JM, Randall TD, Brodeur SR, Goldrath AW, Weinmann AS, Rosenberg AF, Lund FE. T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-? on B Cells. Immunity. 2019 05 21; 50(5):1172-1187.e7. PMID: 31076359; PMCID: PMC6929688.
      Citations: 57     Fields:    Translation:AnimalsCells
    13. Yan Z, Yang W, Parkitny L, Gibson SA, Lee KS, Collins F, Deshane JS, Cheng W, Weinmann AS, Wei H, Qin H, Benveniste EN. Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production. JCI Insight. 2019 04 02; 5. PMID: 30939124; PMCID: PMC6538334.
      Citations: 24     Fields:    Translation:AnimalsCells
    14. Webb TJ, Weinmann AS. Defining Barriers that Impede Choices. Immunity. 2019 03 19; 50(3):542-544. PMID: 30893582.
      Citations:    Fields:    Translation:Cells
    15. Chisolm DA, Weinmann AS. Metabolites, genome organization, and cellular differentiation gene programs. Curr Opin Immunol. 2018 04; 51:62-67. PMID: 29525347; PMCID: PMC6015741.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Chisolm DA, Weinmann AS. Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation. Annu Rev Immunol. 2018 04 26; 36:221-246. PMID: 29328786.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    17. Botta D, Fuller MJ, Marquez-Lago TT, Bachus H, Bradley JE, Weinmann AS, Zajac AJ, Randall TD, Lund FE, León B, Ballesteros-Tato A. Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nat Immunol. 2017 Nov; 18(11):1249-1260. PMID: 28892471; PMCID: PMC5679073.
      Citations: 115     Fields:    Translation:AnimalsCells
    18. Chisolm DA, Savic D, Moore AJ, Ballesteros-Tato A, León B, Crossman DK, Murre C, Myers RM, Weinmann AS. CCCTC-Binding Factor Translates Interleukin 2- and a-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs. Immunity. 2017 08 15; 47(2):251-267.e7. PMID: 28813658; PMCID: PMC5654635.
      Citations: 59     Fields:    Translation:AnimalsCells
    19. Yamada K, Huang ZQ, Raska M, Reily C, Anderson JC, Suzuki H, Ueda H, Moldoveanu Z, Kiryluk K, Suzuki Y, Wyatt RJ, Tomino Y, Gharavi AG, Weinmann A, Julian BA, Willey CD, Novak J. Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy. Kidney Int Rep. 2017 Nov; 2(6):1194-1207. PMID: 29270528; PMCID: PMC5733772.
      Citations: 28     
    20. Gibson SA, Yang W, Yan Z, Liu Y, Rowse AL, Weinmann AS, Qin H, Benveniste EN. Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation. J Immunol. 2017 06 01; 198(11):4244-4254. PMID: 28468969; PMCID: PMC5512439.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    21. Hough KP, Chisolm DA, Weinmann AS. Transcriptional regulation of T cell metabolism. Mol Immunol. 2015 Dec; 68(2 Pt C):520-6. PMID: 26298576; PMCID: PMC4679508.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    22. Chisolm DA, Weinmann AS. TCR-Signaling Events in Cellular Metabolism and Specialization. Front Immunol. 2015; 6:292. PMID: 26106392; PMCID: PMC4459085.
      Citations: 11     Fields:    
    23. Oestreich KJ, Read KA, Gilbertson SE, Hough KP, McDonald PW, Krishnamoorthy V, Weinmann AS. Bcl-6 directly represses the gene program of the glycolysis pathway. Nat Immunol. 2014 Oct; 15(10):957-64. PMID: 25194422; PMCID: PMC4226759.
      Citations: 112     Fields:    Translation:AnimalsCells
    24. Smale ST, Plevy SE, Weinmann AS, Zhou L, Ramirez-Carrozzi VR, Pope SD, Bhatt DM, Tong AJ. Toward an understanding of the gene-specific and global logic of inducible gene transcription. Cold Spring Harb Symp Quant Biol. 2013; 78:61-8. PMID: 24747344.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Weinmann AS. Roles for helper T cell lineage-specifying transcription factors in cellular specialization. Adv Immunol. 2014; 124:171-206. PMID: 25175776.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Weinmann AS. Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility. Immunol Cell Biol. 2014 Jan; 92(1):34-9. PMID: 24080769.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    27. Buckingham KJ, McMillin MJ, Brassil MM, Shively KM, Magnaye KM, Cortes A, Weinmann AS, Lyons LA, Bamshad MJ. Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats. Mamm Genome. 2013 Oct; 24(9-10):400-8. PMID: 23949773; PMCID: PMC3848309.
      Citations: 25     Fields:    Translation:AnimalsCells
    28. Oestreich KJ, Weinmann AS. Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol. 2012 11; 12(11):799-804. PMID: 23059426; PMCID: PMC3584691.
      Citations: 71     Fields:    Translation:HumansCells
    29. Oestreich KJ, Mohn SE, Weinmann AS. Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol. 2012 Mar 11; 13(4):405-11. PMID: 22406686; PMCID: PMC3561768.
      Citations: 197     Fields:    Translation:AnimalsCells
    30. Oestreich KJ, Weinmann AS. Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol. 2012 Apr; 24(2):191-5. PMID: 22240120; PMCID: PMC3319510.
      Citations: 43     Fields:    Translation:AnimalsCells
    31. Oestreich KJ, Weinmann AS. Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol. 2012; 356:145-64. PMID: 21748629.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    32. Oestreich KJ, Weinmann AS. Ikaros changes the face of NuRD remodeling. Nat Immunol. 2011 Dec 16; 13(1):16-8. PMID: 22179274.
      Citations: 6     Fields:    Translation:AnimalsCells
    33. Oestreich KJ, Weinmann AS. T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol. 2012 Feb; 33(2):78-83. PMID: 22133865; PMCID: PMC3273642.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    34. Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol. 2011 May 29; 12(7):663-71. PMID: 21623380; PMCID: PMC3306165.
      Citations: 278     Fields:    Translation:AnimalsCells
    35. Oestreich KJ, Huang AC, Weinmann AS. The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med. 2011 May 09; 208(5):1001-13. PMID: 21518797; PMCID: PMC3092354.
      Citations: 91     Fields:    Translation:AnimalsCells
    36. Miller SA, Mohn SE, Weinmann AS. Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell. 2010 Nov 24; 40(4):594-605. PMID: 21095589; PMCID: PMC3032266.
      Citations: 184     Fields:    Translation:AnimalsCells
    37. Miller SA, Weinmann AS. Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev. 2010 Nov; 238(1):233-46. PMID: 20969596; PMCID: PMC2988494.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    38. Sekimata M, Pérez-Melgosa M, Miller SA, Weinmann AS, Sabo PJ, Sandstrom R, Dorschner MO, Stamatoyannopoulos JA, Wilson CB. CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity. 2009 Oct 16; 31(4):551-64. PMID: 19818655; PMCID: PMC2810421.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    39. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 2009 Oct 26; 206(11):2469-81. PMID: 19808259; PMCID: PMC2768857.
      Citations: 160     Fields:    Translation:AnimalsCells
    40. Miller SA, Weinmann AS. Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. Immunology. 2009 Mar; 126(3):306-15. PMID: 19302139; PMCID: PMC2669811.
      Citations: 23     Fields:    Translation:HumansCells
    41. Miller SA, Weinmann AS. An essential interaction between T-box proteins and histone-modifying enzymes. Epigenetics. 2009 Feb 16; 4(2):85-8. PMID: 19384057.
      Citations: 11     Fields:    Translation:HumansCells
    42. Miller SA, Huang AC, Miazgowicz MM, Brassil MM, Weinmann AS. Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev. 2008 Nov 01; 22(21):2980-93. PMID: 18981476; PMCID: PMC2577798.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    43. Lewis MD, Miller SA, Miazgowicz MM, Beima KM, Weinmann AS. T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol. 2007 Dec; 27(24):8510-21. PMID: 17923685; PMCID: PMC2169399.
      Citations: 32     Fields:    Translation:AnimalsCells
    44. Beima KM, Miazgowicz MM, Lewis MD, Yan PS, Huang TH, Weinmann AS. T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem. 2006 Apr 28; 281(17):11992-2000. PMID: 16473879.
      Citations: 70     Fields:    Translation:AnimalsCells
    45. Mehta DS, Wurster AL, Weinmann AS, Grusby MJ. NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2016-21. PMID: 15684054; PMCID: PMC548571.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    46. Weinmann AS. Novel ChIP-based strategies to uncover transcription factor target genes in the immune system. Nat Rev Immunol. 2004 May; 4(5):381-6. PMID: 15122203.
      Citations: 14     Fields:    Translation:Cells
    47. Townsend MJ, Weinmann AS, Matsuda JL, Salomon R, Farnham PJ, Biron CA, Gapin L, Glimcher LH. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 2004 Apr; 20(4):477-94. PMID: 15084276.
      Citations: 377     Fields:    Translation:AnimalsCells
    48. Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev. 2002 Jan 15; 16(2):235-44. PMID: 11799066; PMCID: PMC155318.
      Citations: 155     Fields:    Translation:HumansCells
    49. Weinmann AS, Farnham PJ. Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation. Methods. 2002 Jan; 26(1):37-47. PMID: 12054903.
      Citations: 134     Fields:    Translation:AnimalsCells
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