"Immunoglobulin J-Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 15 kD "joining" peptide that forms one of the linkages between monomers of IMMUNOGLOBULIN A or IMMUNOGLOBULIN M in the formation of polymeric immunoglobulins. There is one J chain per one IgA dimer or one IgM pentamer. It is also involved in binding the polymeric immunoglobulins to POLYMERIC IMMUNOGLOBULIN RECEPTOR which is necessary for their transcytosis to the lumen. It is distinguished from the IMMUNOGLOBULIN JOINING REGION which is part of the IMMUNOGLOBULIN VARIABLE REGION of the immunoglobulin light and heavy chains.
| Descriptor ID |
D007144
|
| MeSH Number(s) |
D12.776.124.486.485.705.625 D12.776.124.790.651.705.625 D12.776.377.715.548.705.625
|
| Concept/Terms |
Immunoglobulin J-Chains- Immunoglobulin J-Chains
- Immunoglobulin J Chains
- J-Chains, Immunoglobulin
- J Chains, Immunoglobulin
- Immunoglobulin J-Peptide
- Immunoglobulin J Peptide
- J-Peptide, Immunoglobulin
- Ig J-Peptide
- Ig J Peptide
- J-Peptide, Ig
- Immunoglobulin J Polypeptide
- J Polypeptide, Immunoglobulin
- Polypeptide, Immunoglobulin J
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin J-Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin J-Chains".
This graph shows the total number of publications written about "Immunoglobulin J-Chains" by people in this website by year, and whether "Immunoglobulin J-Chains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin J-Chains" by people in Profiles.
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The immunoglobulin J chain is an evolutionarily co-opted chemokine. Proc Natl Acad Sci U S A. 2024 Jan 16; 121(3):e2318995121.
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Putting J chain back on the map: how might its expression define plasma cell development? J Immunol. 2014 Oct 01; 193(7):3248-55.
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Noncoordinate expression of J-chain and Blimp-1 define nurse shark plasma cell populations during ontogeny. Eur J Immunol. 2013 Nov; 43(11):3061-75.
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Heterologous protection induced by the inner capsid proteins of rotavirus requires transcytosis of mucosal immunoglobulins. J Virol. 2002 Aug; 76(16):8110-7.
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Decreased vaginal disease in J-chain-deficient mice following herpes simplex type 2 genital infection. Virology. 2000 May 25; 271(1):155-62.
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Mechanisms of heterosubtypic immunity to lethal influenza A virus infection in fully immunocompetent, T cell-depleted, beta2-microglobulin-deficient, and J chain-deficient mice. J Immunol. 1997 Feb 01; 158(3):1222-30.
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Lack of association of secretory component with IgA in J chain-deficient mice. J Immunol. 1996 Jul 15; 157(2):750-4.
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Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med. 1995 Dec 01; 182(6):1905-11.
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Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul; 19(7):766-76.
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How immunoglobulin V kappa genes rearrange. J Immunol. 1987 Dec 01; 139(11):3834-9.