Immunoglobulin Constant Regions
"Immunoglobulin Constant Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The domains of the immunoglobulin molecules that are invariable in their amino acid sequence within any class or subclass of immunoglobulin. They confer biological as well as structural functions to immunoglobulins. One each on both the light chains and the heavy chains comprises the C-terminus half of the IMMUNOGLOBULIN FAB FRAGMENT and two or three of them make up the rest of the heavy chains (all of the IMMUNOGLOBULIN FC FRAGMENT)
| Descriptor ID |
D007127
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| MeSH Number(s) |
D12.776.124.486.485.538 D12.776.124.790.651.538 D12.776.377.715.548.538
|
| Concept/Terms |
Immunoglobulin Constant Regions- Immunoglobulin Constant Regions
- Constant Regions, Immunoglobulin
- Constant Region, Ig
- Immunoglobulin Constant Region
- Constant Region, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Constant Regions".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Constant Regions".
This graph shows the total number of publications written about "Immunoglobulin Constant Regions" by people in this website by year, and whether "Immunoglobulin Constant Regions" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Constant Regions" by people in Profiles.
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The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8155-60.
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Cloning of a hamster anti-mouse CD79B antibody sequences and identification of a new hamster immunoglobulin lambda constant IGLC gene region. Immunogenetics. 2013 Jun; 65(6):473-8.
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Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain. Mol Immunol. 2007 Feb; 44(6):1417-28.
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The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions. J Exp Med. 2005 Nov 21; 202(10):1443-54.
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Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant region. J Immunol Methods. 2005 Nov 30; 306(1-2):93-103.
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Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. J Clin Invest. 2004 Apr; 113(8):1188-201.
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A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Immunity. 2002 Feb; 16(2):245-55.
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Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2282-6.
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Identification and localization of an enhancer for the human lambda L chain Ig gene complex. J Immunol. 1991 Oct 01; 147(7):2354-8.
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Human immunoglobulin G and immunoglobulin G subclasses: biochemical, genetic, and clinical aspects. Crit Rev Clin Lab Sci. 1989; 27(1):27-58.