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Nishant Agrawal

TitleProfessor
InstitutionUniversity of Chicago
DepartmentSurgery-Ohns
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Agrawal’s lab is devoted to the study of the genetics and molecular diagnostics of head and neck cancer. The group has described the genomic landscape of head & neck squamous cell carcinoma, esophageal cancer and medullary thyroid cancer, and has developed assays using tumor DNA as a biomarker in saliva and plasma. His lab’s research is focused on the application of cancer genetics to design diagnostic approaches to reduce morbidity and mortality from head and neck cancer.


    Collapse Biography 
    Collapse education and training
    Memorial Sloan Kettering Cancer Center, New York, NYFellowship2008Head and Neck Surgical Oncology
    Johns Hopkins University, Baltimore, MDPost-doc2007Molecular Genetics
    Johns Hopkins University, Baltimore, MDResidency2007Otolaryngology-Head and Neck Surgery
    Johns Hopkins University , Baltimore, MDMD2001Medicine
    Rutgers University, New Brunswick, NJBA1997Biology
    Collapse awards and honors
    1997Marvin Harold Cheiten Award (1st in class), Rutgers University, Rutgers University
    1999Johns Hopkins University School of Medicine Scholarship, Johns Hopkins University
    2001Owsei Temkin Scholarship, Johns Hopkins University
    2001Richard Westcott Appleton Scholarship, Johns Hopkins University
    2012George T Nager Award for Excellence in Teaching, Johns Hopkins University
    2015Editorial Board, Scientific Reports
    2016 - 2017Expert Panel, Early Detection (Screening) of Oral Cancer Clinical Practice Guidelines, American Dent, ADA
    2016Reviewer (member), NIH Cancer Genetics Study Section
    2016Senior Faculty Scholar, Bucksbaum Institute for Clinical Excellence, University of Chicago
    2017AACR Team Science Award, American Association for Cancer Research, AACR
    2019Editorial Board, PLOS ONE

    Collapse Research 
    Collapse research activities and funding
         (Agrawal)Jan 1, 2018 - Mar 21, 2020
    Tata Trust, Tata Centre for Development
    Salivary DNA as a diagnostic tool in oral cavity squamous cell carcinoma
    Role: PI

    U01CA230691     (PAPADOPOULOS, NICKOLAS)Sep 19, 2018 - Aug 31, 2023
    NIH
    Earlier Detection of Cancers using Non-Plasma Based Liquid Biopsies
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gooi Z, Agrawal N. Tonsil Cancer. N Engl J Med. 2019 Jul 25; 381(4):e8. PMID: 31340096.
      View in: PubMed
    2. Saloura V, Izumchenko E, Zuo Z, Bao R, Korzinkin M, Ozerov I, Zhavoronkov A, Sidransky D, Bedi A, Hoque MO, Koeppen H, Keck MK, Khattri A, London N, Kotlov N, Fatima A, Vougiouklakis T, Nakamura Y, Lingen M, Agrawal N, Savage PA, Kron S, Kline J, Kowanetz M, Seiwert TY. Immune profiles in primary squamous cell carcinoma of the head and neck. Oral Oncol. 2019 Sep; 96:77-88. PMID: 31422218.
      View in: PubMed
    3. Ren L, Leisegang M, Deng B, Matsuda T, Kiyotani K, Kato T, Harada M, Park JH, Saloura V, Seiwert T, Vokes E, Agrawal N, Nakamura Y. Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma. Oncoimmunology. 2019; 8(4):e1568813. PMID: 30906664.
      View in: PubMed
    4. Gallia GL, Zhang M, Ning Y, Haffner MC, Batista D, Binder ZA, Bishop JA, Hann CL, Hruban RH, Ishii M, Klein AP, Reh DD, Rooper LM, Salmasi V, Tamargo RJ, Wang Q, Williamson T, Zhao T, Zou Y, Meeker AK, Agrawal N, Vogelstein B, Kinzler KW, Papadopoulos N, Bettegowda C. Genomic analysis identifies frequent deletions of Dystrophin in olfactory neuroblastoma. Nat Commun. 2018 12 21; 9(1):5410. PMID: 30575736.
      View in: PubMed
    5. Yan K, Agrawal N, Gooi Z. Head and Neck Masses. Med Clin North Am. 2018 Nov; 102(6):1013-1025. PMID: 30342605.
      View in: PubMed
    6. Trinh G, Rettig E, Noureldine SI, Russell JO, Agrawal N, Mathur A, Prescott JD, Zeiger MA, Tufano RP. Surgical Management of Normocalcemic Primary Hyperparathyroidism and the Impact of Intraoperative Parathyroid Hormone Testing on Outcome. Otolaryngol Head Neck Surg. 2018 10; 159(4):630-637. PMID: 30105919.
      View in: PubMed
    7. Chan JYK, Zhen G, Agrawal N. The role of tumor DNA as a diagnostic tool for head and neck squamous cell carcinoma. Semin Cancer Biol. 2019 04; 55:1-7. PMID: 30082187.
      View in: PubMed
    8. Rettig EM, Bishop JA, Agrawal N, Chung CH, Sharma R, Zamuner F, Li RJ, Koch WM, Califano JA, Guo T, Gaykalova DA, Fakhry C. HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma. Oral Oncol. 2018 07; 82:168-175. PMID: 29909892.
      View in: PubMed
    9. Foster CC, Melotek JM, Brisson RJ, Seiwert TY, Cohen EEW, Stenson KM, Blair EA, Portugal L, Gooi Z, Agrawal N, Vokes EE, Haraf DJ. Definitive chemoradiation for locally-advanced oral cavity cancer: A 20-year experience. Oral Oncol. 2018 05; 80:16-22. PMID: 29706184.
      View in: PubMed
    10. Fundakowski CE, Hales NW, Agrawal N, Barczynski M, Camacho PM, Hartl DM, Kandil E, Liddy WE, McKenzie TJ, Morris JC, Ridge JA, Schneider R, Serpell J, Sinclair CF, Snyder SK, Terris DJ, Tuttle RM, Wu CW, Wong RJ, Zafereo M, Randolph GW. Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement. Head Neck. 2018 04; 40(4):663-675. PMID: 29461666.
      View in: PubMed
    11. Yan K, Yesensky J, Hasina R, Agrawal N. Genomics of mucoepidermoid and adenoid cystic carcinomas. Laryngoscope Investig Otolaryngol. 2018 02; 3(1):56-61. PMID: 29492469.
      View in: PubMed
    12. Yesensky JA, Hasina R, Wroblewski KE, Bellairs J, Gooi Z, Saloura V, Cipriani NA, Vokes EE, Portugal LG, Seiwert TY, Blair ED, Agrawal N. Role of dental hardware in oral cavity squamous cell carcinoma in the low-risk nonsmoker nondrinker population. Head Neck. 2018 04; 40(4):784-792. PMID: 29356169.
      View in: PubMed
    13. Ren L, Matsuda T, Deng B, Kiyotani K, Kato T, Park JH, Seiwert TY, Vokes EE, Agrawal N, Nakamura Y. Similarity and difference in tumor-infiltrating lymphocytes in original tumor tissues and those of in vitro expanded populations in head and neck cancer. Oncotarget. 2018 Jan 09; 9(3):3805-3814. PMID: 29423084.
      View in: PubMed
    14. Lingen MW, Tampi MP, Urquhart O, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D'Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Banfield L, Carrasco-Labra A. Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association. J Am Dent Assoc. 2017 11; 148(11):797-813.e52. PMID: 29080605.
      View in: PubMed
    15. Lingen MW, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D'Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Tampi MP, Urquhart O, Banfield L, Carrasco-Labra A. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: A report of the American Dental Association. J Am Dent Assoc. 2017 10; 148(10):712-727.e10. PMID: 28958308.
      View in: PubMed
    16. Faden DL, Thomas S, Cantalupo PG, Agrawal N, Myers J, DeRisi J. Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma. Oral Oncol. 2017 11; 74:8-14. PMID: 29103756.
      View in: PubMed
    17. Bellairs JA, Hasina R, Agrawal N. Tumor DNA: an emerging biomarker in head and neck cancer. Cancer Metastasis Rev. 2017 09; 36(3):515-523. PMID: 28801876.
      View in: PubMed
    18. Yesensky J, Agrawal N, Bayan S, Blair E, Portugal L, Chan J, Goldenberg D, Gooi Z. AHNS Series - Do you know your guidelines? Principles of treatment for glottic cancer: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2017 09; 39(9):1729-1732. PMID: 28653453.
      View in: PubMed
    19. Agrawal N, Evasovich MR, Kandil E, Noureldine SI, Felger EA, Tufano RP, Kraus DH, Orloff LA, Grogan R, Angelos P, Stack BC, McIver B, Randolph GW. Indications and extent of central neck dissection for papillary thyroid cancer: An American Head and Neck Society Consensus Statement. Head Neck. 2017 07; 39(7):1269-1279. PMID: 28449244.
      View in: PubMed
    20. Marur S, Li S, Cmelak AJ, Gillison ML, Zhao WJ, Ferris RL, Westra WH, Gilbert J, Bauman JE, Wagner LI, Trevarthen DR, Balkrishna J, Murphy BA, Agrawal N, Colevas AD, Chung CH, Burtness B. E1308: Phase II Trial of Induction Chemotherapy Followed by Reduced-Dose Radiation and Weekly Cetuximab in Patients With HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx- ECOG-ACRIN Cancer Research Group. J Clin Oncol. 2017 Feb 10; 35(5):490-497. PMID: 28029303.
      View in: PubMed
    21. Chan JY, Gooi Z, Mydlarz WK, Agrawal N. Risk of thyroid malignancy following an index head and neck squamous cell carcinoma: A population-based study. Ear Nose Throat J. 2016 Dec; 95(12):E7-E11. PMID: 27929600.
      View in: PubMed
    22. Gooi Z, Richmon J, Agrawal N, Blair E, Portugal L, Vokes E, Seiwert T, de Souza J, Saloura V, Haraf D, Goldenberg D, Chan J. AHNS Series - Do you know your guidelines? Principles of treatment for nasopharyngeal cancer: A review of the National Comprehensive Cancer Network guidelines. Head Neck. 2017 02; 39(2):201-205. PMID: 27898198.
      View in: PubMed
    23. Trinh G, Noureldine SI, Russell JO, Agrawal N, Lopez M, Prescott JD, Zeiger MA, Tufano RP. Characterizing the operative findings and utility of intraoperative parathyroid hormone (IOPTH) monitoring in patients with normal baseline IOPTH and normohormonal primary hyperparathyroidism. Surgery. 2017 01; 161(1):78-86. PMID: 27863787.
      View in: PubMed
    24. Azene E, Mitchell S, Radvany M, Agrawal N, Eisele D, Weiss C. Foamed bleomycin sclerosis of airway venous malformations: The role of interspecialty collaboration. Laryngoscope. 2016 12; 126(12):2726-2732. PMID: 27437862.
      View in: PubMed
    25. Noureldine SI, Najafian A, Aragon Han P, Olson MT, Genther DJ, Schneider EB, Prescott JD, Agrawal N, Mathur A, Zeiger MA, Tufano RP. Evaluation of the Effect of Diagnostic Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2016 07 01; 142(7):676-82. PMID: 27196108.
      View in: PubMed
    26. Abt NB, Richmon JD, Koch WM, Eisele DW, Agrawal N. Assessment of the Predictive Value of the Modified Frailty Index for Clavien-Dindo Grade IV Critical Care Complications in Major Head and Neck Cancer Operations. JAMA Otolaryngol Head Neck Surg. 2016 07 01; 142(7):658-64. PMID: 27258927.
      View in: PubMed
    27. Kang H, Tan M, Bishop JA, Jones S, Sausen M, Ha PK, Agrawal N. Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma. Clin Cancer Res. 2017 Jan 01; 23(1):283-288. PMID: 27340278.
      View in: PubMed
    28. Al-Saraf A, Yassan L, Cipriani NA, Agrawal N, Chang P, Ginat DT. Desmoid-Type Fibromatosis of the Tongue. Head Neck Pathol. 2016 Dec; 10(4):527-529. PMID: 27091208.
      View in: PubMed
    29. Taghipour M, Sheikhbahaei S, Wray R, Agrawal N, Richmon J, Kang H, Subramaniam RM. FDG PET/CT in Patients With Head and Neck Squamous Cell Carcinoma After Primary Surgical Resection With or Without Chemoradiation Therapy. AJR Am J Roentgenol. 2016 May; 206(5):1093-100. PMID: 26999264.
      View in: PubMed
    30. Rettig EM, Talbot CC, Sausen M, Jones S, Bishop JA, Wood LD, Tokheim C, Niknafs N, Karchin R, Fertig EJ, Wheelan SJ, Marchionni L, Considine M, Ling S, Fakhry C, Papadopoulos N, Kinzler KW, Vogelstein B, Ha PK, Agrawal N. Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prev Res (Phila). 2016 04; 9(4):265-74. PMID: 26862087.
      View in: PubMed
    31. Yang W, McNutt TR, Dudley SA, Kumar R, Starmer HM, Gourin CG, Moore JA, Evans K, Allen M, Agrawal N, Richmon JD, Chung CH, Quon H. Predictive Factors for Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement and Use in Head and Neck Patients Following Intensity-Modulated Radiation Therapy (IMRT) Treatment: Concordance, Discrepancies, and the Role of Gabapentin. Dysphagia. 2016 Apr; 31(2):206-13. PMID: 26753929.
      View in: PubMed
    32. Kiess AP, Agrawal N, Brierley JD, Duvvuri U, Ferris RL, Genden E, Wong RJ, Tuttle RM, Lee NY, Randolph GW. External-beam radiotherapy for differentiated thyroid cancer locoregional control: A statement of the American Head and Neck Society. Head Neck. 2016 Apr; 38(4):493-8. PMID: 26716601.
      View in: PubMed
    33. Fakhry C, Qualliotine JR, Zhang Z, Agrawal N, Gaykalova DA, Bishop JA, Subramaniam RM, Koch WM, Chung CH, Eisele DW, Califano J, Viscidi RP. Serum Antibodies to HPV16 Early Proteins Warrant Investigation as Potential Biomarkers for Risk Stratification and Recurrence of HPV-Associated Oropharyngeal Cancer. Cancer Prev Res (Phila). 2016 Feb; 9(2):135-41. PMID: 26701665.
      View in: PubMed
    34. Clark JH, Feng AL, Morton K, Agrawal N, Richmon JD. Neck Incision Planning for Total Laryngectomy with Pharyngectomy. Otolaryngol Head Neck Surg. 2016 Apr; 154(4):650-6. PMID: 26671904.
      View in: PubMed
    35. Vokes EE, Agrawal N, Seiwert TY. HPV-Associated Head and Neck Cancer. J Natl Cancer Inst. 2015 Dec; 107(12):djv344. PMID: 26656751.
      View in: PubMed
    36. Noureldine SI, Olson MT, Agrawal N, Prescott JD, Zeiger MA, Tufano RP. Effect of Gene Expression Classifier Molecular Testing on the Surgical Decision-Making Process for Patients With Thyroid Nodules. JAMA Otolaryngol Head Neck Surg. 2015 Dec; 141(12):1082-8. PMID: 26606459.
      View in: PubMed
    37. Joseph AW, Guo T, Hur K, Xie Y, Yin L, Califano JA, Ha PK, Quon H, Richmon JD, Eisele DW, Agrawal N, Fakhry C. Disease-free survival after salvage therapy for recurrent oropharyngeal squamous cell carcinoma. Head Neck. 2016 04; 38 Suppl 1:E1501-9. PMID: 26558328.
      View in: PubMed
    38. Feng AL, Clark JH, Agrawal N, Moussa W, Richmon JD. Neck incision planning for total laryngectomy: A finite element analysis. J Biomech. 2015 Nov 26; 48(15):4149-54. PMID: 26556716.
      View in: PubMed
    39. Izumchenko E, Chang X, Brait M, Fertig E, Kagohara LT, Bedi A, Marchionni L, Agrawal N, Ravi R, Jones S, Hoque MO, Westra WH, Sidransky D. Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA. Nat Commun. 2015 Sep 16; 6:8258. PMID: 26374070.
      View in: PubMed
    40. Chan JY, Gooi Z, Mydlarz WK, Agrawal N. Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population-based study. Head Neck. 2016 04; 38 Suppl 1:E1130-6. PMID: 26314805.
      View in: PubMed
    41. Baxter M, Chan JY, Mydlarz WK, Labruzzo SV, Kiess A, Ha PK, Aygun N, Agrawal N. Retropharyngeal lymph node involvement in human papillomavirus-associated oropharyngeal squamous cell carcinoma. Laryngoscope. 2015 Nov; 125(11):2503-8. PMID: 26227748.
      View in: PubMed
    42. Wang Y, Springer S, Zhang M, McMahon KW, Kinde I, Dobbyn L, Ptak J, Brem H, Chaichana K, Gallia GL, Gokaslan ZL, Groves ML, Jallo GI, Lim M, Olivi A, Quinones-Hinojosa A, Rigamonti D, Riggins GJ, Sciubba DM, Weingart JD, Wolinsky JP, Ye X, Oba-Shinjo SM, Marie SK, Holdhoff M, Agrawal N, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Bettegowda C. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):9704-9. PMID: 26195750.
      View in: PubMed
    43. Wang Y, Springer S, Mulvey CL, Silliman N, Schaefer J, Sausen M, James N, Rettig EM, Guo T, Pickering CR, Bishop JA, Chung CH, Califano JA, Eisele DW, Fakhry C, Gourin CG, Ha PK, Kang H, Kiess A, Koch WM, Myers JN, Quon H, Richmon JD, Sidransky D, Tufano RP, Westra WH, Bettegowda C, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Agrawal N. Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas. Sci Transl Med. 2015 Jun 24; 7(293):293ra104. PMID: 26109104.
      View in: PubMed
    44. Fakhry C, Andersen KK, Christensen J, Agrawal N, Eisele DW. The Impact of Tonsillectomy upon the Risk of Oropharyngeal Carcinoma Diagnosis and Prognosis in the Danish Cancer Registry. Cancer Prev Res (Phila). 2015 Jul; 8(7):583-9. PMID: 25896236.
      View in: PubMed
    45. Guo T, Qualliotine JR, Ha PK, Califano JA, Kim Y, Saunders JR, Blanco RG, D'Souza G, Zhang Z, Chung CH, Kiess A, Gourin CG, Koch W, Richmon JD, Agrawal N, Eisele DW, Fakhry C. Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer. Cancer. 2015 Jun 15; 121(12):1977-84. PMID: 25782027.
      View in: PubMed
    46. Hayashi M, Wu G, Roh JL, Chang X, Li X, Ahn J, Goldsmith M, Khan Z, Bishop J, Zhang Z, Zhou XC, Richmon J, Agrawal N, Koch WM. Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma. Cancer. 2015 Jun 15; 121(12):1957-65. PMID: 25773145.
      View in: PubMed
    47. Rettig EM, Chung CH, Bishop JA, Howard JD, Sharma R, Li RJ, Douville C, Karchin R, Izumchenko E, Sidransky D, Koch W, Califano J, Agrawal N, Fakhry C. Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features. Cancer Prev Res (Phila). 2015 Apr; 8(4):287-95. PMID: 25633867.
      View in: PubMed
    48. Ozgursoy OB, Vuica-Ross M, Agrawal N. Rapidly enlarging midline neck mass. Diffuse large B-cell lymphoma of the thyroid gland. JAMA Otolaryngol Head Neck Surg. 2015 Jan; 141(1):85-6. PMID: 25356784.
      View in: PubMed
    49. Califano JA, Khan Z, Noonan KA, Rudraraju L, Zhang Z, Wang H, Goodman S, Gourin CG, Ha PK, Fakhry C, Saunders J, Levine M, Tang M, Neuner G, Richmon JD, Blanco R, Agrawal N, Koch WM, Marur S, Weed DT, Serafini P, Borrello I. Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma. Clin Cancer Res. 2015 Jan 01; 21(1):30-8. PMID: 25564570.
      View in: PubMed
    50. Izumchenko E, Sun K, Jones S, Brait M, Agrawal N, Koch W, McCord CL, Riley DR, Angiuoli SV, Velculescu VE, Jiang WW, Sidransky D. Notch1 mutations are drivers of oral tumorigenesis. Cancer Prev Res (Phila). 2015 Apr; 8(4):277-286. PMID: 25406187.
      View in: PubMed
    51. Noureldine SI, Genther DJ, Lopez M, Agrawal N, Tufano RP. Early predictors of hypocalcemia after total thyroidectomy: an analysis of 304 patients using a short-stay monitoring protocol. JAMA Otolaryngol Head Neck Surg. 2014 Nov; 140(11):1006-13. PMID: 25321339.
      View in: PubMed
    52. Li R, Faden DL, Fakhry C, Langelier C, Jiao Y, Wang Y, Wilkerson MD, Pedamallu CS, Old M, Lang J, Loyo M, Ahn SM, Tan M, Gooi Z, Chan J, Richmon J, Wood LD, Hruban RH, Bishop J, Westra WH, Chung CH, Califano J, Gourin CG, Bettegowda C, Meyerson M, Papadopoulos N, Kinzler KW, Vogelstein B, DeRisi JL, Koch WM, Agrawal N. Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck. 2015 Nov; 37(11):1642-9. PMID: 24954188.
      View in: PubMed
    53. Fakhry C, Agrawal N, Califano J, Messing B, Liu J, Saunders J, Ha P, Coquia S, Hamper U, Gillison M, Blanco R. The use of ultrasound in the search for the primary site of unknown primary head and neck squamous cell cancers. Oral Oncol. 2014 Jul; 50(7):640-5. PMID: 24819862.
      View in: PubMed
    54. Guerrero-Preston R, Michailidi C, Marchionni L, Pickering CR, Frederick MJ, Myers JN, Yegnasubramanian S, Hadar T, Noordhuis MG, Zizkova V, Fertig E, Agrawal N, Westra W, Koch W, Califano J, Velculescu VE, Sidransky D. Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer. Epigenetics. 2014 Jul; 9(7):1031-46. PMID: 24786473.
      View in: PubMed
    55. Khan AS, Dwivedi RC, Sheikh Z, Khan S, Dwivedi RC, Kanwar N, Agrawal N, Ui Hassan MS, Kazi R, Rhys-Evans P. Systematic review of carcinoma arising in pharyngeal diverticula: a 112-year analysis. Head Neck. 2014 Sep; 36(9):1368-75. PMID: 23996210.
      View in: PubMed
    56. Smith DF, Maleki Z, Coughlan D, Gooi Z, Akpeng B, Ogawa T, Bishop JA, Frick KD, Agrawal N, Gourin CG, Ha PK, Koch WM, Richmon JD, Westra WH, Pai SI. Human papillomavirus status of head and neck cancer as determined in cytologic specimens using the hybrid-capture 2 assay. Oral Oncol. 2014 Jun; 50(6):600-4. PMID: 24630260.
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    57. Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 Feb 19; 6(224):224ra24. PMID: 24553385.
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    58. Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, Loyo M, Agrawal N, Howard J, Li R, Ahn S, Fertig E, Sidransky D, Houghton J, Buddavarapu K, Sanford T, Choudhary A, Darden W, Adai A, Latham G, Bishop J, Sharma R, Westra WH, Hennessey P, Chung CH, Califano JA. Activation of the NOTCH pathway in head and neck cancer. Cancer Res. 2014 Feb 15; 74(4):1091-104. PMID: 24351288.
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    59. Jara SM, Carson KA, Pai SI, Agrawal N, Richmon JD, Prescott JD, Dackiw A, Zeiger MA, Bishop JA, Tufano RP. The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 2013 Dec; 154(6):1272-80; discussion 1280-2. PMID: 24238047.
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    60. Tan M, Myers JN, Agrawal N. Oral cavity and oropharyngeal squamous cell carcinoma genomics. Otolaryngol Clin North Am. 2013 Aug; 46(4):545-66. PMID: 23910469.
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    61. Bettegowda C, Agrawal N, Jiao Y, Wang Y, Wood LD, Rodriguez FJ, Hruban RH, Gallia GL, Binder ZA, Riggins CJ, Salmasi V, Riggins GJ, Reitman ZJ, Rasheed A, Keir S, Shinjo S, Marie S, McLendon R, Jallo G, Vogelstein B, Bigner D, Yan H, Kinzler KW, Papadopoulos N. Exomic sequencing of four rare central nervous system tumor types. Oncotarget. 2013 Apr; 4(4):572-83. PMID: 23592488.
      View in: PubMed
    62. Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IeM, Kurman R, Dao F, Levine DA, Giuntoli R, Roden R, Eshleman JR, Carvalho JP, Marie SK, Papadopoulos N, Kinzler KW, Vogelstein B, Diaz LA. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med. 2013 Jan 09; 5(167):167ra4. PMID: 23303603.
      View in: PubMed
    63. Agrawal N, Jiao Y, Sausen M, Leary R, Bettegowda C, Roberts NJ, Bhan S, Ho AS, Khan Z, Bishop J, Westra WH, Wood LD, Hruban RH, Tufano RP, Robinson B, Dralle H, Toledo SP, Toledo RA, Morris LG, Ghossein RA, Fagin JA, Chan TA, Velculescu VE, Vogelstein B, Kinzler KW, Papadopoulos N, Nelkin BD, Ball DW. Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. J Clin Endocrinol Metab. 2013 Feb; 98(2):E364-9. PMID: 23264394.
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    64. Paidpally V, Chirindel A, Lam S, Agrawal N, Quon H, Subramaniam RM. FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma. Imaging Med. 2012 Dec; 4(6):633-647. PMID: 23482696.
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    65. Chan JY, Sanguineti G, Richmon JD, Marur S, Gourin CG, Koch W, Chung CH, Quon H, Bishop JA, Aygun N, Agrawal N. Retrospective review of positron emission tomography with contrast-enhanced computed tomography in the posttreatment setting in human papillomavirus-associated oropharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2012 Nov; 138(11):1040-6. PMID: 23165378.
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    66. Loyo M, Li RJ, Bettegowda C, Pickering CR, Frederick MJ, Myers JN, Agrawal N. Lessons learned from next-generation sequencing in head and neck cancer. Head Neck. 2013 Mar; 35(3):454-63. PMID: 22907887.
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    67. Agrawal N, Jiao Y, Bettegowda C, Hutfless SM, Wang Y, David S, Cheng Y, Twaddell WS, Latt NL, Shin EJ, Wang LD, Wang L, Yang W, Velculescu VE, Vogelstein B, Papadopoulos N, Kinzler KW, Meltzer SJ. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov. 2012 Oct; 2(10):899-905. PMID: 22877736.
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    68. Jiao Y, Killela PJ, Reitman ZJ, Rasheed AB, Heaphy CM, de Wilde RF, Rodriguez FJ, Rosemberg S, Oba-Shinjo SM, Nagahashi Marie SK, Bettegowda C, Agrawal N, Lipp E, Pirozzi C, Lopez G, He Y, Friedman H, Friedman AH, Riggins GJ, Holdhoff M, Burger P, McLendon R, Bigner DD, Vogelstein B, Meeker AK, Kinzler KW, Papadopoulos N, Diaz LA, Yan H. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget. 2012 Jul; 3(7):709-22. PMID: 22869205.
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    69. Bettegowda C, Papadopoulos N, Agrawal N. Mapping genes for oligodendroglioma. Per Med. 2012 May; 9(3):311-313. PMID: 29758792.
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    70. Sanguineti G, Ricchetti F, Wu B, Agrawal N, Gourin C, Agbahiwe H, Marur S, Clemente S, McNutt T, Forastiere A. Volumetric change of human papillomavirus-related neck lymph nodes before, during, and shortly after intensity-modulated radiation therapy. Head Neck. 2012 Nov; 34(11):1640-7. PMID: 22267196.
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    71. Richmon JD, Agrawal N, Pattani KM. Implementation of a TORS program in an academic medical center. Laryngoscope. 2011 Nov; 121(11):2344-8. PMID: 21993984.
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    72. Xing JC, Bishop JA, Mathioudakis N, Agrawal N, Tufano RP. A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinement. Case Rep Med. 2011; 2011:583978. PMID: 21912554.
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    73. Wu G, Pai SI, Agrawal N, Richmon J, Dackiw A, Tufano RP. Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery. Otolaryngol Head Neck Surg. 2011 Nov; 145(5):727-31. PMID: 21860058.
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    74. Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, Yan H, Papadopoulos N, Kinzler KW. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science. 2011 Sep 09; 333(6048):1453-5. PMID: 21817013.
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    75. Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug 26; 333(6046):1154-7. PMID: 21798897.
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    76. Starmer HM, Agrawal N, Koch W, Richmon J, Webster K, Gourin CG. Does prosthesis diameter matter? The relationship between voice prosthesis diameter and complications. Otolaryngol Head Neck Surg. 2011 May; 144(5):740-6. PMID: 21493364.
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    77. Dwivedi RC, Kazi R, Agrawal N, Chisholm E, St Rose S, Elmiyeh B, Rennie C, Pepper C, Clarke PM, Kerawala CJ, Rhys-Evans PH, Harrington KJ, Nutting CM. Comprehensive review of small bowel metastasis from head and neck squamous cell carcinoma. Oral Oncol. 2010 May; 46(5):330-5. PMID: 20189444.
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    78. Durr ML, Agrawal N, Saunders JR, Ha PK. Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review. Ear Nose Throat J. 2010 Jan; 89(1):34-7. PMID: 20155698.
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    79. Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Aggrawal N, Hester L, Doré S, Snyder SH, Sawa A. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009 Jul 16; 63(1):81-91. PMID: 19607794.
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    80. Agrawal N, Goldenberg D. Primary and salvage total laryngectomy. Otolaryngol Clin North Am. 2008 Aug; 41(4):771-80, vii. PMID: 18570958.
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    81. Agrawal N, Ha PK. Management of early-stage laryngeal cancer. Otolaryngol Clin North Am. 2008 Aug; 41(4):757-69, vi-vii. PMID: 18570957.
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    82. Miller NR, Agrawal N, Sciubba JJ, Lane AP. Image-guided transnasal endoscopic resection of an orbital solitary fibrous tumor. Ophthalmic Plast Reconstr Surg. 2008 Jan-Feb; 24(1):65-7. PMID: 18209653.
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    83. Farrag TY, Agrawal N, Sheth S, Bettegowda C, Ewertz M, Kim M, Tufano RP. Algorithm for safe and effective reoperative thyroid bed surgery for recurrent/persistent papillary thyroid carcinoma. Head Neck. 2007 Dec; 29(12):1069-74. PMID: 17563908.
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    84. Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One. 2007 Oct 10; 2(10):e1007. PMID: 17925855.
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    85. Diehl F, Schmidt K, Choti MA, Romans K, Goodman S, Li M, Thornton K, Agrawal N, Sokoll L, Szabo SA, Kinzler KW, Vogelstein B, Diaz LA. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008 Sep; 14(9):985-90. PMID: 18670422.
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    86. Farrag TY, Boahene KD, Agrawal N, Turner L, Byrne PJ, Earnest L, Koch WM, Tufano RP. Use of fibrin sealant in closing mucocutaneous fistulas following head and neck cancer surgery. Otolaryngol Head Neck Surg. 2007 Jul; 137(1):159-61. PMID: 17599585.
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    87. Diaz LA, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, Garrett-Mayer E, Kobrin B, Pomper M, Zhou S, Kinzler KW, Vogelstein B, Huso DL. Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicol Sci. 2005 Dec; 88(2):562-75. PMID: 16162850.
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    88. Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron. 2005 Jul 07; 47(1):29-41. PMID: 15996546.
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    89. Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol. 2005 Jul; 7(7):665-74. PMID: 15951807.
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    90. Bettegowda C, Foss CA, Cheong I, Wang Y, Diaz L, Agrawal N, Fox J, Dick J, Dang LH, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1145-50. PMID: 15653773.
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    91. Nanda A, Buckhaults P, Seaman S, Agrawal N, Boutin P, Shankara S, Nacht M, Teicher B, Stampfl J, Singh S, Vogelstein B, Kinzler KW, St Croix B. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res. 2004 Dec 01; 64(23):8507-11. PMID: 15574754.
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    92. Agrawal N, Bettegowda C, Cheong I, Geschwind JF, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, Vogelstein B. Bacteriolytic therapy can generate a potent immune response against experimental tumors. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15172-7. PMID: 15471990.
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    93. Dang LH, Bettegowda C, Agrawal N, Cheong I, Huso D, Frost P, Loganzo F, Greenberger L, Barkoczy J, Pettit GR, Smith AB, Gurulingappa H, Khan S, Parmigiani G, Kinzler KW, Zhou S, Vogelstein B. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents. Cancer Biol Ther. 2004 Mar; 3(3):326-37. PMID: 14739784.
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    94. Zhou S, Bettegowda C, Agrawal N. Combination bacteriolytic cancer therapy: Attacking cancer from inside out. Discov Med. 2004 Feb; 4(20):33-7. PMID: 20705017.
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    95. Bettegowda C, Dang LH, Abrams R, Huso DL, Dillehay L, Cheong I, Agrawal N, Borzillary S, McCaffery JM, Watson EL, Lin KS, Bunz F, Baidoo K, Pomper MG, Kinzler KW, Vogelstein B, Zhou S. Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15083-8. PMID: 14657371.
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    96. Agrawal N, Sewell DA, Griswold ME, Frank SM, Hessel TW, Eisele DW. Hypothermia during head and neck surgery. Laryngoscope. 2003 Aug; 113(8):1278-82. PMID: 12897545.
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