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A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations.
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A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations.
A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations. Nat Commun. 2014 Oct 30; 5:5352.
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PubMed
subject areas
Amino Acid Sequence
Bacteriophage M13
Cyclopropanes
Drug Resistance, Viral
Evolution, Molecular
Gene Expression
Genetic Techniques
Hepacivirus
Humans
Isoindoles
Isoquinolines
Lactams
Lactams, Macrocyclic
Molecular Sequence Data
Mutation
Peptide Hydrolases
Proline
Protease Inhibitors
Sulfonamides
Viral Proteins
authors with profiles
Bryan Dickinson