Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels.

Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels. Pediatr Res. 2002 Jul; 52(1):19-24.

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subject areas

3',5'-Cyclic-GMP Phosphodiesterases
Animals
Cyclic GMP
Cyclic Nucleotide Phosphodiesterases, Type 5
Ductus Arteriosus
Large-Conductance Calcium-Activated Potassium Channels
Oxygen
Phosphodiesterase Inhibitors
Phosphoric Diester Hydrolases
Piperazines
Potassium Channels, Calcium-Activated
Purines
Rabbits
Sildenafil Citrate
Sulfones
Vasoconstriction
Vasodilation

authors with profiles

Stephen Archer