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Dario De Jesus

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Genetic Medicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Gonzales VS, Tsuji T, Wei S, Blüher M, Tseng YH, He C, Kulkarni RN. Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism. Nat Commun. 2025 Jan 09; 16(1):533. PMID: 39788955; PMCID: PMC11718074.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, Pirouz M, Gregory RI, He C, Kulkarni RN. m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Nov; 43(22):5445-5468. PMID: 39322760; PMCID: PMC11574190.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN. m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1. Cell Metab. 2024 Oct 01; 36(10):2207-2227.e9. PMID: 39255799; PMCID: PMC11891809.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Sabadell-Basallote J, Astiarraga B, Castaño C, Ejarque M, Repollés-de-Dalmau M, Quesada I, Blanco J, Núñez-Roa C, Rodríguez-Peña MM, Martínez L, De Jesus DF, Marroquí L, Bosch R, Montanya E, Sureda FX, Tura A, Mari A, Kulkarni RN, Vendrell J, Fernández-Veledo S. SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes. J Clin Invest. 2024 May 07; 134(12). PMID: 38713514; PMCID: PMC11178533.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN. Redox regulation of m6A methyltransferase METTL3 in ß-cells controls the innate immune response in type 1 diabetes. Nat Cell Biol. 2024 Mar; 26(3):421-437. PMID: 38409327; PMCID: PMC11042681.
      Citations: 15     Fields:    
    6. Kahraman S, Shibue K, De Jesus DF, Kim H, Hu J, Manna D, Wagner B, Choudhary A, Kulkarni RN. Fluorescein-based sensors to purify human a-cells for functional and transcriptomic analyses. Elife. 2023 Sep 21; 12. PMID: 37732504; PMCID: PMC10567109.
      Citations:    Fields:    Translation:HumansCells
    7. Kahraman S, De Jesus DF, Wei J, Brown NK, Zou Z, Hu J, He C, Kulkarni RN. m 6 A mRNA Methylation Regulates Early Pancreatic ß-Cell Differentiation. bioRxiv. 2023 Aug 03. PMID: 37577492; PMCID: PMC10418275.
      Citations:    
    8. St-Louis JL, El Jellas K, Velasco K, Slipp BA, Hu J, Helgeland G, Steine SJ, De Jesus DF, Kulkarni RN, Molven A. Deficiency of the metabolic enzyme SCHAD in pancreatic ß-cells promotes amino acid-sensitive hypoglycemia. J Biol Chem. 2023 08; 299(8):104986. PMID: 37392854; PMCID: PMC10407745.
      Citations:    Fields:    Translation:AnimalsCells
    9. De Jesus DF, Kimura T, Gupta MK, Kulkarni RN. NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes. Cell Chem Biol. 2023 09 21; 30(9):1144-1155.e4. PMID: 37354909; PMCID: PMC10529627.
      Citations:    Fields:    Translation:HumansCells
    10. Basile G, Vetere A, Hu J, Ijaduola O, Zhang Y, Liu KC, Eltony AM, De Jesus DF, Fukuda K, Doherty G, Leech CA, Chepurny OG, Holz GG, Yun SH, Andersson O, Choudhary A, Wagner BK, Kulkarni RN. Excess pancreatic elastase alters acinar-ß cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 2023 07 11; 35(7):1242-1260.e9. PMID: 37339634; PMCID: PMC10834355.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN. m 6 A mRNA Methylation in Brown Adipose Tissue Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis. bioRxiv. 2023 May 26. PMID: 37292780; PMCID: PMC10245942.
      Citations:    
    12. De Jesus DF, Zhang Z, Brown NK, Li X, Gaffrey MJ, Kahraman S, Wei J, Hu J, Basile G, Xiao L, Rana TM, Mathews C, Powers AC, Atkinson MA, Eizirik DL, Dhe-Paganon S, Parent AV, Qian WJ, He C, Kulkarni RN. Redox Regulation of m 6 A Methyltransferase METTL3 in Human ß-cells Controls the Innate Immune Response in Type 1 Diabetes. bioRxiv. 2023 Feb 16. PMID: 36824909; PMCID: PMC9948953.
      Citations:    
    13. Wang X, Li Y, Qiang G, Wang K, Dai J, McCann M, Munoz MD, Gil V, Yu Y, Li S, Yang Z, Xu S, Cordoba-Chacon J, De Jesus DF, Sun B, Chen K, Wang Y, Liu X, Miao Q, Zhou L, Hu R, Ding Q, Kulkarni RN, Gao D, Blüher M, Liew CW. Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. Nat Commun. 2022 11 28; 13(1):7323. PMID: 36443308; PMCID: PMC9705309.
      Citations: 7     Fields:    Translation:HumansAnimals
    14. Shirakawa J, Togashi Y, Basile G, Okuyama T, Inoue R, Fernandez M, Kyohara M, De Jesus DF, Goto N, Zhang W, Tsuno T, Kin T, Pan H, Dreyfuss JM, Shapiro AMJ, Yi P, Terauchi Y, Kulkarni RN. E2F1 transcription factor mediates a link between fat and islets to promote ß cell proliferation in response to acute insulin resistance. Cell Rep. 2022 10 04; 41(1):111436. PMID: 36198264; PMCID: PMC9617565.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    15. Patel SJ, Liu N, Piaker S, Gulko A, Andrade ML, Heyward FD, Sermersheim T, Edinger N, Srinivasan H, Emont MP, Westcott GP, Luther J, Chung RT, Yan S, Kumari M, Thomas R, Deleye Y, Tchernof A, White PJ, Baselli GA, Meroni M, De Jesus DF, Ahmad R, Kulkarni RN, Valenti L, Tsai L, Rosen ED. Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. Sci Transl Med. 2022 03 23; 14(637):eabh3831. PMID: 35320000; PMCID: PMC9162056.
      Citations: 18     Fields:    Translation:Animals
    16. De Jesus DF, Orime K, Kaminska D, Kimura T, Basile G, Wang CH, Haertle L, Riemens R, Brown NK, Hu J, Männistö V, Silva AM, Dirice E, Tseng YH, Haaf T, Pihlajamäki J, Kulkarni RN. Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. J Clin Invest. 2020 05 01; 130(5):2391-2407. PMID: 32250344; PMCID: PMC7190992.
      Citations: 31     Fields:    Translation:Animals
    17. De Jesus DF, Kulkarni RN. More is better: combinatorial therapy to restore ß-cell function in diabetes. Nat Metab. 2020 02; 2(2):130-131. PMID: 32694691.
      Citations: 2     Fields:    
    18. Shirakawa J, Tajima K, Okuyama T, Kyohara M, Togashi Y, De Jesus DF, Basile G, Kin T, Shapiro AMJ, Kulkarni RN, Terauchi Y. Luseogliflozin increases beta cell proliferation through humoral factors that activate an insulin receptor- and IGF-1 receptor-independent pathway. Diabetologia. 2020 03; 63(3):577-587. PMID: 31897526; PMCID: PMC7574158.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    19. Zhang Z, Zhan Q, Eckert M, Zhu A, Chryplewicz A, De Jesus DF, Ren D, Kulkarni RN, Lengyel E, He C, Chen M. RADAR: differential analysis of MeRIP-seq data with a random effect model. Genome Biol. 2019 12 23; 20(1):294. PMID: 31870409; PMCID: PMC6927177.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    20. De Jesus DF, Kulkarni RN. "Omics" and "epi-omics" underlying the ß-cell adaptation to insulin resistance. Mol Metab. 2019 09; 27S:S42-S48. PMID: 31500830; PMCID: PMC6768500.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    21. De Jesus DF, Zhang Z, Kahraman S, Brown NK, Chen M, Hu J, Gupta MK, He C, Kulkarni RN. m6A mRNA Methylation Regulates Human ß-Cell Biology in Physiological States and in Type 2 Diabetes. Nat Metab. 2019 08; 1(8):765-774. PMID: 31867565; PMCID: PMC6924515.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    22. Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased ß-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 05; 1(5):509-518. PMID: 31423480; PMCID: PMC6696912.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    23. Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Human duct cells contribute to ß cell compensation in insulin resistance. JCI Insight. 2019 04 18; 4(8). PMID: 30996131; PMCID: PMC6538348.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    24. Jungtrakoon P, Shirakawa J, Buranasupkajorn P, Gupta MK, De Jesus DF, Pezzolesi MG, Panya A, Hastings T, Chanprasert C, Mendonca C, Kulkarni RN, Doria A. Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes. Diabetes. 2019 05; 68(5):1084-1093. PMID: 30833467; PMCID: PMC6477897.
      Citations: 9     Fields:    Translation:Humans
    25. Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab. 2018 12; 18:153-163. PMID: 30316806; PMCID: PMC6308035.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic ß Cell Proliferation. Cell Metab. 2016 Jan 12; 23(1):194-205. PMID: 26701651; PMCID: PMC4715773.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    27. Gupta MK, Teo AK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive Cellular Proliferation Negatively Impacts Reprogramming Efficiency of Human Fibroblasts. Stem Cells Transl Med. 2015 Oct; 4(10):1101-8. PMID: 26253715; PMCID: PMC4572895.
      Citations: 7     Fields:    Translation:HumansCells
    28. El Ouaamari A, Zhou JY, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Aug 07; 14(8):3111-3122. PMID: 26151086; PMCID: PMC4615688.
      Citations: 13     Fields:    Translation:AnimalsCells
    29. Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15; 307(10):E906-18. PMID: 25249504; PMCID: PMC4233258.
      Citations: 20     Fields:    Translation:AnimalsCells
    30. De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. Trends Endocrinol Metab. 2014 Dec; 25(12):628-36. PMID: 25246382.
      Citations: 17     Fields:    Translation:HumansCells
    31. Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo AK, Hu J, Kawamori D, Gaglia JL, Mathis D, Kulkarni RN. Soluble factors secreted by T cells promote ß-cell proliferation. Diabetes. 2014 Jan; 63(1):188-202. PMID: 24089508; PMCID: PMC3868047.
      Citations: 48     Fields:    Translation:AnimalsCells
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